6.To investigate the problem of anesthesia drugs influence on the children at birth and afterwards (could they be the reason for fetal hypoxia and newborn asphyxia?).

7.To make the differential study of the newborns’ traumas and their reasons in the maternity house № 5.

“Pharmacotherapy in obstetrics.Pharmacokinetics and pharmacodynamics of medical drugs”

1.Actually of theme.

Acceptability of use different medicines during pregnancy is a very important question, as setting pregnant potentially dangerous medication can harm a fetus. Also it is important, as exactly presence at many preparations of contra-indications in relation to application during pregnancy considerably limits possibilities of high-quality valuable treatment in this period. It is necessary to remember that graviora quadem sunt remedia persculis (some

medications worse illnesses – lat.)

2. Goal of the study.

- Academical:

Acquaint the students with the pharmacotherapy in obstetrics, pharmacokinetics and pharmacodynamics of medical drugs.

- Educational:

In the process of teaching of material for students clinical thought is formed within the limits of this theme which in future will allow to decide a question related to setting of medicinal preparations during pregnancy.

I.Objectives

1.Recognize factors which determine drug passage across the placenta and into breast milk.

2.Identify aspects of medications that determine safety during lactation.

3.Review anti-infectives and migraine meds in pregnancy and lactation

II.Teratogens

• A substance, organism, physical agents or deficiency state capable of inducing abnormal structure or function such as:

–Gross structural abnormalities

–Functional deficiencies

–Intrauterine growth restriction

–Behavioral aberrations

–Demise

III.Teratogenic Factors

• Timing of exposure

• Developmental stage during exposure

• Maternal dose and duration

• Maternal pharmacokinetics