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Urartu Özgür Şafak Şeker (Ed.)
Synthetic Biology for Therapeutics

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Synthetic Biology
for Therapeutics
Engineering Cells for Living Drugs
Edited by
Urartu Özgür Şafak Şeker

Editor
Urartu Özgür Şafak Şeker, Ph.D.
National Nanotechnology Research Center (UNAM)
Bilkent University
Ankara 06800
Turkey
urartu@bilkent.edu.tr
ISBN 978-3-11-132948-2
e-ISBN (PDF) 978-3-11-132949-9
e-ISBN (EPUB) 978-3-11-132962-8
Library of Congress Control Number: 2024943047
Bibliographic information published by the Deutsche Nationalbibliothek
The Deutsche Nationalbibliothek lists this publication in the Deutsche Nationalbibliografie;
detailed bibliographic data are available on the internet at http://dnb.dnb.de.
© 2025 Walter de Gruyter GmbH, Berlin/Boston
Cover image: Design Cells/iStock/Getty Images Plus
Typesetting: Integra Software Services Pvt. Ltd.
Printing and binding: CPI books GmbH, Leck
www.degruyter.com
https://t.me/med1917

This book is dedicated to the memory of Mustafa Kemal Ataturk and the first cente-
nary of the Turkish Republic founded by him, celebrating its rich history.
https://t.me/med1917

Dr. Şeker dedicates this work to his mother Guldane Şeker and his father Casim
Şeker.
https://t.me/med1917

Contents
List of contributing authors XI
Recep Erdem Ahan, Derin Akman, Ece Avcı,
and Urartu Özgür Şafak Şeker
Chapter 1
Programming cells with synthetic biology 1
Merve Yavuz, Ahmet Hınçer, Aslı Semerci,
and Urartu Özgür Şafak Şeker
Chapter 2
Biological devices for cellular targeting and decision-making 31
Melis Karaca, Senem Şen, Fayiti Fuerkaiti,
and Urartu Özgür Şafak Şeker
Chapter 3
Engineering mammalian cell for cancer 59
Doğuş Akboğa, Aslı Doğruer, Damla Albayrak, Gozeel Binte Shahid,
and Urartu Özgür Şafak Şeker
Chapter 4
Engineering microbial cells for cancer 87
Nazlıcan Tunç, Mehmet Emin Bakar, Burak Çalışkan, Tolga Tarkan Ölmez,
and Urartu Özgür Şafak Şeker
Chapter 5
New generation cellular engineering for living therapeutics 119
Index 171
https://t.me/med1917

List of contributing authors
Recep Erdem Ahan
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Ece Avcı
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Derin Akman
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Merve Yavuz
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Ahmet Hınçer
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Aslı Semerci
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Melis Karaca
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Senem Şen
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Fayit Fuerkati
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Doğuş Akboğa
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Aslı Doğruer
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Damla Albayrak
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
https://doi.org/10.1515/9783111329499-203
https://t.me/med1917

Gozeel Binte Shadid
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Urartu Özgür Şafak Şeker
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Nazlıcan Tunç
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Mehmet Emin Bakar
UNAM–Institute of Materials Science and
Nanotechnology
Bilkent University
Ankara 06800
Turkey
Burak Çalışkan
Department of Biomedical Engineering
TOBB University of Economics and Technology
Ankara 06510
Turkey
Tolga Tarkan Ölmez
Department of Biomedical Engineering
Başkent University
Ankara 06790
Turkey
XII List of contributing authors
https://t.me/med1917
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