Добавил:
Sekretar
kiopkiopkiop18@yandex.ru
t.me/Prokururor I Вовсе не секретарь, но почту проверяю
Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз:
Предмет:
Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5932_Библиотеки_им_академика_М_И_Перельмана
.pdf
236 Carbon-Based Nanocarriers for Drug Delivery
[104] S. Ediyilyam, B. George, S.S. Shankar, T.T. Dennise, S. Wacławek, M. Cerník, V.V.T.
Padil, Chitosan/gelatin/silver nanoparticles composites lms for biodegradable food
packaging applications, Polym. 13 (2021). doi:10.3390/POLYM13111680.
[105] F. Ortega, V.B. Arce, M.A. Garcia, Nanocomposite starch-based lms containing silver
nanoparticles synthesized with lemon juice as reducing and stabilizing agent, Carbhydr.
Polym. 252 (2021). doi:10.1016/J.CARBPOL.2020.117208.
[106] T.T. Tsai, T.H. Huang, C.J. Chang, N. Yi-Ju Ho, Y.T. Tseng, C.F. Chen, Antibacte-
rial cellulose paper made with silver-coated gold nanoparticles, Sci. Rep. 7 (2017).
doi:10.1038/S41598-017-03357-W.
[107] K. Kraśniewska, S. Galus, M. Gniewosz, Biopolymers‐based materials containing sil-
ver nanoparticles as active packaging for food applications–a review, Int. J. Mol. Sci.
21 (2020). doi:10.3390/IJMS21030698.
[108] V. Sadanand, N. Rajini, B. Satyanarayana, A.V. Rajulu, Preparation and properties of
cellulose/silver nanoparticle composites with in situ-generated silver nanoparticles
using Ocimum sanctum leaf extract, Int. J. Polym. Anal. Charact. 21 (2016) 408–416.
doi:10.1080/1023666X.2016.1161100.
[109] I. Popescu, M. Constantin, I.M. Pelin, D.M. Suet, D.L. Ichim, O.M. Daraba, G. Fun-
dueanu, Eco-friendly synthesized pva/chitosan/oxalic acid nanocomposite hydrogels
embedding silver nanoparticles as antibacterial materials, Gels. 8 (2022). doi:10.3390/
GELS8050268.
[110] K. Santiago-Castillo, A.M. Torres-Huerta, D. Del Ángel-López, M.A. Domínguez-
Crespo, H. Dorantes-Rosales, D. Palma-Ramírez, H. Willcock, In situ growth of silver
nanoparticles on chitosan matrix for the synthesis of hybrid electrospun bers: Analysis of microstructural and mechanical properties, Polym. 14 (2022). doi:10.3390/
POLYM14040674.
[111] E. Fortunati, F. D’Angelo, S. Martino, A. Orlacchio, J.M. Kenny, I. Armentano, Carbon
nanotubes and silver nanoparticles for multifunctional conductive biopolymer composites, Carbon. 49 (2011) 2370–2379. doi:10.1016/J.CARBON.2011.02.004.
[112] S. Kumar, S. Raj, S. Jain, K. Chatterjee, Multifunctional biodegradable polymer nano-
composite incorporating graphene-silver hybrid for biomedical applications, Mater.
Design. 108 (2016) 319–332. doi:10.1016/J.MATDES.2016.06.107.
[113] P. Kesharwani, V. Gajbhiye, N.K. Jain, A review of nanocarriers for the delivery of
small interfering RNA, Biomater. 33 (2012) 7138–7150. doi:10.1016/j.biomaterials.
2012.06.068.
[114] P. Kesharwani, A. Gothwal, A.K. Iyer, K. Jain, M.K. Chourasia, U. Gupta, Dendrimer
nanohybrid carrier systems: An expanding horizon for targeted drug and gene delivery,
Drug Dis. Today. 23 (2018) 300–314. doi:10.1016/j.drudis.2017.06.009.
[115] S. Chandrasekaran, M.R. King, Microenvironment of tumor-draining lymph nodes:
opportunities for liposome-based targeted therapy, Int. J. Mol. Sci. 15 (2014) 20209–
20239. doi:10.3390/ijms151120209.
[116] D. Bhadra, S. Bhadra, S. Jain, N.K. Jain, A PEGylated dendritic nanoparticulate carrier of
uorouracil, Int. J. Pharm. 257 (2003) 111–124. doi:10.1016/S0378-5173(03)00132-7.
[117] P. Agrawal, U. Gupta, N.K. Jain, Glycoconjugated peptide dendrimers-based nanopar-
ticulate system for the delivery of chloroquine phosphate, Biomater. 28 (2007) 3349–
3359. doi:10.1016/j.biomaterials.2007.04.004.
[118] G. Purohit, T. Sakthivel, A.T. Florence, Interaction of cationic partial dendrimers
with charged and neutral liposomes, Int. J. Pharm. 214 (2001) 71–76. doi:10.1016/
S0378-5173(00)00635-9.
[119] A.J. Khopade, F. Caruso, P. Tripathi, S. Nagaich, N.K. Jain, Effect of dendrimer on
entrapment and release of bioactive from liposomes, Int. J. Pharm. 232 (2002) 157–162.
doi:10.1016/S0378-5173(01)00901-2.
237Carbon-Based Nanocomposites for Drug Delivery
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
[120] A. Papagiannaros, K. Dimas, G.T. Papaioannou, C. Demetzos, Doxorubicin–PAMAM
dendrimer complex attached to liposomes: Cytotoxic studies against human cancer cell
lines, Int. J. Pharm. 302 (2005) 29–38. doi:10.1016/j.ijpharm.2005.05.039.
[121] B. Pan, F. Gao, L. Ao, H. Tian, R. He, D. Cui, Controlled self-assembly of thiol-
terminated poly(amidoamine) dendrimer and gold nanoparticles, Colloids Surf. A Physicochem. Eng. Asp. 259 (2005) 89–94. doi:10.1016/j.colsurfa.2005.02.009.
[122] Y. Nakanishi, T. Imae, Synthesis of dendrimer-protected TiO2 nanoparticles and pho-
todegradation of organic molecules in an aqueous nanoparticle suspension, J. Colloid
Interface Sci. 285 (2005) 158–162. doi:10.1016/j.jcis.2004.11.055.
[123] T. Pietsch, D. Appelhans, N. Gindy, B. Voit, A. Fahmi, Oligosaccharide-modied den-
drimers for templating gold nanoparticles: Tailoring the particle size as a function of
dendrimer generation and -molecular structure, Colloids Surf. A
Physicochem. Eng.
Asp. 341 (2009) 93–102. doi:10.1016/j.colsurfa.2009.03.044.
[124] C. Li, D. Li, Z.-S. Zhao, X.-M. Duan, W. Hou, Platinum nanoparticles from hydrosilyl-
ation reaction: Carbosilane dendrimer as capping agent, Colloids Surf. A
Physicochem.
Eng. Asp. 366 (2010) 45–49. doi:10.1016/j.colsurfa.2010.05.013.
[125] H. Liu, M. Shen, J. Zhao, R. Guo, X. Cao, G. Zhang, X. Shi, Tunable synthesis
and
acetylation of dendrimer-entrapped or dendrimer-stabilized gold–silver alloy
nanoparticles, Colloids Surf. B Biointerfaces. 94 (2012) 58–67. doi:10.1016/j.
colsurfb.2012.01.019.
[126] X. Sun, Y. Luo, Size-controlled synthesis of dendrimer-protected gold nanopar-
ticles by microwave radiation, Mater. Lett. 59 (2005) 4048–4050. doi:10.1016/j.
matlet.2005.07.060.
[127] W.-M. Liu, Y.-N. Xue, W.-T. He, R.-X. Zhuo, S.-W. Huang, Dendrimer modied mag-
netic iron oxide nanoparticle/dna/pei ternary complexes: A
novel strategy for magneto-
fection, J. Con. Rel. 152 (2011) e159–e160. doi:10.1016/j.jconrel.2011.08.061.
[128] N. Krasteva, B. Guse, I. Besnard, A. Yasuda, T. Vossmeyer, Gold nanoparticle/PPI-
dendrimer based chemiresistors: Vapor-sensing properties as a function of the dendrimer
size, Sens. Actuators B Chem. 92 (2003) 137–143. doi:10.1016/S0925-4005(03)00250-8.
[129] N. Krasteva, H. Möhwald, R. Krastev, Structural changes in stimuli-responsive nan-
oparticle/dendrimer composite lms upon vapor sorption, Comptes Rendus Chimie.
12 (2009) 129–137. doi:10.1016/j.crci.2008.09.001.
[130] Y.-M. Chung, H.-K. Rhee, Partial hydrogenation of 1,3-cyclooctadiene using dendrim-
er-encapsulated Pd–Rh bimetallic nanoparticles, J. Mol. Catal. A
Chem. 206 (2003)
291–298. doi:10.1016/S1381-1169(03)00418-7.
[131] F.N. Crespilho, F.C. Nart, O.N. Oliveira, C.M.A. Brett, Oxygen reduction and diffu-
sion in electroactive nanostructured membranes (ENM) using a layer-by-layer dendrimer-gold nanoparticle approach, Electrochim. Acta. 52 (2007) 4649–4653. doi:10.1016/j.
electacta.2007.01.048.
[132] A. Kesavan, P. Ilaiyaraja, W. So Beaula, V. Veena Kumari, J. Sugin Lal, C. Arunkumar,
G. Anjana, S. Srinivas, A. Ramesh, S.K. Rayala, D. Ponraju, G. Venkatraman, Tumor
targeting using polyamidoamine dendrimer–cisplatin nanoparticles functionalized
with diglycolamic acid and herceptin, Eur. J. Pharm. Biopharm. 96 (2015) 255–263.
doi:10.1016/j.ejpb.2015.08.001.
[133] Y. Fan, S. Yuan, M. Huo, A.S. Chaudhuri, M. Zhao, Z. Wu, X. Qi, Spatial controlled
multistage nanocarriers through hybridization of dendrimers and gelatin nanoparticles
for deep penetration and therapy into tumor tissue, Nanomed. Nanotechnol. Biol. Med.
13 (2017) 1399–1410. doi:10.1016/j.nano.2017.01.008.
[134] P. Zhang, Y. Zhang, M. Gao, X. Zhang, Dendrimer-assisted hydrophilic magnetic nan-
oparticles as sensitive substrates for rapid recognition and enhanced isolation of target
tumor cells, Talanta. 161 (2016) 925–931. doi:10.1016/j.talanta.2016.08.064.
238 Carbon-Based Nanocarriers for Drug Delivery
[135] B.I. Lemon, R.M. Crooks, Preparation and characterization of dendrimer-encapsulated
CdS semiconductor quantum dots, J. Am. Chem. Soc. 122 (2000) 12886–12887.
doi:10.1021/ja0031321.
[136] Z. Li, P. Huang, R. He, J. Lin, S. Yang, X. Zhang, Q. Ren, D. Cui, Aptamer-conjugated
dendrimer-modied quantum dots for cancer cell targeting and imaging, Mater. Lett.
64 (2010) 375–378. doi:10.1016/j.matlet.2009.11.022.
[137] Z. Li, P. Huang, J. Lin, R. He, B. Liu, X. Zhang, S. Yang, P. Xi, X. Zhang, Q. Ren,
D. Cui, Arginine-glycine-aspartic acid-conjugated dendrimer-modied quantum dots
for targeting and imaging melanoma, J. Nanosci. Nanotechnol. 10 (2010) 4859–4867.
doi:10.1166/jnn.2010.2217.
[138] B. Reddy, Advances in Nanocomposites: Synthesis, Characterization and Industrial
Applications, BoD—Books on Demand, Rijeka (2011).
[139] H. Yin, Y. Zhou, S. Ai, Q. Chen, X. Zhu, X. Liu, L. Zhu, Sensitivity and selectivity
determination of BPA in real water samples using PAMAM dendrimer and CoTe quantum dots modied glassy carbon electrode, J. Hazard. Mater. 174 (2010) 236–243.
doi:10.1016/j.jhazmat.2009.09.041.
[140] P. Kesharwani, R. Ghanghoria, N.K. Jain, Carbon nanotube exploration in cancer cell
lines, Drug Dis. Today. 17 (2012) 1023–1030. doi:10.1016/j.drudis.2012.05.003.
[141] J. Geng, H. Li, D. Zhou, W.T.S. Huck, B.F.G. Johnson, A dendrimer-based Co32 nano-
cluster: Synthesis and application in diameter-controlled growth of single-walled carbon nanotubes, Polyhedron. 25 (2006) 585–590. doi:10.1016/j.poly.2005.08.036.
[142] H. Yoshioka, M. Suzuki, M. Mugisawa, N. Naitoh, H. Sawada, Synthesis and appli-
cations of novel uorinated dendrimer-type copolymers by the use of uoroalkanoyl
peroxide as a key intermediate, J. Colloid Interface Sci. 308 (2007) 4–10. doi:10.1016/j.
jcis.2006.12.046.
[143] L. Tang, Y. Zhu, X. Yang, C. Li, An enhanced biosensor for glutamate based on self-
assembled carbon nanotubes and dendrimer-encapsulated platinum nanobiocomposites-doped polypyrrole lm, Anal. Chim. Acta. 597 (2007) 145–150. doi:10.1016/j.
aca.2007.06.024.
[144] E. Murugan, G. Vimala, Effective functionalization of multiwalled carbon nanotube
with amphiphilic poly(propyleneimine) dendrimer carrying silver nanoparticles for better dispersability and antimicrobial activity, J. Colloid Interface Sci. 357 (2011) 354–
365. doi:10.1016/j.jcis.2011.02.009.
[145] Y. Shen, Q. Xu, H. Gao, N. Zhu, Dendrimer-encapsulated Pd nanoparticles anchored
on carbon nanotubes for electro-catalytic hydrazine oxidation, Electrochem. Comm.
11 (2009) 1329–1332. doi:10.1016/j.elecom.2009.05.005.
[146] S. Choudhary, A. Jain, M.C.I.M. Amin, V. Mishra, G.P. Agrawal, P. Kesharwani, Stom-
ach specic polymeric low density microballoons as a vector for extended delivery of
rabeprazole and amoxicillin for treatment of peptic ulcer, Colloids Surf. B Biointerfaces. 141 (2016) 268–277. doi:10.1016/j.colsurfb.2016.01.048.
[147] B.M. Cummins, J. Lim, E.E. Simanek, M.V. Pishko, G.L. Coté, Encapsulation of a
Concanavalin A/dendrimer glucose sensing assay within microporated poly (ethylene glycol) microspheres, Biomed. Opt. Express. 2 (2011) 1243–1257. doi:10.1364/
BOE.2.001243.
[148] L.-Z. Kong, C.-Y. Pan, Preparation of dendrimer-like copolymers based on polystyrene
and poly(l-lactide) and formation of hollow microspheres, Polymer. 49 (2008) 200–210.
doi:10.1016/j.polymer.2007.11.042.
[149] G. Dang, Y. Shi, Z. Fu, W. Yang, Polymer particles with dendrimer@SiO2–Ag hier-
archical shell and their application in catalytic column, J. Colloid Interface Sci.
369 (2012) 170–178. doi:10.1016/j.jcis.2011.11.054.
[150] A.Z. Wilczewska, K. Niemirowicz, K.H. Markiewicz, H. Car, Nanoparticles as drug deliv-
ery systems, Pharm. Rep. 64 (2012) 1020–1037. doi:10.1016/S1734-1140(12)70901-5.
239Carbon-Based Nanocomposites for Drug Delivery
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
[151] S. Nummelin, V. Liljeström, E. Saarikoski, J. Ropponen, A. Nykänen, V. Linko, J. Sep-
pälä, J. Hirvonen, O. Ikkala, L.M. Bimbo, M.A. Kostiainen, Self-assembly of amphiphilic janus dendrimers into mechanically robust supramolecular hydrogels for sustained
drug release, Chem. Eur. J. 21 (2015) 14433–14439. doi:10.1002/chem.201501812.
[152] M. Wróblewska, K. Winnicka, The effect of cationic polyamidoamine dendrimers
on physicochemical characteristics of hydrogels with erythromycin, Int. J. Mol. Sci.
16 (2015) 20277–20289. doi:10.3390/ijms160920277.
[153] R.J. Seelbach, P. Fransen, M. Peroglio, D. Pulido, P. Lopez-Chicon, F. Duttenhoefer,
S. Sauerbier, T. Freiman, P. Niemeyer, C. Semino, F. Albericio, M. Alini, M. Royo,
A. Mata, D. Eglin, Multivalent dendrimers presenting spatially controlled clusters
of binding epitopes in thermoresponsive hyaluronan hydrogels, Acta Biomaterialia.
10 (2014) 4340–4350. doi:10.1016/j.actbio.2014.06.028.
[154] T. Cheng-An, Z. Hao, W. Fang, Z. Hui, Z. Xiaorong, W. Jianfang, Mechanical properties
of graphene oxide/polyvinyl alcohol composite lm, Polym. Polym. Compos. 25 (2017)
11–16. doi:10.1177/096739111702500102.
[155] A. Mohandas, S. Deepthi, R. Biswas, R. Jayakumar, Chitosan based metallic nanocom-
posite scaffolds as antimicrobial wound dressings, Bioact. Mater. 3 (2018) 267–277.
doi:10.1016/J.BIOACTMAT.2017.11.003.
[156] R. Chawla, S. Sivakumar, H. Kaur, Antimicrobial edible lms in food packaging: Cur-
rent scenario and recent nanotechnological advancements- a review, Car. Polym. Technol. Appl. 2 (2021). doi:10.1016/J.CARPTA.2020.100024.
[157] Kusmono, I. Abdurrahim, Water sorption, antimicrobial activity, and thermal and
mechanical properties of chitosan/clay/glycerol nanocomposite lms, Heliyon.
5 (2019). doi:10.1016/J.HELIYON.2019.E02342.
[158] Y. Cui, Q. Wu, J. He, M. Li, Z. Zhang, Y. Qiu, Porous nano-minerals substituted apa-
tite/chitin/pectin nanocomposites scaffolds for bone tissue engineering, Arab. J. Chem.
13 (2020) 7418–7429. doi:10.1016/J.ARABJC.2020.08.018.
[159] S. Nazir, M. Umar Aslam Khan, W. Shamsan Al-Arjan, S. Izwan Abd Razak, A. Javed,
M. Raq Abdul Kadir, Nanocomposite hydrogels for melanoma skin cancer care and
treatment: In-vitro drug delivery, drug release kinetics and anti-cancer activities, Arab.
J. Chem. 14 (2021). doi:10.1016/J.ARABJC.2021.103120.
[160] C. Li, H. Ye, S. Ge, Y. Yao, B. Ashok, N. Hariram, H. Liu, H. Tian, Y. He, G. Guo,
A.V. Rajulu, Fabrication and properties of antimicrobial exible nanocomposite polyurethane foams with in situ generated copper nanoparticles, J. Mater. Res. Technol.
19 (2022) 3603–3615. doi:10.1016/J.JMRT.2022.06.115.
[161] H. Munir, K. Tahira, A.R. Bagheri, M. Bilal, Biodegradation of materials in pres-
ence of nanoparticles, Biodegr. Biodet. Nanoscale. (2021) 9–30. doi:10.1016/
B978-0-12-823970-4.00002-6.
[162] Z. Peng, X. Liu, W. Zhang, Z. Zeng, Z. Liu, C. Zhang, Y. Liu, B. Shao, Q. Liang,
W. Tang, X. Yuan, Advances in the application, toxicity and degradation of carbon
nanomaterials in environment: A review, Environ. Int. 134 (2020). doi:10.1016/J.
ENVINT.2019.105298.
[163] F. Candotto Carniel, L. Fortuna, D. Zanelli, M. Garrido, E. Vázquez, V.J. González,
M. Prato, M. Tretiach, Graphene environmental biodegradation: Wood degrading
and saprotrophic fungi oxidize few-layer graphene, J. Hazard. Mater. 414 (2021).
doi:10.1016/J.JHAZMAT.2021.125553.
[164] R.P. Feazell, N. Nakayama-Ratchford, H. Dai, S.J. Lippard, Soluble single-walled car-
bon nanotubes as longboat delivery systems for platinum(IV) anticancer drug design,
J. Am. Chem. Soc. 129 (2007) 8438–8439. doi:10.1021/JA073231F.
[165] W. Wu, R. Li, X. Bian, Z. Zhu, D. Ding, X. Li, Z. Jia, X. Jiang, Y. Hu, Covalently
combining carbon nanotubes with anticancer agent: Preparation and antitumor activity,
ACS Nano. 3 (2009) 2740–2750. doi:10.1021/NN9005686.
240 Carbon-Based Nanocarriers for Drug Delivery
[166] A. Kulamarva, P.M.V. Raja, J. Bhathena, H. Chen, S. Talapatra, P.M. Ajayan, O. Nal-
amasu, S. Prakash, Microcapsule carbon nanotube devices for therapeutic applications,
Nanotechnol. 20 (2009). doi:10.1088/0957-4484/20/2/025612.
[167] A. Kulamarva, J. Bhathena, M. Malhotra, S. Sebak, O. Nalamasu, P. Ajayan, S. Prakash,
In vitro cytotoxicity of functionalized single walled carbon nanotubes for targeted gene
delivery applications, Nanotoxicol. 2 (2008) 184–188. doi:10.1080/17435390802464994.
[168] A.A. Bhirde, V. Patel, J. Gavard, G. Zhang, A.A. Sousa, A. Masedunskas, R.D. Leap-
man, R. Weigert, J.S. Gutkind, J.F. Rusling, Targeted killing of cancer cells in vivo and
in vitro with EGF-directed carbon nanotube-based drug delivery, ACS Nano. 3 (2009)
307–316. doi:10.1021/nn800551s.
[169] R. Krajcik, A. Jung, A. Hirsch, W. Neuhuber, O. Zolk, Functionalization of carbon
nanotubes enables non-covalent binding and intracellular delivery of small interfering
RNA for efcient knock-down of genes, Biochem. Biophys. Res. Comm. 369 (2008)
595–602. doi:10.1016/j.bbrc.2008.02.072.
[170] Z. Zhang, X. Yang, Y. Zhang, B. Zeng, S. Wang, T. Zhu, R.B.S. Roden, Y. Chen,
R. Yang, Delivery of telomerase reverse transcriptase small interfering RNA in complex
with positively charged single-walled carbon nanotubes suppresses tumor growth, Clin.
Cancer Res. 12 (2006) 4933–4939. doi:10.1158/1078-0432.CCR-05-2831.
[171] G. Pastorin, W. Wu, S. Wieckowski, J.P. Briand, K. Kostarelos, M. Prato, A. Bianco,
Double functionalisation of carbon nanotubes for multimodal drug delivery, Chem.
Comm. (2006) 1182–1184. doi:10.1039/B516309A.
[172] M.J. O’Connell, S.M. Bachilo, C.B. Huffman, V.C. Moore, M.S. Strano, E.H. Haroz,
K.L. Rialon, P.J. Boul, W.H. Noon, C. Kittrell, J. Ma, R.H. Hauge, R.B. Weisman, R.E.
Smalley, Band gap uorescence from individual single-walled carbon nanotubes, Sci.
297 (2002) 593–596. doi:10.1126/science.1072631.
[173] N.W.S. Kam, M. O’Connell, J.A. Wisdom, H. Dai, Carbon nanotubes as multifunctional
biological transporters and near-infrared agents for selective cancer cell destruction, Proc.
Natl. Acad. Sci. U.S.A. 102 (2005) 11600–11605. doi:10.1073/PNAS.0502680102.
[174] N. Shao, S. Lu, E. Wickstrom, B. Panchapakesan, Integrated molecular targeting of
IGF1R and HER2 surface receptors and destruction of breast cancer cells using single
wall carbon nanotubes, Nanotechnol. 18 (2007). doi:10.1088/0957-4484/18/31/315101.
[175] N. Poovaiah, Z. Davoudi, H. Peng, B. Schlichtmann, S. Mallapragada, B. Narasimhan,
Q. Wang, Treatment of neurodegenerative disorders through the blood–brain barrier
using nanocarriers, Nanoscale. 10 (2018) 16962–16983. doi:10.1039/C8NR04073G.
[176] S. Ramanathan, G. Archunan, M. Sivakumar, S. Tamil Selvan, A.L. Fred, S. Kumar, B.
Gulyás, P. Padmanabhan, Theranostic applications of nanoparticles in neurodegenerative disorders, Int. J. Nanomed. 13 (2018) 5561–5576. doi:10.2147/IJN.S149022.
[177] M. Wei, P. Lin, Y. Chen, J.Y. Lee, L. Zhang, F. Li, D. Ling, Applications of ion level
nanosensors for neuroscience research, Nanomed. 15 (2020) 2871–2881. doi:10.2217/
nnm-2020-0320.
[178] I. Cacciatore, M. Ciulla, E. Fornasari, L. Marinelli, A. Di Stefano, Solid lipid nanopar-
ticles as a drug delivery system for the treatment of neurodegenerative diseases, Expert
Opin. Drug Deliv. 13 (2016) 1121–1131. doi:10.1080/17425247.2016.1178237.
[179] M. Bilal, M. Barani, F. Sabir, A. Rahdar, G.Z. Kyzas, Nanomaterials for the treatment
and diagnosis of Alzheimer’s disease: An overview, NanoImpact. 20 (2020) 100251.
doi:10.1016/j.impact.2020.100251.
[180] B. Wilson, M.K. Samanta, K. Santhi, K.P.S. Kumar, N. Paramakrishnan, B. Suresh,
Poly(n-butylcyanoacrylate) nanoparticles coated with polysorbate 80 for the targeted
delivery of rivastigmine into the brain to treat Alzheimer’s disease, Brain Res. 1200
(2008) 159–168. doi:10.1016/j.brainres.2008.01.039.
241Carbon-Based Nanocomposites for Drug Delivery
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
[181] J.L. Gilmore, X. Yi, L. Quan, A.V. Kabanov, Novel nanomaterials for clinical
neuroscience, J. Neuroimmune Pharmacol. 3 (2008) 83–94. doi:10.1007/s11481-0079099-6.
[182] G. Modi, V. Pillay, Y.E. Choonara, V.M.K. Ndesendo, L.C. du Toit, D. Naidoo, Nano-
technological applications for the treatment of neurodegenerative disorders, Prog. Neurobiol. 88 (2009) 272–285. doi:10.1016/j.pneurobio.2009.05.002.
[183] P. Shah, S.K. Cho, P.W. Thulstrup, M.J. Bjerrum, P.H. Lee, J.-H. Kang, Y.-J. Bhang,
S.W. Yang, MicroRNA biomarkers in neurodegenerative diseases and emerging nanosensors technology, J. Movement Dis. 10 (2017) 18. doi:10.14802/jmd.16037.
[184] F. Mesiti, P.A. Floor, A.N. Kim, I. Balasingham, On the modeling and analysis of the RF
exposure on biological systems: A
potential treatment strategy for neurodegenerative
diseases, Nano Comm. Net. 3 (2012) 103–115. doi:10.1016/j.nancom.2012.02.001.
[185] K.K. Jain, The role of nanobiotechnology in drug discovery, Drug Dis. Today. 10 (2005)
1435–1442. doi:10.1016/S1359-6446(05)03573-7.
[186] D. Carradori, C. Balducci, F. Re, D. Brambilla, B. Le Droumaguet, O. Flores, A. Gau-
din, S. Mura, G. Forloni, L. Ordoñez-Gutierrez, F. Wandosell, M. Masserini, P. Couvreur, J. Nicolas, K. Andrieux, Antibody-functionalized polymer nanoparticle leading
to memory recovery in Alzheimer’s disease-like transgenic mouse model, Nanomed.
Nanotechnol. Biol. Med. 14 (2018) 609–618. doi:10.1016/j.nano.2017.12.006.
[187] T. Ali, M.J. Kim, S.U. Rehman, A. Ahmad, M.O. Kim, Anthocyanin-loaded PEG-
gold nanoparticles enhanced the neuroprotection of anthocyanins in an Aβ1–42 mouse
model of Alzheimer’s disease, Mol. Neurobiol. 54 (2017) 6490–6506. doi:10.1007/
s12035-016-0136-4.
[188] S.K. Sahoo, V. Labhasetwar, Nanotech approaches to drug delivery and imaging, Drug
Dis. Today. 8 (2003) 1112–1120. doi:10.1016/S1359-6446(03)02903-9.
[189] L. Juillerat-Jeanneret, The targeted delivery of cancer drugs across the blood–brain bar-
rier: Chemical modications of drugs or drug-nanoparticles? Drug Dis. Today. 13 (2008)
1099–1106. doi:10.1016/j.drudis.2008.09.005.
[190] S. Okumoto, L.L. Looger, K.D. Micheva, R.J. Reimer, S.J. Smith, W.B. Frommer,
Detection of glutamate release from neurons by genetically encoded surface-displayed
FRET nanosensors, Proc. Natl. Acad. Sci. U.S.A. 102 (2005) 8740–8745. doi:10.1073/
pnas.0503274102.
[191] Bhavna, S. Md, M. Ali, S. Baboota, J.K. Sahni, A. Bhatnagar, J. Ali, Preparation, char-
acterization, in vivo biodistribution and pharmacokinetic studies of donepezil-loaded
PLGA nanoparticles for brain targeting, Drug Dev. Indus. Pharm. 40 (2014) 278–287.
doi:10.3109/03639045.2012.758130.
[192] T. Hirano, IL-6 in inammation, autoimmunity and cancer, Int. Immunol. 33 (2021)
127–148. doi:10.1093/intimm/dxaa078.
[193] Y.S. Lee, J. Olefsky, Chronic tissue inammation and metabolic disease, Genes Dev. 35
(2021) 307–328. doi:10.1101/gad.346312.120.
[194] T. Palaniyandi, K. B, P. Prabhakaran, S. Viswanathan, M. Rahaman Abdul Wahab, S.
Natarajan, S. Kumar Kaliya Moorthy, S. Kumarasamy, Nanosensors for the diagnosis
and therapy of neurodegenerative disorders and inammatory bowel disease, Acta Histochemica. 125 (2023) 151997. doi:10.1016/j.acthis.2023.151997.
[195] D.C. Baumgart, S.R. Carding, Inammatory bowel disease: Cause and immunobiology,
Lancet. 369 (2007) 1627–1640. doi:10.1016/S0140-6736(07)60750-8.
[196] J. Lu, T. Van Stappen, D. Spasic, F. Delport, S. Vermeire, A. Gils, J. Lammertyn, Fiber
optic-SPR platform for fast and sensitive iniximab detection in serum of inammatory bowel disease patients, Biosens. Bioelectron. 79 (2016) 173–179. doi:10.1016/j.
bios.2015.11.087.
242 Carbon-Based Nanocarriers for Drug Delivery
[197] R. Akro, P.-L. Zhang, Q.-Y. Chen, Functional BOD-Ad-Cmyc@BSA complex nano-
sensor for Cu(II) and the detection of live E. coli, Spectrochim. Acta A Mol. Biomol.
Spectrosc. 239 (2020) 118483. doi:10.1016/j.saa.2020.118483.
[198] M. Wlodarska, A.D. Kostic, R.J. Xavier, An integrative view of microbiome-host
interactions in inammatory bowel diseases, Cell Host Microbe. 17 (2015) 577–591.
doi:10.1016/j.chom.2015.04.008.
[199] M. Yang, Y. Zhang, Y. Ma, X. Yan, L. Gong, M. Zhang, B. Zhang, Nanoparticle-based
therapeutics of inammatory bowel diseases: A narrative review of the current state and
prospects, J. Bio-X Res. 03 (2020) 157–173. doi:10.1097/JBR.0000000000000078.
[200] J. Zhao, W. Gao, X. Cai, J. Xu, D. Zou, Z. Li, B. Hu, Y. Zheng, Nanozyme-mediated
catalytic nanotherapy for inammatory bowel disease, Theranostics. 9 (2019) 2843.
doi:10.7150/thno.33727.
Smart Carbon-Based
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
9
Nanocarriers for
Drug Delivery
9.1 INTRODUCTION TO INTELLIGENT
NANOMATERIALS FOR DRUG DELIVERY
Humans have been trying to imitate nature by modeling the behavior of other species since prehistoric times. It is well established that natural biological systems can
dynamically alter their attributes to adapt to their surroundings intelligently. “Intelligent materials,” or those that can “react to changes in the surroundings at the most
optimum scenario and exhibit their particular activities according to these changes,”
were initially reported in detail for the rst time by Toshinori Takagi in the 1990s [1].
Though the scope and feasibility of this idea were incomprehensible at the time,
it was believed that it would pave the way for novel discoveries and innovations in
the scientic and technological arenas. With the advent of cutting-edge technology
and the subsequent demand for novel materials to fulll these needs, the concept of
“intelligent material” (also known as “stimuli-responsive material” or “smart material”) has attracted increasing attention from researchers [2].
Researchers were inspired to develop “stimuli-responsive” substances with biomimetic functionality having excellent potential for use in sophisticated or intelligent
technologies by the remarkable ability of biological systems to transform energy and
perform numerous functions. In the rst decade of the 21st century, nanomaterials
were intensely investigated and eventually implemented in practice. The need for
highly functionalized biomaterials is growing due to advancements in biomedical
engineering. Acommon ability throughout all biological systems is the ability to
respond to shifts in their environment, which is vital for maintaining the optimal
functioning of any organism. Due to this need for adaptability, “smart nanomaterials” that can change their physical properties in response to external stimuli have
been developed. These properties include morphology, permeability, solubility, and
mechanical attributes. The ability of the nanomaterial to recover from the altered
state determines whether or not the reaction may be reversed.
In recent years, the space between biology and the materials sciences has shrunk
signicantly, allowing signicant advancements in interdisciplinary techniques,
notably those that utilize nanostructures for applications in medicine and biology.
The pharmaceutical industry has been at the forefront of the rapid growth of nanotechnology. Many medications are now being produced in nanostructured delivery
systems to treat and diagnose a wide range of disorders; these systems offer several
benets, including fewer adverse effects, more precise drug dosing, and enhanced
DOI: 10.1201/9781003358114-9 243
244 Carbon-Based Nanocarriers for Drug Delivery
pharmacokinetics. Many of the drawbacks associated with free therapeutic entities,
including poor solubility, low stability, nonspecic toxicity, rapid inactivation or
degradation in-vivo, poor biodistribution, and unfavorable pharmacokinetics, can
be overcome by the use of drug-loaded nanoparticles as pharmaceutical carriers,
which can appropriately be called a drug delivery system (DDS) [3]. It is possible
to create nanocarriers that can encapsulate both hydrophilic and hydrophobic molecules as drugs, increase their stability, enable drug targeting to pathological organs
and tissues, provide controlled release, and modify the pharmacokinetics as desirable, that is, supersede the drug’s pharmacokinetics with the explicitly designed
pharmacokinetics of the DDS. Figure9.1 illustrates the plethora of nanomaterials that can be employed to deliver therapeutics at targeted locations. Unwanted
side effects of the therapy can thereby be signicantly reduced. In response to
certain inherent stimuli features of diseased tissues or external stimuli provided
from outside the body, nano-sized DDSs can be precisely tailored to modify some
parameters or functions (for example, improve medication release or intracellular absorption) [4,5]. Pathological areas, including atherosclerotic lesions, infarcts,
tumors, infection sites, and transplant rejection zones, differ from normal tissues
due to the presence of internal stimuli, such as local changes in pH, temperature,
and chemical concentrations, that is, the presence of specic hormones, enzymes,
protein factors, antigens, and other bioactive molecules. External stimuli include
magnetic eld, electric eld, heat, electromagnetic waves, and ultrasound [3], as
shown in Figure9.2.
Several new materials and engineering methodologies have been created to produce DDSs that can specically respond to the peculiar circumstances of aficted
tissues, owing to a more profound knowledge of the microenvironmental changes at
diseased sites. The stimuli-sensitive DDSs are able to activate specic mechanisms
that regulate drug release or the effectiveness of cellular ingestion with exposure to
an extrinsic or endogenous stimulus. Drug release is regulated through morphological changes, such as degradation or permeability enhancement, and the breakdown
of chemical bonds intended to bind the medication to the nano-sized carriers. The
stimuli-responsive DDSs are designed to exploit the unique biochemistry of each
FIGURE 9.1 Various Nanomaterials as Carriers for Drug Delivery.
245Smart Carbon-Based Nanocarriers for Drug Delivery
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
FIGURE 9.2 Classication of Stimuli.
aficted region, enabling them to acclimatize to the local environment, ensuing in
targeted drug delivery at precisely the correct time and location to enhance efcacy
while minimizing adverse effects [6,7].
This chapter focuses on targeted drug delivery strategies via smart or intelligent
nanomaterials that are aware of their surroundings and respond to either internal or
external stimuli. Primary emphasis has been given to pH-responsive nanocarriers
and their application in different therapies. The oral administration of medicine and
its release in the gastrointestinal tract (GIT) is also discussed in detail.
9.2 STRATEGIES FOR THERAPEUTIC TARGETING
AND CONTROLLED DELIVERY OF DRUGS
Modern DDSs consider a variety of factors, including the ideal time to administer
medication, the drug’s bioavailability, the body’s drug absorption capacity, and its
pharmacokinetics. Following are the four conditions that any effective drug delivery
system must accomplish:
1. Retention.
2. Evasion.
3. Targeting.
4 Releasing.
The DDS must have a long residence time in circulation so that it can travel to the
site of interest and be released there at the precise time required for the drug to
Соседние файлы в папке Библиотека им академика М.И. Перельмана