- •Scope
- •What Genes are Mutated in Cancers?
- •Principles of Systemic Therapy
- •Cancer Chemotherapy
- •Cancer Chemotherapy
- •Clinical Application of Chemotherapy
- •Primary Induction Chemotherapy
- •Primary Induction Chemotherapy
- •Primary Induction Chemotherapy
- •Palliative Chemotherapy
- •Neoadjuvant Chemotherapy
- •Neoadjuvant Chemotherapy
- •Neoadjuvant Chemotherapy
- •Adjuvant Chemotherapy
- •Adjuvant Chemotherapy
- •Adjuvant Chemotherapy
- •Molecular Targets in Oncology
- •Approved EGFR-Targeted Therapies
- •Conclusion
Palliative Chemotherapy
Small cell lung cancer
Bladder cancer
Breast cancer
Cervical cancer
Colorectal cancer
Esophageal cancer
Gastric cancer
Head and neck cancer
Nasopharyngeal cancer
Non small cell lung cancer
Ovarian cancer
Pancreatic cancer
Prostate cancer
Neoadjuvant Chemotherapy
Administration of chemotherapy to cancer patients with localized diseases before local treatments
Localized cancers for which alternative local therapies exist but less than completely effective
Neoadjuvant Chemotherapy
Advantages:
àPreservation of tumor mass as a biologic marker of chemosensitivity
àSparing of vital normal organs: larynx, anal sphinctor, bladder
àTreating micrometastatic disease
Clinical end points:
àResponse rate
àProgression-free survival
àOverall survival
Neoadjuvant Chemotherapy
Anal cancer
Bladder cancer
Breast cancer
Esophageal cancer
Head and neck cancer
Non small cell lung cancer
Osteogenic sarcoma
Rectal cancer
Soft tissue sarcoma