Гистология книги2 / Репин В.С., Ржанинова А.А. - Эмбриональные стволовые клетки
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(Gershon A.A., Ridnick J., Kalam L. et al., 2000).
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goosecoid
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goosecoid (Boncinelli E., Mallamaci A., 1995).
goosecoid .
noggin, chordin, follistatin, Xnr3
-7/ -4,
. ( FGF -2, FGF-5, Wnt1, Wnt3, Sonic Hedgehog - SHH-A) .
SHH-/-
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. ( 2-2). Mash-1 -/-
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(Helms A.W., Abney A.L., Ben-Arie N. et al., 2000).
102
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SHH |
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Chordin |
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BMP4 BMP7 |
Noggin |
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Follistetin |
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TGF- |
Xnr3 |
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FGF-2 |
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FGF-5 |
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Wnt-1 |
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Wnt-3 |
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2-2.
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TGF-beta). -3 -6
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Noggin, |
chordin, follistatin |
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SHH |
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SHH-A,
RPTK ( Conti L., Sipione S., Magrassi L. et al , 2001). SHC-A
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, (Dalstrand J., Lardelli M., Lendahl U.,1995).
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(Doetsch, F., Caille, I., Lim, D.A., et al., 1999). in situ ,
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(Lim D.A., Tramontin A.D.,Trevejo J.M. et al., 2000). bFGF, EGF
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(Abe K., Saito H., 2001; Fricker-Gates R.A., Winkler C., Kirik D. et al.,2000)
Noggin -4.
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-4 -7.
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105
1999).
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( Catala M., 1998). in vitro
( Gabrion J.B., Herbute S., Bouille C. et al., 1998)
« » ,
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= 1-2,5%) ( Kalyani A., Hobson K., Rao M.S., 1997).
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bFGF + .
, 1-5 % GFAP.
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, , EGF,bFGF, NGF ( Kalyani A., Hobson K., Rao M.S., 1997). ,
106
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pia mater.
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FGF-2. |
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