Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5932_Библиотеки_им_академика_М_И_Перельмана

Problems with solubility and cell penetration are common when using chemother­apeutic drugs. The lack of specic therapeutic targeting for cancer cells further restricts clinical uses by causing systemic toxicity [61]. The search for safe and ef­cient medication administration has become the forefront of scientic inquiry. The potential of CNTs as a novel and developing nanomaterial for use in drug delivery carriers has garnered considerable interest in recent years. Functionalized carbon nanotubes delivered several tiny molecules of anticancer medication to tumor cells. Several types of human cancer have been successfully treated with the chemo­therapeutic drug doxorubicin (DOX). Branched PL-PEG functionalized SWCNTs have had DOX loaded onto their sidewalls by π-π stacking [164]. The DOX load­ing ratio tested in this research was 2.5 g/g of SWCNTs. Unlike free DOX and DOXIL, SWCNT-formulated DOX demonstrated signicantly higher therapeutic effectiveness in a mouse breast cancer model while exhibiting signicantly reduced toxicity. The same research team also used SWCNTs with paclitaxel loaded onto them; they did this by attaching the medication to the amino group of the branching phospholipid-PEG chains via cleavable ester linkages, which are hydrolyzed in the cellular milieu [165]. The resulting substance, SWCNT-PEG-paclitaxel, is soluble in water. In a 4T1 murine breast cancer model, the generated SWCNT-PTX conjugate showed more efciency than clinical Taxol in reducing tumor development [166]. The SWCNT-PTX was also more blood-stable and less toxic than the control. The anticancer prodrug cisplatin was conjugated to PL-PEG-SWCNT using a similar method [167].