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7 Elective Surgery forPatients withSubstance Use Disorder or Recent Substance Misuse
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Chapter 8
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Illicit Drugs andCandidates forEndoscopy andSurgery
JohnP.Gallagher, PatrickA.Twohig, AgnesCrnic, andFedjaA.Rochling
Abbreviations
HIV Human immunodeciency virus IDU Illicit drug use THC Tetrahydrocannabinol UDS Urine drug screen
Introduction
Scope oftheProblem
Illicit drug use (IDU) encompasses a broad spectrum of substances and patterns of use, and it is a common occurrence in the healthcare system. Patients with IDU are frequently encountered during preprocedural evaluation in outpatient and emergent settings. IDU is projected to rise as drug legalization continues to expand [1, 2]. These patients are at increased risk for complications from anesthesia and intraoperative complications related to recent drug use. When encountering patients with IDU, pro­viders must decide whether to cancel the procedure or proceed while managing
J. P. Gallagher Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA e-mail: john.gallagher@unmc.edu
P. A. Twohig ( Division of Gastroenterology and Hepatology, The University of Nebraska Medical Center, Omaha, NE, USA e-mail: frochling@unmc.edu
A. Crnic Department of Anesthesiology and Pain Medicine, University of Ottawa, The Ottawa Hospital, Ottawa, ON, Canada e-mail: acrni047@uottawa.ca
Switzerland AG 2024 J. Faintuch, S. Faintuch (eds.), Recent Strategies in High Risk Surgery,
https://doi.org/10.1007/978-3-031-56270-9_8
*) · F. A. Rochling
127© The Author(s), under exclusive license to Springer Nature
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potential complications. Careful consideration must be taken to prevent anesthetic interactions with commonly used drugs, as it can be challenging to ascertain the recency of use, the severity of intoxication, and the potential for interactions with anesthesia. Procedural delays are associated with signicant negative impacts on both patients and the healthcare system. They should not be used universally in patients with positive UDS, especially those who may appear non-toxic at presentation [3].
Delays or cancelations in elective procedures can create a signicant burden to both patients and the healthcare system. It results in increased costs, care delays, and decreased trust in the medical community [4, 5]. In addition, IDU is associated with socioeconomically disadvantaged populations with greater comorbidity and limited healthcare utilization [5]. Procedural delays may risk further marginalizing this population and preventing access to care. It is critical to examine each patient individually to determine procedural candidacy.
J. P. Gallagher et al.
Current Practices
The management of elective procedures in cases with IDU varies signicantly across institutions [1, 6, 7]. The absence of standardized guidelines often leads phy­sicians to rely on individual practices and expert recommendations when dealing with such cases, despite a clear desire by practitioners for additional guidance [1].
Current practice patterns often delay elective procedures by up to 7days since the last use as determined by urine or serum testing [8]. The majority of established guidelines for administering anesthesia to patients with IDU focus on emergency cases and managing the effects of acute intoxication [9, 10]. In such cases, specic measures are required to mitigate potential interactions with anesthetics. Patients who undergo emergency surgery have been found to require higher levels of seda­tion and exhibit an association with increased perioperative morbidity. There is also an association between patients presenting for emergency surgery and increased rates of the human immunodeciency virus (HIV) and Syphilis, which can compli­cate perioperative care [11]. However, multiple studies have demonstrated compa­rable 30-day clinical outcomes to the general population for patients who test positive for illicit drugs in urine drug screen (UDS) but are non-toxic [6, 1214]. Most literature also examines cases with general anesthesia rather than the lighter sedation used for endoscopy. Here we discuss the systemic effects of frequently encountered illicit drugs and procedural management considerations.
Anesthetic Considerations
The impact of IDU depends on the type of sedation being used. In the United States, most endoscopies are performed using conscious sedation [1517]. Notably, endo­scopic procedures use signicantly lower doses of anesthetics when compared to general anesthesia, and it is unknown what degree of procedural risk exists in this clinical setting [17].
8 Illicit Drugs andCandidates forEndoscopy andSurgery
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129
Cannabis
Physiologic Effects andPharmacodynamics
Cannabis is the most used illicit drug in the United States. It targets the cannabinoid receptors, CB1 and CB2, located throughout the body and acting as G-protein­coupled receptors [18, 19]. It is a psychoactive agent that can act as a depressant, stimulant, or hallucinogen in different settings. It is available in various forms, but delta-9 tetrahydrocannabinol (THC) is the most psychoactive compound. The effects of acute intoxication are highly variable and related to dose, formulation, route of ingestion, and frequency of use. Physiologic manifestations of acute intoxi­cation may include hypertension, tachypnea, tachycardia, euphoria, increased appe­tite, and conjunctival injection (Table8.1). The onset of action for acute intoxication is approximately 15min when inhaled and up to 1–2h when ingested [19]. Duration is 3–4h when inhaled and up to 12h if ingested. It is highly lipid soluble and can be detected on urine drug testing for up to 30days after use [20].
Table 8.1 Duration of Urine drug screen positivity and anesthetic complications associated with commonly encountered drugs. All values included in the table serve as estimates for general use (Adapted with permission from “Illicit drug use and endoscopy: when do we say no?”)
Anesthetic
Duration of intoxication
Drug
Marijuana Inhaled: Up to 4
Cocaine Intravenous: 0.5–1
Methamphetamines Indeterminate, ranges from
Heroin 0.5, up to 4–5 for active
Ecstasy Ingested: 4–6 48h Tachycardia,
Phencyclidine (PCP)
(hours)
Ingested: Up to 12
Intranasal: 1–2 Inhaled: 0.5–1 Ingested: Indeterminate
4h to 48h with residual psychologic changes
metabolites (6-monoacetylmorphine)
Intravenous: 1–2 Intranasal: Indeterminate Inhaled: 1–2 Ingestion: 1–3 May experience prolonged intoxication with delayed release from adipose tissue
Duration of urine positivity
3–30days with chronic use
1–8days in most cases, up to 22days reported with high-dose, chronic use (30g/d inhaled)
1–7days, longer in chronic use
24–48h Respiratory depression,
>1week Pulmonary
complications with acute toxicity
Airway irritability, hypotension, increased anesthetic requirements
Tachyarrhythmias, bronchospasm, hemodynamic instability, agitation
Hemodynamic instability, myocardial ischemia, tachyarrhythmias
hypotension, increased sedation requirements
hypertension, hyperthermia, hyperglycemia
hypertension, tachycardia, psychosis, cerebral hemorrhage
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Procedural Considerations
Patients with coronary artery disease are at increased risk of coronary spasms, which are associated with myocardial ischemia, as well as arrhythmias, including atrial brillation and ventricular brillation [21, 22].
When inhaled, cannabis use is associated with an increased risk for reactive air­way disease, bronchospasm, laryngospasm, vocal cord dysfunction, uvular inam­mation, and airway edema. These risks can result in signicant intraoperative complications, including hypoxemia when undergoing airway manipulation and intubation and a higher risk of obstruction with airway instrumentation [21]. There is limited data regarding the duration of increased risk after smoke exposure, but it appears to be highest within 1–2h of use [21, 23]. Lastly, patients should be treated with the same precautions as tobacco users, as there has been a similar risk prole demonstrated with chronic cannabis use. Additional associations include increased risk for cerebrovascular events, psychosis, hypothermia, and venous thromboembo­lism [24].
Anesthetic Interactions
Patients using cannabis have been shown to have inconsistent responses to various forms of anesthesia and a need for increased analgesia postoperatively. Patients with chronic use note more refractory pain and may require increased doses of as-needed pain medication postoperatively compared to controls [21, 24]. In addition, patients require more anesthesia to achieve sedation for both general anesthesia, deep seda­tion, and conscious sedation [2426]. Due to the potential for tachycardia with acute intoxication, drugs with chronotropic stimulation should be avoided, includ­ing ketamine, pancuronium, and atropine [27].
Perioperative Recommendations
The American Society of Regional Anesthesia and Pain Medicine released a 2023 consensus guidelines statement addressing periprocedural management of cannabis use [28]. These included universal screening for THC prior to surgery, postponing elective procedures in patients with signs of acute intoxication by at least 2h, and counseling cannabis users on potential negative effects on postoperative pain con­trol. It was also recommended to counsel pregnant patients on the fetal/neonatal risks of cannabis use. Preprocedural UDS was not recommended due to inconsisten­cies and the inability to predict recency of use.
Due to the risk of increased anesthesia requirements and risk for withdrawal, patients should be counseled on abstaining from cannabis use for up to 7 days
Marijuana
8 Illicit Drugs andCandidates forEndoscopy andSurgery
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Preoperative Considerations
Universal UDS screening
Counseling on negative effects
Cessation 7 days prior to procedure
Perioperative Risks
Reactive airway disease
Coronary spasm, arrhythmias
Hypotension, bradycardia
Increased anesthetic needs
Drugs to avoid: Ketamine, pancuronium, atropine
Postoperative Considerations
Increased pain tolerance
Fig. 8.1 Procedural guidance with recent Marijuana use. UDS Urine drug screen
Hypoxia
Procedural Timing
Acute intoxication: Delay by 2 hours
Chronic use: Proceed
prior to planned procedures. It is reasonable to delay cases in the setting of acute intoxication by at least 2 h, but non-toxic patients with recent use should be allowed to proceed with procedures on a case-by-case basis. Special consider­ations must be taken intraoperatively and with pain management in the postopera­tive setting to avoid adverse outcomes in this population. In emergent cases where the surgery will occur in less than 1day, it is important to note that patients with acute intoxication may require increased sedation and have variable hemodynamic responses to anesthesia with an increased risk of hypotension and bradycardia at high doses [9, 29]. In patients with chronic use, weaning or cessation is not recom­mended due to the risk of cannabis withdrawal and/or increased anxiety or pain (Fig.8.1) [23].
Cocaine
Physiologic Effects andPharmacodynamics
Cocaine is a stimulant and can be used in multiple formulations, including inhala­tion, intranasal, intravenous, and less commonly ingestion. The onset of action is rapid and less than 5min, and the duration is between 60min to 2h [30]. Cocaine blocks catecholamine uptake in the central nervous system and peripheral tissues,