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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5907_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Preface
- •1.1: Polymer Chains Behavior in Solutions
- •1.1.1: Basic Interaction of Polymer Chain in Solution
- •1.2.1: Self-Assembly of Block Copolymers
- •1.2.2: Self-Assembly of Liposomes
- •1.2.2.1: Formation of liposomes
- •1.1.2: Solubility of Polymer
- •1.1.2.1: Solubility parameter
- •1.1.2.2: Real polymer solutions
- •1.1.3.1: Dynamics of self-assembly
- •1.1.3.2: Free energy of self-assembly systems
- •1.1.3.3: Basic morphology of self-assembly systems
- •1.2.2.2: Phase behaviors of lipid bilayers
- •1.3: Stability of Nanosystems in Solutions
- •1.3.1: DLVO Theory
- •1.3.1.1: Interaction energy between nanoparticles
- •1.3.1.2: Effects of DLVO theory
- •1.3.3: Limitations of Classical DLVO
- •1.4: The Powerful Tool for Study of Nano Physical Pharmaceutics
- •1.4.1.1: Scattering by a small particle
- •1.4.2.1: Power spectrum of scattered light
- •2.1: Classification of Micelle
- •2.1.1: Ionic Surfactant Micelle
- •2.1.2: Non-Ionic Surfactant Micelle
- •2.1.3: Mixed Micelle
- •2.2: Preparation of Micelles
- •2.3: Effects on Micelle Assembly
- •2.3.1: Critical Micelle Concentration
- •2.3.2: Mechanism of Micellization
- •2.3.3: Influence of the Surfactant Structure on CMC
- •2.3.3.1: Volume of hydrophobic groups
- •2.3.3.2: Chemical structure and volume of hydrophilic groups
- •2.3.4: Influence of External Conditions on CMC
- •2.3.4.1: Temperature
- •2.3.4.2: Electrolytes
- •2.3.4.3: Organic substances
- •2.4: Structure and Stability of Polymeric Micelles
- •2.4.1: Thermodynamical Stability
- •2.4.2: Structural Stability
- •2.4.3: Micelle Structural Tailoring
- •2.5: NPP of Polymeric Micelles in Drug Delivery
- •2.5.1: Physiochemical Properties of Micelles
- •2.5.1.2: Critical micelle concentration
- •2.5.1.3: Zeta potential
- •2.5.2: Stability of Micelles
- •2.5.3: Drug-Loading Profile of Micelles
- •2.5.4: Endocytosis of Micelles
- •2.5.5: Drug Release Behavior of Micelles
- •2.5.6.1: pH-responsive micelles
- •2.5.6.2: Redox-responsive micelles
- •2.5.6.3: Temperature-responsive micelles
- •2.5.6.4: Photo-responsive micelles
- •2.6: Summary and Perspective
- •3.1: Classification of Liposome
- •3.2: Preparation of Liposomes
- •3.2.2: Reverse-Phase Evaporation Method
- •3.2.3: Injection Method
- •3.2.4: Detergent Depletion Method
- •3.3: Theory of Liposome Formation
- •3.4: NPP of Liposomes in Drug Delivery
- •3.4.1: Physiochemical Properties of Liposome
- •3.4.1.1: Size of liposome
- •3.4.1.2: Phase transition temperature of liposome
- •3.4.1.3: Membrane permeability of liposome
- •3.4.1.4: Membrane charge of liposome
- •3.4.2: Drug-Loading Behavior of Liposome
- •3.4.3: Stability of Drug-Loaded Liposome
- •3.4.3.1: Physical stability of drug-loaded liposome
- •3.4.3.2: Chemical stability of drug-loaded liposome
- •3.4.4: Clearance and in vivo Circulation of Liposome
- •3.4.5: Targeting Ability of Liposome
- •3.4.6: Drug Release Behavior of Liposome
- •3.5: Summary and Perspective
- •4.1: Classification of Inorganic Nanoparticles
- •4.3.1: Nucleation Mechanism of Inorganic Nanoparticles
- •4.3.2: Growth Mechanism of Inorganic Nanoparticles
- •4.3.3: Morphology Control Strategy
- •4.3.3.1: Control of nucleation rate
- •4.3.3.2: Control of growth phases
- •4.3.4: Dynamic Stability
- •4.3.4.1: Brownian motion
- •4.3.4.2: Sedimentation and sedimentation equilibrium
- •4.3.4.3: Interparticle interactions
- •4.3.5: Thermodynamic Stability
- •4.3.5.1: Electrical double layer theory and zeta potential
- •4.3.5.2: Electrolyte
- •4.3.5.3: DLVO theory
- •4.3.5.4: Stability in aqueous system
- •4.3.5.5: Impact of polymer compounds on stability
- •4.4: NPP of Inorganic Particles
- •4.4.1: Properties of Inorganic Nanoparticles
- •4.4.1.1: Electronic and optical properties
- •4.4.1.2: Magnetism
- •4.4.1.3: Mechanical properties
- •4.4.1.4: Thermal properties
- •4.4.2: Biological Application of Inorganic Nanoparticles
- •4.4.2.1: Au nanoparticles
- •4.4.2.2: Magnetic nanoparticles
- •4.4.2.3: Quantum dots
- •4.4.2.4: Carbon nanotubes
- •4.4.2.5: MXene
- •4.5: Summary and Perspective
- •5.1: Classification of Nanogels
- •5.2: Preparation of Nanogels
- •5.2.1: Non-Covalent Bonding Method
- •5.2.2: Chemical Cross-Linking Reaction
- •5.2.3: Template Method
- •5.3: Mechanism of Nanogel Formation
- •5.3.1: Cross-Linking of Nanogel
- •5.3.1.1: Gelation theory of nonlinear polycondensation
- •5.3.3: Structure and Stability of Nanogel
- •5.4: NPP of Nanogels in Drug Delivery
- •5.4.1: Physiochemical Properties of Nanogels
- •5.4.1.1: Expansion of nanogels
- •5.4.1.2: Swelling mechanism
- •5.4.1.3: Affecting factors of nanogel swelling
- •5.4.1.4: Thixotropy and desizing effect of nanogels
- •5.4.2: In vivo Circulation of Nanogels
- •5.4.3: Drug Release Behavior of Nanogels
- •5.4.4: Factors Affecting the Release of Drug-Loaded Nanogels
- •5.4.4.1: Drug-loading methods
- •5.4.4.2: Medium pH
- •5.4.4.3: Solvent
- •5.4.4.4: Particle size
- •5.4.4.5: Surface charge
- •5.4.5.1: Temperature-responsive nanogels
- •5.4.5.2: pH-responsive nanogels
- •5.4.5.3: Glucose-responsive nanogels
- •5.4.5.4: Photoresponsive nanogels
- •5.4.5.5: Other stimulation-responsive nanogels
- •5.4.6.1: Delivery of small-molecule therapeutic drugs
- •5.4.6.2: Delivery of oligonucleotides
- •5.4.6.3: Delivery of therapeutic proteins
- •5.5: Summary and Perspective
- •6.1: Classification of Microspheres
- •6.2: Preparation of Microspheres
- •6.2.1: Emulsification: Chemical Cross-Linking Method
- •6.2.2: Solvent Evaporation
- •6.2.3: Phase Separation
- •6.2.4: Salting-Out Method
- •6.2.5: Spray Drying
- •6.2.6: Ultrasound Method
- •6.2.7: Supercritical Fluid Method
- •6.3: Mechanism of Microsphere Formation
- •6.3.1: Stability of Nano-Microspheres and DLVO Theory
- •6.3.2: Factors Affect the Potential Energy
- •6.3.3: Factors Affect the Stability of Microspheres
- •6.3.3.1: Properties of polymers
- •6.3.3.2: Surface charge of microspheres
- •6.4: NPP of Microspheres
- •6.4.1: Physicochemical Properties of Microspheres
- •6.4.1.2: Factors affecting the particle size of microspheres
- •6.4.3: Drug Release Behavior of Microspheres
- •6.4.3.1: Mechanism of drug release by microspheres
- •6.4.3.2: PLA microspheres delivery system
- •6.4.4: Route of Administration of Microspheres
- •6.4.4.1: Cavity administration
- •6.4.4.2: Injection administration
- •6.4.4.3: Administration by arterial embolism
- •6.4.4.4: Magnetic microsphere administration
- •6.4.4.5: Oral administration
- •6.4.4.6: Mucosal administration
- •6.4.4.7: Ocular administration
- •6.4.5: Biological Application of Microspheres
- •6.4.5.1: Sustained-release microsphere formulation
- •6.5: Summary and Perspective
- •Index

234
Index
139
189
linear 73
186, 205, 211
nanogel drug 180
translational 38
77
see
190
double emulsion method 226
DOX, see
226
drug absorption 228
212, 217

Index
235
82
180, 183, 185, 189
degradable 178
191, 212, 223, 225
passive 101
179
227
unstable 203
rapid 80, 98
sustained 198, 202
drugs
59
liposomal 111
liposome 110, 112
liquid 198
peptide 223
platinum 189
protein peptide 225
traditional antitumor 226
see
ammonium bromide
16

236
Index
181, 190
endosomes 152, 178
ferromagnetism 121
parameters 10, 69
gelatin solutions 218
gelation 65, 166
92
see gold nanorod
guanidine salts 65
see giant unilamellar
162
162, 186, 218
of 61
see
design of 155
125

Index
237
INPs, see
186
221
63
see intelligent
iron 131, 152
131
see
temperature
relationship equation 78
formation 97
98
101
formulations,
liposomes
113
drug release behavior of 112
multilamellar 92

238
Index
multiphase 93
phase transition temperature
of 99
99
targeting 111
thermosensitive 98
liver 97, 109, 176, 220, 222
see
185
see
see
see large unilamellar
191
administration 221
125, 152
monodisperse 125
181, 221
see
103
63
177, 211

Index
239
72
215
bioadhesion 228
bioadhesive 228
degradable 217
dried 218
hollow 198
223
221
225
211
route of administration of 219
solid 198
130
monomers 2, 52, 58, 163, 166,

240
Index
see
imaging
188
nanogel Formation 165, 167,
169
aging 175
drug release behavior of 178
photoresponsive 187
170
porous 183
solid 166
187
161, 163, 182
amorphous 120

Index
241
nanospheres 197, 226
185
see
NPP, see
see
oral administration 222
Ostwald ripening 129
138
ovalbumin 163
phase separation 1, 7, 12, 73,
phase transition temperature 55,
99, 107
temperature 100
see
biodegradable 217
see
see
221
218, 226
198, 217
186, 209
long 68

242
Index
natural 198
inverse emulsion 191
163
biodegradable 198
170
natural 153, 163, 198
175, 183, 188
porogen 211
see programmed
see
QDs, see quantum dots
see
176, 220

Index
243
see
sedimentation equilibrium 133
122
sound waves 203
see
see strong segregation limit
release behavior of 82
drug release behavior of
see small unilamellar
see
template imprinting 165
96, 131, 136
150, 189, 220
tumor tissues 82, 85, 182, 220,
226
see
temperature
185
urea 65
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