- •Dedication
- •Editors and Contributors
- •Foreword
- •Preface
- •Contents
- •PREPARING FOR THE SURGERY CLERKSHIP
- •SURGICAL NOTES
- •COMMON ABBREVIATIONS YOU SHOULD KNOW
- •RETRACTORS (YOU WILL GET TO KNOW THEM WELL!)
- •SUTURE MATERIALS
- •WOUND CLOSURE
- •KNOTS AND EARS
- •INSTRUMENT TIE
- •TWO-HAND TIE
- •COMMON PROCEDURES
- •NASOGASTRIC TUBE (NGT) PROCEDURES
- •CHEST TUBES
- •NASOGASTRIC TUBES (NGT)
- •FOLEY CATHETER
- •CENTRAL LINES
- •MISCELLANEOUS
- •THIRD SPACING
- •COMMON IV REPLACEMENT FLUIDS (ALL VALUES ARE PER LITER)
- •CALCULATION OF MAINTENANCE FLUIDS
- •ELECTROLYTE IMBALANCES
- •ANTIBIOTICS
- •STEROIDS
- •HEPARIN
- •WARFARIN (COUMADIN®)
- •MISCELLANEOUS AGENTS
- •NARCOTICS
- •MISCELLANEOUS
- •ATELECTASIS
- •POSTOPERATIVE RESPIRATORY FAILURE
- •PULMONARY EMBOLISM
- •ASPIRATION PNEUMONIA
- •GASTROINTESTINAL COMPLICATIONS
- •ENDOCRINE COMPLICATIONS
- •CARDIOVASCULAR COMPLICATIONS
- •MISCELLANEOUS
- •HYPOVOLEMIC SHOCK
- •SEPTIC SHOCK
- •CARDIOGENIC SHOCK
- •NEUROGENIC SHOCK
- •MISCELLANEOUS
- •URINARY TRACT INFECTION (UTI)
- •CENTRAL LINE INFECTIONS
- •WOUND INFECTION (SURGICAL SITE INFECTION)
- •NECROTIZING FASCIITIS
- •CLOSTRIDIAL MYOSITIS
- •SUPPURATIVE HIDRADENITIS
- •PSEUDOMEMBRANOUS COLITIS
- •PROPHYLACTIC ANTIBIOTICS
- •PAROTITIS
- •MISCELLANEOUS
- •CHEST
- •ABDOMEN
- •MALIGNANT HYPERTHERMIA
- •MISCELLANEOUS
- •OVERVIEW
- •CHOLECYSTOKININ (CCK)
- •SECRETIN
- •GASTRIN
- •SOMATOSTATIN
- •MISCELLANEOUS
- •GROIN HERNIAS
- •HERNIA REVIEW QUESTIONS
- •ESOPHAGEAL HIATAL HERNIAS
- •PRIMARY SURVEY
- •SECONDARY SURVEY
- •TRAUMA STUDIES
- •PENETRATING NECK INJURIES
- •MISCELLANEOUS TRAUMA FACTS
- •PEPTIC ULCER DISEASE (PUD)
- •DUODENAL ULCERS
- •GASTRIC ULCERS
- •PERFORATED PEPTIC ULCER
- •TYPES OF SURGERIES
- •STRESS GASTRITIS
- •MALLORY-WEISS SYNDROME
- •ESOPHAGEAL VARICEAL BLEEDING
- •BOERHAAVE’S SYNDROME
- •ANATOMY
- •GASTRIC PHYSIOLOGY
- •GASTROESOPHAGEAL REFLUX DISEASE (GERD)
- •GASTRIC CANCER
- •GIST
- •MALTOMA
- •GASTRIC VOLVULUS
- •SMALL BOWEL
- •APPENDICITIS
- •CLASSIC INTRAOPERATIVE QUESTIONS
- •APPENDICEAL TUMORS
- •SPECIFIC TYPES OF FISTULAS
- •ANATOMY
- •COLORECTAL CARCINOMA
- •COLONIC AND RECTAL POLYPS
- •POLYPOSIS SYNDROMES
- •DIVERTICULAR DISEASE OF THE COLON
- •ANATOMY
- •ANAL CANCER
- •ANATOMY
- •TUMORS OF THE LIVER
- •ABSCESSES OF THE LIVER
- •HEMOBILIA
- •ANATOMY
- •PHYSIOLOGY
- •PATHOPHYSIOLOGY
- •DIAGNOSTIC STUDIES
- •BILIARY SURGERY
- •OBSTRUCTIVE JAUNDICE
- •CHOLELITHIASIS
- •ACUTE CHOLECYSTITIS
- •ACUTE ACALCULOUS CHOLECYSTITIS
- •CHOLANGITIS
- •SCLEROSING CHOLANGITIS
- •GALLSTONE ILEUS
- •CARCINOMA OF THE GALLBLADDER
- •CHOLANGIOCARCINOMA
- •MISCELLANEOUS CONDITIONS
- •PANCREATITIS
- •PANCREATIC ABSCESS
- •PANCREATIC NECROSIS
- •PANCREATIC PSEUDOCYST
- •PANCREATIC CARCINOMA
- •MISCELLANEOUS
- •ANATOMY OF THE BREAST AND AXILLA
- •BREAST CANCER
- •DCIS
- •LCIS
- •MISCELLANEOUS
- •MALE BREAST CANCER
- •BENIGN BREAST DISEASE
- •CYSTOSARCOMA PHYLLODES
- •FIBROADENOMA
- •FIBROCYSTIC DISEASE
- •MASTITIS
- •BREAST ABSCESS
- •MALE GYNECOMASTIA
- •ADRENAL GLAND
- •ADDISON’S DISEASE
- •INSULINOMA
- •GLUCAGONOMA
- •SOMATOSTATINOMA
- •ZOLLINGER-ELLISON SYNDROME (ZES)
- •MULTIPLE ENDOCRINE NEOPLASIA
- •THYROID DISEASE
- •ANATOMY
- •PHYSIOLOGY
- •HYPERPARATHYROIDISM (HPTH)
- •PARATHYROID CARCINOMA
- •SOFT TISSUE SARCOMAS
- •LYMPHOMA
- •SQUAMOUS CELL CARCINOMA
- •BASAL CELL CARCINOMA
- •MISCELLANEOUS SKIN LESIONS
- •STAGING
- •INTENSIVE CARE UNIT (ICU) BASICS
- •INTENSIVE CARE UNIT FORMULAS AND TERMS YOU SHOULD KNOW
- •SICU DRUGS
- •INTENSIVE CARE PHYSIOLOGY
- •HEMODYNAMIC MONITORING
- •MECHANICAL VENTILATION
- •PERIPHERAL VASCULAR DISEASE
- •LOWER EXTREMITY AMPUTATIONS
- •ACUTE ARTERIAL OCCLUSION
- •ABDOMINAL AORTIC ANEURYSMS
- •MESENTERIC ISCHEMIA
- •MEDIAN ARCUATE LIGAMENT SYNDROME
- •CAROTID VASCULAR DISEASE
- •CLASSIC CEA INTRAOP QUESTIONS
- •SUBCLAVIAN STEAL SYNDROME
- •RENAL ARTERY STENOSIS
- •SPLENIC ARTERY ANEURYSM
- •POPLITEAL ARTERY ANEURYSM
- •MISCELLANEOUS
- •PEDIATRIC IV FLUIDS AND NUTRITION
- •PEDIATRIC BLOOD VOLUMES
- •FETAL CIRCULATION
- •ECMO
- •NECK
- •ASPIRATED FOREIGN BODY (FB)
- •CHEST
- •PULMONARY SEQUESTRATION
- •ABDOMEN
- •INGUINAL HERNIA
- •UMBILICAL HERNIA
- •GERD
- •CONGENITAL PYLORIC STENOSIS
- •DUODENAL ATRESIA
- •MECONIUM ILEUS
- •MECONIUM PERITONITIS
- •MECONIUM PLUG SYNDROME
- •ANORECTAL MALFORMATIONS
- •HIRSCHSPRUNG’S DISEASE
- •MALROTATION AND MIDGUT VOLVULUS
- •OMPHALOCELE
- •GASTROSCHISIS
- •POWER REVIEW OF OMPHALOCELE AND GASTROSCHISIS
- •APPENDICITIS
- •INTUSSUSCEPTION
- •MECKEL’S DIVERTICULUM
- •NECROTIZING ENTEROCOLITIS
- •BILIARY TRACT
- •TUMORS
- •PEDIATRIC TRAUMA
- •OTHER PEDIATRIC SURGERY QUESTIONS
- •POWER REVIEW
- •WOUND HEALING
- •SKIN GRAFTS
- •FLAPS
- •SENSORY SUPPLY TO THE HAND
- •CARPAL TUNNEL SYNDROME
- •ANATOMY
- •MISCELLANEOUS
- •NOSE AND PARANASAL SINUSES
- •ORAL CAVITY AND PHARYNX
- •FACIAL FRACTURES
- •ENT WARD QUESTIONS
- •RAPID-FIRE REVIEW OF MOST COMMON CAUSES OF ENT INFECTIONS
- •THORACIC OUTLET SYNDROME (TOS)
- •CHEST WALL TUMORS
- •DISEASES OF THE PLEURA
- •DISEASES OF THE LUNGS
- •DISEASES OF THE MEDIASTINUM
- •DISEASES OF THE ESOPHAGUS
- •ACQUIRED HEART DISEASE
- •CONGENITAL HEART DISEASE
- •CARDIAC TUMORS
- •DISEASES OF THE GREAT VESSELS
- •MISCELLANEOUS
- •BASIC IMMUNOLOGY
- •CELLS
- •IMMUNOSUPPRESSION
- •OVERVIEW OF IMMUNOSUPPRESSION MECHANISMS
- •MATCHING OF DONOR AND RECIPIENT
- •REJECTION
- •ORGAN PRESERVATION
- •KIDNEY TRANSPLANT
- •LIVER TRANSPLANT
- •PANCREAS TRANSPLANT
- •HEART TRANSPLANT
- •INTESTINAL TRANSPLANTATION
- •LUNG TRANSPLANT
- •TRANSPLANT COMPLICATIONS
- •ORTHOPAEDIC TERMS
- •TRAUMA GENERAL PRINCIPLES
- •FRACTURES
- •ORTHOPAEDIC TRAUMA
- •DISLOCATIONS
- •THE KNEE
- •ACHILLES TENDON RUPTURE
- •ROTATOR CUFF
- •MISCELLANEOUS
- •ORTHOPAEDIC INFECTIONS
- •ORTHOPAEDIC TUMORS
- •ARTHRITIS
- •PEDIATRIC ORTHOPAEDICS
- •HEAD TRAUMA
- •SPINAL CORD TRAUMA
- •TUMORS
- •VASCULAR NEUROSURGERY
- •SPINE
- •PEDIATRIC NEUROSURGERY
- •SCROTAL ANATOMY
- •UROLOGIC DIFFERENTIAL DIAGNOSIS
- •RENAL CELL CARCINOMA (RCC)
- •BLADDER CANCER
- •PROSTATE CANCER
- •BENIGN PROSTATIC HYPERPLASIA
- •TESTICULAR CANCER
- •TESTICULAR TORSION
- •EPIDIDYMITIS
- •PRIAPISM
- •ERECTILE DYSFUNCTION
- •CALCULUS DISEASE
- •INCONTINENCE
- •URINARY TRACT INFECTION (UTI)
- •MISCELLANEOUS UROLOGY QUESTIONS
- •Rapid Fire Power Review
- •TOP 100 CLINICAL SURGICAL MICROVIGNETTES
- •Figure Credits
- •Index
Chapter 45 / Appendix 299
CLASSIC INTRAOPERATIVE QUESTIONS
What is the difference between a McBurney’s incision and a Rocky-Davis incision?
What are the layers of the abdominal wall during a McBurney incision?
What are the steps in laparoscopic appendectomy (lap appy)?
Do you routinely get peritoneal cultures for acute appendicitis (nonperforated)?
How can you find the appendix after identifying the cecum?
Which way should your finger sweep trying to find the appendix?
How do you get to a retrocecal and
retroperitoneal appendix?
Why use electrocautery on the exposed mucosa on the appendiceal stump?
McBurney’s is angled down (follows ext oblique fibers), and Rocky-Davis is straight across (transverse)
1.Skin
2.Subcutaneous fat
3.Scarpa’s fascia
4.External oblique
5.Internal oblique
6.Transversus muscle
7.Transversalis fascia
8.Preperitoneal fat
9.Peritoneum
1.Identify the appendix
2.Staple the mesoappendix (or coagulate)
3.Staple and transect the appendix at the base (or use Endoloop® and cut between)
4.Remove the appendix from the abdomen
5.Irrigate and aspirate until clear
No
Follow the taeniae down to where they converge on the appendix
Lateral to medial along the lateral peritoneum—this way you will not tear the mesoappendix that lies medially!
Divide the lateral peritoneal attachments of the cecum
To kill the mucosal cells so they do not form a mucocele
300 Section II / General Surgery |
|
If you find Crohn’s disease |
Yes, if the cecal/appendiceal base is not |
in the terminal ileum, will |
involved |
you remove the appendix? |
|
If the appendix is normal |
Terminal ileum: Meckel’s diverticulum, |
what do you inspect |
Crohn’s disease, intussusception |
intraoperatively? |
Gynecologic: Cysts, torsion, etc. |
|
Groin: hernia, rectus sheath hematoma, |
|
adenopathy (adenitis) |
Who first described the |
Reginald Fitz |
classic history and treatment |
|
for acute appendicitis? |
|
Who performed the first |
Harry Hancock in 1848 (McBurney |
appendectomy? |
popularized the procedure in 1880s) |
Who performed the first lap |
Dr. Semm (GYN) in 1983 |
appy? |
|
APPENDICEAL TUMORS |
|
|
|
What is the most common |
Carcinoid tumor |
appendiceal tumor? |
|
What is the treatment of |
Appendectomy (if not through the bowel |
appendiceal carcinoid less |
wall) |
than 1.5 cm? |
|
What is the treatment of |
Right hemicolectomy |
appendiceal carcinoid larger |
|
than 1.5 cm? |
|
What percentage of |
5% |
appendiceal carcinoids are |
|
malignant? |
|
What is the differential |
Carcinoid, adenocarcinoma, malignant |
diagnosis of appendiceal |
mucoid adenocarcinoma |
tumor? |
|
What type of appendiceal |
Malignant mucoid adenocarcinoma |
tumor can cause the dreaded |
|
pseudomyxoma peritonei if |
|
the appendix ruptures? |
|
|
Chapter 46 / Carcinoid Tumors 301 |
What is “mittelschmerz”? |
Pelvic pain caused by ovulation |
Should one remove the |
Yes, unless the base of the appendix is |
normal appendix with |
involved with Crohn’s disease, the normal |
Crohn’s disease found |
appendix should be removed to avoid |
intraoperatively? |
diagnostic confusion with appendicitis in |
|
the future |
C h a p t e r 46 Carcinoid Tumors
What is a carcinoid tumor?
Tumor arising from neuroendocrine cells (APUDomas), a.k.a. Kulchitsky cells; basically, a tumor that secretes serotonin
Why is it called “carcinoid”? Suffix “-oid” means “resembling”; thus, carcinoid resembles a carcinoma but is clinically and histologically less aggressive than most GI carcinomas
How can you remember that Kulchitsky cells are found in carcinoid tumors?
What is the incidence?
What are the common sites of occurrence?
Think: “COOL CAR” or KULchitsky CARcinoid
Between 0.2% and 1.0% and about 25% of all small bowel tumors
“AIR”:
1.Appendix (most common)
2.Ileum
3.Rectum
4.Bronchus
Other sites: jejunum, stomach, duodenum, colon, ovary, testicle, pancreas, thymus
What are the signs/ |
Depends on location; most cases are |
symptoms? |
asymptomatic; also SBO, abdominal |
|
pain, bleeding, weight loss, diaphoresis, |
|
pellagra skin changes, intussusception, |
|
carcinoid syndrome, wheezing |
Why SBO with carcinoid? |
Classically severe mesenteric fibrosis |
302 Section II / General Surgery |
|
|
What are the pellagra-like |
Think “3-D”: |
|
symptoms? |
1. |
Dermatitis |
|
2. |
Diarrhea |
|
3. |
Dementia |
What causes pellagra in |
Decreased niacin production |
|
carcinoid patients? |
|
|
What is carcinoid syndrome? |
Syndrome of symptoms caused by release |
|
|
of substances from a carcinoid tumor |
|
What are the symptoms of |
Remember the acronym “B FDR”: |
|
carcinoid syndrome? |
Bronchospasm |
Flushing (skin) Diarrhea
Right-sided heart failure (from valve failure)
What is a complete memory aid for carcinoid?
Why does right-sided heart failure develop but not left-sided heart failure?
What is the incidence of carcinoid SYNDROME in patients who have a carcinoid TUMOR?
Think: B FDR CARcinoid, or “Be FDR in a cool CAR” (COOL KULchitsky cells)
Lungs act as a filter (just like the liver); thus, the left heart doesn’t see all the vasoactive compounds
10%
What released substances |
Serotonin and vasoactive peptides |
cause carcinoid syndrome? |
|
What is the medical treatment |
Octreotide IV |
for carcinoid syndrome? |
|
What is the medical |
Odansetron (Zofran®)—serotonin |
treatment of diarrhea alone? |
antagonist |
How does the liver prevent carcinoid syndrome?
Why does carcinoid syndrome occur in some tumors and not in others?
What tumors can produce carcinoid syndrome?
Chapter 46 / Carcinoid Tumors 303
By degradation of serotonin and the other vasoactive peptides when the tumor drains into the portal vein
Occurs when venous drainage from the tumor gains access to the systemic circulation by avoiding hepatic degradation of the vasoactive substances
Liver metastases
Retroperitoneal disease draining into paravertebral veins
Primary tumor outside the GI tract, portal venous drainage (e.g., ovary, testicular, bronchus), or both
What does the liver break down serotonin into?
What percentage of patients with a carcinoid have an elevated urine 5-HIAA level?
5-hydroxyindoleacetic acid (5-HIAA)
50%
What are the associated |
Elevated urine 5-HIAA as well as |
diagnostic lab findings? |
elevated urine and blood serotonin |
|
levels |
How do you remember |
Think of a 5-HIGH CAR pile up |
5-HIAA for carcinoid? |
5-HIAA CARcinoid |
hrf
‘07
5
4 3
2
1
What stimulation test can |
Pentagastrin stimulation |
often elevate serotonin |
|
levels and cause symptoms |
|
of carcinoid syndrome? |
|
304 Section II / General Surgery
How do you localize a GI carcinoid?
What are the special radiologic (scintigraphy) localization tests?
What is the surgical treatment?
What is the medical treatment?
How effective is octreotide?
Barium enema, upper GI series with small bowel follow-through, colonoscopy, enteroscopy, enteroclysis, EGD, radiology tests
131I-MIBG (131 metaiodobenzylguanidine)
111In-octreotide
PET scan utilizing 11C-labeled HTP
Excision of the primary tumor and single or feasible metastasis in the liver (liver transplant is an option with unresectable liver metastasis); chemotherapy for advanced disease
Medical therapy for palliation of the carcinoid syndrome (serotonin antagonists, somatostatin analogue [octreotide])
It relieves diarrhea and flushing in more than 85% of cases and may shrink tumor in 10% to 20% of cases
What is a common |
Cyproheptadine |
antiserotonin drug? |
|
What is the overall prognosis? |
Two thirds of patients are alive at 5 years |
What is the prognosis of |
50% are alive at 3 years |
patients with liver metastasis |
|
or carcinoid syndrome? |
|
What does carcinoid tumor look like?
For appendiceal carcinoid, when is a right hemicolectomy indicated versus an appendectomy?
Which primary site has the highest rate of metastasis?
Can a carcinoid tumor be confirmed malignant by looking at the histology?
Usually intramural bowel mass; appears as yellowish tumor upon incision
If the tumor is 1.5 cm, right hemicolectomy is indicated; if there are no signs of serosal or cecal involvement and tumor is 1.5 cm, appendectomy should be performed
Ileal primary tumor
No, metastasis must be present to diagnose malignancy