In hypothyroidism the following type of hyperlipoproteinemia (according Fridricson e. Classification) is evident:

*A. Type IV

B. Type V

C. Type II

D. Type I

E. Type III

Which of the following is present intracellulary in muscular cells:

A. Epinephrine

B. Insulin

C. Glucagon

*D. Corticosteroid

E. Nor-epinephrine

Steroid-receptor complex binds to a specific region on DNA through:

A. Leucine zipper motif

*B. Zinc finger motif

C. Histone

D. Helix turn helix

E. Histidine

Periodic renal colics attacks are observed in a woman with primary hyperparathyroidizm. Ultrasonic examination revealed small stones in the kidneys. What is the most plausible reason of the stones's formation?

A. Hyperuricemia

B. Hypercholesterinemia

C. Hyperkalemia

*D. Hypercalcemia

E. Hyperphosphatemia

Biochemical abnormalities in primary hyperparathyroidism is the change in the blood plasma:

*A. Increase calcium, decrease phosphate

B. Increase calcium, increase phosphate

C. None of the proposed

D. Decrease calcium, increase phosphate

E. Decrease calcium, decrease phosphate -

Which of the following amino acid residues in the structure of thyroglobulin is involved in the synthesis of thyroxine?

A. Cysteine

*B. Tyrosine

C. Glycine

D. Methionine

E. Threonine

A girl has been diagnosed with adrenogenital syndrome (pseudohermaphroditism). This pathology is caused by hypersecretion of the following adrenal hormone:

A. Glucocorticoids

B. Catecholamines

*C. Androgens

D. Estrogens

E. Mineralocorticoids

Estrogen receptors are seen in:

A. Cytoplasmic membrane bound

B. Microsomes

C. Mitochondria

*D. Nucleus

E. EPR rough part

A 2 y.o child has convulsions as a result of reduced concentration of calcium ions in the blood plasma. It is caused by the reduced function of:

A. Adrenal cortex

*B. Parathyroid glands

C. Pineal gland

D. Hypophysis

E. Thymus

Point out the most important function of androgens in muscles:

A. To inhibit lipogenesis

B. To stimulate muscular contraction

C. To stimulate lipolysis

*D. To stimulate protein synthesis

E. To stimulate protein degradation

The precursor of testosterone is:

A. Aldosterone

B. Cortisol

*C. Pregnenolone

D. Methyl testosterone

E. Estrone

Name the precursor for calcitriol formation:

A. Arachidonic acid

*B. Cholesterol

C. Citric acid

D. Stearic acid

E. Linolenic acid

A 4 year old child with hereditary renal lesion has signs of rickets, vitamin D concentration in blood is normal. What is the most probable cause of rickets development?

A. Inreased excretion of calcium

B. Hyperfunction of parathyroid glands

C. Hypofunction of parathyroid glands

D. Lack of calcium in food

*E. Impaired synthesis of calcitriol

Kidneys of a man under examination show increased reabsorption of calcium ions and decreased reabsorption of phosphate ions. What hormone causes this phenomenon?

A. Calcitriol

*B. Parathormone

C. Thyrocalcitonin

D. Aldosterone

E. Vasopressin

The biochemical research of the patient's blood confirmed the hypoglycemia, abnormally high potassium concentration and low sodium concentration. Point out the hormones whose secretion is violated:

A. Insulin

B. All the hormones from anterior lobe of pituitary gland

C. Calcitonin

*D. Glucocorticoids, aldosterone

E. Thyroid hormones T3, T4

Thyrotoxicosis leads to increased production of thyroidal hormones T3 and T4, weight loss, tachycardia, psychic excitement and so on. How do thyroidal hormones influence energy metabolism in the mitochondrion of cells?

*A. Uncouple the oxidative phosphorylation

B. Activate substrate phosphorylation

C. Activate oxidative phosphorylation

D. Stop respiratory chain

E. Stop substrate phosphorylation

Point out the major sex hormone of luteal phase in females:

A. Aldosterone

*B. Progesterone

C. Androstenedione

D. Cortisol

E. 17-ketosteroid

Hypocalciemia can be caused by the violation of one hormone secretion. Point out this hormone:

A. Thyroxine

B. Somatotropic hormone

C. Corticotropic hormone

*D. Parathyroid hormone

E. Aldosterone

A patient has osmotic pressure of blood plasma at the rate of 350 mOsmol/l (norm is 300 mOsmol/l). This will cause hypersecretion of the following hormone:

A. Vasopressin

B. Cortisol

C. Adrenocorticotropin

D. Aldosterone

*E. Natriuretic

Examination of a patient revealed overgrowth of facial bones and soft tissues, tongue enlargement, wide interdental spaces in the enlarged dental arch. What changes of the hormonal secretion are the most likely?

A. Hypersecretion of insulin

*B. Hypersecretion of the somatotropic hormone

C. Hyposecretion of the somatotropic hormone

D. Hyposecretion of insulin

E. Hyposecretion of thyroxine

A middle-aged man went to a foreign country because he had been offered a job there. However he had been unemployed for quite a long time. What endocrine glands were exhausted most of all in this man?

A. Parathyroid glands

B. Seminal glands

C. Thyroid gland

*D. Adrenal glands

E. Substernal gland

Choose the true about prostaglandins:

A. Some require cAMP for their action

*B. All are true

C. Present in many tissues

D. Short acting

E. Synthesized from arachidonic acid

All increases serum glucose except:

A. Cortisol

B. Glucagon

C. Epinephrine

D. Nor-epinephrine

*E. Vasopressin

Insulin causes lipogenesis by all except:

A. Increasing acetyl-CoA carboxylase activity

B. Activation of phosphodiesterase

*C. Inhibiting of pyruvate dehydrogenase

D. Increasing the rate of glucose transport into the cells

E. Decreasing the intracellular cAMP level

Which of the following compound antagonizes the actions of insulin in the liver?

*A. Growth hormone

B. Neuropeptide Y

C. Neuropeptide A

D. Substance P

E. Vasoactive intestinal peptide

Insulin stimulates all the processes except:

A. Glycolysis

*B. Gluconeogenesis

C. Lipogenesis

D. Glycogen synthesis

E. Hexose monophosphate shunt

Which compound does not inhibit platelet aggregation?

A. Benoxaprofen

B. Bufferin

C. Aspirin

D. Prostacyclin

*E. Thromboxane A2

Name the factor of protein nature produced by T- or B-lymphocytes at viral infections in patients:

A. Calmodulin

B. Parathyroid hormone

C. Calcitonin

D. Calcitriol

*E. Interferon gamma

Hyperpigmentation is considered at patients with Addison`s disease. Propose the hormone whose high level in the blood can cause this state:

A. TSH

B. Prolactin

C. FSH

D. ACTH

*E. MSH

For glucose entry into the cells, insulin is required in all cells except that of:

*A. Red Blood Cells

B. Renal medulla

C. Pancreas

D. Liver

E. Heart