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Some patients have pressing psychosocial problems but cannot be admitted to the hospital because of restricted admission criteria.
The intensity of serv ice needs should be limited and consistent with the staffing pattern of the ward. This must be matched to the patients ill­ness severity (which should be limited to one organ system).
The severity of illness must not preclude the expectation that the patient will be discharged within established time limits. A time limit is very important and should be carefully monitored and strictly enforced.
Observation Ward Admission Paperwork
An admission note must be generated, detailing:
time admitted in EC
time admitted into Observation Ward
the reason for observation
the working diagnosis (and other possible
conditions needing exclusion)
treatment plan and aims
outstanding special investigations results
a clearly defined end point for patient
disposition
Documentation (both medical and nursing) should be simple and goal driven.
All medical and nursing notes, drug cardex,
fluid charts and observation sheets should
transfer with the patient from the EC to the
Observation Ward; they should continue until
discharge.
There should be standardized designed
cover sheets, which only get completed
upon admission to the EC obs ward.
Segments should be kept simple and aim
driven.
1) Time admitted in EC
2) Time admitted in Observation Ward
3) Working Diagnosis (and other possible conditions needed exclusion)
4) Outstanding special investigations resu lts
5) Treatment plan and aims
Suggested Admission Criteria
The following are ideal for Observation Ward admission:
Diagnostic evaluation of haemodynamically stable patients with:
Abdominal pain
Chest pain with low probability of myocardial infarction (following a diagnostic pathway)
Flank pain (evaluation and pain management of suspected kidney stones)
Gastrointestinal bleeding (with no evidence of ongoing bleeding)
Chest trauma (normal initial evaluation and CXR)
Drug overdose (clinically stable)
Syncope (negative initial evaluation following diagnostic pathway)
Nonpregnancy related vaginal bleeding awaiting Ultrasound/Gynaecological evaluation
Trauma patients with minor injuries but significant mechanism of injury
Mixed alcohol intoxication and minor head injury
Short-term therapy of patients with:
Allergic reactions
Asthma/COPD
Acute exacerbation of chronic congestive cardiac failure
Dehydration
Hyperglycemia
Hypertensive urgencies
Selected infections (e.g., pyelonephritis, cellulitis, pneumonia with low CURB score, etc.)
Blood transfusion
Seizure disorders requiring anticonvulsant loading or observation
Meeting psychosocial needs of patients with:
Acute alcohol withdrawal
Depression with ongoing suicide ideation (with documented risk assessment; after discussion with Psychiatry)
All patients remain the responsibility of the EC.
Patients who should not be admitted:
The following patients SHOULD NOT be accom­modated in Observation Ward bed:
Heather Tuffin and LA Wallis
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Patients referred to, or admitted to, an inpatient speciality
Psychiatric patients at any point of their admission
Patients for planned surgery
Postoperative patients
Patients admitted from outpatient clinics, awaiting an inpatient bed
South Africa
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Subpart VIB
Chapter
72
International – Asia
Singapore
Malcolm Mahadevan, MD FRCS (A&E), MRCP (Int Med), FAMS Chew Yian Chai, MD, MCEM, FAMS
Introduction
Origins
It was in 1998 and early 1999 after reading the first edition of Observation Medicine by Louis Graff that the author was first intro duced to the concept of observation medicine. This concept was presented and the possibility explored with the hospital administration of setting up such a unit at the National University Hospital Singa­pore. With their blessing an application for a scholarship under the human manpower devel­opment award was made and obtained. The author (MM) successfully completed a fellowship program in Observation Medicine with Louis G. Graff, MD, FACEP at the University of Con­necticut Medical School in Hartford, Connecti­cut. Subsequently the first formal observation medicine unit in Singapore was approved and set up in 2004 at the National University Hos­pital, and was named Extended Diagnostic Treat­ment Unit (EDTU) as a pilot project.
Challenges
The hurdles initially encountered in setting up and running the unit included reimbursement for observable conditions, acceptance by the local hospital as a recognized site for continued care, as well as establishing its role and utility in a hospital system. For reimbursement there needed to be approval from the government that patients could utilize their medical savings (called medisave).
When the first protocols were being written there was consultation with relevant specialties related to the observed conditions. Examples included cardiology for chest pain patients to rule out myocardial injury. Utilizing repeat enzyme testing was done by our unit, but the investigation for possible coronary artery or ischemia by tread­mill stress test, dobutamine echo or technetium
sestamibi scan was done by the cardiology service. There had to be a meeting of minds as well as agreement for continuity of care.
Following the National University Hospital, most of the major restructured government hos­pitals in Singapore started developing their own observation units (OUs). Also fostering the growth of observation medicine in Singapore, two additional physicians from Singapore completed fellowships in observation medicine in Cleveland, Ohio in 2006–2007 with the editor of this text­book, Dr. Mace. To date, six major hospitals offer formal observation services. As all OUs are in various stages of their development, hospital-to­hospital variation occurs in terms of size, number of protocols available, staffing ratio, and extended services available; however, they all work on the same fundamentals of observation medicine and are largely protocol driven.
The National University Hospitals EDTU started with 8 beds and 8 protocols. Over the years, we have expanded to 16 beds, and we now have 32 protocols in place. We are still continu­ously seeking improvement and refining our workflows and processes. Table 72.1 lists the protocols we have in place.
Guidelines on Concept, Staffing
OUs are generally housed adjacent to the emer­gency department (ED) and are staffed and run by ED physicians. Rounds are made twice daily. The staffing ratio of nurses to patients is kept at 1:5, thus allowing close monitoring of patients. In our current model of care, no provision for additional physician staff has been fa ctored in for running the OU. This has limited the size of the units and placed some strain on manpower. Moving for­ward there should be better rationalization of needed resources to enable more efficient safe care delivery.
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Unique Features of Observation Medicine in Singapore
Our protocols are evidence based as far as possible. On occasion we have discovered that there is a dearth of evidence available and this has led us to push the boundaries through research and publi­cation of observable conditions. One example would be the management of primary spontaneous pneumothorax. We initially placed a normal bore chest drain utilizing open dissection with the drain being connected to an underwater seal. This was a painful procedure and patients experienced dis­comfort with the drain. We then tried aspirating and observing but soon realized that many
reaccumulated their pneumothorax. We then went on to utilize a small bore drain inserted with a seldinger technique and aspirated the pneumo­thorax after we which we connected to an under­water seal and observed the patients over 24 hours. This has proven to be much more favorable, with a 39% reduction in insertion of chest tubes; 65% of our patients were manag ed with mini chest tubes and 56% of those admitted to our OU were suc­cessfully discharged within 24 hours.
The utility of our abdominal pain protocol allows us to observe those with moderate prob­ability of appendicitis (Alvarado score) hence minimizing unnecessary CT scans of the abdomen.
Table 72.1 EDTU Protocols, National University Hospital
Diagnostic Conditions
Therapeutic Conditions Diagnostic & Therapeutic Conditions
Appendicitis Atrial fibrillation Dehydration
Chest pain Anaphylaxis Dyspepsia
Pneumothorax – Apical and rim Headache
Asthma Seizure
Back pain Stable head injury
Blunt chest trauma Syncope
Cellulitis Vertigo/Dizziness
Colorectal conditions
Congestive heart failure
Chronic obstructive pulmonary disease (COPD)
Dengue
Deep vein thrombosis
Gastroenteritis
Gastrointestinal bleeding
Hyperglycemia
Hypoglycemia
Pneumonia
Renal or ureteric colic
Toxic smoke inhalation
Transient Ischemic attack
Urinary tract infection/pyelonephritis
Vertebral compression fracture
Singapore
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Our asthma and COPD pathways involved the input and assistance of inpatient nurses specially trained to assess and follow up with these patients at home. This helps us discharge our patients safely with timely follow-up. The management of our COPD patients presenting to the ED in the EDTU is part of a continuum of care, which includes early recognition in ED for noninvasive ventilation (NIV) (which we initiate) and has shown a mortality reduction from 11.8% to
1.7%. This decision is based on postth erapy arter­ial blood gas. If the initial pH is below 7.25 then NIV is initiated. If the patient has a pH of greater than 7.25 posttherapy and is deemed suitable for EDTU care, then he or she is admitted to the EDTU for further treatment and assessment.
The advent of observation medicine in Singa­pore has also greatly helped limit our inpatient admissions. As many of our facilities like those in other countries have access block issues with bed limitations, it has helped us as part of the hospital system to cope better.
What is the Role of Observation Medicine in the Health System?
The introduction of observation medicine has seen increased merits in the health care system. A review of the statistics over the past 2 years shows that on the average, 444 patients in a month are placed in our OU, which amounts to 4% of our ED volume. Discharge rates are as high as 82%. This has greatly helped to reduce overall length of stay in the hospital, thus freeing up more inpatient beds for the needy and sicker patients. In addition, patients admitted to the OU get earlier access to short-term specialized services such as cardiac stress tests, gastroduode­noscopies, abdominal ultrasound, electroenceph­alograms, and doppler ultrasounds (to exclude deep vein throm bosis). Early follow-up can be arranged in our early access clinics called Hot Clinics.All these improve the continuity of care and translate to overall high-quality patient care in a cost-effective environment.
References
1. Wilder JL, Ross MA, Ginde
AA. National Study of Emergency Department Observation Services. Acad Emerg Med 2011 Sep; 18(9): 959–965.
2. Venkatesh AK, Geisler BP,
Gibson Chambers JJ, et al. Use of Observation Care in US Emergency Departments, 2001 to 2008. PloS One 2011; 6(9):e24326.
3. Baugh CW, Venkatesh AK,
Bohan JS. Emergency Department Observation Units. A clinical and financial benefit for hospitals. Health Care Manage Rev. 2011 Jan–Mar; 36(1):28–37.
4. Graff L, Mucci D, Radford MJ.
Decision to hospitalize:
Objective diagnosis-related group criteria versus clinical judgement. Ann Emerg Med 1988; 17:943–952.
5. Ng CW, Lim GH, McMaster F, et al. Patient satisfaction in an Observation Unit: the Consumer Assessment of Health Providers and Systems Hospital Survey. Emerg Med J. 2009 Aug; 26(8):586–589.
6. American College of Emergency Physicians. Management of Observation Units. Ann Emerg Med 1988; 17:1348–1352.
7. Realdi G, Giannini S, Floretto P, et al. Diagnostic pathways of the complex patients: rapid intensive observationin an acute medical unit. Intern Emerg Med 2011 Oct; 6 Suppl 1:85–92.
8. Graff LG, Radford MJ. Formula for emergency physician staffing. Ann Emerg Med 1990; 8:194–199.
9. Observation Medicine Guidelines 2009. Victorian Government Department of Human Services, Melbourne, Australia.
10. Graff LG. The observation patient in the DRG era. Am J Emerg Med 1988; 6:93–103.
11. Neville L, Rowland RS. Short stay unit solves emergency overcrowding. Dimens Health Serv 1983; 60:26–27.
12. Kellerman A, Andrulis A, Hackman B. Hospital and emergency medicine department overcrowding. Results of a National Survey. Ann Emerg Med 1990; 19:447.
Malcolm Mahadevan and Chew Yian Chai
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Subpart VIC
Chapter
73
International – Australia/New Zealand
Australia
John Burke, FACEM
Introduction
Observation Medicine has become an essential adjunct to emergency medicine practice in Australasia, and dedicated Observation Wards (OW) are now featured in the design of most modern metropolitan hospitals. While their func­tion may vary according to local flow models and resource constraints, their common focus is the rapid turnover of selected patient groups for the purposes of admission avoidance and early dis­charge. Successful implementation requires not only well-defined operational parameters but also a clear understanding of how the unit contributes to overall patient flow.
Australasian Model of Care
While many international authors endorse an expanded role for observation facilities, the Australasian OW is typically based in the emer­gency department (ED) and does not provide care for inpatients under normal circumstances. It may, however, coexist with short-stay units governed by internal medicine departments (Emergency Medical Units, Medical Assessment and Planning Units, etc.) that focus upon more complex inpatient services. The different respon­sibilities (and governance) of each of these units need to be explicitly stated to avoid confusio n.
Australasian OWs target specific patient groups whose care may be augmented by early intensive workup and/or treatment that falls within the resources and skill set of Emergency Physicians (EPs). These include:
Undifferentiated presentations that may
benefit from serial examination and/or further
diagnostic studies;
Stable patients who require a brief period of
specific therapy prior to outpatient
management;
Vulnerable or socially disadvantaged patients who require additional supports in place prior to discharge.
Boarding inpatients are not a preferred category of OW patients and the use of the OW as a holding unit compromises the efficiency of the main department. For similar reasons, patients who clearly require admission for > 24 hours are unlikely to benefit from interim care in the OW and their presence reduces the functional capacity of the unit.
Minimum Requirements
A sustained improvement in patient flow out­comes is dependent upon several key features:
Geographical proximity to the Emergency Department, which provides all medical/
nursing/allied health personnel. This maintains the emphasis on regular review and early decision making with respect to disposition. Provision for optimal staffing is normally made in the main departmental roster, which ensures that personnel are competent to perform duties in all areas.
Admitting rights for specialist emergency physicians who retain clinical responsibility
and provide regular review. If the patient stays beyond the end of a staff specialists shift, case knowledge is handed over to ED -based house staff who maintain care on behalf of the admitting doctor.
Strict inclusion/exclusion criteria to identify suitable patients. Some departments are more
prescriptive than others in their approach to patient selection. As mentioned earlier, patients whose trajectory may be changed or improved by OW admission should be considered, while those with a high chance of eventual admission should be referred directly
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to inpatient services, particularly those requiring specialized beds.
Well-defined assessment/management plans with clear end-points. Further workup
should address a specific differential diagnosis and revolve around simple binary decision points. Management should be limited to a single clinical problem w ith clearly documented therapies and discharge criteria.
Priority access to diagnostic services such as pathology and medical imaging. Larger
departments typically have co-located radiology services and early reporting.
Priority referral to allied health services. Poor mobility and a need for social supports are significant predictors of failed discharge planning.
A nominal time limit (usually 24 hours) enforced by an unambiguous transfer policy.
Inpatient review on the wards traditionally occurs during once-daily rounds, meaning that the inpatient length of stay (IPLOS) tends to be measured in whole days once the patient leaves the ED. Not only does the OW offer an alternative pathway measured in hours, but it identifies and discharges diagnostic groups that are not funded for longer stays under activity-based business models.
Consistent management guidelines for the most common diagnostic groups, such as:
: Chest pain for investigation : Asthma : Renal colic : Overdose : Cellulitis : Pyelonephritis : Minor head injuries : Migraine, etc.
Impact of Observation Wards
In 2000 Williams et al.1reported on the ability of Australasian OWs to reduce total length of stay for certain diagnostic-related groups (DRGs) by reducing ward admissions (at the expense of a greater number of short-stay admissions). Since that time there have been few prospective inter­ventional trials examining the utility of Australian OWs. The implementation of OWs is frequently part of a greater structural and operational redesign that makes it difficult to control for confounders.
Local experience supports the commonly held international view that OWs may safely reduce LOS and inappropriate admissions, while increas­ing staff and patient satisfaction. Areas of uncer­tainty in the literature include the ideal size/ capacity of an OW and the overall financial bene­fit of observation medicine across a range of eco­nomic conditions.
Observation Medicine Culture
In order for any short-stay unit to improve the performance of a hospital, its beds must function as more than simply additional capacity – they must add something of value that is not available further along the patient journey. In this case, the advantage is discharge facilitation via front­loaded senior expertise. This opportunity is lost by passively allowing boarding inpatients to be heldin the OW, a practice that demonstrates a lack of understanding of hospital bed dynamics.
In addition to clinical support, the OW model of care requires the advocacy of emergency phys­icians, who can demonstrate the value of observa­tion medicine by way of example. A proactive approach to patient selection and early discharge will prevent the OW from becoming an easy target during times of economic hardship or bed shortage.
Case Study – Royal Brisbane and Womens Hospital
Royal Brisbane & Womens Hospital
Brisbane, Queensland.
Hospital
Bed capacity (no Pediatrics) Emergency admissions Average inpatient LOS
Total beds ~ 850 Acute overnight beds ~ 600 ~24,000
5.5 days
John Burke
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References
1. Williams A, Jelinek G, Rogers I, et al. The effect of establishment of an observation ward on hospital admission profiles. Med Journal Aust 2000; 173:411–414.
2. Ross M, Graff L.. Principles of observation medicine. Emerg Med Clin Nth Am 2001; 19(1) 1–17.
3. Williams, A. Emergency department observation wards. In: Cameron et al. (ed).
Textbook of Adult Emergency Medicine. 2nd ed. Churchill
Livingstone; 2004. pp. 710–712.
4. Cooke MW, Higgins J, Kidd P. Use of emergency observation and assessment wards: a systematic literature review. Emerg Med J 2003;20: 138–142.
5. Chan T, Arendts G, Stevens M. Variables that predict admission to hospital from an emergency department observation unit. Emerg Med Aust 2008; 20: 216–220.
6. Lucas BP, Kumapley R. A hospitalist-run short-stay unit: features that predict length-of-stay and eventual
admission to traditional inpatient services. J Hosp Med 2009; 4(5): 276–283.
7. Clinical Epidemiology & Health Service Evaluation Unit. Models of care to optimise acute length of stay – Short Stay/Observation Unit (SOU), Medical Assessment and Planning Unit (MAPU), Emergency Medical Unit (EMU). Available from www.royalmelbourne hospital.org/project-reports/ w1/i1017258/ (Accessed March
2016).
Emergency Department
Annual ED presentations (adult) 74,000
Admission rate 32%
ED capacity Resuscitation + Trauma bays: 7
Acute cubicles: 27 Fast-track bays: 5 + Physiotherapy
Observation Ward
Bed capacity 18 (unmonitored)
Staffing (0800–1800 hours) 5 nurses, 1 Registrar, 1 Staff Specialist
Admissions ED ~ 8000 per annum (LOS 10 hours)
Inpatient (boarding) ~ 500 per annum (LOS 23 hours)
Discharge rate (ED patients) 86%
Top 10 DRGs Chest pain (15%)
Abdominal pain Cellulitis Pyelonephritis Acute back pain
Headache Syncope Pharmaceutical overdose Asthma Renal colic
Chest pain pathway (protocol) ~ 1,000 intermediate risk patients (negative biomarkers and ECG)
0.2% admitted with positive markers at 6 hours 5% admitted with positive exercise stress test (EST)
Novel patient groups Post-aspiration of spontaneous pneumothorax
Snake bite* Decompression illness (hyperbaric unit)** Hospital in the Nursing Home*** (HINH)
LOS = length of stay * Snakebites that do not produce clinical or biochemical envenomation are observed in the OW during a 12-hour serial
assessment and treatment program. (See snakebite protocols in Chapters 84 and 85)
** The hyperbaric patients are managed by a visiting hyperbaric specialist who admits to the OW under a special arrangement
with the hospital.
*** HINH = Hospital in the Nursing Home is a locally developed hospital avoidance program that features a team of ED specialists
and registered nurses who liaise with local aged care facilities. Many presentations to the hospital ED can be avoided by way of nursing home visits, phone consultation, or brief ED assessment and OW management.
Australia
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Subpart VIC
Chapter
74
International – Australia/New Zealand
New Zealand
Michael Ardagh, ONZM, PhD, MbChB, DCH, FACEM
National Overview
In 2009 overcrowding of New Zealand (NZ) emergency departments (EDs) prompted the adoption of an ED length of stay (LOS) target. The Shorter Stays in Emergency Departments health target is one of six government health priorities and is defined as follows: 95% of patients will be admitted, discharged or trans­ferred from an ED within 6 hours of arrival. Admission, in this regard, includes admission to an ED observation unit (OU). Consequently the target has encouraged, among many other things, the development of observation units.
ED LOS targets have the potential for both good and bad consequences and an explicit part of pursuing the target in NZ has been to discour­age mere compliance and instead to encourage changes which result in genuine improvements in the quality of patient care.
1
To this end a government sponsored advisory group, composed mostly of Emergency Physicians and Emergency Nurses, published a document
2
intended to encourage the development of these units for the right reasons. Specifically it states:
ED Observation Units are valuable for reasons of efficiency, patient comfort and patient safety. They allow prolonged ED care in a more conducive environment (on a bed rather than a stretcher, with less light and noise than the main ED), and provide an alternative to either the admission of patients to inpatient wards or the discharge of patients when it may be unsafe or inappropriate to do so (e.g., elderly patients at night).
ThedocumentsuggestsEDOUsshould
allow a short period of observation, further treatment, or further investigation by ED staff;
be for patients who are perceived to be safe for discharge at the end of that period;
be for patients for whom there is usually no need, or an unlikely need, for input from inpatient staff/teams;
have a duration of stay of usually 6 to 8 hours, but up to a maximum of 24 hours.
It recommends that governance of an ED OU, including resourcing, clinical management, stand­ards, policies, and procedures, should be with the ED. It goes on to define the circumstances under which admission to an ED OU should allow stopping the clockfor the purposes of the Shorter Stays in the ED Health Target, emphasiz­ing that units should have dedicated staffing, patients in beds rather than trolleys, and be located in a dedicated space. Consequently, obser­vation medicine in NZ is not intended to be practiced in corridors or waiting rooms.
In early 2010 just over half of NZ EDs, includ­ing most of the busiest EDs, had an OU and others are planning them.
3
In 2011, there was a major earthquake in Christchurch, NZ so popula­tions changed and services were affected. We are now back to a reasonably stable state with services resurrected.
An Example
Christchurch Hospital serves a population of approximately 500,000 for secondary care and provides tertiary services for much of the popula­tion of the South Island of NZ. In 2010, the ED saw 72,000 presentations per annum. Currently, the ED sees in excess of 90,000 presentations per annum. It has approximately 40 treatment cubicles and 10 beds in a co-located OU. It is unable to divertto other local EDs, and historically has been prone to considerable peaks of demand and episodes of overcrowding.
Observation beds have been operational since 1995, and in their current form since 2008. Patients will be admitted to the unit under the following conditions, according to the guidelines for admission to the unit:
The patient has an 80 to 90% perceived chance
of discharge home from the observation unit.
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The patient will likely be ready for discharge within 8 hours of admission to the OU (although with the expectation that they will stay overnight if the 8 hours finishes late at night).
The patient will be under the care of ED doctors and is unlikely to need input from inpatient specialist teams.
The patient should have one of the following conditions (or some other condition consistent with the above criteria, at the discretion of the senior doctor on duty):
- Clinically stable drug overdose
- Clinically stable allergic reaction
- Minor head injury (GCS 14 or 15) without skull fracture or significant other injuries
- Acute alcohol intoxication with no other significant illness
- Social disposition problem
- Mild asthmatic promptly responsive to treatment
- Single seizures with full recove ry
- Hypoglycemia with full recovery
An increasing trend has been the overnight admis­sion of elderly after falls or other presentations not mandating hospital admission. An emergency physician does a round each morning and a multi­disciplinary team, consisting of social workers, physiotherapists and occupational therapists, helps facilitate discharge. A Psychiatric Emergency Ser­vice assesses relevant patients routinely in the
mornings or on call. A community-based acute demand” team, funded by the District Health Board to provide a number of admission avoid­ance/discharge facilitation services, often will assist with discharge arrangements.
Like most NZ OUs there is not a specific pathway for rule out acute coronary syndrome (ACS) in low-risk chest pain. This function tends to be undertaken in the ED itself, or after referral to Cardiology or Internal Medicine inpatient ser­vices. However, an accelerated pathway for rule out of ACS in low–risk patients is the subject of research
4
and the practice is likely to change in
the future.
In the calendar yea r of 2010 the Christchurch Hospital ED OU admitted 5,154 patients, with an average LOS of 7.3 hours (median of 6 hours) and a su bsequent a dmission rate to hospital of 15%. Common diagnostic groups included delib­erate self-poisoning, alcohol intoxication (often associated with assault or falls with head and /or facial injuries), elderly with falls or syncope (often associate d with soft tissue injury or minor fractures limiti ng mobility), minor head injur ies, gastroenteritis requiring intravenous rehydra­tion, renal colic, back pain, and constipation.
Summary
Observation medicine in NZ is active, but variable and evolving. Our challenge is to ensure that the growth of this service is guided by good reason.
References
1. Ardagh M. How to achieve
New Zealands shorter stays in emergency departments health targets. New Zealand Medical Journal. 11 June 2010, Vol. 123 No. 1316; ISSN 1175 8716 www.nzma.org.nz/journal/ 123–1316/4152/ (Accessed March 2016).
2. Streaming and the use of Emergency Department Observation Units and Inpatient Assessment Units.
www.hiirc.org.nz/page/18737/ guidance-statement-ed­obervation-and-inpatient/? tab=4179&contentType=451& section=9088
3. Ardagh M, Tonkin G, Possenniskie C. Improving acute patient flow and resolving emergency department overcrowding in New Zealand hospitalsthe major challenges and the promising initiatives. New Zealand Medical Journal.
14 October 2011, Vol. 124 No. 1344; ISSN 1175 8716
http://
journal.nzma.org.nz/journal/ 124–1344/4904/
4. Than M, Cullen L, Reid CM, et al. A 2-h diagnostic protocol to assess patients with chest pain symptoms in the Asia-Pacific region (ASPECT): a prospective observational validation study The Lancet. 26 March 2011, Vol. 377, No. 9771, Pages 1077–1084. DOI: 10.1016/S0140-6736(11) 60310-3.
New Zealand
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