Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5690_Библиотеки_им_академика_М_И_Перельмана
.pdf
antagonistic cross-talk amongst the major stress-respons ive phytohormones which
include SA, JA, ABA, and ET along with other signaling phytohormones like BR,
CKs, AUXs, GAs, strigolactones, and nitric oxide play a vital role in plants to adapt
and develop tolerance to the ambient freezing temperature (Shi et al.
2015; Peleg and
Blumwald 2011).
11 Signaling Molecules in Medicinal Plants Response to Cold Stress 181
Abscisic
Acid
ABA,
isoprenoid
horm
o
ne
produced during plastidal 2-C methyl
D-erythritol-4-
phosphate pathway hold a prominent role in seed dormancy, stomatal regulation,
biogenesis of lipids and storage proteins, regulation of ambient/environmental
stresses, hydration status, and others. Due to low temperature the levels of ABA
significantly shoot up due to the activation and overexpression of ABA-regulated
genes via two cis-acting elements known as ABA-responsive elements (ABREs),
activated by AREB/ABF transcription factors and CRT/D RE, activated by MYB96–
HHP complexes, ICE1, and CAMTA (Yoshida et al. 2010; Eremina et al. 2016). As
a part of the defens e mechanism, ABA accentuates the genesis of ROS consequen-
tially leading to the accumulation of several antioxidant and non-antioxidant defense
mechanisms leading facilitating cold acclimation (Xue-Xuan et al.
2010). Panax
ginseng, (aka. Asian or Korean ginseng) a traditional herb utilized in Korea and
China for the medicament of inflammatory diseases, CVDs, Diabetes, Cancer, etc.
The active secondary metabolite that elates its therapeutic property is called
ginsenoside whose biosynthesis is greatly influenced by the biotic and abiotic
stresses (Kim
2018). T. hemsleyanum (Aka. Natural plant antibiotic), a traditional
Chinese herbal medicine taken in the form tea or dietary supplement play a predom-
inant role in the treatment of fever, convulsion, pneumonia, asthma, rheumatism,
hepatitis, PCOD, scrofula, etc. Alkaloids, polysaccharides, and flavonoids released
in both tubers and areal parts of the plant are of substantial interest (Peng et al.
2021).
High-altitude Himalayan Alpine Herbs Bistorta affinis (Aka. Border jewel) and
Sibbaldia procumbens are perennial plants investigated widely for their curative
effects for cold, cough, GIT disorders, and other conditions (Rahman et al. 2019).
The pharmaceutically active medicaments in these plants are greatly infl uenced by
cold stress and cold-stress induced desiccation. In this regard, ABA act as a distant
signalling molecule and elicits antioxidant systems preventing oxidative damage,
modifies stomatal oscillations and reduces transpiration and regulates the osmotic
homeostasis.
Gibberellin
Oxidative enzymes like GA 20-oxidases, KAO-oxidases, and GA 3-oxidases from
trans-geranylgeranyl diphosphate produce bioactive GAs in plants and they are
catabolized via GA 2-oxidases and feedback inhibition of the biogenetic pathway.
The catabolic pathways of GA are further governed by negative signaling regulators,
DELLA belonging to the GRAS protein family that act immediately after the
interaction of GA to its soluble receptor (GID1) and bring about its degradation
via Ubiquitin proteasomal pathway (Schwechheimer
2012). Also, they are
repressors of PIF3, PIF4, BRI1, and BES1/BZR1 transcription factors, play a key
https://t.me/medicina_free
role in the anabolic pathways of bioactive GA (Feng et al. 2008; Li et al. 2012). This
bioactive hormone plays a critical role in the regulation of membrane fluidity,
osmolyte homeostasis, activation/over-expression of genes encoding vital enzyme
systems, etc., and thereby facilitates plant defense against cold stress (Emamverdian
et al.
2020). Species belonging to the genus Nicotiana are well known for their
catastrophic effects on health which has led to the negligence of traditional pharma-
copeia. Back in the day, the concoctions of the green leaves and roots of Tobacco
were widely employed in traditional Ayurvedic therapies for the treatment of
ulcerated abscesses, fistulas, sores, polyps, purgative, and narcotics (Charlton
2004). Lycopene, a non-provitamin A carotenoid is one the active SMs released
by tomatoes manifesting anti-cancer, anti-inflammatory, and anti-diabetic properties,
and potential usage in traditional medicines (Collins et al. 2022
). The release of
medicinally prominent SMs from both these plants are predominantly influenced by
environmental stresses. During cold stress overexpression of CBFs (mainly CBF1)
promote the activity of catabolic effectors i.e., DELLA RGL3 and anabolic
inhibitors like GA2oxy resulting in the increased hydroxylation and inactivation of
the bioactive GA. Such an inactivation in GA establishes ross-talk with other
hormones like Auxins, Jasmonic acid and Brassinoste
roids to exert their growth-
promoting signals (Eremina et al. 2016).
182 G. K. Dugganaboyana et al.
Methyl Jasmonates
Jasmon
ates are bioactive lipid soluble hormones derived from linolenic acid via the
COX, LOX, and Cytochrome p450 pathways. The biosynthesis of jasmonic acids is
widely influenced by ambient temperature and other stress conditions. Under cold
stress, oxygenase-mediated JA biosynthesis from PUFA is greatly disturbed and
further genesis is ceased. As a result, during cold acclimation JA tackles the cold
injury by promoting the overexpression of certain COR genes that translates into
effector signaling molecules that could rewire/repair the detrimental effects of cold
injury in plants (Zhao et al.
2005). The primary responses are the accumulation of
antioxidant enzyme systems that could minimize the oxidative damage and protects
the membrane homeostasis. Jasmonate Zim Domain (JZD) i.e., JZD1 and JZD2 in
conjugation with the repressors ICE1 and ICE2 repress or cease the expression of JA
responsive genes and also influence the CBF activity. Inactivation of this complex
and abundant biogenesis of JA is another downstream signal transduction mecha-
nism elicited in response to cold stress.
Gymnema sylvestre (Aka. Gurmar), a reputed herb in Ayurveda is widely known
for its SMs like triterpene saponins, gymnemic acid, gurmarin, etc. all of which are
envoys in suppressing sugars in the blood and maintain sugar homeostasis. The herb
also evinces several curative properties against anemia, osteoporosis, infections,
bowel disorders, cholesterol, lipid storage disorders, etc. Activation of Jasmonate
responsive genes during cold stress consequently triggers the enzymes needed for
the biogenesis of gymnemic acid along with several other SMs like alkaloids,
flavonoids, phenylpropanoids, etc. and acclimate the herbal plant to cold stress and
protect it from the repercu ssions of cold injuries (Chodisetti et al.
2015).
https://t.me/medicina_free
11 Signaling Molecules in Medicinal Plants Response to Cold Stress 183
Salicylic Acid
Ubiquitously distrib uted SA has comprehensive roles in regulating the development,
growth, pathogen infection, and defense mechanisms against abiotic and biotic stress
signals. It is one of the components of Choristmate that accumulate during cold
stress and results in hypersensitive response (HR). Primarily, SA induces free
radicals or ROS in response to chilling or freezing temperatures. ROS further
activate the antioxidant and non-antioxidant enzyme systems promoting the cold
acclimation in plants. Large-scale omics studies have been well established to
determine changes in the expression and accumulation of SA in the Genus Jasminum
grown in cold temperatures. Jasminum offcinale, pharmacologically active herb
releases several SMs like anthocyanins, saponins, steroids, emodine, terpenes,
tannins, coumarins, flavonoids, etc. with certain antimicrobial, antioxidant, insecti-
cidal and dermatologic benefits (Al-Snafi
2018). Jatropha curcas L. and
Andrographis paniculate are amongst other herbal plants in which SA acid under
cold stress conditions promote a dramatic increase in MDA leading to electrolyte
leakage and oxidative stress. This greatly disrupts the biogenesis and accumulation
of principal SMs. The accumulated MDA elicits the antioxidant systems and in turn
also increases the photosynthetic rates in these plants leading to cold accli mation.
Further, the cross-talk between the SA and GA ceases plant growth and development
in during cold injury and prioritizes the activation of repair and stress tolerant
mechanisms during cold acclimation (Eremina et al. 2016).
Ethylene
Ethylene is a multi-functional phytohormone synthesized from S-adenosyl-
L-Methi-
onine to form aminocyclopropane-1-carboxylic acid (ACC), a rate-limiting step
catalyzed by ACC synthase. The role of ethylene in plants is a balanced contrast
i.e., based on the ambient conditions, time of application and/or diversity in the
species ethylene either promote growth or foster senescence. Unlike the other plant
hormones, the role of ethylene during cold stress is often debated as it is species
specific and not certain.
Medicago sativa (Aka. Alfalfa), deep-rooted leguminous plant o f Fabaceae
family is widely used in traditional medicine for its phytochemical constitution.
Isoflavanoids, flavones, phenolic acids, tannins, alkaloids, terpenes, carotenoids,
phytoestrogens, and glycosides are some of the prominent SMs effective against
infections, CVDs, diabetes, oxidative stress, liver diseases, Rheumatoid arthritis,
neurodegenerative diseases and so on (Bora and Sharma
2011). On the other hand,
Rheum australe (Aka. Himalayan Rhubarb), an endangered Himalayan medicinal
herb propertied with diverse SMs like stilbenes, flavonoids, anthraquinones, etc. are
well known for numerous ethnomedical applications for the treatment of arthritis,
gastritis, liver disorders, bronchitis, dysentery, flatulence, scabies, swelling and so on
(Pandith et al.
2018). In both these cases the expression levels of SAM synthase
2 (SAM2) and ACC oxidase is upregulated and facilitates the increased biogenesis
of ethylene. Due to the cold stress, it is understood that, increase in ethylene
terminate the growth of the plant and initiate the expression of several COR genes
and species-specific TFs like CBF1–3/DREB which in turn initiate the biogenesis of
https://t.me/medicina_free
several enzymatic systems (specifically, peroxidase, superoxide dismutase, and
catalase) and osmolytes to fight the oxidative damage and increase freeze tolerance
(Echeverria et al. 2021).
184 G. K. Dugganaboyana et al.
The negative regulation of
cold stress by ethylene is more predominant than its
positive defense mechanisms. Ethylene-arbitrated hypersensitivity to cold stress in
Medicago truncatula is one of the notable examples that evince contrasting and
species-specific roles of ethylene during cold stress. The expression of MtCBF1,
MtCAS15 and MtCBF3, (Cold Acclimation Specific genes) is greatly compromised
by a negative signal transduction pathway. Ethylene due to cold stress binds to ETR1
(Ethylene Responsive gene 1) and activates CTR1 (Constitutive Triple Response 1)
which phosphorylates the downstream transcription factors like EIN2 (ethylene
insensitive 2) which further upregulate EIN3 and ein3-like 1 (EIL1). These tran-
scription factors suppress CBFs expression leading to the hypersensitivity of plants
to cold stress (Eremina et al. 2016).
11.2.1.6 Secondary Metabolites: Prerequisites for the Sanative Actions
of Medicinal Plants
Recent studies estimated roughly about 80% of the global population has switched
from synthetic drugs to herbal therapies as they are natural nutraceutical products
that succor to overcome ailments and promote healthy aging (Pant et al. 2021).
Secondary plant metabolites (SMs) are the conspicuous bioactive metabolic
by-products or signaling molecules derived from the primary catabolic pathways
in the plant cells. Polyphenolics, alkaloids, saponins, terpenes, coumarins,
flavonoids, lipids, carbohydrates, etc. derived from different plant parts (root,
stem, leaves, flowers, fruits, and seeds) have been procl aimed to underpin various
pharmacological benefits in herbal plants (Hussein and El-Anssary 2018). In addi-
tion to the therapeutic properties, SMs are of equal prominence in plant defense
mechanisms. Therefore, the biogen esis, distribution, and accumulation of these
bioactive molecules rely on several biotic and abiotic stresses owning to herbal
predators and environmental influences. The Intergovernmental Panel on Climate
Change (IPCC) has announced that temperature variations have a significant impact
on the SM profile in medicinal plants resulting in their amendment. Previous sections
address certain striking effects of cold on the biogenesis of certain pharmaco-
logically pronounced SMs and underlying cold acclimation/tolerance mechanisms
adopted by medicinal plants during cold stress and their repercussions on their
therapeutic value. It is essential to understand the role of certain SMs themselves
in achieving cold acclimation/tolerance.
Brassica rapa (Aka. Turnip) is one of the classic medicinal herbs known to have
curative effects on several diseases that are part-and-parcel of human life.
2-phenylethyl isothiocyanate, phenyl propionitrile, brassica phenanthrene A,
flavonoids, and phenolics are the most prominent SMs with pharmacopeial
investigations in the treatment of headaches, angina, rheumatisms, STDs, hyperten-
sion, diabetes, neurodegenerative diseases, brain disorders and so forth (Paul et al.
2019). The phenolic extracts of this plant are widely known to possess anti-oxidant
mechanisms that facilitate in cold accli mation. O-glycoside, prominent flavanol in
https://t.me/medicina_free
Role during cold acclimation Reference
turnip govern the growth and development of radical and plumule during seed
germination. Chilling and freezing temperature induced physiological alterations
dormant the seed growth leading to their death. The indigenous gene makeup in
these plants enable the expression of COR genes that encode several SMs predomi-
nantly, polyphenols and flavonoids that promote several carbohydrate anabolic
pathways, protein folding in the ribosomes, activation of the photosynt
hetic systems
in chloroplast, upregulation of antioxidant enzymes, and others. Facilitating the plant
to get away from cold-induced injuries (Ilyas et al.
2022).
11 Signaling Molecules in Medicinal Plants Response to Cold Stress 185
Table 11.1 Concerted role of diverse secondary metabolites released in Rhodiola semenovii under
cold stress
Secondary
metabolite
Site of
biosynthesis
β, γ- Sitosterol Roots Integral component of the plasma membrane.
Prevents membrane-crystallization and
promotes fluidity
Stabilizes the damage of the thylakoid
membrane and magnifies the chlorophyll
synthesis
Shahzad
et
al. (
2021)
γ-Tocopherol Shoot Natural antioxidants that form phenoxy
radicals in conjugation with hydrogen
peroxide and transform into quinones, dimers,
and trimers
Rontani
et al. (
2007)
Linoleic and
linolenic fatty
acids
Shoot Intrinsic to plasma membrane these PUFAs
help in regulating micro viscosity,
permeability of electrolytes, deaden
excitability, and activate enzymes that are
responsible for the biosynthesis of membrane
proteins and lipids
Terletskaya
et al. (
2021)
Oxylipins Shoot and
root
Oxylipins are complex interactive molecules
that establishes a cross-talk with various
phytohormones like SA, ET, IAA, BA, GA,
ABA, etc. and bring about a cascade of
downstream hormonal interactions and
promote tolerance in plants
Pushkina
(
2020)
Phenols Shoot and
root
Prevents mitochondrial autolysis, promote
membrane stability by inhibiting/blocking the
ROS generation
Pushkina
(
2020)
Terpenes Shoot Diterpene like phytol promote chlorophyll
synthesis and triterpene like squalene are
scavengers of ROS, protectants of the LHC
from photoinhibition
Edge et al.
(
1997)
Rhodiola semenovii Boriss. is a succulent whose concoctions have been used
widely as traditional medicine in Central Asia for treating inflammatory diseases,
diabetes, cancer and many others (Terletskaya et al. 2021). It is famed for its
mult
imode acclimation strategies against abiotic stresses with rich and diversified
SMs (Table
11.1).
https://t.me/medicina_free
186 G. K. Dugganaboyana et al.
Ocimum basilicum L. hoard a hub of mono and sesquiterpenes especially during
cold stress. At the onset of cold injury, genes encoding various terpenoids like
linalool synthase (LIS), β-myrcene synthase (MYS), geraniol synthase (GES),
germacrene D synthase (GDS), Farnesyl diphosphatase, and γ-cadinene synthase
(CDS) expression levels show a prepotent expression leading to their increased
biosynthesis. This indicates that the cold responsive genes (COR) are present within
the promoter region of the terpenoids. These compounds therefore help the plant
battle the effects of cold injury and attain acclimation or tolerance (Senji and
Mandoulakani 2018).
11.3 Conclusion
The role of medicinal plants and the efficacy of their critical metabolites in the
deterrence of diverse illnesses have been a prime focus of research since time
immemorial. The seed, fruit, tuber, root, leaf, and bark extracts housing enormous
phytochemicals have been conceded in the healing science for its holistic, natural,
and safe curative strategies. Attempt has been made globally for a substantial
cultivation of these traditional herbs, recognize the salient phytochemicals with
therapeutic properties, develop formulations, and proffer to the expanding popula-
tion. Climate change and increasing biotic and abiotic stresses primarily transcend
the overall yield and phytochemical constitution of these medicinal plants. To
prevail over these damages especially, the chilling and freezing injuries, plants
have evolved numerous defense mechanisms governed by a troop of signalling
molecules and downstream signal transduction cascades. In this chapter, attempt
has been made to understand various cold acclimation strategies adopted by medici-
nal plants to protect themselves from the desecration of cold stress. Consorted
physiological, morphological, and biochemical alterations in plants due to cold
injury evoke the expression of several COR genes and associated transcription
factors like CBF/DREB leading to the activation and accumulation of several
cryoprotectants in various parts of the plant. In addition to the primary cold-induced
injury, secondary oxidative and osmotic damage also contribute to the death of the
plants. Several Antioxidant and non-antioxidant mechanisms including enzymes,
proteins and vital phytohormones are functionally activated in plants to combat the
oxidative damage and protect the membrane integrity. Likewise, severa l sugars,
amino acids, and amines act as cryoprotectants to maintain the osmo tic homeostasis.
Secondary metabolites formed during the primary catabolic pathways play a critical
role in altering the gene expression pattern, establish cross-talk amongst the
phytohormones, ensure membrane stability, scaveng e the generated free-radicals,
promote photosynthesis, prevent dehydration , and thereby protect the plants from
cold-induced damages and death. In the recent times, engineering the COR genes
and associated cryoprotective proteins in transgenic plants have improved the cold
tolerance mechanisms and promote the biogenesis of clinically eminent secondary
metabolites.
https://t.me/medicina_free
11 Signaling Molecules in Medicinal Plants Response to Cold Stress 187
Acknowledgement The authors are sincerely thanks to the authorities of JSS Academy of Higher
Education and Research, Mysuru, India for infrastructural
and computational facilities.
References
Aarti PD, Tanaka R, Tanaka A (2006) Effects of oxidative stress on chlorophyll biosynthesis in
cucumber (Cucumis sativus) cotyledons. Physiol Plant 128(1):186–197
Abid M, Khan AA, M. (2019) Medicinal plant: environment interaction and mitigation to abiotic
stress. In: Medically important plant biomes source secondary metabolism. Springer, Singapore,
pp 21–50
Ahmad P, Jaleel CA, Salem MA, Nabi G, Sharma S (2010) Roles of enzymatic and nonenzymatic
antioxidants in plants during abiotic stress. Crit Rev Biotechnol 30(3):161–175
Alcázar R, Cuevas JC, Planas J, Zarza X, Bortolotti C, Carrasco P et al (2011) Integration of
polyamines in the cold acclimation response. Plant Sci Int J Exp Plant Biol 180(1):31–38
Alhaithloul HA, Soliman MH, Ameta KL, El-Esawi MA, Elkelish A (2019) Changes in ecophysi-
ology, osmolytes, and secondary metabolites of the medicinal plants of Mentha piperita and
Catharanthus roseus subjected to drought and heat stress. Biomol Ther 10(1):43
Al-Snafi AE (2018) Pharmacology and medicinal properties of Jasminum officinale-a review. Indo
Am J Pharm Sci 5(4):2191–2197
Arora D, Rani A, Sharma A (2013) A review on phytochemistry and ethnopharmacological aspects
of genus calendula. Pharmacogn Rev 7(14):179
Asif Khan M, Yadav R, Singh VK, Singh VK, Mehrotra P, Singh B et al (2022) Phytochemical and
pharmacological potential of wheat herb (Triticum aestivum): a review. Acta Sci Pharm Sci 6:
16–22
Barria C, Malecki M, Arraiano C (2013) Bacterial adaptation to cold. Microbiology 159(Pt_12):
2437–2443
Bohnert HJ, Sheveleva E (1998) Plant stress adaptations—making metabolism move. Curr Opin
Plant Biol 1(3):267–274
Bora KS, Sharma A (2011) Phytochemical and pharmacological potential of Medicago sativa: a
review. Pharm Biol 49(2):211–220
Campos Alvarez F, Cruz García F, Torres Espinosa A, Sánchez Jiménez M, Colmenero Flores JM,
Smith Espinoza C et al (2002) Expression of late embryogenesis abundant (LEA) protein
codifying genes during osmopriming of maize and bean seeds. Agrociencia 36:461–470
Carrera-Lanestosa A, Moguel-Ordónez Y, Segura-Campos M (2017) Stevia rebaudiana Bertoni: a
natural alternative for treating diseases associated with metabolic syndrome. J Med Food
20(10):933–943
Charlton A (2004) Medicinal uses of tobacco in history. J R Soc Med 97(6):292–296
Chen Z, Raji M (2020) Role of reactive oxygen species in modulating cross tolerance in plants via
flavonoids. In: Priming-mediated stress and cross-stress tolerance in crop plants. Elsevier,
Amsterdam, pp 203–214
Chen D, Shao Q, Yin L, Younis A, Zheng B (2019) Polyamine function in plants: metabolism,
regulation on development, and roles in abiotic stress responses. Front Plant Sci 9:1945
Chodisetti B, Rao K, Gandi S, Giri A (2015) Gymnemic acid enhancement in the suspension
cultures of Gymnema sylvestre by using the signaling molecules — methyl jasmonate and
salicylic acid. Vitro Cell Dev Biol-Plant 51:88–92
Collins EJ, Bowyer C, Tsouza A, Chopra M (2022) Tomatoes: an extensive review of the associated
health impacts of tomatoes and factors that can affect their cultivation. Biology 11(2):239
Echeverria A, Larrainzar E, Li W, Watanabe Y, Sato M, Tran CD et al (2021) Medicago sativa and
Medicago truncatula show contrasting root metabolic responses to drought. Front Plant Sci 12:
612
Edge R, McGarvey D, Truscott T (1997) The carotenoids as anti-oxidants—a review. J Photochem
Photobiol B 41(3):189
–200
https://t.me/medicina_free
188 G. K. Dugganaboyana et al.
El-Beshbishy H, Bahashwan S (2012) Hypoglycemic effect of basil (Ocimum basilicum) aqueous
extract is mediated through inhibition of α-glucosidase and α-amylase activities: an
in vitro
study. Toxicol Ind Health 28(1):42–50
Emamverdian A, Ding Y, Mokhberdoran F (2020) The role of salicylic acid and gibberellin
signaling in plant responses to abiotic stress with an emphasis on heavy metals. Plant Signal
Behav 15(7):1777372
Ercoli L, Mariotti M, Masoni A, Arduini I (2004) Growth responses of sorghum plants to chilling
temperature and duration of exposure. Eur J Agron 21(1):93–103
Eremina M, Rozhon W, Poppenberger B (2016) Hormonal control of cold stress responses in
plants. Cell Mol Life Sci 73:797–810
Eskandari A, Leow TC, Rahman MBA, Oslan SN (2020) Antifreeze proteins and their practical
utilization in industry, medicine, and agriculture. Biomol Ther 10(12):1649
Feng S, Martinez C, Gusmaroli G, Wang Y, Zhou J, Wang F et al (2008) Coordinated regulation of
Arabidopsis thaliana development by light and gibberellins. Nature 451(7177):475–479
Fernandez O, Béthencourt L, Quero A, Sangwan RS, Clément C (2010) Trehalose and plant stress
responses: friend or foe? Trends Plant Sci 15(7):409–417
Garay-Arroyo A, Colmenero-Flores JM, Garciarrubio A, Covarrubias AA (2000) Highly hydro-
philic proteins in prokaryotes and eukaryotes are common during conditions of water deficit. J
Biol Chem 275(8):5668–5674
Gechev T, Willekens H, Van Montagu M, Inzé D, Van Camp W, Toneva V et al (2003) Different
responses of tobacco antioxidant enzymes to light and chilling stress. J Plant Physiol 160(5):
509–515
Ghassemi S, Delangiz N, Lajayer BA, Saghafi D, Maggi F (2021) Review and future prospects on
the mechanisms related to cold stress resistance and tolerance in medicinal plants. Acta Ecol Sin
41(2):120–129
Gill SS, Tuteja N (2010) Reactive oxygen species and antioxidant machinery in abiotic stress
tolerance in crop plants. Plant Physiol Biochem 48(12):909–930
Gupta R, Deswal R (2012) Low temperature stress modulated secretome analysis and purification of
antifreeze protein from Hippophae rhamnoides, a Himalayan wonder plant. J Proteome Res
11(5):2684–2696
Hajihashemi S, Noedoost F, Geuns JM, Djalovic I, Siddique KH (2018) Effect of cold stress on
photosynthetic traits, carbohydrates, morphology, and anatomy in nine cultivars of Stevia
rebaudiana. Front Plant Sci 9:1430
Hekneby M, Antolín MC, Sánchez-Díaz M (2006) Frost resistance and biochemical changes during
cold acclimation in different annual legumes. Environ Exp Bot 55(3):305–314
Sanghera SG, Wani HS, Hussain W, Singh BN (2011) Engineering cold stress tolerance in crop
plants. Curr Genomics 12(1):30
Hussein RA, El-Anssary AA (2018) Plants secondary metabolites: the key drivers of the pharma-
cological actions of medicinal plants. In: Builders PF (ed) Herbal medicine. IntechOpen, Rijeka.
https://doi.org/10.5772/intechopen.76139
Ilyas M, Khan WA, Ali T, Ahmad N, Khan Z, Fazal H et al (2022) Cold stress-induced seed
germination and biosynthesis of polyphenolics content in medicinally important Brassica rapa.
Phytomed Plus 2(1):100185
Isah T (2019) Stress and defense responses in plant secondary metabolites production. Biol Res 52:
39
Jan N, Majeed U, Andrabi KI, John R (2018) Cold stress modulates osmolytes and antioxidant
system in Calendula officinalis. Acta Physiol Plant 40:1–16
Joshi RK (2014) Chemical composition and antimicrobial activity of the essential oil of Ocimum
basilicum L. (sweet basil) from Western Ghats of north West Karnataka, India. Anc Sci Life
33(3):151–156
Kala CP, Dhyani PP, Sajwan BS (2006) Developing the medicinal plants sector in northern India:
challenges and opportunities. J Ethnobiol Ethnomed 2:1
–15
https://t.me/medicina_free
11 Signaling Molecules in Medicinal Plants Response to Cold Stress 189
Kanso M, Hijazi M, Aboul Ela M, El-Lakany A (2022) Medicinal plants’ stress factors: effects on
metabolites and novel perspectives for tolerance. BAU J 5(1):1.
http://digitalcommons.bau.edu.
lb/hwbjournal/vol5/iss1/6
Ke L, Lei W, Yang W, Wang
J, Gao J, Cheng J et al (2020) Genome-wide identification of cold
responsive transcription factors in Brassica napus L. BMC Plant Biol 20(1):1–13
Khan H, Shah SH, Uddin N, Azhar N, Asim M, Syed S et al (2015) Biochemical and physiological
changes of different plants species in response to heat and cold stress. ARPN J Agric Biol Sci
10:213–216
Kim JH (2018) Pharmacological and medical applications of Panax ginseng and ginsenosides: a
review for use in cardiovascular diseases. J Ginseng Res 42(3):264–269
Kishor PK, Sangam S, Amrutha R, Laxmi PS, Naidu K, Rao KS et al (2005) Regulation of proline
biosynthesis, degradation, uptake and transport in higher plants: its implications in plant growth
and abiotic stress tolerance. Curr Sci 88:424–438
Kosová K, Klíma M, Prášil IT, Vítámvás P (2021) COR/LEA proteins as indicators of frost
tolerance in Triticeae: a comparison of controlled versus field conditions. Plan Theory 10(4):
789
Kumar A, Abrol E, Koul S, Vyas D (2012) Seasonal low temperature plays an important role in
increasing metabolic content of secondary metabolites in Withania somnifera (L.) Dunal and
affects the time of harvesting. Acta Physiol Plant 34:2027–2031
Latif A, Ashiq K, Qayyum M, Ashiq S, Ali E, Anwer I (2019) Phytochemical and pharmacological
profile of the medicinal herb: Bryophyllum pinnatum. JAPS J Anim Plant Sci 29(6)
Li QF, Wang C, Jiang L, Li S, Sun SS, He JX (2012) An interaction between BZR1 and DELLAs
mediates direct signaling crosstalk between brassinosteroids and gibberellins in Arabidopsis.
Sci Signal 5(244):ra72
Mahajan S, Tuteja N (2005) Cold, salinity and drought stresses: an overview. Arch Biochem
Biophys 444(2):139–158
Manavalan A, Ramachandran U, Sundaramurthi H, Mishra M, Sze SK, Hu JM et al (2012)
Gastrodia elata Blume (tianma) mobilizes neuro-protective capacities. Int J Biochem Mol
Biol 3(2):219
McAinsh MR, Clayton H, Mansfield TA, Hetherington AM (1996) Changes in stomatal behavior
and guard cell cytosolic free calcium in response to oxidative stress. Plant Physiol 111(4):
1031–1042
Mir BA, Mir SA, Khazir J, Tonfack LB, Cowan DA, Vyas D et al (2015) Cold stress affects
antioxidative response and accumulation of medicinally important withanolides in Withania
somnifera (L.) Dunal. Ind Crops Prod 74:1008–1016
Moradi Peynevandi K, Razavi SM, Zahri S (2018) The ameliorating effects of polyamine supple-
ment on physiological and biochemical parameters of Stevia rebaudiana Bertoni under cold
stress. Plant Prod Sci 21(2):123–131
Mukherjee PK, Banerjee S, Biswas S, Das B, Kar A, Katiyar C (2021) Withania somnifera (L.)
Dunal-modern perspectives of an ancient Rasayana from Ayurveda. J Ethnopharmacol 264:
113157
Neill SJ, Desikan R, Clarke A, Hurst RD, Hancock JT (2002) Hydrogen peroxide and nitric oxide as
signalling molecules in plants. J Exp Bot 53(372):1237–1247
Pandith SA, Dar RA, Lattoo SK, Shah MA, Reshi ZA (2018) Rheum australe, an endangered high-
value medicinal herb of North Western Himalayas: a review of its botany, ethnomedical uses,
phytochemistry and pharmacology. Phytochem Rev 17:573–609
Pant
P, Pandey S, Dall’Acqua S. (2021) The influence of environmental conditions on secondary
metabolites in medicinal plants: a literature
review. Chem Biodivers 18(11):e2100345
Paul S, Geng C, Yang T, Yang Y, Chen J (2019) Phytochemical and health-beneficial progress of
turnip (Brassica rapa). J Food Sci 84(1):19–30
Peleg Z, Blumwald E (2011) Hormone balance and abiotic stress tolerance in crop plants. Curr Opin
Plant Biol 14(3):290–295
https://t.me/medicina_free
190 G. K. Dugganaboyana et al.
Peng X, Li M, Wu H, Chen H, Zhang Z (2021) Co-regulation role of endogenous hormones and
transcriptomics profiling under cold stress in Tetrastigma hemsleyanum. J Plant Growth Regul
40:1992–2006
Penna S (2003) Building stress tolerance through over-producing
trehalose in transgenic plants.
Trends Plant Sci 8(8):355–357
Pollock C, Lloyd E (1987) The effect of low temperature upon starch, sucrose and fructan synthesis
in leaves. Ann Bot 60(2):231–235
Poonkodi K (2016) Chemical composition of essential oil of Ocimum basilicum L. (basil) and its
biological activities-an overview. J Crit Rev 3(3):56–62
Pushkina N (2020) Fatty acids and oxylipins accumulation in Zea Maize L. seedlings under the
influence of the electromagnetic field of the super high-frequency range. Chem Plant Raw Mater
59:93–99
Rahman IU, Hart R, Afzal A, Iqbal Z, Alqarawi AA et al (2019) Ecophysiological plasticity and
cold stress adaptation in Himalayan alpine herbs: bistorta affinis and Sibbaldia procumbens.
Plan Theory 8(10):378
Rajashekar CB, Li PH, Carter JV (1983) Frost injury and heterogeneous ice nucleation in leaves of
tuber-bearing solanum species: ice nucleation activity of external source of nucleants. Plant
Physiol 71(4):749–755
Rezaie R, Abdollahi Mandoulakani B, Fattahi M (2020) Cold stress changes antioxidant defense
system, phenylpropanoid contents and expression of genes involved in their biosynthesis in
Ocimum basilicum L. Sci Rep 10(1):1–10
Rontani JF, Nassiry M, Mouzdahir A (2007) Free radical oxidation (autoxidation) of α-tocopherol
(vitamin E): a potential source of 4, 8, 12, 16-tetramethylheptadecan-4-olide in the environment.
Org Geochem 38(1):37–47
Ruelland E, Vaultier MN, Zachowski A, Hurry V (2009) Cold signalling, and cold acclimation in
plants. Adv Bot Res 49:35–150
Sangwan R, Chaurasiya N, Misra L, Lal P, Uniyal G, Sharma R et al (2004) Phytochemical
variability in commercial herbal products and preparations of Withania somnifera
(Ashwagandha). Curr Sci 86:461–465
Sasaki H, Ichimura K, Oda M (1996) Changes in sugar content during cold acclimation and
deacclimation of cabbage seedlings. Ann Bot 78(3):365–369
Schwechheimer C (2012) Gibberellin signaling in plants–the extended version. Front Plant Sci 2:
107
Senji BM, Mandoulakani BA (2018) The impact of cold stress on genes expression pattern of
mono-and sesquiterpene biosynthesis and their contents in Ocimum basilicum
L. Phytochemistry 156:250–256
Shahzad R, Ewas M, Harlina PW, Khan SU, Zhenyuan P, Nie X et al (2021) β-Sitosterol differen-
tially regulates key metabolites for growth improvement and stress tolerance in rice plants
during prolonged UV-B stress. J Genet Eng Biotechnol 19(1):1–16
Sharma A (2018) Gene expression analysis in medicinal plants under abiotic stress conditions. In:
Plant metabolites and regulation under environmental stress. Elsevier, Amsterdam, pp 407–414
Shi Y, Ding Y, Yang S (2015) Cold signal transduction and its interplay with phytohormones
during cold acclimation. Plant Cell Physiol 56(1):7–15
Solanke AU, Sharma AK (2008) Signal transduction during cold stress in plants. Physiol Mol Biol
Plants 14:69–79
Steffen KL, Arora R, Palta JP (1989) Relative sensitivity of photosynthesis and respiration to
freeze-thaw stress in herbaceous species: importance of realistic freeze-thaw protocols. Plant
Physiol 89(4):1372–
1379
Suryakumar
G, Gupta A (2011) Medicinal and therapeutic potential of sea buckthorn (Hippophae
rhamnoides L.). J Ethnopharmacol 138(2):268–278
Suzuki N, Koussevitzky S, Mittler R, Miller G (2012) ROS and redox signalling in the response of
plants to abiotic stress. Plant Cell Environ 35(2):259–270
Szabados L, Savouré A (2010) Proline: a multifunctional amino acid. Trends Plant Sci 15(2):89–97
https://t.me/medicina_free
Соседние файлы в папке Библиотека им академика М.И. Перельмана