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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5907_Библиотеки_им_академика_М_И_Перельмана.pdf
Nano Physical
Pharmaceutics
Nano Physical
Pharmaceutics
edited by
Wei Li
Published by
Jenny Stanford Publishing Pte. Ltd.
101 Thomson Road
#06-01, United Square
Singapore 307591
Email: editorial@jennystanford.com
Web: www.jennystanford.com
British Library Cataloguing-in-Publication Data
A catalogue record for this book is available from the British Library.
Nano Physical Pharmaceutics
Copyright © 2025 Jenny Stanford Publishing Pte. Ltd.
All rights reserved. This book, or parts thereof, may not be reproduced
in any form or by any means, electronic or mechanical, including
photocopying, recording or any information storage and retrieval system
now known or to be invented, without written permission from the
publisher.
ISBN 978-981-4968-52-2 (Hardcover)
ISBN 978-1-003-51393-3 (eBook)
Preface
1. The Fundamentals and Powerful Tool for Nano
Physical Pharmaceutics 1
Ziya Xia, Yening Xia, and Wei Li
1.1 Polymer Chains Behavior in Solutions 1
1.1.1 Basic Interaction of Polymer Chain
in Solution 1
1.1.1.1 Introduction to the c
parameter 1
1.1.1.2 Relationship between c
parameter and stability of
the solution 3
1.1.2 Solubility of Polymer 6
1.1.2.1 Solubility parameter 6
1.1.2.2 Real polymer solutions 6
1.1.3 Self-Assembly Behavior of Polymers
in Solution 7
1.1.3.1 Dynamics of self-assembly 7
1.1.3.2 Free energy of self-assembly
systems 8
1.1.3.3 Basic morphology of
self-assembly systems 8
1.2 Self-Assembly of Amphiphilic Copolymers
in Solution 10
1.2.1 Self-Assembly of Block Copolymers 10
1.2.2 Self-Assembly of Liposomes 13
1.2.2.1 Formation of liposomes 13
1.2.2.2 Phase behaviors of lipid
bilayers 14
Contents
xi
1.3.1.1 Interaction energy between
nanoparticles 16
8
0
1.3.3 Limitations of Classical DLVO 20
1.4 The Powerful Tool for Study of Nano Physical
Pharmaceutics 21
1.4.1 Static Laser Light Scattering 23
1.4.1.1 Scattering by a small particle 23
1.4.1.2 Scattering by many
small-particle systems 25
1.4.1.3 Scattering by real polymer
solution 25
1.4.2 Dynamic Laser Light Scattering 33
1.4.2.1 Power spectrum of scattered
light 33
1.4.2.2 Siegert relation 35
7
1.4.2.4 Analysis of the correlation
9
1.4.3 Typical Application of Laser Light
Scattering in NPP Accomplished by
Our Group 42
1.4.3.1
1.4.3.2
1.4.3.3
The special in-house designed
powerful tool for NPP study
Characterization of polymer
chains dynamics in solution
Characterization of
42
43
1.4.3.4
self-assembly of polymer
aggregates in solutions
Characterization of the
44
morphology of nanoparticles
in physiological media 44
vi
Contents
1.3 Stability of Nanosystems in Solutions 15
1.3.1 DLVO Theory 15
in-suit
preparation by radical
co-polymerization and
indicated by LLS 45
systems obtained by SLLS 47
2. Nano Physical Pharmaceutics of Micelle-Based
Systems 51
Yening Xia, Ruochen Huang, Fei Duan, and Wei Li
1
3
3
4
4
5
5
6
8
2.3.3.1 Volume of hydrophobic groups 58
2.3.3.2 Chemical structure and volume
of hydrophilic groups 61
2.3.3.3 Synergy of hydrophilic groups
and hydrophobic groups 61
3
3
2.3.4.1 Temperature 63
2.3.4.2 Electrolytes 64
2.3.4.3 Organic substances 65
5
2.4.1 Thermodynamical Stability 66
2.4.2 Structural Stability 67
8
1
Contents
vii
2.5.1.1 Particle size and distribution 72
2.5.1.2 Critical micelle concentration 74
2.5.1.3 Zeta potential 75
6
2.5.3 Drug-Loading Pro 7
9
0
2.5.6 Drug Release Behavior of
St 2
2.5.6.1 pH-responsive micelles 82
2.5.6.2 Redox-responsive micelles 83
2.5.6.3 Temperature-responsive
micelles 84
2.5.6.4 Photo-responsive micelles 84
2.6 Summary and Perspective 85
3. Nano Physical Pharmaceutics of Liposome-Based
System 91
Nian Huang, Mengxin Zhao, Jian Wang, and Wei Li
1
3.2 Preparation of Liposomes 92
2
3
3
4
3.3 Theory of Liposome Formation 94
3.4 NPP of Liposomes in Drug Delivery 99
3.4.1 Physiochemical Properties of Liposome 99
3.4.1.1 Size of liposome 99
3.4.1.2 Phase transition temperature
of liposome 99
liposome 100
0
viii
Contents
2
3.4.3 Stability of Drug-Loaded Liposome 103
3.4.3.1 Physical stability of
drug-loaded liposome 103
3.4.3.2 Chemical stability of
drug-loaded liposome 104
3.4.4 Clearance and in vivo Circulation of
Liposome 105
clearance and in vivo circulation 105
clearance and in vivo circulation 106
clearance and in vivo circulation 107
temperature on clearance and
in vivo circulation 107
liposome on clearance rate and
in vivo circulation 108
3.4.5 Targeting Ability of Liposome 110
3.4.6 Drug Release Behavior of Liposome 112
3.5 Summary and Perspective 114
4. Nano Physical Pharmaceutics of Inorganic
Nanoparticles 119
Xiaodong Zhu, Beibei Liang, Yong Huang, Wei Yao, and Wei Li
9
4.2 Preparation of Inorganic Nanoparticles 122
icle Formation 126
Nanoparticles 127
Nanoparticles 128
9
Contents
ix
3.4.2 Drug-Loading Behavior of Liposome 101
4.3.3.1 Control of nucleation rate 130