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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_6033_Библиотеки_им_академика_М_И_Перельмана.pdf
X
- •Foreword
- •Preface
- •Contents
- •2.1 Introduction
- •2.2 Lumbar Anatomy
- •2.2.1 Vertebra
- •2.2.2 Intervertebral Discs
- •1: History and Rationale for the Minimally Invasive Lateral Approach
- •1.1 Introduction
- •1.2 Historical Approaches to the Lumbar Spine
- •1.4 Validation of the Technique
- •References
- •2: Biomechanics of Lateral Spinal Reconstruction
- •2.2.3 Facets
- •2.2.4 Muscles and Ligaments
- •2.3.1 The Neutral Zone
- •2.3.2 Bending Moments and Load Carrying
- •2.3.3 Lumbar Lordosis
- •2.4 Biomechanics of Lumbar Pathology
- •2.4.1 Lumbar Surgery
- •2.5 Lateral Lumbar Fixation
- •References
- •3.1 Goals of Minimally Invasive Spine Surgery
- •3.2.1 Blood Loss
- •3.2.2 Decreased Infection Rates
- •3.2.4 Pain Control and Recovery
- •References
- •4: Costs and Economic Implications
- •4.1 Introduction
- •4.2 The Costs of Spine Surgery
- •4.3 Comparative Effectiveness of the MIS Lateral Approach
- •4.4 Cost-Effectiveness of the MIS Lateral Approach
- •4.5 Future Directions
- •References
- •5: Workup and Diagnostic Testing
- •5.1 Introduction
- •5.2 Patient History
- •5.3 Physical Examination
- •5.4 Adjunctive Tests
- •5.5 Preoperative Evaluation of the Pain Generator
- •5.6 Radiographic Studies
- •5.7 Summary
- •References
- •6: Literature Evidence of the MIS Lateral Approach
- •6.1 Adult Spinal Deformity
- •6.1.1 Studies
- •6.1.2 Treatment Characteristics
- •6.1.3 Clinical Outcomes
- •6.1.4 Fusion
- •6.1.5 Complications
- •6.1.7 Conclusion
- •6.2 Degenerative
- •6.2.1 Studies
- •6.2.3 Operative Time
- •6.2.4 Length of Stay
- •6.2.5 Clinical Outcomes
- •6.2.6 Fusion
- •6.2.7 Complications
- •References
- •7: Selecting the Proper Patient for Lumbar Lateral Interbody Fusion and Minimally Invasive Spinal Deformity Surgery
- •7.1 Indications for LLIF
- •7.2 The MISDEF Algorithm
- •References
- •8: Positioning and Safety
- •8.1 Introduction
- •8.2 Positioning the Patient
- •8.3.1 Pressure Ulcers
- •8.3.2 Peripheral Nerve Injury
- •8.3.3 Rhabdomyolysis
- •8.3.4 Postoperative Visual Loss
- •References
- •9: Intraoperative Electrophysiologic Monitoring
- •9.1 Introduction
- •9.2 Anatomic Considerations
- •9.3.2 Somatosensory Evoked Potentials (SSEP)
- •9.3.3 Spontaneous Electromyography (spEMG)
- •9.3.4 Triggered Electromyography (trEMG)
- •9.4 Patient Preparation and Anesthesia Requirements
- •9.6 Ongoing Monitoring
- •References
- •10: Motor-Based Monitoring During Minimally Invasive Lateral Spine Surgery
- •10.1 Introduction
- •10.3 Motor-Evoked Potentials
- •10.4 Electromyography
- •10.4.1 EMG Limitations
- •10.5 Mechanomyography
- •References
- •11: Frameless Navigation
- •11.1 Introduction
- •11.2 Technique
- •11.2.1 Positioning
- •11.2.2 Image Acquisition and Registration to CaSN
- •11.2.3 Surgical Approach and Cage Placement with CaSN
- •References
- •12.7 Retraction
- •12.8 Shallow Docking
- •12.9 Oblique Approach
- •References
- •12: Techniques for Avoiding Psoas Muscle and Lumbosacral Plexus Injury
- •12.1 Introduction
- •12.2 Anatomy
- •12.5 Retroperitoneal Dissection
- •12.6 Electromyography
- •13: Single Versus Dual Incisions for Lateral Retroperitoneal Approach
- •13.1 Single Incision
- •13.1.1 Surgical Technique
- •13.2 Dual Incisions
- •13.2.1 Surgical Technique [1]
- •13.2.2 Advantages and Disadvantages
- •References
- •14: Lateral Transpsoas Retractor Technology
- •14.1 Introduction
- •14.2 MaXcess® (NuVasive, Inc.)
- •14.3 Mars® 3V (Globus, Inc.)
- •14.5 Pipeline® (Depuy Synthes, Inc.)
- •14.6 Oracle® (Depuy Synthes, Inc.)
- •14.7 Aira® 3 (Stryker, Inc.)
- •14.8 Ravine® 3 (K2M, Inc.)
- •14.9 Veo® (Baxano, Inc.) [6]
- •References
- •15: Anterior to Psoas (ATP) Fusion of the Lumbar Spine
- •15.1 Introduction
- •15.2 Indications
- •15.3 Contraindications
- •15.4 Equipment
- •15.5 Surgical Technique
- •15.5.1 Patient Positioning
- •15.5.2 Incision
- •15.5.3 Exposure of the Disc
- •15.5.4 Discectomy and Endplate Preparation
- •15.5.4.1 ALL Release
- •15.5.5 Cage and Plate Insertion
- •15.5.5.1 L5/S1
- •15.6 Discussion
- •15.6.1 History
- •15.6.2 Cages
- •15.6.2.1 Clinical Results
- •15.6.3 Retractors
- •15.6.3.1 Neuromonitoring
- •15.6.4 Psoas Retraction
- •15.6.5 Levels
- •15.6.6 Vascular Injuries
- •15.6.7 Nerve Injuries
- •15.7 ALL Section
- •References
- •16: Thoracic MIS Retropleural Access
- •16.1 Introduction
- •16.2 Anterior-Based Approaches
- •16.3 Posterior-Based Approaches
- •16.4 Lateral-Based Approaches
- •16.5 Surgical Technique and Anatomic Considerations
- •16.5.1 Preoperative Planning
- •16.5.2 Preparation and Patient Positioning
- •16.5.3 Surgical Approach
- •16.5.4 Postoperative Care
- •16.6 Outcomes Using a Minimally Invasive Anterolateral Approach
- •16.7 Advantages of the Minimally Invasive Lateral Approach
- •16.8 Limitations of the Minimally Invasive Lateral Approach
- •16.9 Summary
- •References
- •17: Psoas Muscle Management
- •17.1 Introduction
- •17.3 Transpsoas Versus ATP
- •17.4 Traversing the Psoas Major
- •References
- •18: The Extreme Lateral Minimally Invasive Approach to Pure Degenerative Lumbar Disk Disease
- •18.1 Introduction
- •18.2 The Rome Experience
- •18.2.1 Surgical Technique
- •18.3 Results
- •18.3.1 Demonstrative Cases
- •18.3.1.1 Case 1
- •18.3.1.2 Case 2
- •18.3.1.3 Case 3
- •18.4 Discussion
- •References
- •19: Lateral Approach for Spondylolisthesis
- •19.1 Introduction
- •19.2 Treatment
- •19.3 Surgical Technique
- •19.4 Outcomes
- •19.5 Complications
- •References
- •20: Lateral Lumbar Interbody Fusion (LLIF) for the Treatment of Adult Spinal Deformity (ASD)
- •20.1 Introduction
- •20.2 MIS Treatment Algorithm
- •20.3 Surgical Technique
- •20.3.1 Patient and Bed Positioning
- •20.3.2 Fluoroscopic Imaging
- •20.3.3 Access to the Psoas
- •20.3.4 Transpsoas Approach and Retractor Docking
- •20.3.5 Preparing the Disk Space
- •20.3.6 Maximizing Correction
- •20.3.7 Approach Through the Concavity vs. Convexity
- •20.3.8 Sequence of LLIF Instrumentation
- •20.3.9 Wound Closure
- •20.4 Outcomes
- •References
- •21: Neoplasia
- •21.1 Introduction
- •21.2 Clinical Features
- •21.3 Diagnosis
- •21.4 Primary Vertebral Tumor
- •21.4.1 Aneurysmal Bone Cyst
- •21.4.2 Hemangioma
- •21.4.3 Osteosarcoma
- •21.4.4 Giant Cell Tumor
- •21.4.6 Meningioma
- •21.4.7 Nerve Sheath Tumor
- •21.5 Surgical Treatment for Primary and Metastatic Spine Tumors
- •21.5.1 Open Surgery
- •21.5.2 MIS Lateral Approach
- •References
- •22: Minimally Invasive Lateral Spine Surgery in Trauma
- •22.1 Introduction
- •22.3 Indications for the Anterior Approach
- •22.4 Complications Associated with the Open Anterior and Posterior Approaches
- •22.6 Lateral MISS Techniques
- •References
- •23: Lateral MIS Surgery for Spinal Column Infections
- •23.1 Introduction
- •23.2.1.1 Indications
- •23.2.1.2 Contraindication
- •23.2.2 Technique
- •23.2.2.1 Preoperative Preparation
- •23.2.2.2 Operative Procedure
- •23.2.2.3 Postoperative Treatment
- •23.3 Clinical Outcomes
- •23.4 Complications
- •23.4.1 Approach-Related Complications
- •23.4.2 Instrumentation-Related Complications
- •23.4.3 Infection-Related Complications
- •23.5 Case Studies
- •23.5.1 Case 1
- •23.5.2 Case 2
- •Further Reading
- •25: Lateral Lumbar Interbody Fusion: A Review of the Current Clinical Outcomes of Different Supplemental Fixation Techniques
- •25.1 Introduction
- •25.2.1 Case Example
- •25.3 Interspinous Fusion
- •25.3.1 Case Example
- •25.4 Integrated Fixation Fusion
- •25.5 Simultaneous Combined Anterior and Posterior Fusion
- •References
- •26: Anterolateral Fixation in LLIF
- •26.1 Introduction
- •26.3 When? The Indications for Supplemental Fixation
- •26.3.1 Reduced Bone Density
- •26.3.2 Facet Arthropathy
- •26.3.3 Deformity
- •26.3.4 Instability
- •26.3.5 Pars Defects
- •26.3.6 Cage Width and Levels
- •26.3.7 Adjacent Segment Disease
- •26.3.8 Previous Surgery
- •26.4.1 Lateral Fixation
- •26.4.2 Posterior Fixation
- •26.4.3 Combination Lateral and Posterior Fixation
- •References
- •27: Anterior Column Realignment
- •27.1 Introduction
- •27.2 Applications
- •27.3 Regional Anatomy
- •27.4 Surgical Technique
- •27.5 Potential Pitfalls
- •27.6 Complications
- •References
- •28: Subsidence in LLIF
- •28.1 Introduction
- •28.3 Rates
- •28.4 Risk Factors
- •28.4.1 Caudal Endplate
- •28.4.2 Level
- •28.4.3 Bone Quality
- •28.4.4 Cage Size
- •28.4.5 Bone Morphogenetic Protein
- •28.6 Prevention/Recommendations
- •28.6.1 Standalone Cages/Supplemental Posterior Instrumentation
- •References
- •29: Osteobiologics
- •29.1 Introduction
- •29.2 Autografts
- •29.3 Allograft Bone
- •29.3.1 Demineralized Bone Matrix
- •29.4 Ceramics
- •29.5 Bone Morphogenetic Proteins
- •29.6 Bone Marrow Aspirate (BMA)
- •29.7 Platelet Gels
- •29.8 Summary
- •References
- •30: Indirect Decompression
- •30.1 Lumbar Stenosis
- •30.2 Lateral Interbody Fusion
- •References
- •31: Approaching a Deformity from the Concavity Versus Convexity
- •31.1 Introduction
- •31.2 Concavity Approach
- •31.3 Convexity Approach
- •31.4 The Importance of L4/L5
- •31.5 Additional Considerations
- •References
- •32: Awake Lateral Lumbar Fusion
- •33: Managing and Preventing Vascular Complications
- •33.1 Introduction
- •33.3 Incidence of Vascular Complications in Lumbar Spine Surgery
- •33.3.1 Posterior Approach
- •33.3.2 Anterior Conventional Approach
- •33.3.3 Lateral or Extreme Lateral Retroperitoneal Transpsoas Approach
- •33.4 Surgical Features in Lateral Retroperitoneal Transpsoas Interbody Fusion
- •33.5 Preventive Measures of Vascular Complications in Anterior Lumbar Spine Surgery
- •33.5.1 Preoperative Period
- •33.5.2 Operative Period
- •33.5.3 Postoperative Period
- •33.6 Management of Vascular Injuries
- •33.6.1 Venous Injury
- •33.6.2 Arterial Injury
- •References
- •34: Managing and Preventing Soft Tissue Complications
- •34.1 Introduction
- •34.3 Retroperitoneal Injuries
- •34.4 Management of Complications
- •34.5 Prevention of Complications
- •References
- •35: Ileus and Gastrointestinal Complications
- •35.2.1 Neural
- •35.2.3 Pharmacologic
- •35.6 Fiscal Consequences of POI
- •References
- •36: Lumbar Plexus Injury: Lateral MIS Spinal Fusion
- •36.1 Introduction
- •36.2 Sensory Complications
- •36.2.2 Ilioinguinal Nerve (L1): SDZ1
- •36.2.4 Lateral Cutaneous Nerve (L2, L3): SDZ2
- •36.3 Motor Complications
- •36.3.1 Femoral Nerve (Dorsal L2–L4)
- •36.3.2 Obturator Nerve (Ventral L2–L4) and Lumbosacral Trunk (L4, L5)
- •References
- •Index

208
H.-K. Chang and J.-C. Wu
Fig. 21.4 Magnetic resonance image (MRI) of lumbar spine neurofi broma. left : T2-weighted axial view with contrast;
right : T1-weighted axial view with contrast. Arrow indicated tumor
complete facetectomy, or lateral transpsoas
21.5.1 Open Surgery
approaches. Like resection of every other kind of
tumor, instrumented fusion might be needed if
the surgical approach compromises spinal stability, such as facetectomy [
15 ].
The indication of traditional open surgery for
thoracic and/or lumbar spine tumors includes
medical-intractable pain, spinal cord compression, and instability [ 32 ]. The goal of an opera-
tion is to achieve complete tumor removal, local
21.5 Surgical Treatment for Primary and Metastatic Spine Tumors
tumor control, and eventually disease control.
The treatment strategy is mainly dependent on
tumor histology. Each differential diagnosis of a
primary malignant tumor, primary benign tumor,
Surgical treatment for spine tumors ranges from
vertebroplasty [
16 ], open anterior transthoracic,
thoracotomy or retroperitoneal approaches [
26 ], an open posterior approach (transpedicular,
costotransversectomy), a thoracoscopy- combined
approach [ 26 ], and minimally invasive approaches
[ 52 , 80 ].
or metastatic tumor, or of spinal osseous tumors
has different treatment strategies and goals.
23 ,
For primary malignant vertebral tumors, the
standard operative procedure of choice is en bloc
resection plus adjuvant radiotherapy for best cure
[ 11 , 32 ]. On the other hand, intralesional resec-
tion plus radiotherapy may be suffi cient for pri-

21 Neoplasia
209
mary benign tumors [ 24 , 32 ]. Many studies have
demonstrated that en bloc spondylectomy provides a higher rate of tumor control, a lower rate
of recurrence, and a longer term of disease-free
survival for primary malignant vertebral tumors
[ 5 , 9 , 11 , 49 , 70 , 72 – 74 ]. Boriani et al. reported a
lower recurrence rate (22.4 %) following en bloc
resection compared to non-en bloc resection
(100 %) for chondrosarcoma [ 5 ]. In a study by
Talac et al., a signifi cant lower recurrence rate
(11 %) following “en bloc resection with negative
margin” was noted, compared to “piecemeal
resection with negative margin” (33 %) and
“resection with positive margin” (70 %) for primary sarcoma [
73 ]. Sciubba et al. published a
study that Ewing’s sarcoma and osteogenic sarcoma had improved rates of local tumor control
after en bloc resection [ 70 ]. Furthermore, Ozaki
et al. reported signifi cantly better survival rates in
patients with wide resection than those who had
non-wide excision (biopsy or intralesional) for
spine osteosarcoma [ 56 ].
The technique of en bloc resection of these
spinal tumors can be challenging and is sometimes only achievable with sacrifi ce of some neural tissue. Therefore, en bloc spondylectomy
usually involves experienced orthopedic or neurological surgeons, and it is not uncommon to
combine both anterior and posterior/lateral
approaches. There are major perioperative complications, such as spinal cord injury, unintended
durotomy, and vascular injury to aorta and vena
cava. The complex operation often results in
spine instability that requires reconstruction and
instrumented fusion of the vertebral column.
For metastatic tumors of the spine, surgical
management can be effective in the relief of
symptoms and in the improvement of life quality.
Surgical decompression or evacuation of the
tumor mass could provide better pain control,
regain or maintain mobility, and offer improved
sphincter control [
29 ]. For these metastatic
tumors of the spine, the surgical goal is mainly
palliative and is better reserved for patients
whose life expectancy is considered more than
3 months [
10 ]. Although the fi nal outcome
depends on the status of the primary oncological
disease, surgery is often very effective to relieve
intractable pain, spinal instability, or neurologic
compromise.
Surgical strategies to manage spinal osseous
metastatic tumors range from intratumoral resection to en bloc resection. The various approaches
include direct posterior decompression with or
without posterolateral fusion, costotransversectomy with corpectomy and placement of interbody support and bone graft with posterolateral
fusion, thoracotomy with corpectomy and cage
reconstruction, retroperitoneal approaches, and
vertebroplasty/kyphoplasty [ 32 ]. In a landmark
study by Patchell et al., direct decompressive surgery plus postoperative radiotherapy was superior to treatment with radiotherapy alone for
patients with spinal cord compression caused by
metastatic cancer. Direct decompressive surgery
provided improvement in ambulation, greater
pain control, and less corticosteroid use [
60 ].
The optimal paradigm of treatment for these
spinal tumors remains uncertain. Cloyd et al.
published meta-analysis and a systemic review of
the present literature focusing on the prognosis of
primary and metastatic spine tumors after treatment. The median time to recurrence was
113 months for the primary tumors and 24 months
for the metastatic tumors. Disease-free survival
rates at 1, 5, and 10 years were 92.6 %, 63.2 %,
and 43.9 %, respectively, for the primary tumors,
whereas the rates were 61.8 %, 37.5 %, and 0 %,
respectively, for the metastatic tumors [ 11 ].
Furthermore, this review study also pointed out
the risk factors of tumor recurrence, such as old
age, male sex, previous metastatic tumors, and
osteosarcomas. Patients with the aforementioned
characteristics were signifi cantly associated with
tumor recurrence [
11 ].
21.5.2 MIS Lateral Approach
Minimally invasive surgery (MIS) has been
an emerging option in the management of
degenerative spinal diseases to reduce postoperative comorbidities. There has also been more
application of MIS in the management of oncological disorders of the spine, particularly in the
thoracolumbar spine. Traditionally, open surgery

210
H.-K. Chang and J.-C. Wu
for spinal tumors has been divided into anteriorly
based or posteriorly based approaches, which are
associated with different morbidities. Posterior
approach-related morbidities include extended
soft-tissue dissection resulting in excessive
blood loss, a limited window to ventral lesions
and constraints on vertebral body reconstruction and kyphotic correction. Anterior approachrelated morbidities include a large incision for
conventional thoracotomy, entry to the chest
cavity, and pulmonary complications (such as
atelectasis, pneumo- or hemothorax, pleural effusion). Also, most of spine surgeons are unfamiliar thoracoscope- combined techniques. On the
other hand, the MIS lateral approach has been
developed in order to reduce the abovementioned
approach-related morbidities. For example, the
MIS lateral approach to the thoracic and lumbar
spine can minimize muscle destruction, blood
loss, wound pain, and hospital stay, whereas
it can still achieve complete tumor removal
and reconstruction of spinal stability [
75 ]. The
advancement of tubular and expandable retractors, specialized instruments, and fi ber-optic illuminations has helped the MIS lateral approach to
prevail [ 59 ].
There are also disadvantages regarding MIS
lateral approaches. Inevitably, the MIS lateral
approach to the thoracic or lumbar spine requires
a long working distance with a narrow visual
window and depends on fl uoroscopic guidance.
There is a steep learning curve and requires
experienced operators. Due to the limited space,
multiple segments of lesions are diffi cult to operate on within a single approach. Most of the
reports on MIS lateral approaches have so far
dealt with only three vertebral bodies [
15 , 37 ,
46 , 61 , 75 ]. Moreover, posterior transpedicular
percutaneous screw fi xation is frequently necessary to stabilize the vertebral column. Separate
posterior skin incisions are therefore needed.
Occasionally, there are severe adhesions and
infl ammatory infi ltrations caused by metastatic
spinal tumors, and thus the tissue dissection may
be diffi cult and hazardous [ 59 ]. Therefore, the
MIS lateral approach may not be feasible for all
types and anatomic locations of spinal tumors.
Vertebral body tumors and ventral and lateral
lesions of intradural tumors are more favorably
approached by the MIS lateral approach.
Primarily posterior column or pedicle-based
tumors may be better operated on via posterior
or transforaminal approaches. Most experts also
recommend posterior- based approaches for
tumors in the high thoracic region (T1-4) due to
the anatomic restriction of mediastinum and
axilla [
59 , 75 ].
Application of the MIS lateral approach on
spinal tumors is relatively new and there are
scarce reports in the literature. The tumor pathologies most commonly reported using the MIS
lateral approach included neurofi broma [
15 , 75 ],
meningioma [ 75 ], plasmacytoma and multiple
myeloma [ 61 , 75 ], hemangioma [ 75 ], osteosar-
coma [ 75 ], giant cell tumor [ 75 ], aneurysmal
bone cyst [ 61 ], and mostly metastatic tumors [ 37 ,
46 , 48 , 59 , 61 , 75 ]. There was one case report of
extradural foraminal spinal neurofi bromas that
was dealt with by the MIS lateral (retroperitoneal/retropleural) approach for tumor resection in
three patients [ 15 ]. An expandable tube retractor
(MaXcess, NuVasive, San Diego, CA, USA) was
used. All three patients had successful tumor
resection with complete resolution of their pain
and motor defi cits. Complete resection of the
neurofi bromas was noted in two patients and a
tiny residual in the third patient. No instrumentation was needed due to no removal of bone or
critical ligamentous structures. There also was no
instability in postoperative radiographic followups. The earliest case series in the literature was
reported by Kossmann et al. in 2001, which
included six metastatic tumors using the
SynFrame (Stratec Medical, Oberdorf,
Switzerland) retractor system [
37 ] via a mini-
open transthoracic route for thoracic lesion or
mini-open retroperitoneal route for a lumbar
lesion. No intra- or postoperative complications
related to the minimal access developed, and
there were no vascular or visceral complications.
However, no midterm or long-term result was
recognized in this case series. There was another
case series reported in 2008 that described 37
patients who underwent the MIS lateral approach
for a T or L spine traumatic burst fracture or vertebral body tumor [ 61 ]. Single-level corpectomy

21 Neoplasia
211
for the tumor was done in 11 patients through
transthoracic (T5–T11), transthoracic transdiaphragmatic (T12–L2), or retroperitoneal miniopen approaches (L3–4). A SynFrame (Stratec
Medical, Oberdorf, Switzerland) table-mounted
retractor was used. Most of these cases were metastatic malignancies, such as the breast, liver,
renal, and lung carcinoma. Besides metastasis,
there were two cases of multiple myeloma and
one case of ABC. Nine out of the 11 tumor
patients were stabilized with posterior fi xation.
The remaining two tumor patients were reconstructed with only intervertebral cages because
the posterior element was not involved. As a
result, construct stability was achieved in all
patients in postoperative radiographic follow-ups
at 6 months, and no patient needed reoperation.
Clinically, minimal pain was observed at the
postoperative 24-month follow-up, and improvement with no neurological deterioration was
noted in most patients. Six perioperative complications from the anterior approach developed out
of 37 cases, including unintended durotomy,
pneumothroax, transient paralytic ileus, persistent or transient ilioinguinal hypesthesia, and
superfi cial wound infection. However, no longterm tumor results were reported in this
literature.
One case series reported fi ve compression
fractures with painful kyphosis caused by osteoporosis or metastatic malignancy (not specifi ed)
which were evacuated via the extreme lateral
interbody fusion (XLIF, NuVasive, San Diego,
CA, USA) approach in the T or T-L spine. Singlelevel corpectomy with two adjacent diskectomy
was performed in all fi ve cases. All four patients
went on to develop radiographic evidence of
solid fusion, except one patient who died from
widely metastatic cancer 2 months following her
surgery. As well, no long-term tumor-related
results were recognized in this literature [
46 ]. By
far the largest case series of the MIS lateral
approach for spine tumors was reported by Uribe
et al. [ 75 ]. Twenty-one consecutive patients were
operated on for T spine tumors with various
pathologies, including neurofi broma, meningioma, plasmacytoma, hemangioma, osteosarcoma, giant cell tumor, and metastatic tumor, via
the XLIF (NuVasive, San Diego, CA, USA)
approach. Either a mini-open transthoracic or retropleural approach was adopted. Primary tumors
occurred in 76 % of the patients and secondary
(metatstatic) in only 24 % of the patients. The
surgical indications included pain, instability,
spinal cord compression, and neurologic defi cit.
The degree of resection was based on tumor histology. Subtotal resection of metastatic tumors
was not considered a failure. Mean operative
time was 117 min (40–284 min). Mean blood
loss was 291 mL (25–1,650 mL). Average hospital stay was 2.9 days. Of the 21 patients, 5 had
improvement of neurological defi cit, and the rest
without neurological defi cit remained stable.
Postoperative improvement of visual analogue
scales (VAS) and Oswestry disability index
(ODI) were demonstrated. There were no
intraoperative complications. Only one perioperative complication, pneumonia, developed in one
patient, and there was no postoperative pneumothorax in all patients. After a mean follow-up
period of 21 months (range, 6–24 months), two
patients had residual tumor (multiple myeloma
and meningioma), and two patients died at 6 and
12 months (respectively) postoperatively due to
their metastatic cancer.
The development of MIS approaches to the
thoracolumbar spine aimed to alleviate the signifi cant approach-related morbidities in conventional open surgery. Apparently, this is the trend
of spine surgery development, since MIS
approaches allow less muscle and soft-tissue
destruction, reduce blood loss, minimize postoperative pain, shorten hospital stays, and facilitate
early mobilization [
54 ]. To date, the MIS lateral
approach appears to be safe and effective for thoracic or lumbar spinal tumors with all the benefi ts mentioned above [
59 ]. Although there has
been less data on long-term local tumor control
and a lack of strong evidence compared to traditional open surgery, the MIS approaches would
likely prevail along with the advancement of
technology. In the near future, more evidence of
MIS lateral approaches would likely demonstrate that it is a viable and effective option for
treating spinal tumors in the thoracolumbar
spine.

212
H.-K. Chang and J.-C. Wu
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Minimally Invasive Lateral Spine Surgery in Trauma
Joseph Pyun , Tristan Weir , Kelley Banagan ,
and Steven C. Ludwig
2 2
22.1 Introduction
Thoracolumbar trauma patients present unique
challenges to the spine surgeon, whose goals are
to prevent primary or secondary neurological
injury, enhance neurological recovery, stabilize
the spine to promote early mobilization, and minimize surgical morbidity. Minimally invasive surgery (MIS) has become a key tool in the spine
surgeon’s armamentarium in the treatment of
these potentially fragile patients, as it affords an
alternative to traditional open procedures and
their associated increased blood loss and infection rates [ 1 , 2 ]. Specifi cally, lateral minimally
invasive spine surgery (MISS) has recently
become a treatment option in this patient population. The development of minimally invasive
techniques potentially allows surgeons to better
treat spine trauma patients by providing early
decompression or stabilization while minimizing
the morbidity of surgery. In this chapter, the epidemiology of thoracolumbar spinal cord injuries
will be discussed, followed by the indications for
J. Pyun , MD • T. Weir , BS • K. Banagan , MD
Department of Orthopaedics , Spine Division
University of Maryland , Baltimore , MD 21201 , USA
S. C. Ludwig , MD (*)
Department of Orthopaedics , University of Maryland ,
22 South Greene Street, Suite S11B , Baltimore , MD
21201 , USA
sludwig@umoa.umm.edu
e-mail:
the use of lateral MISS procedures versus the
conventional open anterior approaches. The surgical technique for lateral MISS will be outlined,
as well as the pros and cons of this approach.
Finally, a case example will detail the use of lateral MISS in clinical practice.
22.2 Epidemiology
of Thoracolumbar Spinal
Cord Injuries (SCI) in Trauma
Thoracolumbar spinal injuries are relatively common with an incidence of 150,000–160,000 fractures per year, 10 % representing major injuries
[ 3 , 4 ]. Ninety percent of all thoracic and lumbar
fractures occur at the thoracolumbar junction,
and 10–20 % of those fractures are burst fractures
[
5 ]. Burst fractures occur most commonly in men
during their second or third decade of life and
often result from high energy trauma, such as
motor vehicle accidents or falls from height [ 6 ].
Thoracolumbar injuries often result in signifi cant
incurred costs to the individual and society,
including the cost of treatment and lost productivity. The incidence of neurologic injury for
these cases ranges from 10 to 75 %, and those
sustaining incomplete neurologic injuries have
some potential for functional recovery [ 7 ].
Approximately 19.4 % of burst fractures are associated with a neurologic defi cit, especially in
those fractures with more than 33 % spinal canal
© Springer International Publishing Switzerland 2017
M.Y. Wang et al. (eds.), Lateral Access Minimally Invasive Spine Surgery,
DOI 10.1007/978-3-319-28320-3_22
215

216
J. Pyun et al.
narrowing [ 8 ]. The level of spinal cord injury also
correlates with the likelihood of recovery. Injuries
at the level of the cauda equina are most likely to
recover, followed by the conus medullaris and the
spinal cord, respectfully [ 7 ]. The goals of treat-
ment for thoracolumbar spinal injuries are to prevent neurologic deterioration, enhance neurologic
recovery, stabilize the fracture to facilitate rehabilitation, and prevent late pain and deformity.
22.3 Indications for the Anterior Approach
Several factors should be considered when choosing the optimal approach for treating thoracolumbar fractures, including the bony and/or
ligamentous injury pattern, neurologic status,
experience of the treating team, medical comorbidities, body habitus, baseline level of function,
prior history of radiation or surgery, and the condition of the soft tissues. Relative indications for
an anterior approach include severe vertebral
body comminution, incomplete neurologic defi cit, and secondary neural compression following
posterior realignment and stabilization for a fracture dislocation associated with a burst fracture.
In a study by Sasso et al., 91 % of patients with
incomplete injuries improved at least one modifi ed Frankel grade, and 95 % appeared to achieve
stable arthrodesis after anterior decompression
and reconstruction [ 9 ]. Compared to posterior or
lateral decompression, anterior decompression
for thoracolumbar spine fractures with incomplete neurologic defi cits resulted in a higher rate
of neurologic improvement and recovery of
bowel and bladder control [
to suggest that an anterior approach for incomplete injuries results in better neurologic recovery
compared to a posterior approach due to enhanced
visualization and the ability to perform a better
decompression [ 11 ]. Esses et al. found canal
compromise improved from 44.5 to 16.5 % compared to 58 to 4 % when treated with posterior
distraction versus anterior decompression and
instrumentation, respectively [
also confi rmed the ability to achieve and maintain correction of posttraumatic kyphosis with an
10 ]. There is evidence
12 ]. Studies have
anterior approach [ 9 , 12 , 13 ]. Additionally, bio-
mechanical studies have shown that an anterior
corpectomy with instrumentation is superior to
posterior treatment for thoracolumbar burst fractures [ 14 – 16 ]. McCormack et al. developed the
load-sharing score, which was intended to identify fractures that would benefi t from anterior
column reconstruction due to the severity of
injury. This score has been validated and bases its
scoring on the proportion of vertebral body comminution, displacement of fragments, and degree
of kyphotic correction [ 17 ].
22.4 Complications Associated with the Open Anterior and Posterior Approaches
The anterior approach has potentially signifi cant
complications despite the success of this technique. This approach is associated with a complication rate ranging from 17 to 31 %, including
pneumonia, pulmonary embolism, thoracic duct
injury, sympathectomy, retrograde ejaculation,
pneumothorax, atelectasis, bone graft pain, meralgia paresthetica, neurological worsening, instrumentation failure, graft dislodgement, dural tears,
wound infections, stroke, bleeding from the great
vessels, visceral injury, postoperative hernia, diaphragm injury, infection, post- thoracotomy pain
syndrome, and deep venous thrombosis [ 18 – 24 ].
Due to the injury pattern that can occur at the thoracolumbar junction, certain fractures may necessitate both posterior and anterior approaches. The
obvious advantage of this method is that all the
surgical goals can theoretically be accomplished,
but the morbidity of a more invasive procedure is a
drawback. Indications for a circumferential
approach include posterior stabilization following
an anterior decompression and fusion, anterior
column support following a posterior stabilization
procedure, and the need for additional support and
a fusion bed in the treatment of osteoporotic fractures, circumferential decompression, and ankylosing disease. A combined anterior-posterior
approach has an unsurprisingly low pseudarthrosis
rate but has high complication (16–50 %) and mortality (9 %) rates [
20 , 25 ]. Thoracotomy and retro-

22 Minimally Invasive Lateral Spine Surgery in Trauma
217
peritoneal approaches carry signifi cant morbidities,
as well. Due to the complications outlined above,
surgeons have sought less invasive surgical options
that achieve the same operative goals, but with
lower morbidity [ 26 – 33 ].
22.5 Benefi ts of the Lateral MISS
Approach
MISS can be defi ned as a set of surgical techniques and principles that emphasize soft tissue
preservation, while maintaining the principles of
fi xation, decompression, and correction.
Indications for MISS in thoracolumbar trauma
include burst fractures, distraction injuries,
fracture- dislocations, osteoporosis, and unstable
sacral fractures requiring lumbopelvic fi xation.
MISS lacks long-term evidence to support its
use, but several case reports offer evidence to
support its utility in thoracolumbar and lumbar
trauma [
posterior stabilization in the treatment of thoracolumbar fractures has also been supported by
several studies [ 36 – 41 ]. Although MISS tech-
niques appear to offer considerable advantages
over conventional open surgery, such as less
blood loss and lower infection rates [ 1 , 2 ], long-
term data is needed to validate its superiority.
spine has been utilized by surgeons to access both
the disk space and the vertebral body for a variety
of lumbar degenerative conditions. With the
development of surgical tools for the lateral technique, the creation of a safe surgical working zone
allows the surgeon to target a specifi c vertebral
body fracture, decompress the spinal canal, place
a structural device with bone graft, and safely
place instrumentation to stabilize the spine.
34 , 35 ]. The role of minimally invasive
The minimally invasive lateral approach to the
22.6 Lateral MISS Techniques
Smith et al. illustrated the mini-open, lateral
approach for the treatment of thoracolumbar
trauma [
same as the standard retroperitoneal, transpsoas
approach outlined by Ozgur et al. [
2 ]. The approach for L2–L5 injuries is the
42 ], but more
care is taken to avoid excessive lateral fl exion by
using less table break and avoiding the use of a
bump under the contralateral fl ank. Additionally,
a slightly larger incision allows for greater visualization and a larger work area for the corpectomy.
A lateral transpleural approach was used for T5–
T11 and was accomplished with ipsilateral lung
defl ation. A retroperitoneal approach was used for
treating T12–L1 injuries by creating a plane
between the parietal pleura and the ribs, retracting
the pleura and diaphragm anteriorly. The twelfth
rib and iliac crest limit the exposure of the upper
and lower lumbar spine, respectively [
lateral approach requires sequential tubular dilation, docking an expandable retractor on the anterior column to allow for a safe ventral working
zone, performing diskectomies adjacent to the
fracture, coagulating and ligating the segmental
vessels, and, lastly, performing a corpectomy at
the fractured vertebra (Fig. 22.1 ) [ 2 ].
After performing the corpectomy, there are
several options to reconstruct the anterior column.
These options include using a structural allograft,
autograft, or a static or expandable cage. The
expandable cage technology facilitates the reconstruction of the corpectomy defect produced
through the MISS lateral approach. After reconstructing the anterior column, supplemental fi xation can be performed with anterolateral plating
or posterior percutaneous transpedicular screws.
Smith et al. [ 2 ] investigated the use of MISS
lateral techniques in the treatment of thoracolumbar fractures. The study included 52 patients with
thoracolumbar fractures that were treated with
mini-open, lateral corpectomies with anterolateral plating or percutaneous transpedicular
screws to supplement fi xation. The median operative time was 128 min compared to 210–617 min
for open surgery [
approach had signifi cantly lower blood loss of
300 ml compared to 2–3 l in open surgery [ 43 ,
44 ]. This study showed an acceptable complica-
tion rate of 15 % versus literature values that vary
widely for open procedures [ 45 ]. The median
length of stay in the hospital was 4 days compared to the reported 10–35 days for open surgery [ 5 , 46 ]. There was no signifi cant difference
in outcome between the anterolateral plating and
22 , 43 ]. The lateral MISS
42 ]. The
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