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12.9 Preoperative Evaluation andImaging inAnal Fistula
191

12.8.1 Simple Fistula

A stula is simple when the tract is intersphinc­teric or low trans-sphincteric [17]. A stulotomy is the best surgical option since it affects only 30 percent of the external sphincter.

12.8.2 Complex Fistula

Any stula that is not simple is referred to as a complex stula. Following are the complex stulas:
• Any stula that involves over 30% of the external sphincter [17]
• Fistulas with multiple openings
• All recurrent stulas
• Anterior stulas in females
• Fistulas with pre-existing incontinence
• Inammatory bowel and Crohn’s-related stula
• Fistula secondary to radiation [17]
12.9 Preoperative Evaluation
andImaging inAnal Fistula
The objectives of preoperative imaging are:
stula classication. A surgeon must know the type of stula he is dealing with and its path.
Various imaging modalities available are:
• Fistulography
• Computerized Tomography
• Anal Endosonography
• MRI (Magnetic Resonance Imaging)
X-ray Fistulography and Computerized Tomography (CT) are not used because of the suboptimal visualization of stulas with a con­trast medium. X-ray Fistulography has the disad­vantage of missing the secondary tract, difculty in determining the course or location of the abscess with the sphincter complex, and dif­culty determining the level of internal opening due to lack of accurate markers [18]. A CT scan is insufcient for a thorough study of compara­tive stulous anatomy. Unless there is air or con­trast within, CT attenuation of the pelvic oor musculature and sphincter muscles is indistin­guishable from the stula [18].
The stula tract site and direction are referred to as the “anal clock”.
At 12 o’clock in lithotomy position, it is anterior, and at 6 o’clock, it is posterior or a natal cleft [1].
1. To evaluate the stula tract’s relation to the sphincters.
2. To nd secondary stulous tracts and abscesses.
A detailed digital rectal examination might help locate the tract in case of a simple anal s­tula. According to practicing parameters, a com­plex stula or a recurrent stula must be examined using radio-diagnostic procedures [18]. Imaging helps to identify the openings and formulates the

12.9.1 Anal Endosonography

The rectal wall, intersphincteric, and trans­sphincteric stulas and their association with anal sphincters may be seen by anal endosonog­raphy [18]. Endosonography, on the other hand, is inconvenient for assessing extrasphincteric and suprasphincteric tracts or secondary extensions due to the limited eld view. Secondly, they are operator-dependent, and the artifacts can some­times be misinterpreted as tracts [18].
192
12 Clinical Evaluation andClassication ofAnal Fistula
12.9.2 Magnetic Resonance Imaging
(Fig.12.14a–c)
a
EAS
IAS
b
c
12.9.2.1 Indications
• Noncryptoglandular abdominopelvic source
• Suspected supralevator abscess
• Persistent discharge post incision and drainage
• Multiple space abscess
• Horseshoe presentation
• Inability to perform physical examination of an abscess
12.9.2.2 Advantages
• Because of its multiplanar imaging and a great extent of soft-tissue distinction, it helps evalu­ate stula tracts and their specic course and underlying anatomy to plan a surgical proce­dure [19].
• It may be done with or without the use of a contrast medium.
• Complex and recurrent stulas can be cor­rectly identied up to 90% and 70%, respec­tively, using MRI [20].
• The capacity to detect hidden abscesses and secondary extensions to prevent recurrence after surgery [19].
• The potential to examine the anal sphincter complex from any surgically relevant perspec­tive [19].
• The ability to anticipate the risk of postopera­tive incontinence by dening the anatomic relationship of the stula [19].
Fig. 12.14 Magnetic resonance induction (MRI). (a) Normal external and internal anal sphincters as seen in MRI. (b) Intersphincteric stula with sagittal section. (c) With a 6 o’clock position axial section opening-trans­sphincteric stula
Sphincter complex, ischiorectal fossa, and
the levator plate may be seen clearly in unen­hanced T1 MRI scans. Pathologic processes like stulas, uid collections, and secondary tracts are exhibited clearly on T2 [1]. Fistula tracts, abscesses, and inammation present as low- to intermediate- intensity signal areas that are difcult to differentiate from normal tissues.
12.10 Dierential Diagnosis
193
The coronal and axial planes of anatomic MRI were related to the classication given by Park and the radiologists at St. James’s Hospital [19,
20].
12.9.2.3 Classication ofSt James’s
University Hospital
As per the Magnetic Resonance induction results and axial landmarks, the stulas have been graded as follows [1, 21]:
Grade I: Simple intersphincteric linear
tract.
Grade II: Abscess with an intersphincteric
tract.
Grade III: Trans-sphincteric tract.
Grade IV: Abscess associated with trans-
sphincteric tract.
Grade V: Supralevator extensions.
12.9.2.4 Ecacy Results
Detection of stulas using MRI has a specicity of 100% and a sensitivity of 97% [20]. One should always get an MRI done for patients pre­senting with complex stulas, which provides a precise, noninvasive, and rapid presurgical assessment.
Accurate diagnosis and thorough identica­tion of the internal as well as the external open­ings make the surgeon’s task easy, assisting him in mapping and planning the technique.
12.9.2.5 Can MRI BeDeceptive?
“It is not the machine that matters; it is the man behind the machine which matters.”
Sometimes reporting of MRI may be wrongly predictive, which does not correlate clinically, a limitation that I experienced in my practice. In three of my cases, the MRI suggested pilonidal sinus. Clinically the signs of pilonidal sinus were missing, and the internal opening was easily palpable. The age of the patients were more than 50years. I could easily diagnose them to be cases of stula-in-ano. During the surgical exploration, the tracts were present as described in the MRI, but the diagnosis mentioned in the MRI was inaccurate.
Similarly, Mahmoud e. Agha et al. reported false-positive diagnosis in ve of their patients [21]. Therefore, clinical correlation is necessary.
12.10 Dierential Diagnosis
Refer Table12.1.
Table 12.1 Differential stula diagnosis [22]
Infected Bartholin’s cyst Subcutaneous abscess Infected anal ssure Hidradenitis suppurativa Rectorectal vestigial cyst with stula formation Foreign body affected in the rectal wall Crohn’s disorder Infected pilonidal cyst Infections (actinomycosis, tuberculosis, gonococcal
infection, lymphogranuloma venereum) Progressive septic granulomatosis Anal colloid adenocarcinoma Diverge pathologies (prostatic abscess, osteomyelitis,
etc.) Lymphoma
194
12 Clinical Evaluation andClassication ofAnal Fistula

12.11 Evaluating Incontinence

Wexner’s score includes the frequency of soiling and allows for examining the three components of fecal incontinence (liquid, solid, and atus) [23]. The difculty in controlling the transit of the solid part of the stool is referred to as fecal incontinence. Anal incontinence, on the other hand, is the failure to manage the atus and the liquid part of the stool [23]. The primary reason for fecal incontinence may be rectal or sphincter dysfunctions or neurological disorders [24].

12.11.1 Wexner’s Score

It is essential to know the Wexner’s score before stula surgery (Table12.2).
• Never—0
• Rarely—<1/month
• Usually—<1/day1 per week
• Sometimes—1 per month; < 1 per week
• Always—1 per day
• 20—Complete incontinence
• Total score: 0—Perfect
Table 12.2 Wexner score
Frequency
Incontinence type Always Usually Sometimes Never Rarely
Liquid 4 3 2 1 0 Solid 4 3 2 1 0 Lifestyle
alteration Wears pad 4 3 2 1 0 Gas 4 3 2 1 0
4 3 2 1 0
Take-Home Message
Effective stula management requires proper clinical evaluation, including a thorough history and a careful clinical assessment. The purpose of clinical assessment remains twofold: rst, to identify the openings and the tract, and second, to assess the type of stula. Proper classication is mandatory before taking the patient for stula surgery. The amount of sphincter left behind is always more crucial than the amount that will be divided [25]. Imaging is essential when a patient has an intersphincteric abscess, uctuant or sup­purative drainage, multiple space abscesses, a poorly drained or nonresolving infection, or complex stulas. As crucial as anatomy is, understanding pathogenesis is signicant in the detailed mapping of anal stulas. Without proper anatomical markers, it is hard to do s­tula surgery, which may lead to recurrence or incontinence.

References

1. Morris J, Spencer JA, Ambrose NS. MR imag­ing classication of perianal stulas and its impli­cations for patient management. Radiographics. 2000;20(3):623–35.
2. Jimenez M, Mandava N. Anorectal stula. In: Stat Pearls. Treasure Island, FL: Stat Pearls Publishing;
2021.
3. Lunniss PJ. Aspects of stula-in-ano. London: University of London, University College London;
1994.
4. Sigmon DF, Emmanuel B, Tuma F.Perianal Abscess. In: Stat Pearls. Treasure Island, FL: Stat Pearls Publishing; 2021.
5. Murad-Regadas SM, Dealcanfreitas ID, Oliveira MTCCD, Pessoa Morano D, Regadas FSP, Rodrigues LV, Regadas Filho FSP.Anatomical characteristics of
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anal stula evaluated by three-dimensional anorectal ultrasonography: is there a correlation with Goodsall’s theory? J Coloproctol. 2015;35:8389.
6. Hebra A.What is the Goodsall rule for the manage­ment of stulas in the treatment of anorectal abscess? July 24, 2020. https://emedicine.medscape.com/
article/191975-treatment#d9.
7. Cuiñas K, Williams JP.TU-196 Goodsall’s rule—past its sell-by date? Gut. 2015;64:A149.
8. Cirocco WC, Reilly JC. Challenging the predic­tive accuracy of Goodsall’s rule for anal stulas. Dis Colon Rectum. 1992;35(6):537–42. https://doi.
org/10.1007/BF02050532.
9. Kartzer GL, Dockerty MB.Histopathology of the anal ducts. Surg Gynecol Obstet. 1947;84:333–8.
10. Parks AG, Gordon PH, Hardcastle JD.A classication of stula-in-ano. Br J Surg. 1976;63(1):1–12. https://
doi.org/10.1002/bjs.1800630102.
11. Parks AG. Pathogenesis and treatment of stula-in­ano. Br Med J. 1961;1(5224):463.
12. Abcarian H.Classication and management strategies. In: Anal stula. NewYork: Springer; 2014. p.39–44.
https://doi.org/10.1007/978- 1- 4614- 9014- 2_5.
13. Eisenhammer S.The nal evaluation and classication of the surgical treatment of the primary anorectal cryp­toglandular intermuscular (inter-sphincteric) stulous abscess and stula. Dis Colon Rectum. 1978;21(4):237–
54. https://doi.org/10.1007/BF02586698.
14. Shawki S, Wexner SD. Idiopathic stula-in-ano. World J Gastroenterol. 2011;17(28):3277–85. https://
doi.org/10.3748/wjg.v17.i28.3277.
15. Goligher JC, Ellis M, Pissidis AG.A critique of anal glandular infection in the etiology and treatment of idiopathic anorectal abscesses and stulas. Br J Surg. 1967;54(12):977–83. https://doi.org/10.1002/
bjs.1800541202.
16. Frenkel J. Fistula-in-ano: a new classication sys­tem for perirectal stulas. Dis Colon Rectum. 2002;45(4):A25–8.
17. Steele SR, Kumar R, Feingold DL, Rafferty JL, Buie WD, Standards Practice Task Force of the American Society of Colon and Rectal Surgeons. Practice parameters for the management of peri­anal abscess and stula-in-ano. Dis Colon Rectum. 2011;54(12):1465–74.
18. Sharma A, Yadav P, Sahu M, et al. Current imaging techniques for evaluation of stula in ano: a review. Egypt J Radiol Nucl Med. 2020;51:130.
19. de Miguel CJ, del Salto LG, Rivas PF, del Hoyo LF, Velasco LG, de las Vacas MI, Marco Sanz AG, Paradela MM, Moreno EF. MR imaging evaluation of perianal stulas: spectrum of imaging features. Radiographics. 2012;32(1):175–94. https://doi.
org/10.1148/rg.321115040.
20. Buchanan G, Halligan S, Bartram CL, etal. Clinical examination, endosonography, and MR imaging in preoperative assessment of stula in ano. Radiology. 2004;233(30):674–81.
21. Agha ME, Eid M, Mansy H, Matarawy K, Wally M. Preoperative MRI of perianal stula: is it really indispensable? Can it be deceptive? Alexandria J Med. 2013;49(2):133–44.
22. Lo BM. Anal stulas, and ssures differen­tial diagnoses. https://emedicine.medscape.com/
article/776150- differential.
23. Baxter NN, Rothenberger DA, Lowry AC.Measuring fecal incontinence. Dis Colon Rectum. 2003;46(12):1591–605.
24. Jorge JM, Wexner SD. Etiology and manage­ment of fecal incontinence. Dis Colon Rectum. 1993;36(1):77–97.
25. Abcarian H. Clinical assessment of anal s­tula. In: Principles and management. New York: Springer; 2014. p. 27–30. https://doi.
org/10.1007/978- 1- 4614- 9014- 2_5.
Fistulotomy: Still aGold Standard!
13
“Too aggressive stulotomy results in incontinence, too timid stulotomy renders stula to persist.”
Herand Abcarian
Key Concepts
• Fistula surgery aims to cure the stula with minimal complications and recurrence.
• Fistulotomy is still a gold standard for simple stula tracts.
• Fistulotomy means laying open the tract.
• A stulectomy is a surgical intervention that removes the entire stulous tract.
• Fistulotomy combined with primary sphincter repair can be used in selected patients with good results.

13.1 Introduction

The expertise and preference of the surgeon are deciding elements in stula management. The options available are stulotomy, stulectomy, or seton placement. Minimally invasive procedures have become popular recently, including stula plugs, brin glue, LIFT, VAAFT, stem cells, and lasers.
Mention of the stula disease and its manage-
ment can be noticed in the work of Hippocrates, dated 400BC, in which he described stulotomy and the use of horsehair wrapped in lint threads as a cutting seton [1]. The basis of the “lay open tech­nique” was laid by John of Aderene in his descrip­tions of stula treatment in the fteenth century [2].
An anorectal fistula can be simple or com­plex, and fistulotomy may be performed safely for “simple” tracts, including low trans­sphincteric or intersphincteric fistulas [3]. However, for “simple” fistulas, a fistulotomy may cause anal incontinence in about 12% of cases [3].

13.2 Fistulotomy

The fistula tract is opened between the distal external anal sphincter (EAS) and the lower half of the internal anal sphincter (IAS). Only the superficial and subcutaneous portions of the external anal sphincter are divided. As a rule, the deep segment of the external anal sphincter forming an anorectal ring with puborectalis is never divided. Marsupialization of the edges of the fistulotomy can also be done to decrease the size of the wound and maintain hemostasis.

13.2.1 Principle

Fistulotomy is a surgical technique in which a s­tula is cut open and allowed to heal by secondary intention.
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2022 K. Gupta, Lasers in Proctology, https://doi.org/10.1007/978-981-19-5825-0_13
197
198
13 Fistulotomy: Still aGold Standard!
The aim and objectives are to manage the internal opening of the stula tracts. There are two ways to tackle it:
Park’s Technique: The internal opening is
removed by excising the mucosa, submu-
cosa, surrounding tissue, and bers of the
internal anal sphincter reaching the deep
intersphincteric area. An oval incision is
given starting 5mm above the internal open-
ing and carried downwards up to the anal
verge [4].
Eisenhammer’s Technique: The alternative
is to open the tract, curette, and scoop the
primary infected source in the intersphincteric
space [5].
Table 13.1 Intersphincteric stula management—at a glance
Sphincter involvement and amount
Type of intersphincteric stula A1—Simple intersphincteric
stula A2—Intersphincteric stula with
high blind tract A3—Intersphincteric stula with
an opening in the lower rectum A4—High intersphincteric stula
without perineal opening
A5—High intersphincteric stula with pelvic extension
A6—Intersphincteric stula extending from pelvic disease
of sphincter to be cut Outcome and alternatives Only the lower half of IAS No risk of incontinence
The whole IAS can be divided to lay open the tract
The whole IAS can be divided to lay open the tract
The tract can be laid open by dividing IAS
Such stulas should be drained into the rectum A suprasphincteric stula may occur if the ischiorectal fossa is drained
Manage pelvic disease The stula will heal after eradicating the

13.2.2 Indications

• Simple anal stulas involving up to 50% of the external anal sphincter
• A low-lying stula with an abscess (Primary stulotomy)

13.2.3 Contraindications

• Complex stulas
Based on Park’s classication, a stepwise sur-
gical approach to different types of stulas has been discussed. The alternative approach using laser is shown in Tables13.1, 13.2 and 13.3.
No risk of incontinence A hybrid procedure is a better approach
No risk of incontinence A hybrid procedure is a better approach
No risk of incontinence Transanal opening of intersphincteric space with stulotomy at 6 o’clock is done A hybrid procedure is a better approach
No risk of incontinence Transanal opening of intersphincteric space with stulotomy at 6 o’clock is done A hybrid procedure is a better approach
pelvic disease
Table 13.2 Trans-sphincteric stula management—at a glance
Type of trans- sphincteric stula
B1—Uncomplicated The supercial and subcutaneous parts of
B2—Trans- sphincteric
stula with a high blind tract
Table 13.3 Suprasphincteric stula
Type of stula Suprasphincteric stula Avoid sphincter cutting procedures The laser procedure or seton is a
Sphincter involvement and amount of sphincter cut Outcome and alternatives
Little disturbance in continence
EAS and the lower part of IAS are divided Fistulotomy up to the supercial part of
EAS.The upper extension will heal on its own. Always prefer a transanal approach
Sphincter involvement and amount of sphincter cut Outcome and alternatives
Primary sphincter repair can be carried out The laser procedure is a better option
better option
Conjoined longitudinal muscl
tract from inter
Conjoined longitudinal muscle
13.3 Management ofIntersphincteric Fistula
199
13.3 Management ofIntersphincteric Fistula
The surgical approach depends on the type of “intersphincteric tract.”
a
e
External anal sphincter

13.3.1 Simple Intersphincteric Fistula (A1)

When stulotomy is performed, just the lower­most internal anal sphincter is cut (Fig.13.1a, b). Therefore continence is preserved.
Internal opening
Dentate line
Internal anal sphincter
Inter - sphincteric tract
b
Fistulotomy for Inter - sphincteric
Fig. 13.1 (a) Simple intersphincteric stula. (b) Simple intersphincteric stula showing stulotomy
nal to external opeing
External anal sphincter
Excision of internal opeing
Dentate line
Internal anal sphincter
200
Excision of internal opening
Curetting of upward extensio
High blind inter - sphincteri
13 Fistulotomy: Still aGold Standard!
13.3.2 Intersphincteric Fistula
The entire internal sphincter may be divided with minimal compromise to continence (Fig.13.2a, b).
withHigh Blind Tract (A2)
a
c
extension
Inter - sphincteric tract
As the upward extension is secondary to the pri­mary source of infection, it will heal once the pri­mary source is dealt with.
Internal opening
Dentate line
Internal anal sphincter
b
Opening of inter - sphincteric
External anal sphincter
Anorectal ring
n
tract upto anorectal ring
Dentate line
Internal anal sphincter
External anal sphincter
Fig. 13.2 (a) Intersphincteric stula with high blind tract. (b) Fistulotomy including the opening of intersphincteric space
High extension opening
Opening of inter - sphincteric
Excision of internal opening
13.3 Management ofIntersphincteric Fistula
201
13.3.3 Intersphincteric Fistula
As in the A2 type, the tract is intersphincteric, and the entire internal sphincter can be divided with minimal risk of incontinence (Fig.13.3a, b).
withanOpening intheLower Rectum (A3)
a
into the rectum
Inter - sphincteric tract
13.3.4 High Intersphincteric Fistula Without anExternal Opening(A4)
The primary source of infection lies below the internal opening in the deep intersphincteric space. A transanal approach is considered for the manage-
Internal opening
Dentate line
External anal sphincter
b
Curetting of the tract
tract upto anorectal ring
External anal sphincter
Internal anal sphincter
Anorectal ring
Dentate line
Internal anal sphincter
Fig. 13.3 (a) Intersphincteric stula with upward extension opening in the lower rectum. (b) Fistulotomy with excision of internal opening and opening of intersphincteric space up to anorectal ring