1. Plague

2. Influenza

3. Ornitosis

4. *HIV-infection

5. Legionelosis

OB-12 Quite often the cause of secondary immunodeficiency is an infection involvement, when the causative agents propagate directly in the cells of immune system and destroy it. The following diseases are characterized by:

A Infectious mononucleosis, AIDS

B Tuberculosis, mycobacteriosis

C Poliomyelitis, type A hepatitis

D Dysentery, cholera

E Q-fever, epidemic typhus

b-12 The immunoblot detected gp120 protein in the blood serum. This protein is typical for the

following disease:

A HIV-infection

B Virus B hepatitis

C Tuberculosis

D Syphilis

E Poliomyelitis

b-12 HIV has gp41 and gp120 on its surface interacts with target cells of an organism. Which of the following human lymphocyte antigens is gp120 complementary bound with?

A CD 4

B CD 3

C CD 8

D CD 19

E CD 28

Examination of a young man in the AIDS centre produced a positive result of immune-enzyme

assay with HIV antigens. Patient's complaints about state of his health were absent. What can

the positive result of immune-enzyme assay be evidence of?

A HIV infection

B Being ill with AIDS

C Being infected with HBV

D Having had AIDS recently

E HBV persistence

Hepatitis B virus

175. High-sensitivity methods are used for checking the presence of virus hepatitis B antigens in donors' blood. Which test should be used?

A. *Solid-phase enzyme immunoassay. (ELISA)

D. Complement fixation.

B. Immunoelectrophoresis.

C. Indirect hemagglutination.

E. Indirect immunofluorescence.

196. HBs-antigen has been revealed during enzyme immunoassay in serum. What infection can be diagnosed by this antigen detecting?

A. Syphilis.

B.Virus hepatitis A.

C.AIDS.

D. Tuberculosis.

E.*Virus hepatitis B.

*At donor blood assay one from the markers of hepatitis B infection was revealed. What marker detection does not allow to use this blood for hemotransfusion?

*HBs-antigen

HBc-antigen

HAV

Hbe-antibody

Hbe-antigen

b-12 The donor who for a long time didn't donate the blood was investigated with IFA method. Anti-HBs antibodies were revealed. What does positive result of IFA in this case mean?

A Previous hepatitis B

B Acute hepatitis B

C Acute hepatitis C

D Chronic hepatitis В

E Chronic hepatitis С

*A man, 25-year-old, has fever and jaundice. There were not neither HBsAg nor antibody to HBs-antigen in the blood assay asked by doctor. Which from additional test, most probably, may confirm presence of hepatitis B infection?

*HBeAG

Antibody to HBeAg

Antibody to HBcAg

HBxAg

Delta-antigen

*2013* A patient M. complaining of fever, general weakness, and jaundice, was admitted to infectious department. A doctor suspected hepatitis B infection based onto event, that patient had hemotransfusion some months ago. What basic methods of laboratory diagnostics in case of hepatitis B are?

1. *Serology and gene diagnostics

2. Isolation of a virus into cell culture and identification due to CPE

3. Virion detection in the blood at electron microscopy

4. Isolation of a virus into chicken embryo

5. Isolation of the virus in laboratory animals (neutralization test)

*06* 185. The causative agent of hepatitis D (delta-agent) is a defective virus. It can replicate only in cells already infected with one of the viruses. Which one is possible with?

A. Human immunodeficiency.

B.Hepatitis A.

C.Hepatitis E.

D.Epstein-Barr.

E. *Hepatitis B.

191. A patient with a very grave course of hepatitis B has been administered the examination for detecting the possible concomitant agent, which complicates the course of the basic disease. What agent is this?

A.*Delta-virus.

B.Hepatitis C virus.

C.Hepatitis G virus.

D.Hepatitis E virus.

E.HBs-antigen.

b-12 *01*, *02* 192. During an operative intervention (surgery) a patient had blood transfusion. In this blood the presence of the following causative agent should be checked:

A.*Hepatitis B virus.

B.Hepatitis A virus.

C.Hepatitis E virus.

D.Enteroviruses.

E.Adenoviruses.

*02* A patient with jandice has next result of laboratory assay: HBsAg -, HBeAg -, antiHBsG +, anti HBsМ-, HСAg+. Which diagnosis is confirmed on the base of these data?

Hepatitis C

Chronic hepatitis B with low replicative activity

Repeated infection with hepatitis B

*Hepatitis C, last hepatitis B

Recurrence of hepatitis B

*03* During examination of a donor, which has not being given blood for a long time, antiHBs-antibody was revealed with ELISA. What does positive result indicate in this case?

About chronic hepatitis C

About acute hepatitis C

About chronic hepatitis B

*about recovery after hepatitis B

About acute hepatitis B

Hepatitis A virus

76. A patient with viral hepatitis A was admitted to an infectious hospital. What antibodies will be synthesized first in response to this virus reproduc­tion?

A. IgA.

B.IgG.

C.*IgM.

D. IgD.

E. IgE.

188. In a settlement there is registered an outbreak of hepatitis associated with water factor. What virus could induce this outbreak?

A.Hepatitis G.

B.Hepatitis C.

C.Hepatitis D.

D.*Hepatitis A.

E.Hepatitis B.

* A month after returning from summer camp a child was hospitalized into infectious department. A doctor suspected hepatitis A infection based onto complaints. What is the most probable way of hepatitis A infection in this case?

*Fecal-oral

Via contact

By inhalation of dust

transmissive (via vector)

Parenteral

*07* A outbreak of hepatitis has been registered in region, that is connected with water factor. Which virus could cause this outbreak?

Hepatitis G virus

Hepatitis C virus

Hepatitis D virus

*Hepatitis A (E!) virus

Hepatitis B virus

Hepatitis E virus

*A person with general weakness, subfebrility, icteritious sclera and skin visited a hospital. It is known from history, that he was at seaside and ate seafood without cooking 2 weeks ago. Which markers detection allows confirming diagnosis “acute hepatitis E”?

*IgM anti-HEV

IgM anti-HAV

IgG anti-HEV

IgG anti-HAV

22. 169/ A patient with a very grave course of hepatitis B has been administered the examination for detecting the possible concomitant agent, which complicates the course of the basic disease. What agent is this?

A. Delta-virus.

B.Hepatitis C virus.

C.Hepatitis G virus.

D. Hepatitis E virus.

E.HBs-antigen.

172/ High-sensitivity methods are used for checking the presence of virus hepatitis B antigens in donors' blood. Which test should be used?

A. Solid-phase enzyme immunoassay. (ELISA)

D. Complement fixation.

B. Immunoelectrophoresis.

C. Indirect hemagglutination.

E. Indirect immunofluorescence.

194/ A patient is hospitalized with the previous diagnosis of hepatitis B. To diagnose the disease a serological reaction based on interaction of antigen and antibody, chemically linked to peroxidase or alkaline phosphatase, was carried out. Name this reaction.

a.Complement fixation test.

b. Radioimmunoassay.

c. Immunofluorescence test.

d. Enzyme immunoassay.

e. Immobilization.

“07” 186/ HBs-antigen has been revealed during enzyme immunoassay in serum. What infection can be diagnosed by this antigen detection?

A. Syphilis.

B.Virus hepatitis A.

C.AIDS.

D. Tuberculosis.

E.Virus hepatitis B.

182/ a patient (a dentist by profession) with signs of liver failure was hospitalized into infectious department. Which laboratory assay should be made to diagnose hepatitis B infection?

1. HBs-Ag revealing into patient’s blood

2. Virus isolation from patient’s stool

3. Virus isolation from patient’s urine

4. Detection of functional liver probes (bilirubin and cholesterol in the blood)

5. Detection of the enzyme activity (aldolase, transaminase and others)

22. “2013” In order to eliminate occupational risks dentists underwent vaccination. The vaccine should protect them from virus infection whose pathogen may be found into the blood of dental patients who either have had infection or are the chronic carriers. Which vaccine was used?

    1. Gene-engineered HBs-antigen

    2. Inactivated vaccine for hepatitis A prevention

    3. Alive measles vaccine

    4. Subunit influenza vaccine

    5. Anti-rabies vaccine

23. “B” Doctor M. of surgery department has been vaccinated for prevention of virus hepatitis B. Which marker is revealed into the serum after immunization against hepatitis B?

    1. Anti-HBs

    2. HBsAg

    3. Anti-HBe

    4. DNA of HBV

    5. HBcAg

24. “07” 183/ Dentists belong to a risk group of professional infection with hepatitis B. Indicate the effective way for specific active prevention of this disease among stomatologists:

a. Injection of specific immunoglobulin

b. Making all procedures in rubber gloves

c. Vaccination with recombinant vaccine

d. Injection of interferonogenes

e. Reliable sterilization of medical instruments

22. 195/ Dentists belong to a risk group of professional infection with hepatitis B. Choose the reliable medicine for active prevention of this disease:

a. recombinant vaccine with HBsAg

b. alive hepatitis B vaccine

c. specific immunoglobulin

d. antihepatitic serum

e. monoclonal antibody to HBsAg

6/ medical staff of dental clinic must be vaccinated against virus hepatitis B by creation of artificial active immunity. Which medicine must be used?

1. Inactivated virus has been grown into chicken embryo

2. Γ-globulin from donor blood

3. Specific immunoglobulin

4. Monoclonal antibody

5. Recombinant vaccine from viral antigens

22. 159/ Modern diagnostics of hepatitis B infection is made by viral DNA detection in the patient’s blood. Which from given test is it made with?

    1. Complement fixation test

    2. Passive hemagglutination test

    3. Polymerase chain reaction

    4. ELISA

    5. Inhibition of hemagglutination test

23. 193/ A patient with viral hepatitis A was admitted to an infectious hospital. What antibodies will be synthesized first in response to this virus reproduc­tion?

A. IgA.

B.IgG.

C.IgM.

D. IgD.

E. IgE.

A gene of hepatis B virus responsible for HBsAg production has been integrated with variolavaccine viral genome. Recombinant virus is planned to use as medicine for immunization. Which type does this vaccine belong to?

1. Combine

2. Gene-engineering

3. Associated

4. Synthetic

5. Chemical

Hepatitis viruses

“09” It is known infectious hepatitis B is systemic disease which is caused by hepatitis B virus and characterized mainly with liver damage. From the given later list of medicines choose the medidines for etiotropic therapy of this infection:

1. Acyclovir

2. Ftorquinolones

3. Penicillin

4. Tetracycline

5. Sulfonamides

B-2 /LB Workers of regional hemotransfusion station were immunized with recombinant vaccine. Indicate which disease was prevented in that case: