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Renitec

Indications.

Renitec is indicated in the treatment of all grades of essential hypertension and in renovascular hypertension. It may be used alone as initial therapy or concomitantly with other antihypertensive agents, especially diuretics. Renitec is also indicated in the treatment of heart failure.

Dosage and administration.

Since absorption of Tablets Renitec is not affected by blood, the tablets may be administered before, during or after meals.

Essential Hypertension.

The initial dose is 10 to 20mg depending on the degree of hypertension, and is given once daily. The recommended initial dose is 10mg daily. For other degrees of hypertension the initial dose is 20mg daily. The usual maintenance dose is one 20mg tablet taken once daily. The dosage should be adjusted to the needs of the patient to a maximum of 40mg daily.

Heart Failure.

The initial dose of Renitec in patients with heart failure is 25mg and it should be administered under close medical supervision to determine the initial effects on the blood pressure. In the absence of or after effective management of symptomatic hypertension following initiation of therapy with Renitec in heart failure, the dose should be increased gradually to the initial maintenance dose of 20mg given in a single dose of two divided doses as tolerated by the patient. This dose titration may be performed over a 2 to 4 weeks period, or more rapidly if indicated by the presence of residual signs and symptoms of heart failure. This dosage regimen was effective in reducing mortality.

Contraindications.

Renitec is contraindicated in patients who are hypersensitive to any component of this product and in patients with a history of angioneurotic edema relating to previous treatment with an angiotensive – converting enzyme inhibitor.

Precautions.

Symptomatic hypertension, renal function impairment.

Drug interactions.

Additive effect may occur when Renitec is used together with other antihypertensive therapy.

Side effects.

Renitec has been demonstrated to be generally well tolerated in clinical studies, the overall incidence of side effects was no greater with Renitec than with placebo. For the most part, side effects have been mild and transiet in nature and have not required discontinuation of therapy. The following side effects have been associated with the use of tablets and injections Renitec: Dizziness and headache were the most commonly reported side effects. Fatigue and asthenia were reported in 2-3% of patients. Other side effects occurred in less than 2% of patients and included hypertension, nausea, diarrhea, muscle cramps, rash and cough.

Ex. 23.

A. 1. Scan the text "Congenital heart disease".

2. Find and translate the sentences in which the following word-combinations are used: certain abnormalities, spectacular advances, prior to birth, the blood is detoured around, sufficient quantity.

3. Express the main idea of the text in several sentences. Congenital heart disease

This category of heart disease includes certain abnormalities which have been present since birth and which usually represent a failure of normal development. In recent years many of these congenital defects have been remedied by heart surgery, one of the most spectacular advances in modern medicine.

The circulation of the fetus differs in several respects from that of the child after birth, one difference being that the lungs are not used until the child is born. Prior to birth the unused lungs are bypassed by a blood vessel which normally closes of its own once the lungs are in use. Sometimes, however, the vessels fail to close with the results that much of the blood is detoured around the lungs instead of through them, and therefore the blood does not receive enough oxygen. This condition can be corrected by surgery.

Another congenital heart defect is an obstruction of narrowing of pulmonary artery, which prevents the blood from passing in sufficient quantity from the right ventricle to the lungs. This condition also can be remedied by surgery.

B. 1. Read the text “Rheumatic fever and the heart”.