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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5352_Библиотеки_им_академика_М_И_Перельмана
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392 Index
https://t.me/med1917
Bull, S.D., 118
Burkholderia sp., 294
Burnett, D.A, 64, 66
C3-aminothiazoleoxime, 14
C3 heteroatom-substituted β-lactams, 62
C3 unsaturated and saturated β-lactams, 64
C4-dicarboethoxy β-lactams, 171
Cainelli, G., 69
Candida species, 318
Carbacephalsporin, 91
Carbamate salt, 90
Carbapenem antibiotics, 92
Carbapenem-resistant Enterobacterales (CREs), 43, 46
Carbapenems, 55, 337, 363
Carbapenem β-lactams, 105
Carbene insertion, 107
Carbenes, 81
Carbenicillin, 23
Carbenoid insertion, 81
Carbohydrate derivative, 88
Carbonic anhydrase, 317
Carbonyl compounds, 338
Carbonyl cyanide m-chlorophenyl-hydrazone, 11
Carboxypenicillins, 23
Carboxypeptidase, 317
4-[(4 -(car boxyp henyl )-oxy )]-3, 3-die thyl-
1-[[(phenylmethyl)am ino]carbon yl]-2azetidinones, 60
Carboxy-substitute d β-lactams, 64
Carene, 113, 116
Carr, M., 72
Cassia auriculata, 318
Catalytic method, 89, 120
Cathelicidin LL-37, 321
Cavitation, 163
C. diversus, 12
Cefacetrile, 29
Cefaclor, 30, 39
Cefadroxil, 29
Cefalexin, 29
Cefaloglycin, 29
Cefalonium, 29
Cefaloridine, 29
Cefalotin, 29
Cefa-mandole cefmetazole, 30
Cefapir in, 29
Cefatrizine, 29
Cefa zaur, 29
Cefazedone, 29
Cefazolin, 29
Cefbuperazone, 30
Cefcapene, 31
Cefclidine, 34
Cefdaloxime, 31
Cefdinir, 31, 272
Cefditoren, 31
Cefepime, 34, 324
Cefetamet, 31
Cederocol, 34
Cexime, 31
Ceuprenam, 34
Cefmenoxime, 31
Cefminox, 30
Cefodizime, 31
Cefonicid, 30
Cefoperazone, 31
Cefoselis, 34
Cefotaxime, 31, 318
Cefotiam, 31
Cefovecin, 31
Cefozopran, 34
Cefpimizole, 31
Cefpirome, 34
Cefpodoxime, 31
Cefprozil, 30
Cefquinome, 34
Cefradine, 29
Cefroxadine, 29
Ceftaroline, 270, 278
Ceftazidime, 31, 293
Cefteram, 31
Ceftezole, 29
Ceftibuten, 31
Ceftiofur, 31
Ceftiolene, 31
Ceftizoxime, 31
Ceftolozane, 275, 276
Ceftriaxone, 31
Cefuroxime, 30, 272, 318
Cefuzonam, 30
Cellulitis, 19
Centers for Disease Control and Prevention, 363
Cephalexin, 313
Cephaloridine, 4
Cephalosporin, 1, 55, 269, 323, 337, 345, 347, 363, 382
Cephalosporium, see cephalosporin
Cephamycins, cephems, see Cephalosporin
Cervellati, R., 61
Chemiluminescence, 321
Chemotherapy, 348
Chimento, A., 70
C-H insertion reactions, 57
Chiral amino alcohol, 95
Chiral amino ketenes, 10 8
Chiral bis β-lactams, 105
Chiral imines, 83
Chiral ketenes, 99, 109
Chiral ligands, 103
Chiral organoboranes, 103
Chiral propionates, 96
Chitosan-cobalt ion (CSNP-Co2+), 324
Chitosan-copper ion (CSNP-Cu2+), 324
Chitosan derivative, 323
Chloramphenicol, 4, 308, 318, 363
4-[3- Chlor o-4-s ubsti tuted pheny l-2-o xo-az etidi n-1-y
l] benzoic acids, 70
Chlorocardicin, 15, 16
Chlorosulfonyl isocyanate (CSI), 210
Chmielewski, M., 80
Cholesterol absorption (CAIs), 55, 64, 195, 207, 208
Chromobacterium, 2, 293
393 Index
https://t.me/med1917
Chrysene group, 338, 348, 351
Cilastatin, 284
Ciprooxacin, 310, 313, 372
3,4-cis-Disubstituted pyrrolidines and piperidines,
260, 261
Cisplatin, 350
cis-Stereochemistry, 343, 348
3,4-cis-β-lactam, 90
Citrobacter, 6
C. freundii, 316
Clader, J.W., 64
Clavaminate synthase, 40
Clavamine, 85
Clavulanic acid, 40, 55
Clemente, A., 63
Clindamycin, 363
Clostridium difcile, 19, 23, 376, 382
Cloxacillin, 19, 279
Colvin, E.W., 80
Convolutional neural network (CNN), 373, 375
Convulsions, 18
Copper nanoparticle (CuNP), 308, 313
Cordero, F.M., 81
Cossio, F.P., 224, 225, 234
Co-trimoxazole, 316
Cryptophycins, 338
Cyclic oligosaccharides, 329
Cyclic peptides, 2 51, 252
Cyclin-dependent kinase 7 (CDK7), 375
Cyclization in enediynes, 262, 263
Cycloaddition reaction, 229
Cyclodext rins, 322, 329, 377
Cyclopropane, 98
Cystic brosis (CF), 306
Cytochrome P-450 enzymes, 21
D-Ala-D-Ala, 28, 270, 271
Dalfopristin, 363
Daptomyci n, 363
D-Cycloserine, 16
Dean–Stark water separator, 134
Debye (D), 339, 345
Decision system (DS), 366
Deep learning (DL), 364, 373
Deep neural network (DNN), 367
Deglycosylation, 168
Dehydrogenase alcohol, 317
Dehydropeptidase (DHP), 284
De Kimpe, N., 111
Del Buttero, P., 110
δ-lactone proline derivatives, 247
Dendrimers, 322, 329
Densely substituted γ-lactams., 259, 260
Density functional theory (DFT), 352, 353
Deziel, R., 61
D-Glucosamine, 88
Dialkylhydrazones, 107
1,4-Diaryl-substit uted 3-acetoxy/hydroxy-2-
azetidinones, 66
1,4-Diaryl-substituted 3-hydroxy/amino-azetidin-2-ones,
66, 67
Diastereomers, 138
Diastereoselective asymmetric synthesis, 67
1,4-Diazabicyclo[4,3,0]nonanes, 256
2-Diazo-1,2-diarylethanone-generated ketene, 70
3,3-Dichloro-β-lactams, 72
Dicloxacillin, 19, 20
Dielectric materials, 162
Diels–Alder-type reaction, 208
Dihyd ro-1, 4-oxa zines /pyra zine- 2,3-d iones , 254, 255
Dihydrophenanthrenyl imines, 135
3-Dihydropyridone siderophore, 294
Dihydrothiazine, 2, 290
2,4-Dimethoxybenzylamine, 84
2,5-Dimethoxytetrahydrofuran, 150
Dimethyl sulfoxide, 4
Diphenylcyclopropenone (DPP), 260
Dipole moments
α-hydroxy and α-acetoxy-β-lactam derivatives,
341–344
chemical geometries, 341, 342
compound 3 and compound 4 synthesis, 341, 342
dipole moment values, 343
penicillins and related β-lactam antibiotics, 344–347
chemical geometries of penicillin G isomers,
345, 347
chemical geometries of the four derivatives,
345, 346
dipole moment values, 345, 347
polyaromatic cytotoxic β-lactams, 348–357
β-lactam structure, 348, 349
DFT calculation, 354
dipole moment values, 352 –354
electrostatic potential map, 355, 356
local ionization potential map, 356
LUMO map, 357
quantum parameters, 355
structural and physicochemical properties, 354, 355
theoretical calculation, 351
vitro cytotoxicity, 349, 352, 353
Schiff bases, precursors for β-lactams, 338–340
Disk diffusion method, 318
Disubstituted alkene, 262
3,4-Disubstituted and 1,3,4-trisubstituted β-lactams, 70
3,4-Disubstituted beta-lactams, 197, 198
3,4-Disubstituted β-lactams, 68
Dithiolane, 90
Docetaxel, 338
Dolence, E.K., 69
Doripenem, 38, 284, 287
Doyle, T.W., 234
Drazic, T., 69
Drug development process, 373
Drug provocation tests (DPTs), 382, 383
D-Threonine, 88
E. aerogenes, 12
E. coli, 6, 12, 31, 282, 305, 311–313, 365, 379
E-enolate, 165
E. faecalis, 278, 294
Eight α-hydroxy-beta-lactams, 344
E-imines, 340
394 Index
https://t.me/med1917
Electric dipole moment, 337
Electromagnetic radiation, 178
Electron localization function (ELF), 237
Electrophilic addition, 261
Enaminones, 245, 246
Enantiopure 3-amino β-lactams, 184
Encapsulating cefazolin, 326
Endometritis, 5
Enediyne-fused, 262, 264
Energy dispersive spectroscopy (EDS), 313
Energy minimization method, 339
Energy of highest occupied molecular orbital (E HOMO),
354, 357
Energy of lowest unoccupied molecular orbital (E LUMO),
354, 357
Enolate-imine condensation, 82
Enolate-imine method, 99
Enolate method, 102
Enolates-imines method, 82
Enones, 183–185
Enterobacter, 6, 12
Enterobacteriaceae, 12, 279, 287, 323, 376
Enterobacter sp., 279
Enterococcus, 382
Ephedrine derivative, 88
Epicillin, 23, 24
6-Epi-lincosamide, 83
Epoxides, 92
Ertapenem, 38, 284, 285, 287
Erythromycin, 308, 363
E-Schiff base, 231
Ester enolate-imine condensation, 57
Ester-enolate reaction, 98
Euphorbiaceae, 309
Evans, D.A., 89, 90
Extended-spectrum beta-lactamase (ESBL), 28, 273, 275,
320, 365, 381
F. alginoliquefaciens, 16
Fatty acids, 135
Feledziak, M., 63
Felkin-Ahn model, 101
Ferrier rear rangement, 138, 141, 144, 16 4
Ferrocene aldehyde, 182
Ferrocene derivatives, 108
4-Ferrocenyl-β-lactams, 108
Five-membered lactones Conversion, 251, 252
Flavobacterium sp., 31
Fleming, Alexander, 17, 278
Flexibacter, 2, 293
Flopen, 20
Floxapen, 20
Flubex, 20
Flucloxacillin, 19, 20
Fluoroquinolone, 363
Flupen, 20
Food and Dr ug Administration, 19
Formadicins, 16
4-Formyl-1-haloalkyl-β-lactams, 111
Fosfomycin, 318, 363
Fourier transform infrared (FTIR) spectroscopy, 308, 313
Fractional inhibitory concentration index (FICI), 307, 320
Fu, G.C., 102
Fujita, T., 116
Functionalized 3,3-diuoro-β-lactams, 72
Functionalized mannitol, 10 8
Fungi, 4
Galletti, P., 63
Gallic acid-derived 2-azetidinones, 58, 59
Galvez, J.A., 93
γ-Lactam, 247, 248, 254, 255
Garud, D.R., 117
Gastrointestinal tract, 6
Gawande, S.K., 58
4-Gem-dimethyl substitution, 294
Gentamicin, 310
Gerona-Navarro, G., 63
Glaxo 4α-methoxy-tribactam, 42
Gluconobacter, 2, 293
Glutamine synthetase (GS), 9–11
Glutarimides, 258
Glutathione-S-transferase (GST) enzyme, 70
Glyceraldehyde-3-phosphate, 40
Glycerol, 176
Glycopeptides, 363
Glycosylation method, 141
Glycosylation process, 138
Gold nanoparticles (AuNPs), 313
González-Muñiz, R., 10 6, 115
Gowri, M., 70
Gradient-boosted decision tree (GBDT), 372
Gram-negative bacteria, 5, 25, 270, 308, 344, 380
Gram-negative group, 3
Gram-positive bacteria, 6, 14, 270, 308, 344
Gram-positive group, 3
Grande, M, 104
Graph convolutional networks (GCNs), 375
Green, B.G., 60
Green nanotechnology methods, 314
Grignard reagent, 10 2
Group of phenyls, 348, 351
3-(3-Guanidinopropyl)azetidin-2-ones, 73
Guanti, G., 95
Guerrini, A., 114
Guiry, P.J., 111
Guner, V., 72
Haemophilus, 6, 12
Halve, A.K., 58, 59
Harsha, Y.P., 69
Hart, B.P., 105
Hartree–Fock (HF) theory method, 351–353
HeLa cancer cells, 318
Herdewijn, P., 118
Hetacillin, 23, 24
Hetacillinx, 23
Heteroaromatic amino compounds, 134
Heterocycles, 87
Hierarchical multitask deep learning method, 372, 373
Highest occupied molecular orbital (HOMO), 228
High-resolution TEM (HR-TEM), 320
395 Index
https://t.me/med1917
High-throughput screening (HTS), 205
H. inuenzae, 12
HMD-ARG, see Hierarchical multitask deep learning
method
Human blood cancer cells (HL-60), 352
Human breast cancer cells (MDA-231), 352
Human colon cancer cells (HT-29), 352
Human fatty acid amide hydrolase (hFAAH) inhibition, 63
Human leucocyte elastase (HLE), 55, 60, 63, 266
Human melanoma cells (BRO), 352
Human ovarian cancer cells (SKOV-3), 352
Human prostate cancer cells (PC-3), 352
Human renal dehydropeptidase (DHP), 284
Hydoxy-controlled stereoselective synthesis, 89
Hydrazones, 107
Hydrocarbon solvents, 186
Hydrogenation, 93, 108, 138
Hydrogen bond acceptors (HBAs), 354, 357
Hydrogen bond donors (HBDs), 354, 357
Hydrogen bonding, 133
Hydrogen peroxide (H2O2), 317
2-Hydroxy-5-phenylbenzaldehyde, 69
β-Hydroxy amides, 81
β-Hydroxy amides and β-formyl amides, 245
3-Hydroxy carbacephem, 90
(6R)-Hydroxyethyl side chain, 17
1’-Hydroxyl group, 66
8-Hydroxylquinoline-substituted 3-chloro-β-lactams, 69
4-Hydroxymethyl β-lactams, 175
Hydroxy β-lactams, 87, 135, 139
Hypercholesterolemia, 2
Hypokalemia, 21
Ikota, N., 90
Imines, 338
Imipenem, 38, 39, 284
Impetigo, 19
Indium-induced reduction, 134
Indolizidines, 247, 248, 338
Indolyl pyrimidine, 345
Induced dipoles, 337
Instantaneous dipoles, 337
Intermolecular ester-enolate reaction, 120
Interstitial nephritis, 20
Intra-abdominal infections, 5
in vitro antibacterial test, 58
Iodine-catalyzed glycosylation, 138, 140
Ionic gelation method, 324
Iron oxide nanoparticles (IONPs), 321
Isobornyl 2-alkyl derivatives, 93
Isobornyl cyanopropenoate, 94
Isochromans., 258, 259
Isocyanate-alkene cycloadditions, 57
Isosorbide, 112
Isoxazole group, 345
Jarrahpour, A., 67, 68
K-562, see human blood cancer cells
Kanamycin, 4, 308
Ketene-imine cycloaddition reaction, 57
Ketene-imine mechanism, 208
Ketimines, 338
4-Keto-β-lactam, 80
Kinugasa reaction, 239, 265
Kirkup, M. P., 66
Klebsiella, 6
Klebsiella pneumoniae, 317, 326, 367, 372
Koneva, E.A., 116
Lactivicin, 44
Lact-Pred, 380
L-amino acids, 16
Lankacidins, 338
L-arginine, 40
La Rosa, C., 109, 117
Lassaletta, J.M., 107
Least unoccupied molecular orbital (LUMO), 228
Lectka, T., 100
Lefamulin, 363
L-(-)-glyceraldehyde, 84
L-homoserine, 3
Lignin, 329
Linezolid, 363
1,4-Linked glucopyranose, 329
Lipoamino acid-coated IONs (LION14), 321, 322
Lipoglycopeptide, 363
Lipopeotides, 120
Liposomes, 322, 329
Liu, Y., 66
L-N5-hydroxyornithine, 4
Logistic regression (LR), 382
Long, T.E., 118
Lorabid, 40, 79
Loracarbef, 39, 40
Low- and middle-income countries (LMIC), 365
L-pHPG, 4
L-p-hydroxyphenylglycine (L-pHPG), 3
L-Serine, 3, 4
L-Tyrosine, 3
Luria–Bertani, 305
Luteinizing hormone–releasing hormone (LHRH)
antagonist, 55
Machine learning (ML), 364
Macrolides, 363
Magnetic nanoparticles (MNPs), 321
Malonates, 80
Mass transfer, 163
McKittrick, B. A., 61, 66
Mecillinam, 279
Meningitis, 284
Merck molecular force eld (MMFF), 352
Meropenem, 38, 39, 284, 287, 326
Merrield resin-bound imine, 196
Metal-catalyzed carbonylation, 57
Metallo-carbapenemases, 273
Metal-mediated reactions, 112
Metal vapor synthesis (MVS) technique, 213–214
Metampicillin, 23, 24
Methanesulfonic acid, 108
Methanolysis, 98
396 Index
https://t.me/med1917
Methicillin, 19, 21, 279, 316
Methicillin (USAN), 20
Methicillin-resistant Staphylococcus aureus (MRSA), 19,
31, 279, 367
4-Methoxycarbonyl-3-vinyl-2-azetidinons, 247
6-Methoxy penicillin, 25
4-Methoxy-tribactam, 42
5-Methyl-3-phenylisoxazole-4-carboxamide group, 345
Metronidazole, 363
Mezlocillin, 25, 26
Micelles, 322
Microwave-induced synthesis, 117
applications of, 162
aromatic rings, 177–178
benets of, 162
and conventional heating, 162
ferrocenyl β-lactams, 182 –183
heating methods, 161
hydrogenation, 178 –181
indium metal, 181
intramolecular oxa-Michael reaction, 172 –174
microwave-induced bismuth nitrate-catalyzed Michael
reaction, 183–185
microwave-induced enzymatic reactions on, 176 –177
polycyclic β-lactams, 175, 181–182
principles of, 161–162
pyrrole-fused beta-lactams, 171–172
tan δ and dipole moments in, 185 –187
thiena myci n β-lactam, 164 –167
Microwave irradiation method, 58
Microwave-mediated reactions, 2
Miller, M. J., 68
Minimum inhibitory concentration (MIC), 6, 59, 307,
271, 367
MinION, 369
Modied neglect of differential overlap (MNDO), 348, 351
Moller–Plesset (MP), 352, 353
Monobactams, 12, 55, 114, 363
Monocarbams, 16
Monocyclic 2-azetidinone derivatives, 70
Monocyclic 3,3-dialkyl-β-lactams, 60
Monocyclic 4-alkylidene-2-azetidinones, 69
Monocyclic azetidin-2-one derivatives, 69
Monocyclic beta-lactams, 2, 290
Monocyclic N-methylthio-β-lactams, 62
Monocyclic β-lactams, 63
1,4-diaryl-substituted 3-hydroxy/amino-azetidin-2-
ones, 67
1’-hydroxyl group, 66
2-azetidinone derivatives, 66
2-azetidinones, 63
2-diazo-1,2-diarylethanone-generated ketene, 70
2-hydroxy-5-phenylbenzaldehyde, 69
3,4,5-trimethoxyphenyl ring, 60
3,4-disubstituted and 1,3,4-trisubstituted β-lactams, 70
3,4-disubstituted β-lactams, 68
3-(3-guanidinopropyl)azetidin-2-ones, 73
3-acylamino-β-lactams, 67
3-Allyloxy/propyloxy-β-lactams, 60
3-amino-β-lactam derivatives, 68
4-[3- chlor o-4-s ubsti tuted pheny l-2-o xo-az etidi
n-1-y l] benzoic acids, 70
4-alkylidene-β-lactam derivatives, 69
4-aminobenzoic acid-derived β-lactams, 70
8-hydroxylquinoline-substituted 3-chloro-β-
lactams, 69
antibacterial activity, 58, 63, 68
anti-human cytomegalovirus (HCMV) activity, 63
aromatic hydroxylation and benzylic oxidation, 64
benzylazetidin-2-one analogue, 63
14 β-lactam derivatives, 66
C3 heteroatom-substituted β-lactams, 62
C3 unsaturated and saturated β-lactams, 64
diastereoselective asymmetric synthesis, 67
experimental conditions for, 73–74
functionalized 3,3-diuoro-β-lactams, 72
gallic acid-derived 2-azetidinones, 58
human fatty acid amide hydrolase (hFAAH)
inhibition, 63
human leukocyte elastase (HLE) inhibitor, 60, 63
microwave irradiation method, 58
monocyclic 2-azetidinone derivatives, 70
monocyclic 4-alkylidene-2-azetidinones, 69
monocyclic azetidin-2-one derivatives, 69
monocyclic N-methylthio-β-lactams, 62
N1 aromatic group, 64
N-polyaromatic-substituted 2-azetidinones, 66
N-polyaromatic-substituted β-lacta m derivatives, 66
N-thiolated β-lactam antibiotics, 60
N-thiolated β-lactams, 61
N-unsubstituted β-lactam thioethers, 63
phenyl alanine-derived 1-acyl-2-azetidinones, 63
prostate-specic antigens (PSAs), 63
radioiodinated β-lactam analogues, 66
structural modications, 66
structure–activity relationship, 72
sulfanil amide-derived heterocyclic compounds, 70
trans-β-lactam, 64
in vitro antibacterial test, 58
water-soluble CA4 analogues, 72
Monophosphams, 14, 15
Monosulfactam (2-oxoazetidine-1-oxysulfonates), 14
Monosulfactams, 15
Montmorillonite, 17 7
Moraxella catarrhalis, 12
Morganella, 12
Mukaiyama reagent, 108
Multi-component reactions, 57
Multidrug-resistant (MDR), 284, 311, 365
Mupirocin, 363
Mycobacterium sp., 4
M. tuberculosis, 270, 376
N1 aromatic group, 64
N1-aromatic/N1-heterocyclic substituted monocyclic
β-lactams, 16
N1-aza-substituted monocyclic β-lactams, 16
N1-O-sulfate group, 294
N1-oxy-substituted monocyclic β-lactams, 16
N1-sugar-substituted monocyclic β-lactams, 16
N1-sulfonic acid, 293
N1-sulfonyloxy- substituted monocyclic β-lactams, 16
N1-thio-substituted monocyclic β-lactams, 16
N1-unsubstituted monocyclic β-lactams, 16
397 Index
https://t.me/med1917
N2-(2-carboxyethyl)-L-arginine (CEA) synthase, 40
N-Acylethanolamine Acid Amidase (NAAA)
inhibition, 68
Nafcillin, 19, 21, 279
N-Alkylaminated chitosan nanoparticles (CNPs), 323
Nano-antibiotics (NABs), 304
Nanocrystalline zinc oxide, 318
Nanoparticles (NPs), 304
Naphthalene group, 348
Naphthalenyl and indole systems, 230
Natural soil inhabitants, 292
N-benzyloxycarbonyl-N-benzyl-glycine, 107
N-chloroacetyl amino acid derivative, 106
N-chloroacetyl-Phe derivatives, 200
N-chrysenyl system, 138
N-dimethylephedrine, 95
Negaban, 25
Neglect of diatomic differential overlap (NDDO), 345,
348, 351
Neisseria sp., 3, 12, 293
Neural networks (NNs), 367
New Jersey Pine Bar rens, 293
N-formimidoyl group, 284
N-hydrazide/hydrazone-β-lactams, 59
N-hydroxy-β-amino ester, 98
N-iodosuccinimide, 141
Nitrofurantoin, 282, 363
Nitrone-alkyne cycloaddition, 57
Nitrones, 110
Nitzschia diatoms, 313, 314
N-methylmorpholine, 185
N-methylthiotetrazole (NMTT/1-MTT), 35
N,N-dialkylhydrazones, 107
Nocardicin, 16
Nocardicin A, 3, 4, 16
Nocardicin A-agarose, 3
Nocardicins, 3, 55
Nonprotein amino acids, 338
Nonribosomal peptides, 364
Norephedrine-derived oxazolidines, 92
Novartis, 39
N-phenanthrene, 138
N-polyaromatic-substituted 2-azetidinones, 66
N-polyaromatic-substituted β-lacta m derivatives, 66
N-salicylideneamines, 70
N-t-Boc-oxanorstatine methyl ester, 97
N-thiolated β-lactam antibiotics, 60
N-thiolated β-lactams, 61
Nuclear Magnetic Resonance (NMR), 138, 16 6
Nucleophiles, 357
Nucleophilic catalysis process, 115
N-unsubstituted β-lactam thioethers, 63
N-urea-β-lactams, 60
Nyitrai J., 106
Octanol–water partition coefcient (Log P), 354, 357
O-Glycosides, 142
Ohtake, H., 98
Ojirna, I., 90, 139
Oligodeoxynucleotide (ODN), 366
Oligopeptides, 338
Organocatalysis, 348
Otani, T., 116
O-t-butyld iphenylsilylhydroxylamine, 90, 92
Otitis externa, 19
Oxacephem moxalactam/latamoxef, 273
Oxacephems, 35–37
Oxacillin, 19, 20, 22, 279, 318, 345
1,3-Oxazin-6-ones, 246, 247
Oxazines, 251, 253
Oxazinone nitrone, 249
Oxazolidine, 2, 290
Oxazolidinones, 363
Oxazolidone, 90
4-Oxoazetidine-2-carbaldehydes, 101
Oxytetracycline, 318
Paclitaxel, 338
Palladium-catalyzed reaction., 82
Palomo, C., 97, 101
Pancreatoduodenectomy, 273
Parameterized method 7 (PM7), 377
Parametric model 3 (PM3), 341, 348
Parametric model 6 (PM6), 341, 348
Patel, R., 59
PBP2a , 278
Penicillin-binding protein-3, 6
Penicillin-binding proteins (PBPs), 1, 269, 270, 367
Penicillin G, 17
Penicillins, 1, 269, 313, 316, 337, 344, 345, 363
Penicillium sp.
P. chrysogenum, 18
P. ru be ns, 17
Peptidoglycans, 344
Peptidomimetics, 338
Permanent dipoles, 337
Petasis reaction, 206, 207
Phenanthrene group, 338, 348
Phenothiazines, 345
Phenoxymethylpenicillin, 18 , 278, 345
Phenylacetamido, 345
Phenyl alanine-derived 1-acyl-2-azetidinones, 63
Photochemistry, 80
Photophosphorylation, 9
Photothermolysis, 313
Phthalimido amino acid, 118
Phyco-nanotechnological approach, 314
Phylopen, 20
Piperacillin, 26, 282, 323
Piperidines, 251, 252
π-stacking, 133
Pivampicillin, 23, 24, 377
Platinum nanoparticles (PtNP), 315
Pneumococcal meningitis, 18
Pneumonia, 5, 19
Polarizability, 354, 357
Polar surface area (PSA), 354, 357
Polyaromatic amines, 133
Polyaromatic nitro derivatives, 134
Polycyclic beta-lactams, 46
Poly(ethylene glycol) (PEG), 212
(-)-Polyoxamic acid, 84, 244
398 Index
https://t.me/med1917
Polyoxamic Acid, 84
Polypeptides, 363
Polysaccharides, 322
Polyvinylpyr rolidone (PVP), 308
Porcine pancreatic lipase (PPE), 266
Potassium clavulanate, 40
Principal component analysis (PCA), 377
Proline polypeptides, 250, 251
Prostate-specic antigens (PSAs), 63
Proteus sp., 3, 4, 6, 12, 16
P. mirabilis, 311
P. vulgaris, 31
Providencia sp., 12
Pseudo-dilution effect, 19 4
Pseudomonas sp., 3, 4, 12, 16, 290
P. aeruginosa, 5, 12, 26, 272, 278, 279, 284, 311, 313,
322, 372
P. chrysogenum, 278
P. ru be ns, 278
Pyrazine-2,3-dione derivatives, 254
Pyrazolopyridines, 345
Pyr role derivatives, 250, 251
3-Pyrrole-functionalized β-lactams, 150
Pyrrole-substituted-β-lactams, 113
4-Pyrrolidinopyridine, 115
Pyrrolizidines, 246
Quantitative structure–activity relationship (QSAR),
354, 365
Quinazolinones, 345
Quinolones, 345, 382
Racemic compound, 351
Ramsay, William, 163
Rayleigh–Schrodinger perturbation theory (RS-PT), 352
Reactive oxygen species (ROS), 307
Recife model 1 (R M1), 341, 348
Recurrent neural networks (RNNs), 375
Reformatsky reaction, 97, 117, 145
Reinforcement learning, 373
Resin-bound imines, 201
Resin-bound phenoxy acetic acid, 19 6
Retro-Mannich process, 256
Retrospective cohort analysis, 383
Rifamycins, 363
Rigby, J.H., 81
Rimoldi, I., 117
Ring expansion reactions, 57
Rokade, Y., 58
Rosenblum, S.B., 64
S-adenosylhomocysteine, 3
Sakamoto, M., 101
Salmonella sp., 12, 31, 314
Samarium metal-induced reduction, 134
Sanfetrinem, 41
Saturated compound, 138
Scanning electron microscopy (SEM), 309, 313
Semiempirical quantum chemistry method, 339
Semi-supervised learning, 373
Semisynthetic antibiotics, 19
Semisynthetic cephalosporins, 2
Semisynthetic penicillins, 278
Sepsis, 5
Septic arthritis, 19
Serine, 273
Serratia, 6
Serratia marcescens, 12
Setti, E. L., 68
Shah, S. K., 60
Shaikh, A.L., 111
Shan kar, B.B., 96
Shigella sp., 12
Siamese neural networks (SNNs), 366
Siderophore-conjugated monocarbams, 16 –17
Siderophore-conjugated monosulfactams, 17
Signal-to-noise ratio (SNR), 367
Silver nanoparticles (AgNPs), 308
Skin tests (STs), 382
Sodium dodecyl sulfate (SDS), 308
Sodium iodide, 170
Solid lipid nanoparticles (SLNs), 305
Solid-phase method, 116 , 209
Solid support, 103
SPA R TA N 18, 339, 341, 345, 348, 351
Spirocyclopropane, 81
Stacked autoencoder (SAE), 367
Staphylex, 20
Staphylococcal endocarditis, 21
Staphylococcal penicillinase, 19
Staphylococcus infections, 344
Staphylococcus sp., 4, 27, 270
S. aureus, 12, 19, 311–313, 382
S. marcescens, 279
S. pneumoniae, 271, 294
Staudinger, Hermann, 1
Staudinger cycloaddition, 57, 72
Staudinger reaction, 196, 198, 199
least unoccupied molecular orbital (LUMO), 228
mechanism of, 227–240
Stenotrophomonas maltophilia, 376
Stereospecic trans β-lactams, 83
Steroids, 79
Streptococcus sp., 27, 31, 270
S. pneumoniae, 12, 23, 367
S. pyogenes, 23
Streptogram ins, 363
Streptomyces sp., 15
Streptomycin, 4, 308, 316
Strominger, J. L., 270
structural modications, 66
Structure–activity relationships (SARs), 72, 132, 354
Structure–property–activity relationships (SPARs), 354
3-Substituted 4-carboethoxy-β-lactams., 169
Subudhi and Ghosh, 70
Sugar-derived imines, 83
Sugar-derived vinyl ethers, 80
Sugar imines, 84
Sugars, 81
Sulbactam, 41, 55
Sulfanil amide-derived heterocyclic compounds, 70
Sulfonamides, 363
399 Index
https://t.me/med1917
Sulperazon, 41
Sun, L., 66
Supervised learning, 373
Surface-enhanced Raman spectroscopy (SERS), 366
Suslick, Kenneth S., 163
Tabtoxin, 7–12
Tabtoxinine-beta-lactam, 9, 10
Talampicillin, 23, 24
Tang Y., 110
Tartaric acid derivatives, 93, 98
Taxoid s, 338
Taxol , 86
Taxol (paclitaxel), 338
Taxotere (docetaxel), 338
Tazo bac t am, 41, 55
Tebipenem, 38, 39, 284, 290
Tedizolid, 363
Temocillin, 23, 25, 279
TensorFlow deep learning, 365
Tetracyclic beta-lactams, 46
Tetracyclic indolizidinones, 247
Tetracycline, 4, 308
Tetrahydroazocinones, 256
Tetrahydrofurfurylamine, 204
Tetrahydropyridines, 255
2,3,4 ,6-te tra-O -acet yl-β- D-gal actos amine , 85
Tetraoxanes, 345
Thiazolidine, 2, 290
Thiazolidine ring, 344, 345
Thienamycin, 84, 85, 284, 337, 345, 347
Thietane β-lactams, 101
Thiruvazhi, M., 107
Threonine, 96
Thrombin inhibitor, 55
Ticarcillin, 23, 25, 279, 282
Tigecycline, 363
Tipper, D. J., 270
Titanocene monochloride (Cp2 TiCl), 10 2
Topoisomerase inhibitors, 133
Tosyl isocyanate, 80
trans-alpha-hydroxy-beta-lactams, 343
trans-esterication reaction, 245
Transglycosylase, 270
Transition dipole moment, 337
Transmission electron microscopy (TEM), 308, 271,
273, 377
Transmission Fourier transform infrared (tFTIR), 377
Transpeptidase, 270
Triazene esters, 210
Triazolo-oxazepine β-lactam, 175
Tribac tams, 79, 104
Trichoderma viride, 308
Tricyclic beta-lactam, 42, 46
Tricyclic cycloaromatized compound, 250
Triethylamine, 146
Triuoroacetic Acid (TFA), 244
3,4,5-Trimethoxybenzylamine, 204
3,4,5-Trimethoxyphenyl ring, 60
2-Trimethylsilyl)thiazole (TMST), 258
Tripodi, F., 67
1,4,4-Trisubstituted 2-azetidinones, 200
1,3,4-Trisubstituted beta-lactams, 19 9
Turos, E., 60, 132
Ultrasound-assisted reactions
advantages of, 163
applications in, 162
ultrasound-induced principles, 163
Ultrasound-induced synthesis
aromatic rings, 177–178
ferrocenyl β-lactams, 182 –183
hydrogenation, 178 –181
indium metal, 181
intramolecular oxa-Michael reaction, 172 –174
polycyclic β-lactams, 175, 181–182
pyrrole-fused beta-lactams, 171–172
Ultraviolet-visible spectrophotometry, 309, 320
Unsaturated acid chlorides, 135
3-Unsubstituted-4-acyloxy-β-lactam, 246
3-Unsubstituted NH-β-lactams, 80, 81
Unsupervised learning, 373
Uracil der ivatives, 247, 248
Ureidopenicillins, 23
4-Ureido trinems, 45
Urinary tract infection (UTI), 366
Urinary tract infections, 5
Uropathogenic E. coli (UPEC), 366
UV-Vis, see ultravoilet-visible spectrum
Vancomycin, 313, 316, 363
Vassilev, N.G., 116
Veinberg, G, 62, 70
Vicario, J.L., 102
Vilsmeier reagent, 195, 196
Vinyl ethers, 2 61
Vinyl-β-lactams, 16 8
Vitek-2 system, 316
Wakselman, M., 72
Water-soluble CA4 analogues, 72
World Health Organization (WHO), 18, 321, 326
Woulfe, S. R., 68
X-ray diffractogram (XRD), 308, 313
X-ray photoelectron spectroscopy (XPS), 313, 320
Xu, X., 72
Yamamoto, Y., 95
Yeast, 4
Yersinia enterocolitica, 12
Young, Sydney, 163
Z-Aldimine 5 derivative, 340
Z-Aldimine 7 derivative, 340
Z-Imines, 340
Zinc, 114
Zinc oxide nanoparticles (ZnONPs), 317
Z. mays, 9
Zwitterionic system, 256
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