Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5212_Библиотеки_им_академика_М_И_Перельмана.pdf
Скачиваний:
0
Добавлен:
31.08.2026
Размер:
31 Мб
Скачать
Clinical Guide toHeart Transplantation
JonKobashigawa
Editor
SecondEdition
123
Clinical Guide to Heart Transplantation
Jon Kobashigawa
Editor
Clinical Guide to Heart Transplantation
Second Edition
Editor
Jon Kobashigawa DSL/Thomas D. Gordon Professor of Medicine Director, Advanced Heart Disease Division Director, Heart Transplant Program Associate Director, Smidt Heart Institute Associate Director, Comprehensive Transplant Center Cedars-Sinai Medical Center, Los Angeles, CA, USA
ISBN 978-3-031-88289-0 ISBN 978-3-031-88290-6 (eBook)
https://doi.org/10.1007/978-3-031-88290-6
1st edition: © Springer International Publishing AG 2017 2nd edition: © The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer Nature Switzerland AG 2025
This work is subject to copyright. All rights are solely and exclusively licensed by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, expressed or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland
If disposing of this product, please recycle the paper.
This edition of Clinical Guide to Heart Transplantation is dedicated to the memory of our dear colleague and co-author, Jignesh Patel M.D. Ph.D.

Introduction

In the 8 years since the first edition of this Clinical Guide to Heart Transplantation was published, the field of cardiac transplantation has
evolved significantly. Innovations in donor procurement and preserva­tion are being deployed, including the use of donors who suffer circula­tory death, expanding the availability of hearts for patients who need them. New biomarkers and diagnostic tools are being leveraged to better assess risk and to calibrate monitoring and early intervention. New concepts in immunotherapy are being explored as we get closer to the goal of personal­ized medicine. The technology for both artificial and bio-engineered hearts is advancing at a previously unimagined pace and xenotransplantation as a viable therapeutic option is now within our reach. Machine learning is being used to power diagnostics, including the use of big data to improve pathol­ogy assessments by leveraging information at the molecular level. The advent of virtual visits, virtual crossmatching, and virtual reality have pro­pelled our field into a new era. Indeed, transplantation medicine remains a fertile frontier for translational research.
This 2nd Edition incorporates emerging science in the field and provides updates on evidence-based management strategies for patients both pre- and post-heart transplantation. This includes the unexpected and hard-earned knowledge of how to manage immunocompromised patients during a pan­demic, the management of sensitized patients awaiting heart transplantation, and the complexities of patients who require dual-organ transplantation.
Though the science, medicine, and practice of heart transplantation has entered a new and exciting phase, the art of heart transplantation remains the same. The art of caring for a patient, of listening to their story, of under­standing their goals and their fears, of shaping a course of treatment with them rather than for them, remains the hallmark of good medicine. “What is the right thing for this patient?” This is still the question that drives our work, even as we strive to break new ground and cross old barriers.
As practitioners in this field, we are charged with making critical deter­minations in the management of patients, donor organs, and the transplant process itself in order to achieve the greatest benefit in the utilization of a scarce resource, including the hard task of addressing equity and access. This handbook is designed to be a reference for those on the front lines. While this compilation of best practices cannot address the complexity of
vii
viii Introduction
the individual patients we care for on a daily basis, it is my hope that it will serve to help us ask the right questions, access the best evidence, and ulti­mately make the best decisions for the patients we are privileged to serve.
Los Angeles, USA October 2024
Jon Kobashigawa M.D.

Contents

Part I Advanced Heart Failure Treatments 1 Medical Therapy for Patients with End-Stage
Heart Failure ......................................... 3
Michele Hamilton and Yosef Manla
2 Mechanical and Surgical Options for Patients with End-
Stage Heart Failure .................................... 15
Robert M. Cole, Jaime D. Moriguchi, and Yosef Manla
3 Evaluation for Heart Transplant Candidacy ............... 27
Michele Hamilton and Yosef Manla
4 Potential Contraindications to Heart Transplantation ....... 33
Michelle M. Kittleson
Part II Pre-Heart Transplant Considerations 5 Listing Criteria and Optimization of the Pre-transplant
Patient ............................................... 53
Michelle M. Kittleson
6 Overview of Transplantation Immunobiology .............. 61
Xiaohai Zhang
7 The Sensitized Patient Awaiting Heart Transplantation ...... 75
Jignesh Patel and Krishan Patel
8 Donor Organ Procurement and Preservation ............... 93
Pedro Catarino
9 Surgical Considerations in Heart Transplantation .......... 101
Fardad Esmailian and Andrew Lin
Part III Post-Heart Transplant Patient Management
10 Physiology of the Transplanted Heart ..................... 111
Andriana P. Nikolova
ix
x Contents
11 Immediate Post-operative Management After Heart
Transplantation ....................................... 127
Evan Kransdorf, Lily Stern, and Yosef Manla
12 Maintenance Immunosuppression Strategies
in Heart Transplantation ............................... 139
Jignesh Patel and Krishan Patel
13 Induction Strategies in Heart Transplantation .............. 163
Lily Stern, Evan Kransdorf, and Yosef Manla
14 Minimization of Immunosuppression in Heart
Transplantation ....................................... 171
David H. Chang and Yosef Manla
15 Pre-transplant Screening and Post-transplant Infection
Prevention in Heart Transplant Recipients ................. 181
Jillian Oft and Phillip Zakowski
16 Managing Infections After Heart Transplantation .......... 189
Jillian Oft and Phillip Zakowski
17 COVID-19 Considerations in Heart Transplantation ........ 207
Yael Peled
18 Cardiac Allograft Rejection Surveillance .................. 227
David H. Chang and Yosef Manla
19 Cardiac Allograft Rejection Treatment .................... 237
David H. Chang and Yosef Manla
Part IV Long-Term Management of Heart Transplant
Recipients
20 Medical Adherence and Outcomes After Heart
Transplant ........................................... 253
Andriana P. Nikolova
21 Cardiac Allograft Vasculopathy .......................... 259
Lily Stern, Evan Kransdorf, and Yosef Manla
22 Long-Term Complications in Heart Transplantation ........ 271
Lily Stern, Evan Kransdorf, and Yosef Manla
Part V Special Considerations
23 Pediatric Cardiomyopathies ............................. 279
Juan C. Alejos and Majid Husain
24 Pediatric Heart Transplantation ......................... 287
Juan C. Alejos and Majid Husain
25 Adult Congenital Heart Disease—Special Considerations .... 309
Rose Tompkins
26 Combined Heart and Other Organ Transplants ............ 327
Jon Kobashigawa and Yosef Manla
27 Pregnancy in Heart Transplant Recipients ................. 341
Michelle M. Kittleson
Part VI The Future of Heart Transplantation
28 The Total Artificial Heart ............................... 365
Jaime D. Moriguchi
29 Xenotransplantation ................................... 377
Emily Newman, Indranee Rajapreyar, Yevgeniy Brailovsky, and Howard J. Eisen
Part VII Ethical Considerations In Heart Transplantation
30 Quality-of-Life After Heart Transplantation ............... 387
Jignesh Patel and Michelle M. Kittleson
31 Patient Selection in the Context of Organ Scarcity .......... 395
Jignesh Patel and Yael Peled
32 Diversity and Access in Heart Transplantation ............. 401
Andriana P. Nikolova
xiContents