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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_1649_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Contents
- •Preface
- •4. Aetiology
- •4.1. Biliary Disease
- •4.2. Medications
- •4.3. Idiopathic
- •4.4. Multisystem Diseases
- •4.5. Trauma
- •4.6. Infections
- •4.7. Genetic
- •4.8. Metabolic
- •Chapter 1
- •Acute Pancreatitis in Childhood
- •Abstract
- •1. Introduction
- •2.1. Incidence
- •2.2. Length of Hospitalisation
- •3. Pathophysiology
- •4.9. Special Considerations in Acute Recurrent Pancreatitis
- •5. Definitions and Diagnosis
- •5.1. Definitions
- •5.2. Diagnosis
- •5.2.1. Clinical Presentation
- •5.2.2. Elevations in Serum Pancreatic Enzymes
- •5.2.3. Radiological Presentation
- •6. Management and Investigation
- •6.1. Severity
- •6.2. Early Aggressive Intravenous Fluid Resuscitation
- •6.3. Gut Rest and Early Feeding
- •6.4. Other
- •Conclusion
- •References
- •Biographical Sketches
- •Chapter 2
- •Walled-Off Pancreatic Necrosis
- •Abstract
- •Walled-Off Pancreatic Necrosis
- •Definition of WOPN
- •Pathology
- •Epidemiology
- •Clinical Features
- •Diagnosis and Differential Diagnosis of WOPN
- •Management of WOPN
- •Therapeutic Options in WOPN
- •“Wait and See”
- •Drainage
- •Percutaneous Drainage
- •Endoscopic Drainage
- •Endoscopic Transluminal Necrosectomy
- •Surgery
- •Follow-Up
- •The Future
- •References
- •Chapter 3
- •Abstract
- •Introduction
- •Background
- •Ocular Features
- •Case Reports and Series in Literature
- •Pathophysiology
- •Treatment and Management
- •Conclusion
- •References
- •Biographical Sketch
- •Chapter 4
- •Abstract
- •Introduction
- •Acute Pancreatitis
- •Obesity
- •Conclusion
- •References
- •Chapter 5
- •Severe Acute Pancreatitis:
- •Since the Classical
- •Abstract
- •Introduction
- •Complications of SAP
- •Infected Necrotic Pancreatitis
- •Compartmental Syndrome
- •Walled-Off Pancreatic Necrosis (WOPN)
- •Pancreatic Pseudocysts
- •Methods
- •Clinical Evaluation
- •Ranson’s Criteria
- •Ultrasound
- •Radiological Classification Systems
- •Magnetic Resonance
- •Management Alternatives in Acute Pancreatitis
- •Artificial Nutrition
- •Pharmacological Treatment
- •Peritoneal Lavage
- •Management with the ‘Step-Up’ Approach
- •Open Surgical Debridement
- •Vacuum-Assisted Closure System (VAC)
- •References
- •Crystalloids
- •Analgesia
- •Somatostatin
- •Corticosteroids
- •Prophylactic Antibiotics
- •Meropenem
- •Drotrecogin Alpha (Activated)
- •Recombinant Human Soluble Thrombomodulin
- •Surgical Treatment
- •Biographical Sketch
- •Chapter 6
- •Management of Acute
- •Biliary Pancreatitis
- •Abstract
- •Introduction
- •Pathophysiology
- •Etiology
- •Diagnostic Assessment of Biliary Etiology of AP
- •Evolution of ABP
- •Early Assessment of ABP
- •Therapeutic Approach of ABP
- •Conclusion
- •Acknowledgment
- •References
- •Biographical Sketch
- •Chapter 7
- •2 University Hospital Kollárova 2, Martin, Slovakia
- •Abstract
- •Introduction
- •Classification
- •Atlanta Classification of Fluid Collections
- •1. APFC (Acute Peripancreatic Fluid Collection)
- •2. Pancreatic Pseudocyst
- •3. ANC (Acute Necrotic Collection)
- •4. WON (Walled-Off Necrosis)
- •Overview of Imaging Techniques
- •Indications for Use of CT in Patients with Acute Pancreatitis
- •Angiography and Interventional Radiology
- •Endoscopic Retrograde Cholangiopancreatography
- •Complications of Acute Pancreatitis
- •Fluid Collections
- •Solid, Semi-Solid Locoregional Complications
- •Therapy
- •Conclusion
- •Acknowledgments
- •References
- •Chapter 8
- •Antibiotics in Acute Pancreatitis
- •Abstract
- •1. Definition of Acute Pancreatitis
- •Types of AP
- •Phases of AP
- •Severity of AP
- •3. Incidence
- •4. Etiology
- •Acquired Conditions
- •Anatomical Variants
- •Autoinmune Pancreatitis
- •Genetic Causes
- •5. Mortality
- •6. Antibiotic Prophylaxis
- •7. Antibiotic Treatment
- •References
- •Chapter 9
- •Abstract
- •Introduction
- •Materials and Methods
- •Chemicals, Animal Model and Study Design
- •RNA and Western Blot Assay for the Expression of NF-κB
- •Statistical Analysis
- •Results
- •PAF and NF-B Decreased after SMI Treatment
- •SMI Promoted Angiogenesis and Improved Microcirculation
- •Discussion
- •Conflicts of Interest
- •Funding
- •References
- •Biographical Sketch
- •Index

INDEX
A
Abdominal ultrasonography, 152
abuse, 59, 63, 81, 178
access, 16, 39, 42, 46, 138, 195, 198
acid, 7, 78, 180
acute biliary pancreatitis, ERCP/ES,
pancreatic gatherings, 110
acute lung injury, 115, 131
acute pancreatitis, vii, 1, 2, 3, 4, 5, 6, 7, 8, 9,
10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20,
21, 23, 24, 25, 26, 27, 28, 29, 30, 33, 34,
45, 49, 50, 51, 55, 56, 57, 58, 59, 60, 61,
63, 65, 66, 67, 68, 71, 72, 74, 75, 76, 77,
78, 79, 80, 81, 84, 86, 97, 98, 99, 100,
101, 102, 103, 104, 105, 106, 107, 109,
110, 114, 115, 118, 119, 120, 121, 123,
124, 128, 129, 130, 131, 132, 133, 134,
135, 136, 137, 138, 140, 141, 143, 144,
145, 146, 147, 148, 149, 151, 152, 153,
154, 156,
acute respiratory distress syndrome, 203
ADC, 89, 102
adenocarcinoma, 56, 68, 167
adhesion, 45, 201, 202, 203, 205, 206
adipose tissue, 13, 73, 77
adults, 3, 4, 7, 8, 10, 13, 20, 21, 23, 30, 179,
181
adverse effects, 93, 185
aetiology, 2, 3, 5, 6, 8, 16, 21, 23, 25, 97,
129, 152
aggregation, 64, 66, 67
alanine aminotransferase, 6, 85
alcohol abuse, 36, 57, 58, 59, 61, 81
alcohol consumption, 61, 112
alcoholism, 56, 58, 61
algorithm, 48, 123, 135, 187
ALT, 85, 86, 113, 114
ampulla, 91, 112, 113, 181
amylase, 4, 10, 12, 13, 14, 15, 17, 20, 26,
38, 57, 58, 59, 74, 84, 88, 113, 144, 151,
174, 178, 179, 180, 193, 194, 195, 198,
199, 202
anatomy, 52, 62, 67, 89, 127, 161, 180
ANC (Acute Necrotic Collection), 15, 149,
150, 151, 156, 175, 176
angiogenesis, 194, 198, 200, 201, 203, 204,
205
Angiogenetic Factor (AF), 24, 26, 29, 97,
105, 137, 171, 193, 194, 195, 198, 199,
200, 201
angiography, 57, 58, 59, 61, 66, 161
antibiotic, 82, 93, 98, 121, 136, 157, 173,
174, 182, 183, 184, 185, 186, 189, 190,
191, 192
anti-inflammatories, 92
anti-inflammatory agents, 23
anti-inflammatory drugs, 179
antioxidant, 106, 107, 131, 203
APA, 19, 28, 49, 100, 102, 185, 191

Index
212
APFC (Acute Peripancreatic Fluid
Collection), 15, 149, 150, 163, 164, 175
arteries, 56, 57, 62, 63, 154, 159, 160
arterioles, 57, 58, 61, 62, 63, 65
artery, 58, 62, 63, 66, 87, 159, 160, 161,
162, 164, 169, 170
ascites, 36, 145, 148, 165, 166, 205
aspiration, 39, 92, 124, 138, 154, 164, 185
assessment, 16, 49, 87, 97, 99, 100, 102,
109, 113, 114, 117, 118, 122, 126, 133,
135, 140, 143, 144, 145, 151, 168, 171,
176
asymptomatic, 36, 179
Atlanta classification, 11, 38, 49, 71, 72, 76,
79, 81, 84, 90, 97, 100, 146, 150, 154,
168, 187
autoimmune disease, 56, 205
B
bacteria, 9, 40, 90
Balthazar, 88, 100, 101, 118, 119, 124, 135,
145, 146, 147, 148, 154, 158, 159, 165,
168
beneficial effect, 91, 92, 94, 120, 194
benefits, 21, 80, 93, 95
bicarbonate, 2, 10, 181
bilateral, 55, 58, 59, 60, 61, 63, 65, 82
bile, 4, 87, 89, 107, 112, 113, 114, 141, 178,
180, 181
bile duct, 87, 89, 107, 141, 178, 180
biliary obstruction, 36, 39, 112, 122
biliary tract, 161, 166
biological activities, 203
biopsy, 12, 194
bleeding, 43, 45, 46, 47, 72, 84, 96, 99, 123,
126, 144, 155, 159, 166
blood, 2, 19, 39, 42, 59, 61, 62, 85, 91, 107,
118, 134, 151, 159, 164, 186, 195, 201,
203
blood flow, 19, 91, 202
blood urea nitrogen, 85, 86, 118
blood vessels, 2, 39, 42, 159, 164, 203
body mass index (BMI), 45, 71, 73, 75
bone, 56, 60, 66
bowel, 14, 16, 113, 120, 153, 165
C
calcium, 4, 10, 86, 113, 122, 178, 179, 204
capillary, 57, 61, 62, 91, 92, 201
capsule, 37, 84, 149
carcinoma, 140, 207
catheter, 43, 52, 88, 138, 164, 171, 186
CBD, 114, 122, 123, 125, 128
central retinal artery occlusion, 57, 58
CEUS (contrast enhanced ultrasound), 152
childhood, vii, 1, 2, 3, 24, 25, 27, 31, 182
children, vii, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11,
12, 13, 14, 16, 17, 18, 19, 20, 21, 23, 24,
25, 26, 27, 181
China, 193, 195, 196, 202, 206, 207
cholangiography, 17, 207
cholangitis, 87, 110, 122, 123, 128, 161,
181, 186
cholecystectomy, 21, 123, 129, 140, 167
cholecystitis, 165, 186
choledocholithiasis, 89, 158
cholestasis, 109, 110, 122, 128
chronic renal failure, 10, 20, 21, 68
circulation, 14, 19, 42, 55, 57, 63, 115, 159,
160, 202
classical methods, vii, 80
classification, 7, 11, 15, 16, 18, 28, 34, 38,
48, 49, 71, 72, 76, 79, 81, 84, 85, 87, 90,
97, 100, 105, 118, 130, 143, 145, 146,
149, 150, 154, 164, 167, 168, 169, 176,
187
clinical diagnosis, 88, 157
clinical presentation, 2, 3, 23, 72
clinical symptoms, vii, 33, 39, 143, 145
clinical trials, 90, 92, 93
closure, 44, 80, 83, 104, 106, 107
cluster of differentiation, 181
CO2, 42
coil embolization, 159, 170
colic, 95, 113
collateral, 42, 159
colon, 37, 140, 152, 166

Index
213
common bile duct, 17, 87, 109, 114, 130,
178, 180, 181
communication, 11, 38, 44, 167, 180
compartment syndrome, 98, 114, 166
complement, 55, 56, 62, 64, 65, 66, 67, 88,
132
complications, vii, 3, 15, 16, 18, 21, 34, 40,
41, 45, 46, 47, 56, 71, 72, 74, 75, 76, 77,
80, 81, 84, 88, 94, 95, 98, 110, 111, 114,
115, 119, 120, 121, 122, 123, 124, 125,
127, 130, 134, 137, 138, 143, 144, 145,
146, 148, 149, 152, 153, 154, 157, 158,
159, 161, 163, 165, 166, 167, 169, 170,
176, 177, 182, 183, 185, 186, 187, 190
Complications of Acute Pancreatitis, 163
composition, 48, 78
compression, 8, 60, 67, 99
computed tomography, 37, 58, 84, 114, 134,
143, 145, 146, 154, 167, 168, 169, 174
Computed tomography, 86, 87, 100, 101,
132, 134, 144, 152
configuration, 160, 181
consensus, 2, 19, 34, 49, 76, 83, 86, 98, 100,
110, 130, 143, 146, 168, 174, 185, 187
contamination, 120, 190
control group, 195, 199, 200
controlled trials, 21, 40, 92, 104, 137, 191
controversial, 39, 121, 122, 183
coronary arteries, 204
correlation, 17, 39, 88, 101, 113, 130
corticosteroids, 92, 180
cotton, 57, 58, 59, 60, 61, 62
coworkers, 73, 74
creatinine, 85, 117
CRP, 20, 73, 86, 116, 118, 120, 132, 134
CT scan, 27, 100, 152, 156, 157, 166, 167
CTA, 161
cyst, 6, 38, 42, 43, 44, 45, 46, 99, 164, 207
cystic fibrosis, 9, 23, 30
cytokines, 5, 72, 73, 74, 90, 92, 131, 182,
194, 201, 202
cytoplasm, 202, 203
D
debridement, 42, 44, 47, 50, 51, 87, 95, 105,
126, 127, 139
defects, 12, 31, 156
deficiency, 23, 30, 91, 201
destruction, 2, 131, 201
detection, 85, 87, 89, 114, 135, 152, 154,
158, 170, 196
diabetic retinopathy, 106, 107
diagnostic criteria, vii, 1, 3, 7, 12, 113, 170
differential diagnosis, 37, 167
diffusion, 89, 102, 115, 120, 170, 184
Diffusion-weighted magnetic resonance
imaging (DW-MRI), 158
digestion, 36, 81, 110, 201
dilation, 55, 114, 180
diseases, vii, 6, 8, 10, 31, 76, 111, 143, 177
disorder, 2, 15, 18, 181, 182
displacement, 43, 82
disseminated intravascular coagulation, 94,
104
distribution, 73, 77, 109, 112, 183, 186
DNase, 205
double-blind trial, 23, 28
drainage, 34, 39, 40, 41, 42, 43, 44, 45, 46,
47, 48, 50, 51, 52, 53, 83, 95, 96, 105,
110, 125, 126, 127, 128, 138, 161, 164,
166, 170, 171, 172
drugs, 7, 112, 120, 121, 144, 166, 183
duodenum, 2, 4, 10, 37, 41, 45, 87, 111,
128, 181
DWI, 89
DW-MRI, 158
E
E. coli, 40
edema, 111, 112, 113, 174, 178
electrolyte, 89, 119
ELISA, 195, 199
ELISA method, 195
embolization, 55, 56, 68, 159, 160, 162,
164, 170, 172

Index
214
emergency, 58, 177
encapsulation, 126, 149
endocrine, 2, 12
Endoscopic Retrograde
Cholangiopancreatography, 12, 121, 137,
161
endoscopy, 27, 28, 37, 38, 39, 42, 46, 49,
88, 206
endothelial cells, 201, 203, 206
endothelial dysfunction, 204
Endovascular therapy, 144, 159
end-stage renal disease, 26
England, 29, 52, 111
enlargement, 12, 88, 118, 148, 152, 153,
174
enterokinase, 4, 111
enzyme, 10, 12, 13, 17, 151, 163, 164, 195,
198
enzyme-linked immunosorbent assay, 195
enzymes, 2, 8, 13, 15, 17, 27, 81, 85, 91,
111, 159, 178, 182
epidemiology, 65, 129, 188
epithelium, 56, 57
erosion, 36, 159, 164
etiology, 56, 81, 93, 109, 111, 113, 119,
122, 137, 140, 177, 188
EUS (endosonography), 12, 16, 17, 27, 50,
53, 152, 168
evidence, 2, 3, 20, 26, 28, 33, 40, 41, 49, 61,
62, 64, 71, 73, 87, 100, 102, 115, 152,
173, 179, 183, 184, 185, 191, 192
evolution, 35, 81, 84, 87, 96, 109, 110, 113,
115, 116, 118, 119, 120, 121, 123, 124,
125, 126, 128, 173, 174
examinations, 145, 151
exclusion, 25, 160
exposure, 5, 7, 21, 46, 131
extravasation, 120, 155, 159, 164
F
false negative, 39, 154
familial lipoprotein lipase deficiency, 30
fasting, 20, 90, 113, 120, 122
fat, 2, 37, 56, 68, 73, 74, 77, 78, 82, 87, 115,
131, 147, 148, 153, 156, 157, 158, 159,
163, 174, 196
fatty acids, 10, 74, 75, 115, 131
fever, 2, 46, 48, 58, 61, 88, 157
fibrinolytic, 80, 93
fibrosis, 30, 179
flame, 55, 58, 61
flora, 184, 185, 186
fluid, 2, 15, 17, 18, 19, 20, 22, 28, 34, 35,
38, 40, 41, 50, 51, 52, 53, 75, 80, 81, 83,
84, 85, 86, 88, 91, 103, 109, 110, 114,
115, 118, 119, 120, 121, 124, 125, 126,
127, 138, 139, 143, 145, 146, 147, 149,
150, 151, 152, 153, 154, 156, 157, 158,
161, 163, 164, 165, 166, 169, 170, 175,
201
fluorescence, 57, 196
Food and Drug Administration, 195
formation, 16, 35, 36, 40, 87, 88, 111, 152,
156, 159, 163, 201
founding, 76
free radicals, 131, 201, 202
fungal infection, 184, 185, 190
G
gallbladder, 16, 87, 109, 114, 122, 129, 178
gallstones, 5, 6, 25, 27, 85, 87, 109, 112,
114, 122, 129, 134, 137, 152
gastroenterologist, 30, 48
gastrointestinal involvement, 145
gastrointestinal tract, vii, 41, 42, 43, 82,
143, 164
gel, 160, 196
gene therapy, 23, 30
general anaesthesia, 16, 17, 21
genes, 9, 189, 202
genetic mutations, 5, 9, 23
Germany, 92, 206
ginseng, 195, 202, 203
gland, 14, 111, 118, 124, 148, 152, 153,
156, 180, 181, 182
glucose, 12, 74, 85, 134
grades, 88, 146, 176

Index
215
gravity, 130, 141
Great Britain, 27, 172
guidance, 21, 37, 42, 118, 160
guidelines, 18, 28, 38, 39, 49, 76, 98, 100,
101, 102, 120, 131, 170, 172, 185, 187,
191, 192
H
HBV, 207
healing, 44, 96
health, 1, 86, 135
hematocrit, 85, 86, 88, 119, 133, 134, 157
hemolytic uremic syndrome, 56, 68
hemorrhage, 41, 56, 57
hepatitis, 9, 207
hepatocellular carcinoma, 207
history, 5, 33, 35, 36, 38, 50, 57, 58, 59, 61,
65, 113, 130
HIV, 14, 66
hospitalization, 3, 29, 58, 61, 81, 85, 90, 94,
177, 182, 184
human, 27, 28, 74, 78, 80, 93, 94, 104, 130,
131, 188
hypercalcemia, 10, 112, 179
hyperlipidemia, 10, 21, 112
hyperparathyroidism, 10, 179
hypertension, 82, 98, 113, 180
hypothesis, 10, 112, 113, 199
hypovolemia, 72, 91, 120
hypoxia, 82, 201
I
ideal, 39, 88, 89, 166
identification, 9, 10, 38, 123, 145, 158, 177,
189
idiopathic, 6, 36, 81, 97, 102
IL-8, 202
image(s), 17, 36, 37, 38, 48, 84, 87, 96, 118,
119, 147, 148, 152, 153, 157, 158, 159,
165, 166, 196
Imaging techniques, 143, 151
immune function, 102
immune regulation, 202
immune response, 90, 202
immunity, 77, 131
immunoglobulin, 197, 202, 203
immunosuppression, 90, 103
in vitro, 63, 66
in vivo, 201
incidence, 1, 2, 3, 23, 24, 44, 72, 81, 82, 87,
97, 111, 123, 128, 144, 149, 177, 189
incidence of acute pancreatitis, 3, 24, 144
incisional hernia, 95, 107
India, 68, 192
individual characteristics, 94, 96
individuals, 9, 60, 64, 102, 180, 182
induction, 74, 90, 91, 180, 193, 195, 198,
199, 200
infants, 8, 13, 24, 25
infarction, 14, 164
infection, 33, 36, 37, 38, 39, 41, 46, 72, 74,
77, 81, 82, 84, 88, 93, 97, 114, 115, 121,
124, 125, 128, 138, 150, 152, 154, 158,
164, 166, 170, 171, 173, 176, 177, 183,
184, 185, 186, 190, 192
infectious agents, 9, 180
inflammation, 15, 29, 38, 63, 64, 77, 81, 88,
91, 93, 99, 111, 118, 131, 146, 149, 169,
176, 182, 194, 199, 201, 202, 205
inflammatory bowel disease, 181
inflammatory disease, 14, 110, 111, 144
inflammatory mediators, 72, 73, 115, 182,
201, 204
ingredients, 195, 203
inhibition, 74, 121, 204
inhibitor, 9, 23, 73, 74, 113, 136, 182
initiation, 145, 157
injury(ies), 4, 8, 10, 26, 35, 55, 63, 64, 72,
73, 74, 103, 107, 111, 113, 114, 120,
164, 178, 179, 182, 202, 203, 204, 207
integrity, 21, 38, 39, 89, 120, 121
intensive care unit, 18, 21, 135
intervention, 6, 39, 51, 64, 88, 94, 100, 101,
105, 110, 126, 135, 144, 161, 166, 168,
170, 187
intestinal perforation, 88
intravenous fluids, 20, 89

Index
216
ionizing radiation, 37, 89
ischemia, 10, 57, 58, 59, 61, 62, 74, 88, 94,
96
isolation, 9, 170, 186
Italy, 109, 139
L
laboratory tests, 113, 132
laparoscopic cholecystectomy, 94, 123, 137,
207
laparotomy, 43, 46, 47, 83, 95
lead, 4, 8, 18, 35, 41, 42, 43, 55, 65, 74, 82,
178, 201
leakage, 2, 35, 57, 61, 128
lesions, 66, 102, 164, 201
leukocytes, 13, 92, 131, 169, 202
leukocytosis, 179, 186
lipases, 74, 77
Liquid embolic material (Onyx), 160
liver, 109, 113, 114, 122, 140, 164, 166,
177, 201, 206
liver function tests, 109, 113, 114, 122, 140
lumen, 44, 48, 111, 180, 197
lymphoma, 167
M
magnetic resonance (MR), 12, 16, 27, 37,
80, 87, 89, 101, 102, 143, 144, 157, 158
163, 169, 170, 174, 181
Magnetic resonance
cholangiopancreatography (MRCP), 158
magnetic resonance imaging, 16, 37, 80,
101, 143, 151, 158, 169, 170, 174
majority, 4, 5, 15, 17, 23, 39, 83, 84, 86, 89,
92, 109, 114, 122, 123, 179
malignant tumors, 179
management, vii, 2, 3, 6, 8, 10, 17, 18, 19,
20, 21, 23, 24, 25, 26, 28, 33, 36, 38, 39,
41, 42, 45, 48, 49, 50, 51, 52, 64, 76, 80,
82, 83, 90, 94, 95, 96, 97, 100, 102, 103,
105, 106, 107, 119, 124, 127, 128, 129,
134, 136, 137, 138, 139, 144, 161, 168,
169, 170, 171, 172, 177, 182, 187, 188,
190, 191, 192, 207
measurements, 13, 66, 71, 73
mechanical ventilation, 117
mechanical ventilator, 81
mediastinum, 154, 164
medical, 25, 33, 48, 61, 119, 121, 129, 144,
157, 189, 206, 207
medical science, 206, 207
medication, 7, 93
mellitus, 12, 95
meta-analysis, 29, 45, 77, 87, 99, 102, 103,
104, 130, 136, 179, 185, 189, 190, 191
Metabolic, 10, 14, 26, 179
methylprednisolone, 64, 65
microcirculation, 10, 28, 58, 91, 103, 120,
194, 200, 201, 204
migration, 43, 44, 92, 131
molecules, 23, 89, 202, 205
monoclonal antibody, 196
morbidity, 28, 43, 46, 47, 71, 72, 81, 83, 87,
95, 97, 119, 123, 138, 144, 145, 161, 179
morphology, 143, 154, 160
mortality, 19, 20, 28, 29, 41, 43, 45, 46, 71,
72, 74, 75, 76, 77, 80, 81, 82, 83, 85, 87,
90, 92, 93, 94, 95, 97, 99, 114, 115, 116,
118, 119, 120, 123, 125, 126, 131, 135,
138, 144, 145, 149, 152, 167, 171, 173,
176, 177, 178, 179, 182, 183, 187, 188,
189, 190, 191, 194, 198
mortality rate, 45, 46, 75, 81, 82, 92, 114,
126, 149, 173, 177, 179, 182
mortality risk, 116, 118
MRCP, 12, 16, 109, 110, 121, 122, 123,
128, 161
MRI, 12, 16, 37, 38, 48, 102, 114, 117, 118,
119, 143, 144, 157, 158, 174, 175, 187
mRNA, 194, 199
mutation, 9, 23, 30, 113, 181, 182, 189
N
NaCl, 196
nausea, 2, 13, 61, 90, 113

Index
217
necrosis, vii, 2, 5, 15, 16, 19, 29, 33, 34, 35,
39, 42, 44, 46, 48, 49, 50, 51, 52, 53, 72,
74, 75, 77, 80, 81, 82, 83, 84, 86, 87, 89,
90, 92, 94, 95, 96, 97, 98, 101, 104, 105,
110, 111, 114, 115, 116, 118, 120, 121,
123, 124, 125, 126, 131, 132, 133, 138,
143, 144, 145, 146, 147, 148, 149, 150,
151, 152, 153, 154, 156, 157, 158, 159,
163, 164, 166, 168, 171, 173, 174, 175,
176, 177, 182, 183, 184, 185, 189, 190,
191, 194, 201
neovascularization, 42
nephritic syndrome, 68
New South Wales, 1, 30, 31
NK cells, 203
non-Hodgkin’s lymphoma, 167
North America, 100
NSAIDs, 120
nutrition, 20, 21, 27, 29, 30, 80, 89, 90, 102,
119, 120, 121, 206, 207, 208
O
obesity, vii, 71, 73, 74, 75, 76, 77, 78, 81,
85
obstruction, 14, 35, 42, 112, 113, 123, 129,
166, 178, 180, 188
occlusion, 43, 46, 57, 58, 62, 63, 65, 163
oedema, 2, 16, 19, 119, 124, 153
oleic acid, 75, 131
opioids, 91, 120
optic nerve, 57, 58, 62
organ, 2, 8, 18, 19, 20, 28, 47, 56, 67, 72,
73, 74, 78, 80, 81, 82, 85, 88, 89, 91, 97,
99, 100, 102, 111, 114, 115, 119, 121,
123, 124, 125, 134, 135, 144, 146, 148,
176, 177, 182, 185, 189, 194, 201, 203
organs, 13, 17, 45, 81, 102, 128, 164, 179,
202
overweight, 16, 73
oxidative stress, 106, 107, 203, 205
oxygen, 131, 201, 202
P
paediatric patients, 2, 17
PAF, 193, 194, 195, 198, 199, 200, 201
pain, 2, 12, 13, 16, 20, 21, 36, 39, 48, 58,
59, 60, 61, 84, 88, 89, 90, 91, 109, 113,
119, 120, 121, 144, 157, 161, 174, 179,
180
pallor, 56, 57, 58, 62
pancreas, 2, 4, 8, 9, 10, 13, 15, 20, 25, 36,
38, 46, 74, 82, 83, 84, 87, 90, 91, 92, 96,
100, 110, 112, 115, 117, 118, 119, 121,
136, 138, 140, 144, 146, 147, 148, 150,
152, 153, 154, 156, 157, 158, 159, 163,
164, 165, 167, 168, 169, 171, 175, 178,
180, 181, 182, 194, 195, 196, 197, 198,
199, 200, 205
pancreatic acinar cell, vii, 24, 79, 80, 178,
204, 205
pancreatic cancer, 100, 188
pancreatic insufficiency, 12, 181
Pancreatic Pseudocyst, 84, 150
pancreatitis, vii, 1, 2, 3, 4, 5, 6, 7, 8, 9, 10,
11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21,
23, 24, 25, 26, 27, 28, 29, 30, 31, 33, 34,
35, 36, 38, 39, 40, 45, 47, 49, 50, 51, 52,
53, 54, 55, 56, 57, 58, 59, 60, 61, 63, 65,
66, 67, 68, 71, 72, 73, 74, 75, 76, 77, 78,
79, 80, 81, 82, 84, 85, 86, 87, 88, 93, 94,
96, 97, 98, 99, 100, 101, 102, 103, 104,
105, 106, 107, 109, 110, 111, 112, 113,
114, 115, 116, 118, 119, 120, 121, 122,
123, 124, 128, 129, 130, 131, 132, 133,
parenchyma, 2, 8, 15, 75, 81, 87, 111, 118,
119, 123, 124, 144, 147, 149, 151, 153,
158, 174, 175
pathogenesis, 4, 73, 109, 123, 188, 190,
201, 202
pathology, 38, 41, 62, 168, 194, 207
pathophysiological, 130
pathophysiology, 5, 9, 35, 63, 111, 113, 122
pathway(s), 4, 5, 9, 43, 205
PCR, 196, 199
peptide(s), 91, 118, 132, 133, 134, 202, 205
perforation, 43, 45, 167

Index
218
perfusion, 20, 57, 61, 89, 91, 148, 156
peritoneal cavity, 45, 156
peritoneal lavage, 97, 100
permeability, 91, 92, 116, 201
pH, 10, 111, 120, 181, 196
pharmacological treatment, 90
physiology, 86, 117, 135
placebo, 92, 98, 106, 107, 179, 192
Plain film., 151
Platelet Activating Factor (PAF), 193, 195,
198
platelet aggregation, 194
platelets, 60, 201, 203
pleural effusion, 36, 82, 85, 118, 145
PM, 26, 68, 105, 171
pneumonia, 9, 182, 186
population, 3, 97, 99, 111, 130, 135, 177,
181, 182, 187, 188
portal hypertension, 42, 164
portal vein, 39, 42, 115, 154, 164
Positron emission tomography-computed
tomography (PET/CT), 154, 169, 171
potential benefits, 64, 129
prevention, 29, 80, 92, 182, 185, 207
probability, 18, 23, 94
prognosis, 5, 36, 56, 67, 101, 135, 168, 169,
183, 198, 201
pro-inflammatory, 47, 92
project, 167, 204
prophylactic, 82, 92, 129, 183, 185, 191
prophylaxis, 93, 98, 104, 121, 136, 173,
174, 177, 179, 183, 184, 185, 190, 191
protease inhibitors, 23
protective mechanisms, 178
protein kinase C, 5
proteins, 10, 131, 181, 196, 207
proteolytic enzyme, 144, 164
PSA, 159, 163
pseudoaneurysm, 16, 42, 144, 152, 154,
159, 160, 161, 162, 163, 165, 169
pseudocyst, 15, 17, 34, 35, 36, 37, 49, 51,
52, 53, 72, 84, 125, 128, 143, 149, 150,
154, 156, 157, 158, 175
PTEN, 207
pulmonary arteries, 204
R
radiation, 13, 16, 21, 27
Ranson score, 135, 145
RCP, 12
receptor, 107, 131, 133, 201, 205
recognition, 8, 167
recombinant DNA, 93
recommendations, iv, 2, 7, 11, 19, 20, 21,
48, 91
recovery, 29, 56, 61, 63, 64, 65, 102, 126,
199, 201
recurrence, 7, 38, 41, 167, 207
renal failure, 10, 26, 56, 89, 115, 163
requirement, 16, 86, 123
resistance, 185, 186
resolution, 7, 12, 38, 41, 42, 45, 56, 58, 59,
60, 62, 89, 115, 128, 145, 152, 158
resources, 51, 94
respiratory failure, 117
response, 4, 42, 46, 47, 73, 74, 76, 81, 82,
91, 110, 115, 117, 123, 130, 131, 173,
174, 176, 188, 201, 202, 204
retina, 57, 62
retinal ischemia, 57, 58, 61
retinopathy, 55, 56, 57, 58, 59, 60, 61, 62,
63, 64, 65, 66, 67, 68
reverse transcriptase, 196
revised Atlanta classification, 15, 18, 76,
143, 149, 176
risk, 5, 7, 9, 10, 23, 31, 30, 38, 42, 45, 46,
60, 64, 72, 74, 75, 76, 77, 78, 83, 85, 90,
91, 94, 102, 115, 116, 120, 123, 125,
126, 128, 129, 137, 144, 152, 160, 161,
176, 177, 179, 180, 181, 182, 183, 184,
188
risk factors, 5, 9, 10, 72, 144, 184, 188
RNA, 196
room temperature, 195, 196
S
safety, 26, 30, 45, 67

Index
219
SAP, 72, 73, 74, 75, 80, 81, 82, 83, 85, 86,
87, 89, 90, 91, 92, 93, 94, 95, 96
SDS-PAGE, 196
secretin, 17, 27, 38
secretion, 10, 17, 90, 178, 180, 181
sensitivity, 6, 15, 16, 19, 86, 87, 89, 114,
144, 145, 154
sepsis, 8, 21, 39, 41, 45, 80, 88, 93, 94, 104,
106, 119, 125, 126, 144, 166, 183, 186,
189
serum, 2, 6, 10, 12, 13, 14, 15, 17, 18, 19,
20, 27, 57, 59, 74, 84, 85, 90, 113, 122,
132, 134, 144, 151, 174, 179, 181, 193,
194, 198, 199
severe, 18, 19, 20, 21, 23, 28, 29, 30, 34, 35,
39, 43, 58, 59, 67, 71, 72, 74, 75, 77, 78,
80, 81, 82, 93, 94, 97, 98, 101, 102, 103,
104, 106, 107, 109, 110, 111, 114, 115,
116, 118, 119, 120, 121, 122, 123, 125,
128, 131, 132, 133, 134, 135, 136, 143,
144, 145, 146, 148, 149, 151, 152, 156,
157, 159, 164, 167, 171, 173, 174, 176,
177, 181, 182, 183, 184, 185, 186, 187,
189, 190, 191, 192, 194, 201, 202, 205,
207, 208
Shenmai injection, vi, vii, 193, 194, 195,
198, 207
signs, 9, 28, 38, 57, 58, 63, 83, 88, 100, 125,
152, 157, 171, 176, 179, 187
sludge, 6, 109, 112, 114, 121, 122, 178, 180
smoking, 21, 189
society, vii, 143
solution, 20, 29, 91, 103, 120
spleen, 138, 152, 164
Sprague-Dawley rats, 193, 195
stabilization, 41, 64, 123
state(s), vii, 20, 34, 39, 67, 73, 94, 184
stenosis, 38, 112, 113, 179
stent, 43, 44, 45, 46, 48, 160
Stent-graft, 160
sterile, 33, 37, 39, 52, 80, 81, 83, 94, 110,
125, 138, 143, 150, 158, 164, 171, 173,
175, 176, 183, 185
steroids, 64, 92
stimulation, 18, 20, 21, 178, 205
stomach, 13, 17, 37, 41, 42, 45, 95, 128,
157, 166, 167
stratification, 135, 188
stress, 131, 202, 205
structure, 152, 154
success rate, 39, 41, 43, 45, 127
Sun, vi, 99, 102, 135, 187, 193
surgical debridement, 41, 161, 166
surgical intervention, 88, 92, 95, 106, 110,
119, 128
survival, 93, 96, 103, 190, 202
symptoms, 2, 3, 9, 13, 36, 39, 40, 48, 58, 60,
61, 81, 87, 154, 157, 167, 180
syndrome, 8, 12, 56, 67, 72, 81, 82, 83, 111,
115, 123, 176, 186, 194, 201, 202
synthesis, 178, 194
T
T cells, 181, 203
tachycardia, 2, 113, 186
tachypnea, 113, 186
TAP, 116, 118
target, 23, 160, 196, 201, 202, 207
techniques, 39, 40, 46, 89, 143, 151, 160
technology, 93, 206, 207
testing, vii, 4, 143, 145
therapeutic approaches, 41, 47
therapeutic effect, vii, 193
therapy, 23, 28, 30, 40, 41, 42, 51, 64, 82,
91, 94, 103, 106, 107, 120, 126, 144,
145, 159, 166, 168, 177, 181, 185, 190,
192, 207
thrombocytopenic purpura, 56, 68
thrombomodulin, 80, 94, 104
thrombosis, 16, 39, 152, 154, 163, 204
tissue, 15, 33, 35, 36, 37, 45, 46, 62, 73, 74,
75, 77, 78, 83, 84, 88, 89, 91, 94, 96,
110, 114, 115, 123, 124, 126, 127, 145,
149, 153, 154, 158, 164, 174, 181, 182,
183, 184, 186, 192, 193, 196, 199, 202,
203
TNF, 5, 23, 73, 202
TNF-α, 23, 202
toddlers, 13, 24, 25

Index
220
tones, 17, 130
total parenteral nutrition, 102, 136
transcatheter, 170, 172, 207
transcription, 129, 202
translocation, 29, 90, 115, 120, 131
trauma, 6, 8, 14, 33, 35, 36, 38, 56, 58, 64,
65, 179, 188
treatment, 5, 9, 18, 20, 21, 23, 26, 33, 34,
36, 37, 38, 39, 40, 41, 44, 45, 46, 48, 49,
50, 51, 52, 56, 60, 64, 65, 68, 76, 77, 82,
83, 88, 90, 91, 93, 94, 96, 98, 103, 110,
119, 120, 121, 123, 125, 126, 127, 128,
136, 137, 138, 144, 145, 146, 154, 157,
160, 161, 164, 166, 173, 174, 182, 183,
184, 185, 186, 188, 190, 192, 198, 199,
201, 202, 204, 207
trial, 20, 29, 30, 47, 53, 54, 94, 103, 104,
136, 137, 138, 139, 179, 190, 192
triglycerides, 179
trypsin, 4, 9, 10, 24, 63, 111, 112, 113, 182,
201
tumor, 38, 99, 132, 140, 203, 205
tumor necrosis factor, 132
tumours, 112, 140
U
ultrasonography, 12, 16, 17, 51, 102, 144,
152, 174
ultrasound, 12, 16, 28, 37, 38, 40, 42, 44,
48, 49, 53, 58, 87, 143, 151, 152, 153,
160, 168, 169, 178
underlying mechanisms, vii, 10, 193
United States (USA), 24, 129, 188, 196,
197, 206
urinary tract infection, 186
urine, 133, 151
V
vacuum, 80, 83, 104, 106, 107
validation, 6, 48
Vascular Endothelial Growth-Factor
(VEGR), 193, 194, 195, 198
vascular occlusion, 36, 68
vasculature, 57, 62
VEGF, 198, 200, 201, 205
vein, 39, 42, 153, 154, 195
vessels, 2, 62, 63, 67, 197, 202, 203
vision, 42, 56, 57, 58, 59, 60, 61, 63, 64, 65
visual acuity, 56, 57, 60, 61, 63, 65
vomiting, 2, 13, 19, 39, 58, 60, 61, 90, 113,
120
W
water, 89, 154, 195
white blood cell count, 85, 157
WON (Walled-Off Necrosis), 15, 148, 149,
151, 157, 175, 176
wool, 57, 58, 59, 60, 61, 62
worldwide, 76, 111, 123, 126, 144
Y
yield, 2, 17, 18, 27
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