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What are the diagnostic tests of choice?

What is an MRCP?

What is the management of proximal bile duct cholangiocarcinoma?

What is the management of distal common bile duct cholangiocarcinoma?

Chapter 54 / Biliary Tract 381

Ultrasound, CT scan, ERCP/PTC with biopsy/brushings for cytology, MRCP

MRI with visualization of pancreatic and bile ducts

Resection with Roux-en-Y hepaticojejunostomy (anastomose bile ducts to jejunum) unilateral hepatic lobectomy

Whipple procedure

MISCELLANEOUS CONDITIONS

What is a porcelain

Calcified gallbladder seen on

gallbladder?

abdominal x-ray; results from chronic

 

cholelithiasis/cholecystitis with

 

calcified scar tissue in gallbladder wall;

 

cholecystectomy required because of

 

the strong association of gallbladder

 

carcinoma with this condition

What is hydrops of the gallbladder?

Complete obstruction of the cystic duct by a gallstone, with filling of the

gallbladder with fluid (not bile) from the gallbladder mucosa

What is Gilbert’s syndrome?

Inborn error in liver bilirubin uptake

 

and glucuronyl transferase resulting in

 

hyperbilirubinemia (Think: Gilbert’s

 

Glucuronyl)

What is Courvoisier’s

Palpable, nontender gallbladder (unlike

gallbladder?

gallstone disease) associated with cancer

 

of the head of the pancreas; able to distend

 

because it has not been “scarred down”

 

by gallstones

What is Mirizzi’s syndrome?

Common hepatic duct obstruction as a

 

result of extrinsic compression from a

 

gallstone impacted in the cystic duct

382 Section II / General Surgery

C h a p t e r 55 Pancreas

Identify the regions of the pancreas:

 

1.

Head

 

2.

Neck (in front of the SMV)

 

3.

Uncinate process

 

4.

Body

 

5.

Tail

What structure is the tail of

Spleen

the pancreas said to “tickle”?

 

 

Name the two pancreatic

1. Wirsung duct

ducts.

2.

Santorini duct

Which duct is the main

Duct of Wirsung is the major duct

duct?

(Think: Santorini Small duct)

How is blood supplied to the 1. Celiac trunk S gastroduodenal S head of the pancreas? Anterior superior pancreaticoduodenal

artery

Posterior superior pancreaticoduodenal artery

2.Superior mesenteric artery S Anterior inferior pancreaticoduodenal

artery

Posterior inferior pancreaticoduodenal artery

3.Splenic artery S Dorsal pancreatic artery

Why must the duodenum be removed if the head of the pancreas is removed?

They share the same blood supply (gastroduodenal artery)

What is the endocrine function of the pancreas?

What is the exocrine function of the pancreas?

What maneuver is used to mobilize the duodenum and pancreas and evaluate the entire pancreas?

PANCREATITIS

Chapter 55 / Pancreas 383

Islets of Langerhans:-cells: glucagon-cells: insulin

Digestive enzymes: amylase, lipase, trypsin, chymotrypsin, carboxypeptidase

Kocher maneuver: Incise the lateral attachments of the duodenum and then lift the pancreas to examine the posterior surface

ACUTE PANCREATITIS

What is it?

Inflammation of the pancreas

What are the most common

1. Alcohol abuse (50%)

etiologies in the United

2. Gallstones (30%)

States?

3. Idiopathic (10%)

What is the acronym to

“I GET SMASHED”:

remember all of the causes

Idiopathic

of pancreatitis?

 

 

Gallstones

 

Ethanol

 

Trauma

 

Scorpion bite

 

Mumps (viruses)

 

Autoimmune

 

Steroids

 

Hyperlipidemia

 

ERCP

 

Drugs

What are the symptoms?

Epigastric pain (frequently radiates to

 

back); nausea and vomiting

What are the signs of

Epigastric tenderness

pancreatitis?

Diffuse abdominal tenderness

 

Decreased bowel sounds (adynamic ileus)

 

Fever

 

Dehydration/shock

384 Section II / General Surgery

 

What is the differential

Gastritis/PUD

diagnosis?

Perforated viscus

 

Acute cholecystitis

 

SBO

 

Mesenteric ischemia/infarction

 

Ruptured AAA

 

Biliary colic

 

Inferior MI/pneumonia

What lab tests should be

CBC

ordered?

LFT

 

Amylase/lipase

 

Type and cross

 

ABG

 

Calcium

 

Chemistry

 

Coags

 

Serum lipids

What are the associated

Lab—High amylase, high lipase, high

diagnostic findings?

WBC

 

AXR—Sentinel loop, colon cutoff,

 

possibly gallstones (only 10% visible

 

on x-ray)

 

U/S—Phlegmon, cholelithiasis

 

CT—Phlegmon, pancreatic necrosis

What is the most common

Sentinel loop(s)

sign of pancreatitis on

 

AXR?

 

What is the treatment?

NPO

 

IVF

 

NGT if vomiting

 

/– TPN vs. postpyloric tube feeds

 

H2 blocker/PPI

 

Analgesia (Demerol®, not morphine—

 

less sphincter of Oddi spasm)

 

Correction of coags/electrolytes

 

/– Alcohol withdrawal prophylaxis

 

“Tincture of time”

What are the possible complications?

What is the prognosis?

Are postpyloric tube feeds safe in acute pancreatitis?

What are Ranson’s criteria for the following stages:

At presentation?

During the initial 48 hours?

What is the mortality per positive criteria:

0 to 2?

3 to 4?

5 to 6?

7 to 8?

Chapter 55 / Pancreas 385

Pseudocyst Abscess/infection Pancreatic necrosis

Splenic/mesenteric/portal vessel rupture or thrombosis

Pancreatic ascites/pancreatic pleural effusion

Diabetes ARDS/sepsis/MOF Coagulopathy/DIC Encephalopathy Severe hypocalcemia

Based on Ranson’s criteria

YES

1.Age 55

2.WBC 16,000

3.Glc 200

4.AST 250

5.LDH 350

1.Base deficit 4

2.BUN increase 5 mg/dL

3.Fluid sequestration 6 L

4.Serum Ca2 8

5.Hct decrease 10%

6.PO2 (ABG) 60 mm Hg (Amylase value is NOT one of Ranson’s criteria!)

5%

15%

40%

100%

386 Section II / General Surgery

How can the admission Ranson criteria be remembered?

How can Ranson’s criteria at less than 48 hours be remembered?

GA LAW (Georgia law)”: Glucose 200

Age 55

LDH 350

AST 250 WBC 16,000

(“Don’t mess with the pancreas and don’t mess with the Georgia law”)

C HOBBS (Calvin and Hobbes)”:

Calcium 8 mg/dL

Hct drop of 10%

O2 60 (PaO2)

Base deficit 4

Bun 5 increase

Sequestration 6 L

How can the AST versus

Alphabetically and numerically: A before

LDH values in Ranson’s

L and 250 before 350

criteria be remembered?

Therefore, AST 250 and LDH 350

What is the etiology of

Fat saponification: fat necrosis binds to

hypocalcemia with

calcium

pancreatitis?

 

What complication is

Gastric varices (treatment with

associated with splenic vein

splenectomy)

thrombosis?

 

Can TPN with lipids be given

Yes, if the patient does not suffer from

to a patient with pancreatitis?

hyperlipidemia (triglycerides 300)

What is the least common

Scorpion bite (found on the island of

cause of acute pancreatitis

Trinidad)

(and possibly the most

 

commonly asked cause on

 

rounds!)

 

 

Chapter 55 / Pancreas 387

CHRONIC PANCREATITIS

 

 

 

What is it?

Chronic inflammation of the pancreas

 

region causing destruction of the

 

parenchyma, fibrosis, and calcification,

 

resulting in loss of endocrine and

 

exocrine tissue

What are the subtypes?

1. Chronic calcific pancreatitis

 

2. Chronic obstructive pancreatitis (5%)

What are the causes?

Alcohol abuse (most common; 70% of cases)

 

Idiopathic (15%)

 

Hypercalcemia (hyperparathyroidism)

 

Hyperlipidemia

 

Familial (found in families without any

 

other risk factors)

 

Trauma

 

Iatrogenic

 

Gallstones

What are the symptoms?

Epigastric and/or back pain, weight loss,

 

steatorrhea

What are the associated

Type 1 diabetes mellitus (up to one third)

signs?

Steatorrhea (up to one fourth), weight loss

What are the signs of

Steatorrhea (fat malabsorption from lipase

pancreatic exocrine

insufficiency—stools float in water)

insufficiency?

Malnutrition

What are the signs of

Diabetes (glucose intolerance)

pancreatic endocrine

 

insufficiency?

 

What are the common pain patterns?

What is the differential diagnosis?

What percentage of patients with chronic pancreatitis have or will develop pancreatic cancer?

Unrelenting pain

Recurrent pain

PUD, biliary tract disease, AAA, pancreatic cancer, angina

2%

388 Section II / General Surgery

 

What are the appropriate

Amylase/lipase

lab tests?

72-hour fecal fat analysis

 

Glc tolerance test (IDDM)

Why may amylase/lipase be

Because of extensive pancreatic tissue

normal in a patient with

loss (“burned-out pancreas”)

chronic pancreatitis?

 

What radiographic tests

CT—Has greatest sensitivity for gland

should be performed?

enlargement/atrophy, calcifications,

 

masses, pseudocysts

 

KUB—Calcification in the pancreas

 

ERCP—Ductal irregularities with

 

dilation and stenosis (Chain of Lakes),

 

pseudocysts

What is the medical

Discontinuation of alcohol use—can

treatment?

reduce attacks, though parenchymal

 

damage continues secondary to ductal

 

obstruction and fibrosis

 

Insulin for type 1 diabetes mellitus

 

Pancreatic enzyme replacement

 

Narcotics for pain

What is the surgical

Puestow—longitudinal pancreaticojejunos-

treatment?

tomy (pancreatic duct must be dilated)

 

Duval—distal pancreaticojejunostomy

 

Near-total pancreatectomy

What is the Frey procedure?

Longitudinal pancreaticojejunostomy with

 

core resection of the pancreatic head

What is the indication for

Severe, prolonged/refractory pain

surgical treatment of

 

chronic pancreatitis?

 

What are the possible

Insulin dependent diabetes mellitus

complications of chronic

Steatorrhea

pancreatitis?

Malnutrition

 

Biliary obstruction

 

Splenic vein thrombosis

 

Gastric varices

 

Pancreatic pseudocyst/abscess

 

Narcotic addiction

 

Pancreatic ascites/pleural effusion

 

Splenic artery aneurysm

 

Chapter 55 / Pancreas 389

GALLSTONE PANCREATITIS

 

 

 

What is it?

Acute pancreatitis from a gallstone in or

 

passing through the ampulla of Vater (the

 

exact mechanism is unknown)

How is the diagnosis made?

Acute pancreatitis and cholelithiasis

 

and/or choledocholithiasis and no other

 

cause of pancreatitis (e.g., no history of

 

alcohol abuse)

What radiologic tests should

U/S to look for gallstones

be performed?

CT to look at the pancreas, if symptoms

 

are severe

What is the treatment?

Conservative measures and early

 

interval cholecystectomy (laparoscopic

 

cholecystectomy or open cholecystectomy)

 

and intraoperative cholangiogram (IOC) 3 to

 

5 days (after pancreatic inflammation resolves)

Why should early interval cholecystectomy be performed on patients with gallstone pancreatitis?

What is the role of ERCP?

HEMORRHAGIC PANCREATITIS

Pancreatitis will recur in 33% of patients within 8 weeks (so always perform early interval cholecystectomy and IOC in 3 to 5 days when pancreatitis resolves)

1.Cholangitis

2.Refractory choledocholithiasis

What is it?

Bleeding into the parenchyma and

 

retroperitoneal structures with extensive

 

pancreatic necrosis

What are the signs?

Abdominal pain, shock/ARDS, Cullen’s

 

sign, Grey Turner’s sign, Fox’s sign

Define the following terms:

 

Cullen’s sign

Bluish discoloration of the

 

periumbilical area from retroperitoneal

 

hemorrhage tracking around to the

 

anterior abdominal wall through fascial

 

planes

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