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24 Prophylactic Surgery inTrauma
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
269
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58. Teixeira P, Karamanos E, Demetriades D. Splenectomy in patients with traumatic brain injury: protective or harmful? A National Trauma Data Bank analysis. J Trauma Acute Care Surg. 2013;75(4):596–601.
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60. Zarzaur B, Rozycki G. An update on nonoperative management of the spleen in adults. Trauma Acute Care Surg. 2(1):e000075.
61. Kittaka H, Yoshiki Y, Zushi R. The investiga­tion of post-traumtic pseudoaneurysms in patients treated with nonoperative management for blunt abdominal solid organ injuries. PLoS One. 2015;10(3):e0121078.
62. Rowell S, Bif W, Brasel K, Moore E. Western Trauma Association critical decisions in trauma: man­agement of adult blunt splenic trauma—2016 updates. J Trauma Acute Care Surg. 2017;82(4):787–93.
63. Cywes S, Rode H, Millar J. Blunt liver trauma in children: nonoperative management. J Pediatr Surg. 1985;20(1):14–9.
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66. Dumont S, Chys B, Meuleman C. Prophylactic ureteral catheterization in the intraoperative diag­nosis of iatrogenic ureteral injury. Acta Chir Belg. 2020;16;1–6.
67. Coakley K, Kasten K, Sims S.Prophylactic ureteral catheters for colectomy: a national surgical quality improvement program-based analysis. Dis Colon Rectum. 2018;61(1):24–88.
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76. Demetriades D, Murray JA, Chan L, et al. Penetrating colon injuries requiring resection: diver­sion or primary anastomosis? An AAST prospective multicenter study. J Trauma. 2001;50(5):765–75.
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78. McGrath V, Fabian T, Croce M, Minard G.Rectal trauma: management based on anatomic distinc­tions. Am Surg. 1998;64(12):1136–41.
79. Bosarge PL, Como JJ, Fox N, Falck-Ytter Y, Haut ER, Dorion HA, Patel NJ, Rushing A, Raff LA, McDonald AA, Robinson BR, McGwin G, Gonzalez RP. Management of penetrating extra­peritoneal rectal injuries: an Eastern Association for the Surgery of Trauma practice manage­ment guideline. J Trauma Acute Care Surg. 2016;80(3):546–51.
80. Bif W, Moore E, Feliciano D, Albrecht R, Croce M, etal. Management of colorectal injuries: a Western Trauma Association critical decisions algorithm. J Trauma Acute Care Surg. 2018;85(5):1016–20.
81. Sharpe J, Magnotti L, Weinberg J, Parks N.Adherence to a simplied management algorithm reduces morbidity and mortality after penetrating
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82. Navsaria PH, Shaw JM, Zellweger R, Nicol AJ, Kahn D.Diagnostic laparoscopy and diverting sig­moid loop colostomy in the management of civilian extraperitoneal rectal gunshot injuries. Br J Surg. 2004;91(4):460–4.
83. Jo YG, Park YC, et al. Diagnostic laparoscopy and laparoscopic diverting sigmoid loop colostomy in penetrating extraperitoneal rectal injury. J Trauma Injury. 2017;30(4):216–9.
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85. Krouse R, Grant M, Wendel C, Mohler J.A mixed­methods evaluation of health-related quality of life for male veterans with and without intestinal stomas. Dis Colon Rectum. 2007;50(12):2054–66.
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Surgical Prophylaxis ofObesity
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25
ErdincKamer andFevziCengiz
25.1 Introduction
Obesity is a condition where body fat mass exceeds normal acceptable levels and it is a chronic metabolic disease with high mortality and morbidity rate due to metabolic complica­tions. The World Health Organization (WHO) has dened the term “obesity” as excessive fat accumulation that is harmful to health. Obesity, considered as the twenty-rst century’s epidemic, is the primary health problem in developed coun­tries, reducing life expectancy and creating a challenge for the global economy. WHO has dened obesity as a disease in ICD-10 [1, 2]. Obesity is usually dened by the Body Mass Index (BMI) criteria, which is obtained by divid­ing body weight in kilograms by the square meter in meters. According to the BMI, individuals are divided into ve different categories: (1) 18.5–
24.9kg/m
25.0–29.9kg/m2 as overweight, (3) 30–34.9kg/ m2 as class 1 obesity, (4) 35.0–39.9kg/m2 as class 2 obesity, (5) ≥40 kg/m2 as class 3 obesity (Table25.1) [3]. Those with the highest risk in terms of obesity-related consequences are the individuals with BMI ≥40 kg/m2 in the group dened as morbid obese. More than 35% of
E. Kamer (*) · F. Cengiz Department of General Surgery, Izmir Katip Celebi University Ataturk Training and Research Hospital, Izmir, Turkey e-mail: kemalerdinc.kamer@saglik.gov.tr;
fevzi.cengiz@saglik.gov.tr
2
is classied as healthy or normal, (2)
Table 25.1 Indications for bariatric surgery [3]
1.
If BMI is 40kg/m comorbidity requirement related to obesity; surgical treatment should not cause increased risk.
2.
If BMI is 35kg/m associated with obesity should be accompanied. These associated situations are as follows: (a) Type 2 diabetes mellitus (b) Hypertension (c) Dyslipidemia (d) Sleep-apnea syndrome (e) Obesity-hypoventilation syndrome
Pickwick syndrome (coexistence of sleep-
(f)
apnea syndrome and obesity-hypoventilation syndrome)
(g) Non-alcoholic fatty liver disease or “non-
alcoholic steatohepatitis (NASH)” (h) Pseudotumor cerebri (i) Gastro-esophageal reux disease (j) Asthma (k) Venous stasis disease (l) Advanced urinary incontinence (m) Arthritis affecting daily life
adults are obese in the United States and Turkey [4]. According to the “Turkey Nutrition and Health Survey-2010” preliminary studies report issued by the Ministry of Health of the Republic of Turkey, the prevalence of obesity is 30.3% [5].
Increased prevalence of obesity causes an increase in various comorbidities especially in type 2 diabetes, cardiovascular and cerebrovascu­lar diseases, digestion, leukomotor and respira­tory disorders, cancers (such as colon, breast and uterus), and psychosocial complications [6]. If overweight and obesity continue with this rate, it
2
, there is no additional
2
, at least one comorbidity
© The Author(s), under exclusive license to Springer Nature Switzerland AG 2021 O. N. Dilek et al. (eds.), Prophylactic Surgery, https://doi.org/10.1007/978-3-030-66853-2_25
273
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E. Kamer and F. Cengiz
is reported that it will affect 60% of the world population in 2030 (2.2 billion overweight, 1.1 billion obese, 89% male, 85% female) and result in an increase by 97% in obesity-related heart disease prevalence, by 61% in cancer prevalence and by 21% in Type 2 diabetes prevalence [7, 8]. On the other hand, the prevalence of overweight and obesity among children and adolescents has started to increase worldwide. WHO European Childhood Obesity Surveillance Initiative (COSI) routinely measures the overweight and obesity prevalence of children aged 6–9 years, and according to these data, the prevalence of obesity was found to be between 6.0–26.6% in boys and
4.6–17.3% in girls. Overweight among children of 6–9years is dened as a serious public health problem [9].
While obesity causes serious health problems on the one hand, it causes signicant economic impact on the other. The cost of obesity compli­cations and treatments in the United States is approximately $200 billion, accounting for over 20% of all US healthcare spending in 2005. The global economic impact of obesity was estimated at $2.0 trillion in 2014 [10].
25.2 Obesity Comorbidities
The incidence of many chronic diseases has increased in obese people. These risks are higher for class 3 obese individuals, whose BMI is over 40kg/m tality independent of concomitant diseases. Diseases accompanying obesity and complica­tions of obesity are: diseases related to the car­diovascular system (hypertension, atherosclerotic heart and myocardial infarction and cerebral vascular accidents and peripheral vascular dis­ease, peripheral venous insufciency, thrombo­phlebitis, pulmonary embolism), respiratory system related diseases (obesity-hypoventilation syndrome, obstructive sleep apnea, dyspnea), diseases related to the metabolic-endocrine sys­tem (Type 2 diabetes mellitus, dyslipidemia, insulin resistance), diseases related to the gastro­intestinal tract (Hiatus hernia and reux disease, nonalcoholic fatty liver, hepatic cirrhosis,
2
. Obesity is the cause of increased mor-
hepatic carcinoma, gallstones, colectal cancer), diseases related to neurological diseases (nerve compression, carpal tunnel syndrome, sciatica, pseudotumor cerebri), musculoskeletal system (osteoarthritis, at foot, disc diseases), endo­crine and genitourinary system related diseases (stress incontinence, decreased fertility, mechan­ical difculty in sexual intercourse, pregnancy complications, urinary stones, polycystic ovarian syndrome, male hypogonadism, endometrium, breast, ovarian, prostate and pancreatic cancers), related to psychosocial conditions (self dissatis­faction, depression, anxiety, difculty in nding work, high life insurance premiums, unhappiness in marriages, eating disorders), dermatology related diseases (intertriginous dermatitis). Approximately 30% of overweight adolescents in the United States (USA) meet metabolic syn­drome criteria, which increases the risk of type 2 diabetes and coronary heart disease. Obesity ranks second as a preventable cause of cancer in the USA. Obesity causes 40% of the cancers diagnosed to develop in the USA [11]. The International Agency for Research on Cancer­OAC has identied 13 malignancies including obesity-related post-menopausal breast, colorec­tal, kidney, endometrial, thyroid, pancreas, liver, gastric cardia, meningioma, ovarian, esophageal adenocarcinoma, gallbladder and myeloma malignancies [12]. The effect of obesity on long life is well documented. More than 2.5 million deaths per year can be attributed to obesity world­wide [13].
25.3 Patient Selection andTargets
The aim of obesity treatment is to impose ade­quate and balanced eating habits and to improve the quality of life by targeting the individual spe­cic body weight loss in order to reduce obesity­related morbidity and mortality risks. Treatment options for obesity include surgical treatment and non-surgical treatment. Non-surgical treatments include dietary changes, use of various pharma­cological agents, physical exercises, and behav­ioral therapy methods. The rst-line treatment of obesity should be diet and lifestyle changes. If
25 Surgical Prophylaxis ofObesity
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these are not successful, drug treatments are added. Unfortunately, in obese patients, most of these can be ineffective in ensuring and maintain­ing weight loss. Therefore, the use of bariatric surgery methods in morbid obesity is increasing worldwide. Studies have shown that surgical methods in obesity treatment lead to more effec­tive and permanent weight loss in the long term compared to non-surgical methods [14]. Therefore, the use of bariatric or metabolic surgi­cal methods is increasing worldwide. In 2013, 468,609 cases were reported worldwide, with 154,276 cases in the USA/Canada and 3250 cases in Turkey [15, 16]. It is seen that these numbers have increased considerably today.
The principles of the National Institutes of Health (NIH) adopted in 1991 are generally accepted as the basis for patient selection for bar­iatric surgery. General indications are shown in Table25.1. In addition to those, they can be listed as failure in medical treatments applied prior to surgical treatments, stability of the psychological state, presence of family and environmental sup­port, no alcohol and drug addiction, and fully informing the patient about the application [17].
25.4 Surgical Techniques
The bariatric surgery methods used includes “Absorption Degrading Methods” such as bilio­pancreatic diversion (BPD), jejunoileal bypass (JIB), which cause weight loss by shortening the length of the small intestine where absorption takes place, by bypassing the area where absorp­tion takes place and preventing the encounter with biliopancreatic secretions that play a role in absorption, “Intake Restriction Methods” such as Sleeve gastrectomy (SG), adjustable gastric band (AGB), vertical band gastroplasty (VBG) that provides weight loss by reducing food intake by reducing gastric volume and Roux-en-Y gastric bypass (RYGB) performed by combining these two methods, biopancreatic diversion ± duadonal Switch (DS) and mini-gastric bypass. Among many different (over 50) effective surgical meth­ods used for treating obesity, most of the popular bariatric procedures such as Roux-en-Y gastric
bypass (RYGB), sleeve gastrectomy (SG), mini­gastric bypass, and biopancreatic diversion (BPD) are considered as the safest effective pro­cedures in terms of obesity-associated comor­bidities and weight loss [2, 18].
25.5 Prophylactic Surgery andOutcomes
Prophylactic surgery is not a very new concept. The purpose of prophylactic surgery is to prevent the development of the disease. Patients usually leave therapeutic surgery because it is asymp­tomatic and surgery is not required immediately. Prophylactic surgery can be performed in indi­viduals who are prone to develop cancer from the hereditary mutations most frequently diagnosed by genetic testing, as well as for all organs fore­seen to develop the disease. Although bariatric surgery operations are procedures to protect the patient from possible diseases and complications in the future, it has not been dened as a prophy­lactic surgery procedure. There are very few arti­cles in the literature that describe this as a prophylactic procedure [19].
Bariatric surgery operations are applied to patients for metabolic surgery as well as surger­ies that result of weight loss. In the foreword part of the Metabolic Surgery book dated 1978, the discipline of bariatric surgery has dened meta­bolic surgery as “operational manipulation of a normal organ or organ system to achieve a poten­tial health gain and get a biological result.” In Genesis, metabolic surgery has been described as an “operative manipulation” under general anes­thesia on “normal organ” to achieve a “biological result” [20].
Various surgical procedures, generally used in bariatric surgery, result in approximately 34–85.3% partial or total T2D remission depend­ing on criteria applied to dene Type2 DM (T2D) remission and 95% global success in glycemic control [21]. RYGB is also a very effective option for T2D remission. Most patients who were applied RYGB did not require drug use 1year after surgery and T2D remissions of 84–90% and 29–50% were reported respectively 1 and 5years
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after RYGB [2]. However, T2D remission rates vary in the literature. Yan et al. had reported
56.81% (36.8–90.3%) T2S remission, while Chang etal. reported 95.15% (88.38–98.8%) [22,
23]. Sleeve gastrectomy has gained popularity in
recent years due to glycemic control rates similar to RYBG and lower complication rates related to surgery. In the study of the Swiss Multicenter Bypass or Sleeve Study (SMBOSS), which was a randomized controlled study, T2D remission rates were shown as 60% in SG and 77% in RYGB 3years after the surgery [24]. It has been reported that laparoscopic mini-gastric bypass provides successful remission in patients with BM2>35 and 77% in patients with BMI <35in T2D/impaired fasting glucose patients [25]. Surgical Treatment and Medications Potentially Eradicate Diabetes Efciently (STAMPEDE) Trial in a study comparing 150 patients with T2D in terms of bariatric surgery (SG and RYGB) and medical treatment, more weight loss, normaliza­tion of glycine hemoglobin, decreased triglycer­ide levels, reduction in high density lipoprotein levels, and decrease in the use of insulin and other antidiabetic agents were seen more com­pared to the medical group. In addition, a reduc­tion was observed in the use of lipid lowering or antihypertensive in bariatric patients [26]. Brolin etal. reported in their study that, considering that presence of at least one concomitant disease related to obesity is known in 95% of the patients over 45 and who had undergone bariatric surgery, it was obvious that the future development of dis­eases such as T2D (very likely in case of family history), hypertension, and hyperlipidemia could be prevented by the bariatric surgery to be applied to these patients who do not have any additional disease other than obesity [27].
Obesity is known to have risk and negative consequences for increased cardiovascular dis­eases (CVD). A signicant improvement was observed in cardiovascular risk factors such as hypertension, dyslipidemia, and T2D after bariat­ric surgery with the ratios of 63%, 65%, and 72%, respectively [28]. This wide improvement in cardiovascular risk factors led to a signicant reduction in the risk of stroke, myocardial infarc­tion, and death [29]. Many studies clearly show
that obesity is an independent risk factor for early CVD morbidity and mortality in childhood and adolescence [30]. Also, the steady increase in obesity prevalence causes an increase in CVD risks in young people with obesity. On the other hand, it is useful to examine the economic dam­age caused by long-term CVD risk with obesity treatment. Ryder etal. showed in their study that adolescents with severe obesity were at high risk for CVD within 30years, the postoperative MBIs of adolescents who had undergone bariatric sur­gery signicantly reduced the risk of CVD despite having a plateau after a while, and that bariatric surgery was cost-effective as it pre­vented CVDs and CVD related early mortality in adolescents with obesity [23]. Therefore, prophy­lactic bariatric surgery can be considered in ado­lescents without CVD to reduce both the risk of developing CVD and mortality from CVD at a later age.
Given the multiple mechanisms by which obe­sity increases the risk of cancer, it is possible to see that some types of cancer decrease with bar­iatric surgery [31]. In general, bariatric surgery reduces the risk of cancer in women by 42%, while cancer risk in men has not been reduced [32]. For example, it is known that breast and endometrium cancers are very sensitive to estro­gen levels and patients have a history of exposure to estrogen in their etiology and a decrease in the incidence of these two cancers after menopause [32]. Since it has been shown that weight loss reduces the circulating estrogen level and reduces the risk of breast and endometrum cancer, it is obvious that bariatric surgical interventions that will be performed before seeing cancer in obesity patients will provide a prophylaxis for this cancer due to weight loss that takes place with bariatric surgery [33]. In addition, in a study in which bar­iatric surgery was performed with gastric bypass and sleeve gastrectomy, it was reported that there was a decrease in the risk of esophageal adeno­carcinoma in the group that had undergone bar­iatric surgery [33]. A decrease in the risk of colon cancer was also detected in the group treated with bariatric surgery in the same study [33]. As a result, since bariatric surgery decreases the risk of breast, endometrium, esophagus and colon
25 Surgical Prophylaxis ofObesity
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cancer, application of bariatric surgery to obese patients may create a prophylaxis.
There is a relationship between BMI and physical limitation and fatigue. In other words, obesity is closely related to the decrease in a per­son’s health-related quality of life. At the same time, psychosocial problems such as dissatisfac­tion with their body appearance, unhappiness in their marriages, and difculty in their sexual lives are more common in these individuals compared to the normal population [34]. In studies con­ducted in our country, it has been revealed that psychiatric disorders are also common in obesity patients. Eren and Erdi reported in their study that 81.3% of obese patients who applied to the endocrinology department for treatment purposes had major depressive disorder, 71.7% had major depressive episodes in the last month, and other psychiatric distribution distributions were reported to be 22.6% social phobia, 17% nicotine addiction, 5.8% alcohol dependence 5.7% anxi­ety disorder, and 3.8% obsessive compulsive dis­order, respectively [34]. Considering that 81.3% of obese patients had major depressive disorder and 71.7% of them had a major depressive attack in the last month, the rate of encountering psy­chosocial problems in their future life is quite high for an obese patient. Prophylactic bariatric surgery to be performed has important psychoso­cial effects on individuals. Approximately 40% of patients who request bariatric surgery present with at least one mental health condition such as depression, anxiety, overeating disorder, and alcohol use disorder or impulse control disorders [35]. There is a lot of evidence that bariatric sur­gery has a positive effect on psychopathology, quality of life, body appearance, socio-economic status, and social relationships [3638]. Therefore, in order to prevent this, prophylactic BS may be considered for obese patients.
25.6 Conclusion
Considering that bariatric surgery increases the quality of life in obese patients and reduces or eliminates comorbid medical problems and given
the advantages and disadvantages gained, it is seen that operations performed for obesity are prophylactic applications, even if they are not dened as prophylactic surgery. Nevertheless, as a concept that has not been widely used in the literature, we believe that surgical practices in obesity are performed for prophylactic purposes and it will be useful to examine the issue in terms of ethics, medicine, and cost.
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