Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:

Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3787_Библиотеки_им_академика_М_И_Перельмана

.pdf
Скачиваний:
0
Добавлен:
05.09.2026
Размер:
18 Мб
Скачать
Appendix 9: Viscoelasticity 265
https://t.me/med1917
Fig. 4.22 A generalized Maxwell viscoelastic model (a linear spring in serial with m Voigt elements)
εrtðÞ¼εε
0
0
tðÞ¼
μ0, ε
σ
ε
m
X
ε0β
m
1 þ βðÞ
i¼1
μ1, ε
0
η1, ε
i1
1 þ βðÞ
μ2, ε
1
2
μm, ε
m
σ
ε
1
η2, ε
2
1i
ρ
t=τ
e
: ð4:140Þ
ηm, ε
m
Note that for m ¼ 1, the model in Fig. 4.22 is mathematically equivalent to a spring in parallel with a Maxwell body (Fung, 1993; Orosz, Molnarka, & Monos,
1997). Therefore, the Kelvin model considered by Rehal et al. (2006) is a special
case of the generalized Maxwell model in Eq. (4.140).
For a vessel ring cut from no-load state, the analysis assumes the following three steps: (1) Loaded artery is fully relaxed (stress is σ obtained after elastomer removal (stress is σ (3) Vessel ring is cut open at t ¼ t
and all stress is released. It is noted that the second
1
at t ¼ 0); (2) No-load state is
0
from t ¼ 0+to t ¼ t1¼ 1800 s);
1
step is an approximation (i.e., not strictly under constant stress).
According to the superposition principal (Findley et al., 1989), the strain recovery in the artery after the radial cut can be written as:
ε
tðÞ¼σ0J 1ðÞþσ1 σ
n
ðÞJtðÞσ1Jt t
0
ðÞt > t
ðÞ, ð4:141Þ
1
1
where ε
(t) ! 0 when t !1(fully recovered zero-stress state). The substitution of
n
Eqs. (4.137)–(4.140) into Eq. (4.141) results in

1i
i1
ρ
t1=τ
e
m
1 þ βðÞ
1
1i
ρ
e
t=τ
t > t
ðÞ, ð4:142Þ
1
ε
n
where ε
P
m
ε1β
tðÞ¼εrtðÞþ
¼ σ1J(1) is the residual strain due to residual stress σ1.
1
1 þ βðÞ
i¼1
The artery is assumed to be incompressible. The loaded state is a tube with a circular cross section. The circumferential stretch ratio at the inner surface is:
2πr
λ
θ
i
¼
, ð4:143Þ
C
i
and at the outer surface is:
2πr
o
¼
, ð4:144Þ
C
o
where r
λ
θ
and roare the inner and outer radii at the loaded state, Ciand Coare the inner
i
and outer circumferences at the fully relaxed zero-stress state, respectively.
266 4 Constitutive Models of Coronary Vasculature
https://t.me/med1917
In the generalized Maxwell model, a linear stress–strain relation is expected. Although arteries are known to exhibit nonlinear constitutive behavior, Zhang and Kassab (2007) proposed to absorb the material nonlinearity with a new strain measure in the two-dimensional case (Appendix 5). The same idea is then extended to the three-dimensional Hookes law (Appendix 6) where the logarithmic­exponential (log-exp) strain is dened as (no shear deformation):
D
¼ ln λiexp nJ1 3ðÞ½i ¼ θ; z; rðÞ, ð4:145Þ
ii
where λ and J
are stretch ratios, n is a constant that characterizes the material nonlinearity,
i
is the rst invariant of the right Cauchy-Green deformation tensor:
1
2
2
J
¼ λ
þ λ
1
θ
2
þ λ
: ð4:146Þ
z
r
The second Piola–Kirchhoff stress and the log-exp strain in the circumferential direction can be written as (Zhang, Wang, et al., 2007):
S
¼ c11Dθθþ c12Dzzþ c13Drr, ð4:147Þ
θθ
where cs are elastic moduli wi th respect to the log-exp strains.
As an estimate, it is assumed that D axially relaxed. In such a case, D
rr
0(λz 1) which implies that the artery is
zz
¼Dθθ(λ1/λθ) according to Eq. (4.145). The
circumferential strain becomes:

ε ¼ D
¼ ln λθexp n λ
θθ
2
θ
It is noted that Eq. (4.147) can naturally reduce to a 1D linear model (S
þ 1=λ
2
2
: ð4:148Þ
θ
θθ
/ ε).
Other models using Green strain measure (e.g., Fung model) can be used approxi­mately since the strain is small (thus stress–strain relation can be linearized) during the creep process.
The open sector is characterized by an opening angle Φ. Considering the volu­metric incompressibility condition λ
¼ 1, the cross-sectional wall area A0can be
θλzλr
calculated by Chuong and Fung (1986):
where L
and Loare inner and outer circu mferences of the sector (not fully relaxed).
i
Equation (4.149) yields the opening angle expressed by:
A
¼ πλzr
0
Φ tðÞ¼π

2
r
o
2
L
2
o
¼
i
4 π Φ tðÞðÞ
2
L
tðÞL
o
4A
2
tðÞL
0
tðÞ
i
, ð4:149Þ
2
tðÞ
i
: ð4:150Þ
Appendix 10: Active Mechanical Properties (Huo et al., 2012) 267
https://t.me/med1917
For a given A0, Li, and Lo, Φ can be computed from Eq. (4.150). It is found that the change of these measures is negli gible 2 h after the radial cut. Thereafter, the artery is assumed to be fully relaxed, i.e., L The stretch ratio of the open sector λ
(t) ¼ L(t)/C is equal to the circumference at a
θ
, LCo, and Φ ¼ Φ0at t ¼ 7200 s.
Ci
given time over that at the fully relaxed state, which differs from that at the loaded state (Eqs. 4.143 and 4.144). The strain is computed with Eq. (4.148).
Appendix 10: Active Mechanical Properties (Huo et al., 2012)
The blood vessel is assumed to be a thin-walled elastic tube deformed in the circumferential (θ) and axial (z) directions. Green strains are dened as:
D
where λ
¼
θ
D
0
tively; D and D L and L
are axial lengths in the loaded and no-load states, respectively. If the
0

1
2
E
θθ
and λ
are diameters in the loaded and zero-stress states, respectively;
0
λ
¼
1
θ
2
L
are the circumferential and axial stretch ratios, respec-
L
0
and Ezz¼

1
2
λ
1
z
2
ð4:151Þ
densities of vessel wall are identical in the loaded and no-load state, rst Piola– Kirchhoff and Cauchy stresses can be written as:
where S
T
¼ λθS
θθ
Tzz¼ λzS
and SZZare the circumferential and axial second Piola–Kirchhoff stresses,
θθ
θθ
zz
and
σ σzz¼ λ
2
¼ λ
S
θθ
θθ
θ
2
S
zz
z
ð4:152Þ
respectively.
The total strain energy function consists of passive and active components as:
W
where W
passive
caused by the K energy of the K
¼ W
total
is the strain energy of passive vessel; W
+
-induced smooth muscle contraction; and W
+
-induced active vessel.
passive
þ W
active
is the active strain energy
active
is the total strain
total
ð4:153Þ
Passive Strain Energy Function
In Fungs 2D model without shear deformation, the strain energy per unit volume (W
) is given by:
passive
268 4 Constitutive Models of Coronary Vasculature
https://t.me/med1917
C
1
W
passive
exp QðÞ1½ ð4:154aÞ
¼
2
and
where C
1,a1,a2
Q ¼ a
2
E
1
θθ
, and a4are constants. The passive second Piola–Kirchhoff stresses
þ a2E
2
þ 2a4EθθE
zz
zz
ð4:154bÞ
are obtained by differentiating the strain energy with respect to the corresponding Green strains as:
8 >
>
<
>
>
:
S
θθ
S
zz
passive
passive
W
passive
¼
E
W
¼
E
¼ C1a1Eθθþ a4E
θθ
passive
¼ C1a2Ezzþ a4E
zz
ðÞexp QðÞ
ðÞexp QðÞ
zz
θθ
ð4:155Þ
The passive rst Piola–Kirchhoff stresses can be written as:
where C
1,a1,a2
(
T
¼ C1a1Eθθþ a4E
θθ
passive
T
¼ C1a2Ezzþ a4E
zz
passive
ðÞ
ðÞ
, and a4for coronary arteries are determined by experimental
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
2Eθθþ 1pexp QðÞ
zz
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
2Ezzþ 1pexp QðÞ
θθ
ð4:156Þ
measurements.
Active Strain Energy Function
The active strain energy function caused by the K+-induced SMC contraction is proposed as:
W
active
where C
b
0
b
¼
b
, b2, b3, and b4are constants and Erf(X) is the Gauss error function. If
2,b1
b
3
4
þ
, Eq. (4.157) can be simplied as:
b
1
2

¼ C2Erf

¼ C
2
2E
þ 1p b
θθ
b

λθ b
Erf
W
active
1
λz b
3
þ
b
1
b


¼ C2Erf
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi

ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
þ 1p b
2E
3
4
2
λ
θ
b
1
zz
þ
b
4
2
1
ð4:157Þ
1
λ
z
þ
0
b
b
2
1
ð4:158Þ
Appendix 10: Active Mechanical Properties (Huo et al., 2012) 269
https://t.me/med1917
Equation (4.159) has 4 unknown parameters instead of 5 in Eq. (4.157). The active second Piola–Kirchhoff stresses are obtained by differentiating the strain energy with respect to the corres ponding Green strains as:
8 >
>
>
>
>
<
>
>
>
>
>
:
W
S
θθ
active
S
zz
active
active
¼
E
θθ
W
active
¼
E
2C
¼
b
1
2C
¼
b
zz
2
2
ffiffiffiπp
p
2
p
ffiffiffiπp
1
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
2E
θθ
1
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
þ 1
2E
zz
!
exp
þ 1
!
exp
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
p

2E
θθ
b
1
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
p

2E
θθ
b
1
þ 1
þ 1
þ
þ
p
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
2E
p
ffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffiffi
2E
b
þ 1
zz
b
2
þ 1
zz
2
b
b
0
2
0
ð4:159Þ
The active rst Piola–Kirchhoff stresses are obtained by differentiating the strain energy with respect to the corres ponding stretch ratios as:
2
8 >
>
T
<
>
>
:
with

λ
λ
0
Q
¼
z
θ
þ
b
b
b
1
2
θθ
T
zz
2
0
active
active
¼
2C
¼
b
1
2C
¼
b
2

λ
θ
b
1
2
2
2
þ
ffiffiffiπp
exp Q
ffiffiffiπp
exp Q

λ
z
b
2
0
ðÞ
0
ðÞ
2
λ
λ
θ
þ 2
b
b
1

λ
z
2
2
θ
þ
b
1
λ
z
b
b
2
0
þ b0ðÞ
2
ð4:160Þ
The material constants in Eq. (4.160) are determined by biaxial experimental measurements for intact and intima-media layers of coronary artery wall. The material parameters for six RCA coronary arteries are listed below in Tables 4.21 and 4.22 for passive and active states of intact wall and in Tables 4.23 and 4.24 for the intima-media layer, respectively. Reproduced from Huo et al. (2012) with permission.
Table 4.21 Material constants of Fungs passive strain energy function of intact coronary artery
Animal no. C
Heart 1 1.27 2.61 1.59 0.6 0.94 0.73 Heart 2 0.94 2.86 2.09 1.14 0.90 0.94 Heart 3 0.87 3.39 3.91 0.42 0.94 0.94 Heart 4 1.51 2.89 3.29 0.43 0.74 0.90 Heart 5 0.89 3.18 2.82 0.75 0.72 0.74 Heart 6 1.25 2.59 1.55 0.59 0.96 0.94
Fit of all experi-
mental data of
hearts 1–6
Mean SE for
hearts 1–6
(kPa) a
1
1.33 3.08 2.48 0.49 0.96 0.90
1.12 0.11 2.92 0.13 2.54 0.39 0.66 0.11
1
a
2
a
4
R2for T
θθ
passive
R2for T
zz
passive
(continued)
270 4 Constitutive Models of Coronary Vasculature
https://t.me/med1917
Animal no. C1(kPa) a
CV ¼
SD
Mean
100%
23.0% 10.8% 37.7% 40.8%
1
a
2
a
4
T
R2for
R2for T
θθ
passive
zz
Reproduce from Huo et al. (2012) with permission Note: Material constants, C coronary artery (RCA). R
2
Table 4.22 Material constants of K
, and a4, are obtained from experimental measurements of right
1,a1,a2
represents the goodness-of-curve-t
+
-induced active strain energy function (Eq. 4.160) in the
pressure range of 60–200 mmHg for intact coronary artery wall as corresponding to Table 4.21
Animal no. C
(kPa) b
2
1
b
2
0
b
R2for T
R2for T
θθ
active
zz
Heart 1 4.29 0.109 0.212 21.2 0.78 0.83 Heart 2 3.37 0.105 0.185 21.9 0.55 0.79 Heart 3 7.04 0.156 0.297 14.0 0.57 0.61 Heart 4 2.81 0.112 0.127 24.2 0.66 0.74 Heart 5 7.65 0.110 0.209 20.1 0.64 0.74 Heart 6 3.97 0.108 0.21 21.3 0.73 0.85
Fit of all experi-
4.72 0.120 0.182 20.3 0.71 0.78
mental data of
hearts 1–6
Mean SE for
4.86 0.82 0.117 0.008 0.207 0.022 20.5 1.4
hearts 1–6
CV ¼
SD
Mean
100%
41.3% 16.6% 26.5% 16.8%
Reproduced from Huo et al. (2012) with permission Note: Material constants, C coronary artery (RCA). R
, b1, b2, and b0, are obtained from experimental measurements of right
2
2
represents the goodness-of-curve-t
passive
active
Table 4.23 Material constants of Fungs passive strain energy function for intima-media layer of right coronary artery (RCA)
Animal no. C
Heart 1 4.16 4.20 3.02 0.60 0.99 0.99 Heart 2 6.09 1.72 2.93 0.43 0.91 0.98 Heart 3 7.94 3.26 2.19 0.45 0.99 0.99 Heart 4 4.07 3.96 1.64 1.61 0.94 0.93 Heart 5 5.13 3.18 2.14 0.70 0.98 0.99 Heart 6 5.30 1.93 0.51 1.92 0.97 0.96
Fit of all
experimental
data of hearts
1–6
Mean SE
for hearts 1–6
Reproduced from Huo et al. (2013) with permission Note: Material constants, C intima-media layer of RCA using the Broyden-Fletcher-Goldfarb-Shanno (BFGS) method. R represents the goodness-of-curve-t
(kPa) a
1
1
a
2
a
4
T
θθ
passive
4.55 3.05 2.32 1.15 0.98 0.99
5.45 0.59 3.04 0.42 2.07 0.38 0.95 0.26
, a1, a2, and a4, are obtained from experimental measurements of
1
R2for
R2for T
zz
passive
2
Appendix 11: Micromechanics of Heterogeneous Materials (Chen, Zhao... 271
https://t.me/med1917
Table 4.24 Material constants of K+-induced active strain energy function for intima-media layer in the pressure range of 30–110 mmHg
Animal no. C
Heart 1 9.36 0.22 0.44 9.08 0.81 0.75 Heart 2 5.19 0.29 0.73 6.65 0.76 0.66 Heart 3 4.58 0.20 0.39 10.0 0.82 0.52 Heart 4 14.8 0.20 0.32 11.5 0.67 0.73 Heart 5 16.8 0.29 0.46 7.29 0.78 0.58 Heart 6 4.21 0.18 0.34 11.4 0.81 0.62
Fit of all experi-
mental data of
hearts 1–6
Mean SE for
hearts 1–6
Reproduced from Huo et al. (2013) with permission Note: Material constants, C intima-media layer of right coronary artery (RCA). R
(kPa) b
2
7.88 0.24 0.43 8.60 0.93 0.73
9.17 2.25 0.23 0.02 0.45 0.06 9.33 0.83
1
, b1, b2, and b0, are obtained from experimental measurements of
2
b
2
2
represents the goodness-of-curve-t
0
b
R2for T
θθ
active
R2for T
zz
active
Appendix 11: Micromechanics of Heterogen eous Materials (Chen, Zhao, Lu, & Kassab, 2013)
The idea of homogenization of heterogeneous nonbiological materials has been used to predict the macroscopic or effective mechanical properties of composites (Milton,
2002). Rigorous and reliable methods are well established and widely applied to
linear elastic composites, including the classical Voigt and Reuss bounds (Hill,
1952), the variational principles of Hashin-Shtrikman (Hashin & Shtrikman, 1962,
1963), and the general self-consistent approximations (Hershey, 1954; Hutchinson,
1976). For nonlinear composites, however, rigorous methods have become available
only more recently because of difculties in addressing both strong material nonlinearity and heterogeneity. Earlier efforts are made to predict the effective constitutive behaviors of composites by extending linear methods to nonlinear materials, such as the extensions of the self-consistent procedures (Hill, 1965), or the Hashin-Shtrikman variational principles for linear composites (Talbot & Willis,
1985; Willis, 1983).
A general variational procedure for estimating the effective behavior of nonlinear composites is proposed by Ponte Castañeda (1991). He introduced a linear elastic comparison composite(LCC) with the same microstructure of the nonlinear com­posite, which allows for the use of numerous bounds and estimates for linear composites. Ponte Castañeda further proposed an alternative approach with more sophisticated LCC to generate estimates that are exact to the second order in the phase contrast (Ponte Castañeda, 1996; Ponte Castañeda & Willis, 1999). This is the so-called second-order estimate (SOE) homogenization, which yields signicant
272 4 Constitutive Models of Coronary Vasculature
https://t.me/med1917
improvements over previous micromechanics models. During the past decade, successive developments have been made to the SOE approach by Ponte Castañeda and his colleagues to better predict the nonlinear macroscopic properties of hetero­geneous materials (Agoras, Lopez-Pamies, & Ponte Castañeda, 2009; Chen, Liu, Zhao, et al., 2011; Kailasam, Ponte Castañeda, & Willis, 1997; Liu, Gilormini, & Ponte Castañeda, 2003; Liu & Ponte Castañeda, 2004; Lopez-Pamies & Ponte Castañeda, 2004b; Ponte Castañeda, 2002). Applications have been extended to various nonlinear materials with randomly or periodically distributed microstructure, including viscoplastic polycrystal, porous, or reinforced rubbers and ber-reinforced elastomers.
Framework of Nonlinear Micromechanics
Finite strain micromechanics can be used to determine the macroscopic constitutive response of biological soft tissues based on structural and mechanical properties of the microstructure. Based on the principle of minimum strain energy, the framework can provide multiple approximate solutions for the macroscopic strain energy function (SEF) of soft tissues. The upper boundand a second-orderestimate models are discussed below.
Hyperelastic Heterogeneous Material
A heterogeneous material, such as soft tissue, is made up of N +1(N  1) different phases, which are distributed (randomly or with a certain distribution of orientation) in a specimen with a volume Ω and boundary Ω in the reference conguration. The constitutive behavior of each inclusion is characterized by a respective SEF W so that the local SEF W(X, F)of composites is written as:
N
X
r¼0
rðÞ
χ
W X; FðÞ¼
where F is dened as the deformation gradient tensor, and χ
XðÞW
rðÞ
FðÞ ð4:161Þ
(r)
¼ 1 when X 2 Ω
(the volume occupied by phase r), or 0 otherwise to describe the distribution of the microstructure. The local stress eld (i.e., the microscopic constitutive behavior) of the inhomogeneous material is expressed, based on thermodynamics as:
SXðÞ¼
W X; FðÞ
F
pF
T
(r)
(F),
(r)
ð4:162Þ
Appendix 11: Micromechanics of Heterogeneous Materials (Chen, Zhao... 273
https://t.me/med1917
S(X) is the rst PiolaKirchhoff stress tensor, which is related to the Cauchy stress tensor σ by S ¼ σ F
T
, and the hydrostatic stress p is due to incompressibility (det
(F) ¼ 1) of the soft tissue.
According to the principle of minimum strain energy, the effective SEF of a microscopically inhomogeneous hyperelastic material is dened as:
N
DE
F2κ
X
rðÞWrðÞ
c
F
r¼0
(r)
¼hχ
(r)
F I X in Ω
F¼ min
W
F2κ
where the brackets hiand hi over the r-th phase Ω fraction of the r-th phase.

κ
F¼ FjFXðÞ¼I þ
W X; FðÞ
hi
F
(r)
, respectively, so that c
uXðÞin Ω; and uXðÞ¼
X
¼ min
(r)
denote volume averages over the composite Ω and
rðÞ
FðÞ
, ð4:163Þ
i represents the volume
denotes all the admissible deformation gradient eld in the representative volume element (RVE) of the composite with an afne displacement boundary condition u(X). In analogy with the local expression of Eq. (4.162), assuming sufcient smoothness for
W
F, the macroscopic stress of the composite is dened by:
∂W
S ¼
F
∂F
pF
T
ð4:164Þ
whereS ¼ ShiandF ¼ Fhi, which are also called the average stress and average deformation gradient, respectively. The effective SEFW physically represents the average elastic energy stored in the composite. In general, the rigorous minimization solution for Eq. (4.163) is difcult to obtain for a heterogeneous material with complex microstructure since a set of highly nonlinear partial differential equations must be solved. Consequently, approximate solutions or estimates have been pur­sued (Hill, 1965; Lopez-Pamies & Ponte Castañeda, 2006; Ponte Castañeda, 1991,
2002; Ponte Castañeda & Willis, 1999; Talbot & Willis, 1985). The efforts to seek
an approximate minimizing eld F(X) have resulted in several classes of nite strain micromechanics models including the uniform-eld upper bound model and the second-order estimate model.
Uniform-Field Upper Bound Model
The simplest trial eld for Eq. (4.163)is FXðÞ¼F, which assumes a uniform deformation eld in the composite. Hence, the macroscopic SEFW the volumetric sum of the constitu ents,
Fis simply
274 4 Constitutive Models of Coronary Vasculature
https://t.me/med1917
N
X
W
FW
U
F¼
c
r¼0
rðÞWrðÞ
F
ð4:165Þ
This solution leads to an upper bound of the exact SEFW asF is an admissible deformation eld that does not minimize the total strain energy. It is usually referred to as the Voigt upper bound in linear micromechanics. Consequently, the effective stressS
¼ WU=F  pFTis an upper bound of the exact macroscopic stress for
U
a givenF. This approximation requires that all phases must deform with the same deformation regardless of their different material properties (e.g., stiffness). This assumption is not true for composites that have widely different phases. In addition, the afne deformation assumption only includes information on the phase volume fraction c
(r)
(as indicated by Eq. (4.165)) but neglects the inte ractions between
phases that may affect the overall mechanical response of a composite.
Second-Order Estimate Approach
A second-order estimate (SOE) homogenization approach, utilizing the concept of an LCC, is proposed by Ponte Castañeda (Ponte Castañeda, 1996; Ponte Castañeda & Willis, 1999). This method has been widely applied to nonlinear elastomeric composites, including reinforced and porous elastomers, as well as other heteroge­neous elastomeric systems (Agoras et al., 2009;Lopez-Pamies & Ponte Castañeda,
2004a; Ponte Castañeda, 2002). This approach accounts for the statistical micro-
structure beyond the volume fraction of the phases and incorporates interactions among different phases. Hence, it provides a more accurate prediction of the constitutive behavior of nonlinear composites than the uniform-eld upper bound.
Following previous derivations (Lopez-Pamies & Ponte Castañeda, 2004a; Ponte Castañeda, 2002), an LCC is introduced with effective SEFW
rðÞ
W
FðÞto denote that it has the same microstructure as the nonlinear composites, but
T
each of the phases is linearly elastic with the SEF W approximation to the nonlinear SEF W
(r)
). According to generalized Legendre
rðÞ
(i.e., the second-order Taylor
T
transform of the strain energy (Lopez-Pamies & Ponte Castañeda, 2004a ; Ponte Castañeda, 2002), the exact macroscopic SEF expressed in Eq. (4.163), can be approximated by:
F min
W
()
sðÞ;LsðÞ
F
fg
W
no
sðÞ
T
F; F
; L
sðÞ
N
X
þ
r¼0
rðÞVrðÞ
c
P
N
F¼
T
rðÞ
F
; L
rðÞ
rðÞ
χ
r¼0
XðÞ
, ð4:166Þ
where L
(r)
is the unknown reference modulus and F deformation gradient of the r-th phase of LCC, both of which will be determined by the minimization procedure of Eq. (4.166).

rðÞ
; L
rðÞ
rðÞ
V
F
no
¼ sup
^
F
W
rðÞ
^
F W
rðÞ
^
F
T
is a correctorfunction, i.e., the
(r)
is the virtual residual