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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_999_Библиотеки_им_академика_М_И_Перельмана

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pressure of approximately 75mmHg is applied. However, the level of suction pos­sibly needs to be adjusted, especially lowered in the presence of a coagulopathy and increased risk of rebleeding. This procedure takes only a few minutes, which is particularly advantageous in the context of damage control.
NPWT promotes granulation of the adjacent subcutaneous tissue and reduction of tissue edema of the abdominal organs. If completely sealed, the nursing effort with the dressing, other than changing pump canisters and periodically checking the set suction, is minimal, as well as the risk of contamination of the abdomen. The commercial pumps control the set suction and give an alarm in case of problems like obstruction or leakage, which should be corrected promptly.
However, if one assumes that the abdomen will have to remain open for a longer period of time due to a further increasing edema of the abdominal organs, a retro­peritoneal mass as in pancreatitis or hemorrhage, or a questionable perfusion situa­tion of the organs, the incipient retraction of the fascial edges should be prevented. Again, various techniques are described for this, but we prefer the so-called Koblenz model, a combination of a visceral protective layer, negative-pressure wound ther­apy, and dynamic closure techniques [49]. Here, after insertion of the VPL, a poly­glactin mesh inlay is sewn into the fascial defect with continuous suturing using 2-0 polyglactin circumferentially in the sense of continuous (mesh-mediated) fascial traction before the polyurethane sponge is inserted and the dressing is completed with a negative pressure of 75mmHg.
At the next revision, the adhesive sheet and sponge are then removed and the polyglactin mesh is subtotally cut along its longitudinal axis and the abdomen is explored after removal of the VPL.Subtotal cutting of the mesh simplies re-sutured closure of the mesh. At the end of this procedure, the mesh slit is closed again by a continuous suture using 2-0 polyglactin. In this process, the size of the mesh can be diminished at each revision according to the local ndings to approximate the fas­cial edges (Fig.23.2a, b). Of course, this would also be possible with bridging fas­cial sutures, but these increase the risk for fascial defects and soft tissue necrosis with every procedure (Fig.23.3).
In the “Koblenz model” the fascia is only damaged twice, by the mesh xation suture and the nal fascial suture, which is simplied in this technique. In any case, the combination of VPL, NPWT, and continuous (mesh-mediated) fascial traction guarantees a maximized denitive abdominal closure rate.
Another new, alternative technique to prevent fascial retraction in the case of long-term open abdomen is the use of the Fasciotens Abdomen, for which the rst promising experience reports also exist for this indication [50]. However, this tech­nique is more complex and also cost-intensive.
S.-A. Engelien and D. R. Bulian
Revisions
In our opinion, a meticulous adhesiolysis of the entire small intestine should be performed in every revision; otherwise, block formation will occur, which will mas­sively complicate or impede a later complication treatment by, for example, stoma
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Fig. 23.2 (a, b) Approximating the fascial edges
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Fig. 23.3 Soft tissue necrosis after bridging fascial sutures
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creation. We strongly recommend the implementation of all procedures on one patient by the same surgical team. The accomplishment of revisions after the elec­tive program by the surgeon on duty leads, in our opinion, to more complications and a delayed denitive abdominal closure and consequently a prolonged open abdomen therapy, due to the ignorance of previous ndings. The interval between revisions depends on the patient’s condition and should not exceed 72h. Even if some colleagues disagree, in sepsis-related unstable patients as well as in the absence of evidence of an intraabdominal focus, we tend to wait one more day until the patient has recovered. In the case of any suspicion, immediate revision is indicated.
Denitive abdominal closure should be performed as early as possible and as late as necessary, but depends on several factors, especially intraabdominal ndings and volume (abdominal organ edema). The requirements for denitive abdominal clo­sure are an adequate minus balance after control of septic or trauma stress response, resolution of septic capillary leak with consecutive anasarca, secure focal control, an ensured vitality of the bowel, no need for surgical re-exploration, and no evi­dence of persistent abdominal compartment syndrome. General, intensive care treatment recommendations such as uid balance, avoidance of hypothermia, coag­ulation management, substitution for coagulopathy, adapted catecholamine admin­istration, and nutritional support can have a positive impact on early denitive abdominal wall closure.
S.-A. Engelien and D. R. Bulian
Nutritional Replenishment
Sufcient enteral nutrition, including oral nutrition if tolerated, should be provided immediately when possible due to nitrogen loss through the open abdomen and preferred to parenteral nutrition. Contraindications to this are only a lack of bowel continuity after damage control surgery, signs of intestinal obstruction, and high enteroatmospheric stulae, where enteral nutrition via transstular access to aboral positioning is not possible. Within such circumstances, parenteral feeding will be required. Sedation and ventilation are dependent on the patient’s intensive care sta­tus and not on the presence of an open abdomen.
Technique ofDenitive Abdominal Wall Closure
In denitive abdominal closure, complete fascial suture should be aimed. In this regard, fascial suture is possible with or without mesh reinforcement.
Without the use of mesh reinforcement, fascial suture is performed as a direct suture or with the Ramirez component separation technique if complete approxima­tion of the fascia is not primarily possible but can thereby be achieved [51]. Fascia suturing is possible continuously or with interrupted sutures. We prefer the former with a very slowly absorbable monolament elastic thread (poly-4- hydroxybutyrate).
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In any of these cases, the skin should be closed; otherwise, a vacuum therapy kit should be applied subcutaneously. Another alternative is the combination of compo­nent separation with the implantation of a (partially resorbable) mesh in the sublay position, which potentially can reduce the risk of hernia in the future.
If approximation of the fascia and closing of the skin is not achievable by this either, granulation and mesh graft coverage of the remaining defect is an inappropri­ate solution and should be avoided. It results in a thin covering of the abdominal organs that is barely protective, hardly mechanically resilient, and thereby bulging due to the positive intraabdominal pressure. This is often referred to as a hernia mistakenly, but this is not correct, since there is no hernia sac. Therefore, it gener­ally leads to the need for tertiary abdominal wall reconstruction after 6–12months with again a high morbidity and mortality.
It requires excision of the epithelium covering the defect, complete adhesiolysis, and abdominal wall reconstruction, usually with component separation. To achieve this, pretreatment with Botox injections into the oblique abdominal muscles is usu­ally required 4–6weeks beforehand [52].
An alternative bridging of a remaining fascial defect can be done with a mesh in inlay technique. In this case, synthetic meshes should be avoided if possible due to wound contamination and the associated risk of infection. At best, biological meshes should be used, which in turn are quite costly. Polyglactin meshes offer a compa­rable but only short-term benet. They are considerably less expensive, but are also absorbed much more quickly, which means that the redressing effect is quickly eliminated.
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Complications ofEDL andFurther Treatment withOpen Abdomen Therapy
As a result of open abdomen therapy, enteroatmospheric stulas and frozen abdo­men may develop. The potential impossibility of a secondary abdominal wall clo­sure with a persistent laparostoma (by denition not a hernia) and, if necessary, skin-graft coverage has already been described above.
Open abdomen management therefore means keeping an eye on early, secondary abdominal wall closure and the avoidance of secondary complications right from the beginning, that is, already when performing the EDL.
Treatment forEnteroatmospheric Fistula
Due to shear forces, especially in the case of adhesions of the intestine to the ventral abdominal wall at the wound edge of the dehiscent fascia, a defect of the intestinal wall may occur, resulting in an enteroatmospheric stula. The incidence of stula is approximately 10% [53, 54]. Sometimes, due to pathogenesis, more than one stula occurs at the same time.
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Fig. 23.4 Enteroatmo­spheric stula
S.-A. Engelien and D. R. Bulian
The hazards of these stulas are bleeding, uncontrollable loss of uids, electro­lytes, and bile acids, which must be replaced accordingly, as well as the impossibil­ity of enteral nutrition and a leaky coverage of the laparostoma with subsequent dermatitis even of the adjacent healthy skin (Fig.23.4).
In this case, wound dressings no longer adhere here and the resulting skin ero­sion and dermatitis worsen. Repeated suturing of the stula should not be performed in our opinion, because it regularly leads to an enlargement of the defect. It should be preferred to establish a funnel directly over the stula and to attach an ostomy bag in a notch of the abdominal vacuum therapy kit covering the rest of the wound for passive drainage and stula stabilization (Fig.23.5).
Commercial items also exist for this purpose. The stula secretion can then pas­sively drain into the stoma bag via the funnel, protecting the surrounding wound surface from the irritating intestinal secretion. In some cases, it is also possible to feed the patient enterally via a catheter inserted into the aboral branch of the stula. However, this should only be done after exclusion of a passage obstruction aborally of the stula, for example, by means of CT with contrast medium via the aboral stula branch. To make the vacuum dressing tight, additional stoma paste can be applied to the wound edge. We also recommend early skin-graft coverage of the surrounding granulation tissue so that an ostomy bag can then be tightly adhered to
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Fig. 23.5 Dressing for an enteroatmospheric stula
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the skin surrounding the stula. Abdominal wall reconstruction in the presence of an enteroatmospheric stula is otherwise almost impossible in the primary setting. Skin grafting on the surrounding granulation tissue succeeds more frequently than thought, despite the frequent initial fecal contamination.
More than half of enterocutaneous stulas close with conservative therapy, although this is successful in about 75% in the upper gastrointestinal tract and in only about 35% in the lower gastrointestinal tract [55]. However, after open abdo­men, the spontaneous closure rate is only 37% [56]. Conservative therapy is com­plex and consists of uid and electrolyte replacement, pharmacotherapy, nutrition, adequate therapy for sepsis, as well as skin protection and wound care.
The denitive therapy for enteroatmospheric stulas in case of failed conserva­tive treatment is surgical and consists of a combination of complete adhesiolysis, resection of the stula-bearing bowel loop with anastomosis, and abdominal wall reconstruction, possibly with prior bilateral Botox inltration into the oblique abdominal muscles, and possibly with Ramirez component separation. We avoid the use of mesh for reinforcement in these cases because of the risk of infection due to bacterial contamination. Alternatively, a two-staged procedure with secondary abdominal wall reconstruction can be performed by a component separation accord­ing to Ramirez with implantation of a partially absorbable mesh in sublay position.
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S.-A. Engelien and D. R. Bulian
This should be performed approximately 7days after primary adhesiolysis, bowel resection, anastomosis, and temporary abdominal wall closure, for example, accord­ing to the “Koblenz model“for temporary fascial approximation.
Alternatively, the Fasciotens Abdomen can be used, even if this signicantly limits the patient’s mobilization during the treatment [50].
We consider the use of biologic meshes, which is recommended as an ultima ratio in cases of a contaminated situs, because of so far not convincing results. However, surgical revision of the stula with the intention of repairment and recon­struction of the abdominal wall should only be performed after 6–12months at the earliest, as long as the patient has recovered and is able to bear sufcient physical strain for this major intervention by then. In the meantime, the patient should receive adequate enteral and/or parenteral nutrition to optimize the patient’s nutritional and immunologic status, which eventually leads to a decrease in the complication.
Preventing Enteroatmospheric Fistulas
The simplest thing to do is to prevent the formation of enteroatmospheric stulas. In this regard, we believe that complete adhesiolysis of the entire small bowel at each revision to prevent severe adhesions that could later be resolved only at the risk of intestinal wall lesions and extensive insertion of the VPL, as described above, are the key points of treatment [57]. Adhesiolysis should be avoided only if the intesti­nal loops are severely inamed and edematous, as manipulation could backre and result in additional stulas. However, these alterations are usually due to inadequate adhesiolysis in the previous procedures, which underlines the importance of having the same team manage the patient every time.
Acknowledgments The authors would like to thank Arnulf G.Willms, Sebastian Schaaf, and all other members of the Open Abdomen Group within the European Registry of Abdominal Wall Hernia (EuraHS) for their support in the eld of this topic.
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