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Handbook of 3D Printing in
Pharmaceutics
Three-dimensional (3D) printing has evolved as an emerging tool for the design
of customized or personalized medication that provides the maximum therapeutic
benets to patients. The manufacturing of medicines in small batches customized
with tailored dosages, sizes, shapes, and drug release properties is the key prospect of
using 3D printing in pharmaceutics.
Handbook of 3D Printing in Pharmaceutics: Innovations and Applications provides
a detailed and in- depth technical discussion on the various additive manufacturing
processes for the development of pharmaceutical products with experimental justication. It details the characterization, optimization, and numerical modeling of the
processes involved and outlines the industrial implications of the resulting products
as well as offering solutions for patient- tailored drugs processed by additive manufacturing. The handbook goes on to focus on the various post- processing technologies available to fortify the mechanical, chemical, biological, geometrical, and other
characteristics of additively manufactured components and also discusses future
directions and possible research gaps that need to be lled.
The buyers of this cutting- edge handbook will learn the complete information and
methodology for manufacturing drug delivery systems and customized medicine for
biomedical applications. It is also an ideal read for undergraduates, graduates, and
postgraduate research scholars. Industrial and academic professionals working and
studying industrial, manufacturing, and production engineering, along with those
studying mechanical engineering, pharmaceutical sciences, material science, chemical engineering, biomedical engineering, automobile/ aerospace engineering, and
other relevant domains will want this handbook at their ngertips.
Innovations in Smart Manufacturing for Long- Term Development
and Growth
Series Editors: Atul Babbar, Gursel Alici, Yu Dong, Ankit Sharma
Fabrication Techniques and Machining Methods of Advanced Composite Materials
Vikas Dhawan, Atul Babbar, Inderdeep Singh and Jonathan M. Weaver
Advances in Pre- and Post- Additive Manufacturing Processes
Innovations and Applications
Naveen Mani Tripathi and Ankit Sharma
Handbook of 3D Printing in Pharmaceutics
Innovations and Applications
Prakash Katakam, Ranvijay Kumar, Nishant Ranjan and Atul Babbar
For more information about this series, please visit: www.routle dge.com/ Inno vati ons- in- Smart-
Manufa ctur ing- for- Long- Term- Deve lopm ent- and- Gro wth/ book- ser ies/ CRCISM LDG
Handbook of 3D Printing in
Pharmaceutics
Innovations and Applications
Edited by
Prakash Katakam, Ranvijay Kumar,
Nishant Ranjan, and Atul Babbar
https://t.me/med1917
Designed cover image: Shutterstock - asharkyu
First edition published 2025
by CRC Press
2385 NW Executive Center Drive, Suite 320, Boca Raton FL 33431
and by CRC Press
4 Park Square, Milton Park, Abingdon, Oxon, OX14 4RN
CRC Press is an imprint of Taylor & Francis Group, LLC
© 2025 selection and editorial matter, Prakash Katakam, Ranvijay Kumar, Nishant Ranjan and Atul
Babbar; individual chapters, the contributors
Reasonable efforts have been made to publish reliable data and information, but the author and publisher
cannot assume responsibility for the validity of all materials or the consequences of their use. The authors
and publishers have attempted to trace the copyright holders of all material reproduced in this publication
and apologize to copyright holders if permission to publish in this form has not been obtained. If any
copyright material has not been acknowledged please write and let us know so we may rectify in any future
reprint.
Except as permitted under U.S. Copyright Law, no part of this book may be reprinted, reproduced,
transmitted, or utilized in any form by any electronic, mechanical, or other means, now known or hereafter
invented, including photocopying, microlming, and recording, or in any information storage or retrieval
system, without written permission from the publishers.
For permission to photocopy or use material electronically from this work, access www.copyri ght.com or
contact the Copyright Clearance Center, Inc. (CCC), 222 Rosewood Drive, Danvers, MA 01923, 978- 750-
8400. For works that are not available on CCC please contact mpkbookspermissions@tandf.co.uk
Trademark notice: Product or corporate names may be trademarks or registered trademarks and are used
only for identication and explanation without intent to infringe.
ISBN: 978- 1- 032- 57278- 9 (hbk)
ISBN: 978- 1- 032- 57466- 0 (pbk)
ISBN: 978- 1- 003- 43950- 9 (ebk)
DOI: 10.1201/ 9781003439509
Typeset in Times
by Newgen Publishing UK
https://t.me/med1917
Contents
Preface .......................................................................................................................ix
About the Editors ......................................................................................................xi
Contributors ............................................................................................................xiii
SECTION I 3D Printing, Drug Delivery Systems, and
Application Domain Overview
Chapter 1 Advancements in Tailoring Medication Using 3D Printing ................. 3
Bhavaraju Lakshmi Ratna Madhavi, J Joysa Ruby,
Prakash Katakam, Ravi Shankar Ayyanar, and
Shanta Kumari Adiki
Chapter 2 Innovative and Modied Additive Manufacturing Processes:
Extended Applications in the Pharmaceutical Industry ......................25
Popat Mohite, Sudarshan Kakad, and Anil Pawar
SECTION II Quality Characteristics’ Challenge in
3D Printing of Pharmaceutical Products
Chapter 3 Navigating the Terrain of 3DP for Pharmaceutical Products:
Quality Conundrums and Solutions ...................................................51
Kanaka Durga Devi Nelluri, Sk. Abdul Rahaman,
Vijaya Lakshmi Marella, Kakani Anil Kumar, and
Kondabrolu Naga Bhargavi
SECTION III Extrusion- Based 3D Printing in
Pharmaceutics
Chapter 4 Extrusion- Based 3D Printing in Pharmaceuticals .............................. 67
Aastha Singh, Mohit Agrawal, Vijay Kumar Sharma,
Hema Chaudhary, Aakriti Patel, Shivendra Kumar,
Sunam Saha, and Md. Sadique Hussain
v
https://t.me/med1917
vi
Chapter 5 Extrusion- Based 3D Printing Technology: A Revolution in
Pharmaceutical Drug Manufacturing .................................................82
Kiranmai Mandava, Sneha Thakur, Keerthi Kadimcharla,
and Prakash Katakam
Contents
SECTION IV Binder Jetting- Based 3D Printing in
Pharmaceutics
Chapter 6 Binder Jetting: A Versatile and Rapid Fast 3D Printing
Phenomenon ..................................................................................... 103
Bhoopathi Deepika, P. Sunil Kumar Chaitanya,
Naga Raju Kandukoori, Kiranmai Mandava, and
Prakash Katakam
Chapter 7 Binder Jetting- Based 3D Printing in Pharmaceutics ........................ 120
Aakriti Patel, Mohit Agrawal, Aastha Singh, Kuldeep Singh,
Swamita Arora, Swati Arya, and Sameer Rastogi
SECTION V SLS and SLA- Based 3D Printing in
Pharmaceutics
Chapter 8 SLS and SLA Techniques in 3D Printing for Better
Pharmaceutical Applicability of Soft Materials ...............................135
Venu Madhav Katla, Naga Haritha Pamujula,
Somnath De, and Manoj Shahare
SECTION VI Hybrid 3D Printing Techniques in
Pharmaceutical Applications
Chapter 9 Next- Generation Computational Automation- Based Additive
Manufacturing of Pharmaceuticals: An Approach to Fabricate
Precise Medicine ..............................................................................153
Jigar Vyas, Nensi Raytthatha, Sudarshan Singh, and
Bhupendra Prajapati
https://t.me/med1917
Contents
SECTION VII Social, Economic, Environmental,
Quality, and Regulatory Aspects
Chapter 10 Social, Economic, and Environmental Justications for
3D Printing of Pharmaceutical Products .......................................... 179
Himanshu Sharma, Siddhant Jai Tyagi, Neha Pathak,
Adarsh Keshari, Prakhar Varshney, and Rashmi Pathak
Chapter 11 Quality Control Methods for Three- Dimensional Printed
Pharmaceuticals ................................................................................ 195
Tulja Rani Gampa, Prakash Katakam, Shanta Kumari Adiki,
Nagarajan Sriram, and Sowmyaranjan Satapathy
Chapter 12 3D- Printed Pharmaceuticals: Current Regulatory Scenario ............. 211
Raja Rajeswari Kamisetti, Ajmeer Ramkishan,
Prakash Katakam, and Subhas Sahoo
vii
Index ...................................................................................................................... 229
https://t.me/med1917
https://t.me/med1917
Preface
The book entitled 3D Printing in Pharmaceutics: Innovations and Applications aims
to present various experimental outbreaks on the novel methodologies to develop
pharmaceutical products by 3D printing, especially for the drug delivery process.
The purpose of this book is to emphasize the various types of 3D printing techniques,
such as materials extrusion, vat polymerization, binder jetting, inkjet, and associated
hybrid processes for customized drugs, medicine, and biomedical utilities, formation
of shape, size, and dosage tailored medicines, etc. This book is designed to cover the
signicant contribution of the research fraternity, across the world, to different classes
of pharmaceutical products by 3D printing and end applications. This book is a key
source for gathering knowledge about drug delivery processes, 3D printing processes,
and mechanisms for the sustainable development of drug delivery systems. This book
also provides broad coverage of the theory behind this emerging technology, material
development, functional characterization, and the technical details required for
readers to investigate the novel applications of the involved methods for themselves.
Dr. Prakash Katakam
Dr. Ranvijay Kumar
Dr. Nishant Ranjan
Dr. Atul Babbar
ix
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