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8 Nonalcoholic Steatohepatitis (NASH)
32. Mathurin P, Hollebecque A, Arnalsteen L, Buob D, Leteurtre E, Caiazzo R, Pigeyre M,
Verkindt H, Dharancy S, Louvet A, Romon M, Pattou F. Prospective study of the longterm effects of bariatric surgery on liver injury in patients without advanced disease.
Gastroenterology. 2009;137(2):532–40. https://doi.org/10.1053/j.gastro.2009.04.052. Epub
2009 May 4.
33. Taitano AA, Markow M, Finan JE, Wheeler DE, Gonzalvo JP, Murr MM.Bariatric surgery
improves histological features of nonalcoholic fatty liver disease and liver brosis. J Gastrointest
Surg. 2015;19(3):429–36; discussion 436–7. https://doi.org/10.1007/s11605- 014- 2678- y.
Epub 2014 Dec 24.
103

Chapter 9
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Patient Selection
AinitzeIbarzabalOlano, JavierOsorioAguilar,
andAmadorGarciaRuizde Gordejuela
Duodenal switch is one of the most powerful bariatric procedures we have, despite
this, it only represents 2% of the total bariatric procedures performed worldwide
[1]. It was described in the late 1980s-early 1990s by Hess [2] and Marceau [3] as
an evolution of the biliopancreatic diversion (BPD) in order to deal with its side
effects. BPD had shown excellent weight loss results but some severe side effects as
marginal ulceration, excessive diarrhea, and malnutrition.
The rst papers about duodenal switch (DS) were focused on technical facts and
the rationale for vertical gastrectomy and the length of the limbs, but they did not
discuss too much about patient selection [3–5]. Nowadays, there is overall consensus about the benets of this procedure in heavier patients, but special indication in
super-obesity. The greater benets in terms of comorbidity improvement compared
to other procedures are also well known [6, 7]. Finally, it is important to remark that
even if it is a safe procedure, as other hypo-absorptive surgeries, DS is not indicated
for all potential candidates, because factors like social conditions, incomes, access
to supplementation, and good follow-up have to be taken also into account.
A. I. Olano (*)
Gastrointestinal Surgery Department, Hospital Clinic, University of Barcelona,
Barcelona, Spain
e-mail: aibarza@clinic.cat
J. O. Aguilar
Bariatric Surgery Unit, General Surgery Department, Bellvitge University Hospital,
University of Barcelona, L’Hospitalet de Llobregat, Barcelona, Spain
A. G. R. de Gordejuela
Endocrine, Metabolic and Bariatric Surgery Unit, Vall d’Hebron University Hospital,
Autonomous University of Barcelona, Barcelona, Spain
© The Author(s), under exclusive license to Springer Nature
Switzerland AG 2023
A. Teixeira et al. (eds.), Duodenal Switch and Its Derivatives in Bariatric and
Metabolic Surgery, https://doi.org/10.1007/978-3-031-25828-2_9
105

106
A. I. Olano et al.
9.1 Potential Candidates forDuodenal Switch
DS is one of the most powerful bariatric tools we have. It combines the restriction
of a sleeve gastrectomy with the malabsorption of a distal intestinal bypass. The
most common constructions of the bowel limbs consider a total alimentary limb of
250–300cm, with a 75–100cm common channel. Some original descriptions also
took into consideration percentages of the total limb length, leaving a 50% of total
alimentary limb where 10% of the bowel was left as common channel.
In an overall view, DS is considered for the same population as other bariatric
procedures:
• BMI > 40 kg/m2 or BMI > 35 kg/m2 plus other medical condition related
to obesity
• Failed non-operative treatments for weight loss
• Mental health clearance
• No contraindications for surgery
Super-obese patients (SOP) are usually considered the best candidates for hypoabsorptive procedures. Restrictive procedures may have limited effect on this population. DS has important advantages to BPD and distal Roux-n-Y gastric bypass
(RYGB) as it is a less ulcerogenic procedure and because vertical gastrectomy
allows better food tolerance. The earlier descriptions of the duodenal switch already
show good and sustained weight loss results in this population.
Risstad etal. [8] presented in 2015 a randomized controlled trial comparing DS
vs RYGB y patients with BMI 50–60kg/m2. They found after 5years of follow-up
that DS achieved sustained greater weight loss, plus greater improvement in lipid
prole. Quality of life did not differ between both procedures, but DS was associated with more surgical, nutritional, and gastrointestinal adverse effects. There are
also some other comparative studies that show similar results.
The Clinical Guidelines cosponsored by American Association of Clinical
Endocrinologists/American College of Endocrinology, The Obesity Society,
American Society for Metabolic & Bariatric Surgery, Obesity Medicine Association,
and American Society of Anesthesiologists in its last review from 2019 [9] consider
DS as an effective procedure for patients with very high BMI.
However, BMI 50kg/m2 does not represent a frontier line to indicate or not indicate DS.Patients with lower BMI may also benet from this powerful tool. The
metabolic benets of this procedure have been widely published [10–12], so it may
also be indicated in patients with BMI 40–50kg/m2 with strong metabolic comorbid
conditions.

9 Patient Selection
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107
9.2 Selection Algorithms
Buchwald presented a very interesting patient selection algorithm in 2002 [13].
Even though this paper may have severe limitations, it describes the aim of the
potential candidate for duodenal switch. This algorithm considers 6 items: body
mass index (BMI), age, gender, race, body habitus, and comorbidities. Following
this algorithm, the more complex the patient, the more suitable he may be to a DS.
Himpens has also presented some algorithms with the same rationale. The
Himpens Obesity Severity Score follows the same rules from the Buchwald’s algorithm but referring to other factors established the severity of the disease. Some
years ago, the same author published his personal long-term experience with the DS
[7]. In this publication, it is referred to a personal algorithm about his personal
selection protocol. This protocol reected that DS was considered for metabolic
patients, without GERD, and with binge eating.
9.3 Contraindications forDuodenal Switch
Contraindications for DS may be considered the same for all bariatric procedures:
• Pregnancy
• Severe psychiatric illness
• Eating disorders
• Patient-related contraindications to undergo surgery (cardiovascular risk, anes-
thetic risk)
• Substance misuse (alcoholism)
• Severe coagulopathies
We may also add contraindications for sleeve gastrectomy as severe reux
(esophagitis greater than B) or big hiatal hernias; and contraindications for hypoabsorptive procedures:
• Inammatory bowel disease
• Immunosuppressant therapies
• Hypo-absorptive syndromes
• Familial polyposis colonic disease
• Colonic resections
• Fecal incontinence
Some of these contraindications should be considered relative contraindications,
and a tailored approach is mandatory in those cases.

108
The main specic contraindication for DS is related to its potential side effects.
As a hypo-absorptive procedure, with high risk for protein malnutrition and a signicant association with micronutrient deciencies, DS patients will have to follow
a strict supplementation program [14, 15]. Some of these supplementations may be
expensive and patients need to be conscious preoperatively. Patient adherence to the
follow-up program by the multidisciplinary team is crucial to avoid long-term side
effects. Even though it is difcult to predict how the patients will behave after surgery, it is important to try to detect those who may fail postoperative consultations.
In this procedure social conditions and incomes may also play a role as a potential contraindication for DS. Patients with poor incomes with difcult access to
supplementation, or they may be reluctant to continue the follow-up program,
should not be considered for DS.
A. I. Olano et al.
9.4 Duodenal Switch asaStaged Procedure
DS is considered one of the most complex bariatric procedures technically speaking, as it includes sleeve gastrectomy, dissection and section of the rst portion of
the duodenum, and two anastomoses. It is commonly indicated to higher BMI
patients, so it is a difcult combination to deal with. From the paper of Regan and
Gagner in 2003 [16] staging the bariatric surgery in those complex patients is a
strategy to take into account.
Staged DS is thought to convert a high-risk procedure into two low-moderate
risk procedures. Sleeve gastrectomy is challenging in these patients, but the dissection of the duodenum and the duodeno-ileal anastomosis may be very difcult
(heavy and short mesenteries, high volume liver). After a strong weight loss, the
procedure is quite straightforward.
There are some papers [6, 17–19] that demonstrate that DS is not charged with
extra morbidity or mortality in patients with BMI up to 60kg/m2, so the real benet
for this staged strategy might be for BMI over 60kg/m2. Second stage allows at the
end the same weight loss as a primary procedure. This second stage can be scheduled 12 to 24months after surgery, but the ideal time interval has not been dened.
On the other hand, there are also some patients initially planned for staged procedures that continue losing weight and do not require a second stage [20]. They
represent around 10–15% of the primary sleeve gastrectomies.
9.5 Duodenal Switch asaRescue forFailed
Primary Procedure
DS has also been described as an indication to rescue a failed primary procedure
[21]. SG, RYGB, and single anastomosis DS (SADI-S) can be converted into DS.

9 Patient Selection
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SG to DS is a straightforward procedure. Failed SG, especially when SG had not
been properly indicated, can be rescued by converting into DS.It is important to
perform an adequate preoperative workup. GERD has to be excluded prior to going
to the operating room, as it cannot be clearly stated if it may be related to overweight or to sequelae of the SG.On the other hand, it is also important to evaluate
potential dilation of the gastroplasty as the restrictive component may also be
restored.
Failed RYGB can also be converted into DS [22, 23]. It has been stated that con-
version into DS is the most effective solution for a failed RYGB, but it is also the
most challenging. Conversion from RYGB to DS is a complex procedure that can be
performed in one or two stages. We may nd several series of cases in the literature
but high morbidity but with good weight loss results.
Finally, SADI-S can be converted into DS just by adding a Roux anastomosis.
This is the most effective solution in case of bile reux after SADI-S, but it has also
been proposed to fail weight loss. There is just a little evidence about the potential
benet from this conversion.
References
1. Welbourn R, Hollyman M, Kinsman R, etal. Bariatric surgery worldwide: baseline demographic description and one-year outcomes from the fourth IFSO global registry report 2018.
Obes Surg. 2019;29:782–95.
2. Hess S, Hess W.Biliopancreatic switch diversion with a duodenal. Obesity. 1998:267–82.
3. Lagacé M, Marceau P, Marceau S, Hould F-S, Potvin M, Bourque R-A, Biron S.Biliopancreatic
diversion with a new type of gastrectomy: some previous conclusions revisited. Obes Surg.
1995;5:411–8.
4. Hess DS, Hess DW. Biliopancreatic diversion with a duodenal switch. Obes Surg.
1998;8:267–82.
5. Marceau P, Biron S, Bourque RAR, Potvin M, Hould FS, Simard S.Biliopancreatic diversion
with a new type of gastrectomy. Obes Surg. 1993;3:29–35.
6. Biertho L, Lebel S, Marceau S, Hould F-SS, Lescelleur O, Moustarah F, Simard S, Biron S,
Marceau P. Perioperative complications in a consecutive series of 1000 duodenal switches.
Surg Obes Relat Dis. 2013;9:63–8.
7. Bolckmans R, Himpens J.Long-term (>10 Yrs) outcome of the laparoscopic biliopancreatic
diversion with duodenal switch. Ann Surg. 2016;264:1029–37.
8. Risstad H, Søvik TT, Engström M, etal. Five-year outcomes after laparoscopic gastric bypass
and laparoscopic duodenal switch in patients with body mass index of 50 to 60: a randomized
clinical trial. JAMA Surg. 2015;150:352–61.
9. Mechanick JI, Apovian C, Brethauer S, etal. Clinical practice guidelines for the perioperative nutrition, metabolic, and nonsurgical support of patients undergoing bariatric procedures—2019 update: cosponsored by American Association of Clinical Endocrinologists/
American College of Endocrinology. Obesity. 2020;28:175–247.
10. Marceau P, Biron S, Hould F-SS, Lebel S, Marceau S, Lescelleur O, Biertho L, Simard
S.Duodenal switch: long-term results. Obes Surg. 2007;17:1421–30.
11. Biron S, Hould F-S, Lebel S, Marceau S, Lescelleur O, Simard S, Marceau P.Twenty years of
biliopancreatic diversion: what is the goal of the surgery? Obes Surg. 2004;14:160–4.

110
12. Obeid NR, Malick W, Concors SJ, etal. Long-term outcomes after Roux-en-Y gastric bypass:
10- to 13-year data. Surg Obes Relat Dis. 2016;12:11–20.
13. Buchwald H.A bariatric surgery algorithm. Obes Surg. 2002;12:733–46; discussion 747–50.
14. Backes CF, Lopes E, Tetelbom A, Heineck I. Medication and nutritional supplement use
before and after bariatric surgery. Sao Paulo Med J. 2016;134:491–500.
15. Nett P, Borbély Y, Kröll D.Micronutrient supplementation after biliopancreatic diversion with
duodenal switch in the long term. Obesity Surg. 2016;1–6.
16. Regan JP, Inabnet WB, Gagner M, Pomp A.Early experience with two-stage laparoscopic
Roux-en-Y gastric bypass as an alternative in the super-super obese patient. Obes Surg.
2003;13:861–4.
17. Buchwald H, Kellogg TA, Leslie DB, Ikramuddin S.Duodenal switch operative mortality and
morbidity are not impacted by body mass index. Ann Surg. 2008;248:541–7.
18. Topart P, Becouarn G, Ritz P.Should biliopancreatic diversion with duodenal switch be done
as single-stage procedure in patients with BMI 50 kg/m2? SOARD. 2010;6:59–63.
19. Rezvani M, Sucandy I, Klar A, Bonanni F, Antanavicius G.Is laparoscopic single-stage biliopancreatic diversion with duodenal switch safe in super morbidly obese patients? Surg Obes
Relat Dis. 2014;10:427–30.
20. Hidalgo M, Vilallonga R, Ruiz de Godejuela AG, etal. Effectiveness of laparoscopic sleeve
gastrectomy in super-obese and non-super-obese patients. Surg Laparosc Endosc Percutan
Tech. 2020;30:403–7.
21. Cheung D, Switzer NJ, Gill RS, Shi X, Karmali S.Revisional bariatric surgery following failed
primary laparoscopic sleeve gastrectomy: a systematic review. Obes Surg. 2014;24:1757–63.
22. Parikh M, Pomp A, Gagner M.Laparoscopic conversion of failed gastric bypass to duodenal switch: technical considerations and preliminary outcomes. Surg Obes Relat Dis.
2007;3:611–8.
23. Trelles N, Gagner M. Revision bariatric surgery: laparoscopic conversion of failed gastric
bypass to biliopancreatic diversion with duodenal switch. Minerva Chir. 2009;64:277–84.
A. I. Olano et al.

Chapter 10
Данная книга находится в списке для перевода на русский язык сайта https://meduniver.com/
Psychological andPsychiatric Workup
HélioTonelli andAndréiaTonelli
10.1 Introduction
Bariatric surgery is the most effective treatment for morbid obesity [1], a condition
that is increasingly common worldwide and that affects children particularly.
Shortly, the costs of preventing and treating obesity, as well as its metabolic complications, shall not be fully covered by health systems [2]. Biliopancreatic diversion
with duodenal switch (BPDDS), along with gastric bypass (RYGBP), is among the
surgical techniques leading to weight loss and its maintenance over time [3].
BPDDS includes three specic components: (1) a longitudinal gastrectomy, providing caloric restriction and decreasing acid production, while maintaining normal
gastric emptying; (2) a 250cm total alimentary limb whose role is to reduce caloric
absorption; and (3) a 100cm common channel where the bolus mixes with biliopancreatic juices, resulting in decreased absorption of protein and fat [4]. Although
long-term data on health-related quality of life (HRQL) after BPDDS is scarce,
Aasprang et al. [5] accessed HRQL through a self-administered questionnaire,
before and 1, 2, 5, and 10years after BPDDS, showing long-term improvement in
physical and mental scores. Søvik etal. [6] showed a reduction in uncontrolled and
emotional eating behaviors, as well as an improvement in psychosocial function
both after duodenal switch and RYGBP. Despite these results, 20% of patients
undergoing bariatric surgery fail to maintain weight loss 2years after surgery [1]. A
signicant number of these patients suffer from dysfunctional eating behaviors
H. Tonelli (*)
Psychiatrist at the Caetano Marchesini Clinic, Invited Professor of Psychopathology,
Neuroscience and Social Cognition at FAE Business School, Curitiba, Brazil
A. Tonelli
Neuroscience and Social Cognition at FAE Business School, Curitiba, Brazil
© The Author(s), under exclusive license to Springer Nature
Switzerland AG 2023
A. Teixeira et al. (eds.), Duodenal Switch and Its Derivatives in Bariatric and
Metabolic Surgery, https://doi.org/10.1007/978-3-031-25828-2_10
111

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(DEB) leading to a recurrence of obesity after bariatric surgery [7], which makes the
prompt identication and treatment of DEB in bariatric patients imperative. This
chapter aims to discuss the many psychological and psychiatric variables that may
jeopardize BPDDS short-, medium-, and long-term outcomes. It is important to
highlight that the literature on psychological and psychiatric aspects specically
related to BPDDS is still scarce; hence, many of the points discussed here stem from
studies not necessarily performed with patients undergoing BPDDS.
H. Tonelli and A. Tonelli
10.2 Important Psychological Aspects ontheEvaluation
andFollow-Up ofCandidates forBariatric Surgery
Despite the countless benets currently documented of bariatric surgery, not only
related to signicant weight loss and its long-term maintenance, but also regarding
measures of quality of life and psychopathology, less is known about the origin of
post-surgical undesirable psychological and behavioral outcomes affecting patients’
eating behavior [8]. Data on patients undergoing BPDDS are even more scarce.
Undesirable psychological and behavioral outcomes possibly reect psychological
and behavioral problems present before surgery, which, if not properly identied
and treated, will certainly interfere negatively with BPDDS results. Nevertheless, it
is important to remember that obesity is a complex pathological condition in which
behavior is only one of the many dimensions to be addressed for obesity’s suitable
comprehension. Biological factors such as chronic low-grade systemic inammation triggered by obesity [9], alterations of the intestinal microbiome [10], and brain
insulin resistance [11] have been widely described as protagonists in the pathophysiology of obesity, which are known to impact the brain and the minds of patients
with obesity. Such impacts are reected, for instance, in the ability to control food
consumption and adhere to physical activity programs [8]. It is possible that these
factors have an even broader participation in how they modify the mind of people
with obesity, altering their cognition [12], emotions [13], motivation [14], selfregulatory processes [15], and even their ability to identify emotions and other mental states in others [7].
Neuroimaging studies show that bariatric surgery can reverse anomalous recruitment and connectivity patterns in different brain areas related to both the processing
of pleasure and reward associated with eating, and brain areas associated with cognitive control [16, 17]. This strongly suggests that bariatric surgery may help normalize several neuropsych pathological processes favoring DEB such as binges,
emotional eating (EE), and food addiction (FA). Potential mechanisms for regulating brain activity by bariatric surgery include, in addition to improving inammation, changes in the expression of dopaminergic receptors in key areas such as the
ventral striatum, putamen, caudate, thalamus, and hypothalamus, as well as postsurgical changes in the concentration of peptides such as ghrelin, GLP-1, and peptide YY [18]. Findings like these are, however, still controversial. Therefore, the

10 Psychological andPsychiatric Workup
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complexity of the mechanisms through which obesity and bariatric surgery can
affect the mind and behavior requires that the mental health professional working
with bariatric patients have a broad knowledge about the countless variables at
stake, which, when not properly controlled, may threaten the surgical results.
The processing of emotions seems to be affected by obesity, favoring BED,
which interferes in the results of BPDDS and all other surgical techniques. Indeed,
patients with obesity frequently say that their emotions drive or determine their eating behaviors. These patients usually state that they consume food—usually caloric
ones—in order to relieve emotions—typically the unpleasant ones.
Emotions are dened as short-term affective responses triggered by environmental stimuli, situations, or events with reinforcing potential [19]. They have different
motivational functions and contribute to the control of basic behavioral systems in
animals and humans. Emotions may affect all eating behavior, including motivation
to eat, affective responses to food, food choices, chewing, speed of eating, amount
of food ingested, and even metabolism and digestion [19]. Thus, emotions and eating behavior are closely linked; however, the nature of this connection is not yet
fully understood. Hunger is indeed a potent emotional modulator. In fact, hungry
animals and humans tend to be more alert and irritable and diverse stimuli elicit different emotional responses in individuals with and without hunger [20]. Nevertheless,
there is an individual variation in how emotions may affect eating behavior. Several
experiments have shown that individuals restricting food in order to decrease or
maintain weight eat more in response to fear and negative moods than individuals
who do not [19]. These studies also show that emotional eaters tend to consume
more sweet and fatty foods in response to emotional stress, and compulsive eaters
tend to have binges when facing negative emotions [19]. Negative emotions need to
be regulated and it is possible that, in at least a percentage of individuals with obesity, they will be anomalously regulated with caloric foods. Emotion regulation
(ER) is a multidimensional construct encompassing the ability to respond to personal and social demands with acceptable and exible behaviors and emotions, as
well as the ability to postpone and even suppress spontaneous reactions when this is
necessary or convenient. ER is achieved through psychological processes such as
monitoring, appreciating, and changing the magnitude of emotional reactions [21].
Many patients compare their relationship with food with that displayed by
addicts to psychoactive substances, a similarity with an irresistible intuitive appeal,
since individuals who consider themselves addicted on food present behavioral phenomena such as cravings, feelings of loss of control, excessive consumption, tolerance, and even signs of food withdrawal. Indeed, obesity and addictions share
neurobiological processes that result in compulsive consumption, which are consequences of problems on the suitable functioning of reward processing circuits,
where dopamine plays an essential role.
The particularly reinforcing character of food in obesity characterizes its addic-
tive dimension [22]. The neurobiological factors traditionally studied in both condi-
tions include three interconnected brain systems that control eating behavior: the
hypothalamus (which responds to internal signals about the energy balance); limbic
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