- •Increased serum uric acid levels occur in:
- •Xeroderma pigmentosum is produced as a result of a defect in:
- •In mammals, dna synthesis occurs in which part of the cell cycle:
- •In the dna molecule the coding region reads 5’-cgt- 3’. This would code in the rna as:
- •In e.Coli structural gene of lac operon is stimulated in:
- •Insulin mediated glucose uptake in myocyte is through:
- •In hypothyroidism the following type of hyperlipoproteinemia (according Fridricson e. Classification) is evident:
- •Insulin increases the activities of all of the following enzymes, except
- •Infection diseases are treated with antibiotics (streptomycin, erythromycin, chloramphenicol). They inhibit the following stage of protein synthesis:
- •Inhabitants of territories with cold climate have high content of an adaptive thermoregulatory hormone. What hormone is it?
In e.Coli structural gene of lac operon is stimulated in:
*A. Presence of lactose and absence of glucose
B. Presence of lactose only
C. Presence of glucose and absence of lactose
D. Presence of galactose only
E. Presence of glucose only
CAP (Catabolite active gene protein) in Lac operon is an example of:
*A. Positive regulator of transcription
B. Negative regulator of transcription
C. Regulatory region of DNA
D. Constitutive expression
E. Attenuation
Amber codon refers to:
*A. Stop codon
B. Initiating codon
C. Mutant codon
D. Codon for more than one amino acid
E. Codon for Alanine
Amino acid with a single codon is:
A. Alanine
B. Threonine
C. Tyrosine
D. Phenylalanine
*E. Tryptophan
Point out the chemical nature of gene:
A. The fragment of Ribonucleic acid
B. Lipoprotein
C. Chromoprotein
*D. The fragment of Deoxyribonucleic acid
E. Glycoprotein
The degeneration of the genetic code is explained therefore:
A. Genetic Code is composed of various triplets
*B. Two or more triplets may be for one amino acid
C. “Punctuation marks” are absent in the genetic code
D. The Code is single for all biologic systems
E. Each amino acid is coded for one triplet, only
Which of the following acts on nuclear receptor:
A. Glucagon
B. Epinephrine
C. TSH
D. Growth hormone
*E. Estrogen
Which of the following hormone mechanism of action is associated with cyclic AMP formation in a target cell?
*A. Vasopressin
B. Aldosterone
C. Atrial natriuretic peptide
D. Angiotensinogen I
E. Renin
Metabolic product of epinephrine inactivation excreted in urine is:
A. Androstenedione
B. Estrone
*C. Metanephrine
D. Dopamine
E. Nor metanephrine
The following hormone does not have any intracellular receptor:
A. Calcitriol
*B. Adrenaline
C. Aldosterone
D. Cortisol
E. Thyroxine
Insulin mediated glucose uptake in myocyte is through:
A. GLUT 1
B. GLUT 3
C. GLUT 2
D. GLUT 5
*E. GLUT 4
Which of the following acts via cAMP
*A. LH
B. Thyroxine
C. All positions are correct
D. Estrogen
E. Testosterone
Find out the feature of releasing factors (RF) structure:
A. RF are amino acid derivatives
B. Both of RF contain sialic acid
C. RF are simple proteins with quaternary structure
D. RF are glycoproteins
*E. RF are short peptides
Nor-epinephrine is converted to epinephrine by:
*A. N-methylation
B. Dopamine hydroxylase
C. S-methylation
D. DOPA-decarboxylase
E. O-methylation
Name a membrane bound enzyme that catalyzes the formation of cyclic AMP from ATP:
A. ATP synthase
*B. Adenylate cyclase
C. RNA polymerase
D. Lactate dehydrogenase
E. Tyrosine kinase
Try to name a small Ca<sup>2+</sup>binding protein that modifies the activity of many enzymes and other proteins in response to changes of Ca<sup>2+</sup> concentration.
A. Collagen
B. Elastin
*C. Calmodulin
D. Kinesin
E. Cycline
Point out the chemical nature of hormone receptors:
*A. Proteins
B. Vitamins
C. Lipids
D. Nucleic acids
E. Carbohydrates
Find out the type of activity that is considered for insulin-receptor complex function in the intracellular space of target cell:
A. cAMP-dependent proteinkinase activity
B. Similar to Phospholipase C activity
C. Tyrosine aminotransferase activity
D. cAMP-dependent polymerase activity
*E. Tyrosine kinase activity
Which of the following belongs to steroid superfamily
*A. Calcitriol
B. Epinephrine
C. Growth hormone
D. ACTH
E. Insulin
Thyroxine and catecholamine are derived from:
A. Leucine
B. Tryptophan
C. Alanine
*D. Tyrosine
E. Isoleucine
Which of the following acts through tyrosine kinase receptor?:
A. Glucagon
B. Follicle stimulating hormone
C. Growth gormone
*D. Insulin
E. Epinephrine
All are secondary messenger except:
*A. mRNA
B. cAMP
C. Diacylglycerol
D. Phosphatidyl inositol triphosphate
E. Calcium
Adenylate cyclase enzyme is inhibited by:
A. Calcitonin
B. Thyroxine
C. Epinephrine
*D. Somatostatin
E. Nor-epinephrine
Which of the following substances acts to increase the release of Ca<sup>2+</sup>from endoplasmic reticulum in muscular cell?
A. Diacylglycerol
B. 1,25-dihydroxy cholecalciferol
*C. Inositol triphosphate
D. Monoacylglycerol
E. Parathyroid hormone
For which hormone is cGMP secondary messenger?
A. Epinephrine
B. Cortisone
*C. Atrial natriuretic peptide
D. Growth hormone
E. Thyroxine
Adenylate Cyclase is activated of :
*A. GTP-dependant regulatory protein
B. Nuclear receptor
C. cAMP
D. Phosphodiesterase
E. Membrane receptor
The Simple goiter (enlarged thyroid) may be caused by:
A. Uncontrolled production of T3 and T4
*B. Iodide deficiency
C. Production of thyroid-stimulating IgG
D. Excessive intake of exogenous TSH
E. Decrease of TSH secretion