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- •Contents
- •1. Thyroid Embryology, Anatomy, and Physiology: A Review for the Surgeon
- •2. The Assessment of Thyroid Nodules
- •3. Thyroid: Fine-Needle Aspiration Biopsy
- •4. Thyroid Imaging
- •5. Multinodular Goiter
- •6. Thyrotoxicosis and Thyroiditis: Causes, Investigation, and Management
- •7. Molecular Biology of Thyroid Cancer
- •8. Well-Differentiated Thyroid Cancer: An Overview and the Chernobyl Effect
- •9. Poorly Differentiated and Undifferentiated Thyroid Cancer
- •10. Postoperative Management of Well-Differentiated Thyroid Cancer
- •11. Medullary Thyroid Cancer
- •12. Technique of Thyroidectomy
- •13. Lymph Node Dissection in Thyroid Cancer
- •14. Management of the Laryngeal Nerves and Voice
- •15. Embryology, Anatomy, and Physiology of the Parathyroid Glands
- •16. Presentation and Diagnosis of Primary Hyperparathyroidism
- •17. Parathyroid Localization and Imaging
- •18. Intraoperative PTH Monitoring
- •19. Focused Parathyroidectomy
- •20. Parathyroid: Bilateral Neck Exploration
- •21. Reoperative Parathyroid Surgery
- •22. Management of Secondary and Tertiary Hyperparathyroidism
- •23. Parathyroid Carcinoma
- •24. Adrenal Embryology, Anatomy, and Physiology
- •25. Adrenal Imaging
- •26. Adrenal Venous Sampling
- •27. Primary Hyperaldosteronism
- •29. Pheochromocytoma and Paraganglioma
- •30. Adrenocortical Carcinoma
- •31. Incidentaloma
- •32. Adrenal Metastases and Rare Adrenal Tumors
- •33. Technique of Open and Laparoscopic Adrenalectomy
- •34. Laparoscopic Retroperitoneal Adrenalectomy
- •35. Pancreas: Embryology, Anatomy, and Physiology
- •36. Pancreatic Imaging: The Value for Surgery of Neuroendocrine Pancreatic Tumors


Springer
Specialist
Surgery
Series

Other titles in this series include:
Transplantation Surgery edited by Hakim & Danovitch, 2001
Upper Gastrointestinal Surgery edited by Fielding & Hallissey, 2004
Neurosurgery edited by Moore & Newell, 2005
Vascular Surgery edited by Davies & Brophy, 2006
Tumor Neurosurgery edited by Moore & Newell, 2006

Johnathan G.H. Hubbard, William B. Inabnet,
and Chung-Yau Lo (Eds)
Endocrine
Surgery
Principles and Practice
Series Editor: J.S.P. Lumley
Foreword by: Jon van Heerden
13

Editors
Johnathan G.H. Hubbard
Guys & St Thomas’ NHS Foundation Trust
London, UK
Chung-Yau Lo
University of Hong Kong Medical Center
Queen Mary Hospital
Hong Kong, China
William B. Inabnet
Columbia University Medical Center
New York, NY, USA
ISBN 978-1-84628-880-7 e-ISBN 978-1-84628-881-4
DOI 10.1007/978-1-84628-881-4
British Library Cataloguing in Publication Data
A catalogue record for this book is available from the British Library
Library of Congress Control Number: 2009920953
# Springer-Verlag London Limited 2009
Apart from any fair dealing for the purposes of research or private study, or criticism or review, as permitted
under the Copyright, Designs and Patents Act 1988, this publication may only be reproduced, stored or
transmitted, inany formor by anymeans, withthe prior permissionin writing ofthe publishers, or in thecase
of reprographic reproduction in accordance with the terms of licenses issued by the Copyright Licensing
Agency. Enquiries concerning reproduction outside those terms should be sent to the publishers.
The use of registered names, trademarks, etc., in this publication does not imply, even in the absence of a
specific statement, that such names are exempt from the relevant laws and regulations and therefore free for
general use.
The publisher makes no representation, express or implied, with regard to the accuracy of the information
contained in this book and cannot accept any legal responsibility or liability for any errors or omissions that
may be made.
Printed on acid-free paper
Springer ScienceþBusiness Media
springer.com

To my wife Kathleen, and children Frances and William, whose dedication and unconditional love keeps me motivated. And to my endocrine surgery patients, who allow me the
opportunity to practice my profession with grace. WBI
To my late father, who inspired me to pursue a medical career, and to my wife, Sabrina, and
my children, Bryan and Jenny, who have given me so much support. CYL
‘For Chloe Margaux’ JGHH

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Foreword
This latest addition to the Endocrine Surgical library is a gem to be savored at leisure. It is a
comprehensive review and is on the cutting edge of current knowledge regarding surgical
endocrinology.
The fact that the three outstanding editors of Endocrine Surgery are from widely
separated geographic continents (Europe, Asia and America) clearly establishes the flavor
for this international contribution. The surgical arena and the endocrine surgical subspecialty, in particular, is truly international in scope, as it should be, and today represents a
unique close knit family. This is a healthy phenomenon for it allows rapid and constant
exchange of information and ideas by dedicated surgeons, endocrinologists, pathologists,
radiologists, and researchers who personally know and respect each other, and who share a
clear cut common goal – to simply do what is best for each and every patient afflicted with
an endocrine disorder.
The astute reader of this encompassing collection of contributions will notice a ‘‘changing
of the guard’’ phenomenon as well. Although there are well-known players in this endocrine
surgical orchestra, there are, pleasingly, a number of less well-known (albeit for a short time
only) contributors. This is very good indeed and is something that pleases me – a member
of the old guard, immensely. The success of surgical education, and as a consequence, of
patient care, is that each successive generation should be better and wiser than the preceding one. If this is not so, the previous generation has dismally failed. This compendium
wonderfully demonstrates that the authors (the three all star editors in particular) have not
failed in this mission and that the prior generation can be justifiably proud. The authors are
the brightest intellects in endocrine surgery today. They are, one and all, better than their
educators and mentors – they have raised the bar appropriately. This is good. It should
please us all. Peruse this volume with pleasure and reflect on each of your obligations to the
generations that shall follow you.
As a lifelong surgical educator, I am optimistic about the future of surgery. This optimism
is, in part, based on the knowledge that our art is in the capable and trustworthy hands of
Barry, Johnathan and Chung-Yau Lo.
Jon van Heerden
vii

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Preface
As we enter the twenty-first century, the field of endocrine surgery is poised for greatness.
Although we must never forget that the fundamental principles of surgery were passed
down to us from the pioneers of endocrine surgery, including such legends as Billroth,
Halsted, Cushing, and the Mayo brothers, endocrine surgery is evolving continuously, in
particular over the last several decades. In addition to technological advances, tremendous
strides have been made in our understanding of the endocrine system, leading to improved
diagnosis and treatment of various endocrine disorders. Genetic understanding of disease
basis permits earlier diagnosis and curative treatment of hereditary thyroid cancer in
infancy before clinical presentation. Localizing techniques such as radioisotope scanning
and venous sampling allow accurate localization of endocrine tumors, while positron
emission tomography and radioisotope scintigraphy provide a reliable method for diagnosis and surveillance as well as treatment of endocrine malignancy. Improved localization
and intraoperative parathyroid hormone monitoring have led to an evolution in the
treatment of hyperparathyroidism. In addition, the advent of laparoscopic surgery permits
increased application of minimally invasive techniques in the field of endocrine surgery.
Various intraoperative monitoring such as neuromonitoring potentially enhances the
safety of endocrine surgical procedures.
In this setting, we present to you Endocrine Surgery, a book which encompasses these
advances in endocrine surgery with incorporation of fundamental basic concepts and
principles. The editors are active endocrine surgeons practicing in three different
continents – Asia, North America, and Europe. The editors communicated by Skype
conference calling and utilized Google documents so that the concept, design, and organization of the book occurred in real time. In a sign of the times, the quality of the book has
been enhanced by an expert list of contributors to whom we are extremely grateful for their
participation. We also believe that the collective worldwide experience from our international contributors should facilitate current understanding of the state-of-the-art practice
of endocrine surgery in managing various endocrine surgical problems. We hope that you
find this book informative and useful as we strive to perfect the care of our endocrine
surgery patients throughout the world.
Johnathan GH Hubbard
London, UK
William B Inabnet
New York, USA
Chung-yau Lo
Hong Kong, China
ix
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