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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5524_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Table of Contents
- •Dedication
- •Foreword
- •Contributing Authors
- •Balancing limited resources and care of the individual patient
- •Reducing waste in the ICU
- •Practical Algorithms/Diagram
- •I: Background
- •1. Critical Care Responsibility in Healthcare Reform
- •Take Home Points
- •Background
- •Main Body
- •Review of Current Literature with References
- •2. Initial Approach to the Trauma Patient
- •Take Home Points
- •Background
- •Main Body
- •Review of Current Literature with References
- •3. Systems-based Approach to the Critically Ill Surgical Patient
- •Take Home Points
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •II: System-Based Management
- •4. Central Nervous System
- •Take Home Points
- •Background
- •Main Body
- •Take Home Points
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagram
- •Review of Current Literature with References
- •5. Cardiovascular
- •Take Home Points
- •Background
- •Main Body
- •Cellular metabolism
- •Assessment of cellular metabolism
- •Oxygen delivery
- •Assessment of Oxygen Content
- •Assessment of CO
- •Assessing oxygen balance and cellular metabolism
- •Assessments of VO2
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Recognition of shock
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Resuscitation strategies
- •Resuscitation markers
- •Practical Algorithm(s) /Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Cardiac support
- •Vasoconstrictors
- •Vasodilators and sympathetic antagonists
- •Practical Algorithm(s)/ Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •The conduction system of the heart
- •Cardiac electrophysiology and understanding the electrocardiogram
- •Main Body
- •Arrhythmia in the postoperative period
- •The evaluation of a patient with an arrhythmia
- •Bradyarrhythmias
- •Tachyarrhythmias
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Treatment of acute coronary syndrome
- •Background
- •Main Body
- •Defining the acute coronary syndromes
- •Evaluation of a patient with a suspected acute coronary syndrome
- •Early diagnostic measures
- •Cardiac imaging
- •Definitive therapy for ACS
- •Sequelae of myocardial infarction
- •Post-myocardial infarction hospital care
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •6. Respiratory
- •Take Home Points
- •Background
- •Main Body
- •ICU patient/physiology
- •Airway equipment/management
- •Extubation
- •Practical Algorithm(s)/ Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •I. Common indications for ABG:
- •II. ABG interpretation
- •III. Common causes of acid base disturbances in the ICU
- •IV. Sample ABG analyses
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Initiation of ventilation: modes of ventilation and phase variables
- •Positive-end expiratory pressure
- •Ventilator asynchrony
- •Acute hypoxic events during mechanical ventilation
- •Practical Algorithm(s)/ Diagrams
- •Take Home Points
- •Background
- •Main Body
- •Predicting the need for prolonged mechanical ventilation early
- •Transitioning the work of breathing to the patient
- •Determining successful transitioning
- •The myth of “minimal ventilator settings”
- •Extubation
- •The difficult to wean patient
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Complex pleural effusion/empyema
- •Hemothorax
- •Mediastinitis
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •7. Renal
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s) / Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Definition
- •Causes of oliguria
- •Work-up of oliguria
- •Initial management of oliguria
- •Commonly used medications associated with renal injury (not a comprehensive list)
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Key concepts of RRT
- •Hemodialysis versus hemofiltration: Mechanisms
- •Indications for CRRT and clinical considerations
- •Dosing
- •Practical Algorithm(s) / Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Literature
- •Take Home Points
- •Background
- •Main Body
- •Pathology
- •Diagnosis
- •Treatment
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •8. Gastrointestinal
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •History
- •Controversial issues
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s) / Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s) / Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s) / Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s) / Diagrams
- •Review of Current Literature with References
- •9. Hematology
- •Take Home Points
- •Background
- •Main Body
- •Theoretical basis for pRBCs transfusion
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •10. Infectious Disease
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background
- •Main Body
- •Practical Algorithm(s)/Diagrams
- •Review of Current Literature with References
- •Take Home Points
- •Background

218 J. Haenel
{ Based on the breath types and phases used to initiate a ventilator breath
conventional ventilators today offer only five basic breath types:
Volume-Controlled: time-triggered, flow-targeted and volume-cycled
Volume-Assisted: effort-triggered, flow-targeted and volume cycled
Pressure-Controlled: time-triggered, pressure-targeted and time-cycled
Pressure-Assisted: effort-triggered, pressure-targeted and time-cycled
Pressure-Support: effort-triggered, pressure-targeted and flow-cycled
{ Once the mode, breath type, respiratory rate and FIO
are selected then
2
the clinician will then set a peak inspiratory flow rate in liters/minute in
Volume-Control or a % inspiratory time in seconds or fraction thereof in
Pressure-Control.
Fundamentally, the peak flow setting (in L/M) is what fine tunes the
I:E ratio. In volume ventilation, the I:E ratio is generated by a combination of the Vt, RR and peak inspiratory flow setting. The flow wave
selection (generally either a square wave or decelerating waveform)
will also impact the I:E ratio.
The peak inspiratory flow rate delivered in the volume modes is a
fixed or flow-targeted setting. This means that if the patients demand
for ventilation increases for any reason and the RR increases then the
I:E ratio will decrease. Conversely, with pressure-targeted breaths, the
flow will adjust to maintain the pressure target. An inadequate delivered flow of gas is a common reason for ventilator asynchrony and
must be addressed.
Positive-end expiratory pressure
• As discussed above the mode selection and manipulation of phase variables
all deal with manipulation of inspiration. Conversely PEEP is the management of end-expiratory pressure above atmospheric pressure. There are two
primary indications for PEEP:
{ To recruit lung volume and attempt to return the functional residual capac-
ity (FRC) towards normal and thus improve or reverse hypoxemia.
{ To reduce or minimize the inspiratory work of breathing associated with
severe acute restrictive lung disease or that associated with dynamic
hyperinflation and Auto-PEEP.
By recruiting and stabilizing collapsed small airways and alveoli
PEEP may increase the respiratory system compliance and thus the FRC, and

Mechanical Ventilation 219
therefore mitigate the effects of intrapulmonary shunting associated with acute
lung injury.
{ Much controversy still exists regarding how to select the optimal PEEP/
FIO2 levels. Whether PEEP should be titrated to optimize compliance,
minimize the intrapulmonary shunt fraction, prevent dorsal alveolar collapse from hydrostatic imposed pressures or minimize ventilator induced
lung injury from atelectatrauma or stretch induced over-inflation from
high tidal volumes remains to be determined.
• Setting Positive End Expiratory Pressure
{ First and foremost, there is no compelling evidence for a low versus high
PEEP setting nor is there strong evidence that performance of pressurevolume curves used to identify the lower or upper inflection points is
necessary to optimize an individual PEEP setting.
The vast majority of patients have been satisfactorily managed with PEEP
values of 5–15 cm H
{ The ARDS Network titration table for determining PEEP/FIO
2
O.
has been
2
available for over a decade and has performed well in thousands of
patients enrolled in various ARDS Network trials.
{ Arguments against the PEEP/FIO
titration table are that it is “cook book”
2
and that not all ARDS are the same. ARDS may be classified as either
Pulmonary ARDS or Extrapulmonary ARDS. It has been noted that the
main difference between the two types of ARDS is that chest wall
compliance is normal in Pulmonary ARDS but significantly lower in
Extrapulmonary ARDS thus the response to PEEP may be dramatically
different.
{ To account for the differences in types of ARDS as well as different
patient’s body habitus, potential for mixed obstructive defects complicating the acute restrictive defects an individual approach may be needed.
{ Recruitment maneuver(s) to identify optimal PEEP:
Use Pressure-control mode
Set RR to 10/min
Adjust I”E ratio to 1:1
Set peak inspiratory pressure to 20 cm H
O
2
Increase baseline PEEP to 20–40 cm H2O for 1–2 minutes
• Generally, recruitment maneuvers are used in response to a patient who has
experienced a sudden decline in oxygenation while on their baseline ventilator settings. Recruitments should be performed while closely monitoring the

220 J. Haenel
patient’s hemodynamic response. It is not unusual to see a decrease in blood
pressure or even saturation during the maneuver. Changes greater than 20%
may require stopping the maneuver. Certainly any decrease in heart rate
necessitates immediate discontinuation. The recruitment maneuver should be
repeated in response to new or continued desaturation events and the baseline
PEEP increased by 2.5–5.0 cm H2O following each recruitment until
oxygenation has improved or there is no further positive response.
{ Adverse effects of PEEP
Elevation of PEEP levels will necessarily increase both end-inspiratory
as well as the mean airway pressures. The potential exists for a fall in
cardiac output as a result of decreased venous return to the right side of
the heart. In lieu of a decrease in cardiac function, any increase in PaO2
will be negated based on the principal of oxygen delivery (DO
= CaO2
2
[Hb × 1.36 × SPO2]). Strong consideration of monitoring cardiac output should be made when PEEP levels > 15 cm H2O are used. Also, any
unexplained tachycardia or the need for inotropic agents would suggest
the need for monitoring of cardiac output.
Ventilator asynchrony
Ventilator synchrony requires a perfect matching of the patient’s inspiratory effort
to be in concert with the ventilators ability to provide both flow and pressure.
There are three crucial periods where this relationship between patient and
ventilator may become uncoupled: during triggering, flow delivery or at breath
termination. Failure of the ventilator to respond at the appointed time may result
in the patient experiencing excessive muscle loads, compromised alveolar ventilation, ventilator induced injury or excessive periods of dyspnea resulting in use
of excess sedation. Evidence for asynchrony includes new respiratory distress,
diaphoresis, tachycardia and anxiety.
• Types of Asynchronies
During trigger phase
{ Ineffective triggering — missed triggers
Auto-PEEP
{ Autocycling
{ Double triggering
{ Triggering delay

Mechanical Ventilation 221
During flow delivery phase
{ Inadequate set peak flow in volume mode
{ Excessive set peak flow/excessive I:E ratios
During cycling phase
{ Increased neural inspiratory demand
{ Prolonged machine inspiratory time
Ventilator asynchrony has been reported to occur in upwards to 25%
of patients receiving positive pressure ventilation. Interestingly, the
adverse effects of patient-ventilator asynchrony remain unknown in
terms of duration of ventilator days or increase length of weaning
times.
{ Approach to management of Ventilator Asynchrony
During breath triggering
Delayed or miss triggers are common in the presence of Auto-PEEP. First
and foremost, treat Auto-PEEP. Try adding set PEEP to offset Auto-PEEP.
Change from pressure trigger to flow trigger.
Autocycling occurs when sensitivity is set inappropriately low i.e. “Hair
Trigger.” Decrease sensitivity. Extra triggers may be caused by chest tube negative pressure in setting of a bronchopleural fistula (BPF) and will respond to
decreasing pressure trigger sensitivity. To and fro motion from excessive water
in vent circuits is not uncommon and easily addressed. Cardiac oscillations may
occur in the hyperdynamic heart when sensitivity is overly low.
{ During flow delivery
Increase set peak inspiratory flow until patient appears comfortable (in
volume modes).
Switch from volume mode to pressure mode for variable flow rates.
If plateau pressures are not excessive, increase set tidal volume.
Decrease flow or pressure if patient is actively making expiratory efforts to
terminate breath.
{ During cycling phase
If secondary to altered neural inspiratory times are greater than machine
inspiratory times, then lengthening of cycle criteria may help (volume, time,
flow).
If secondary to prolonged machine inspiratory time compared to neural inspiratory time, then decreasing cycle variables may result in a better
match.

222 J. Haenel
Acute hypoxic events during mechanical ventilation
Nothing is more stressful for the patient’s cardiopulmonary and neurologic
system, not to mention the stress put on the responsible bedside staff, than having
to respond to a serious life-threatening acute hypoxic event. Acute hypoxemia is
a frequent ICU event and has been reported to occur in up to 25% of patients
receiving mechanical ventilation, that is 1 out of every 4! As a result, it is incumbent upon all critical care personnel to be capable of an immediate and cogent
response to identify and reverse this potentially life-threatening situation.
Over two decades ago, we developed a bedside algorithm that specifically
addresses both the immediate response required to address life-threatening
hypoxemia in the ventilated patient as well as the steps to identify the primary
etiologic cause. See Fig.1.
The algorithm is divided into a primary and secondary survey. The thought
behind this was that immediate threats to life must be identified and managed
within minutes. Once an acute hypoxic event is identified, the patient should
instantly be hand ventilated with a high flow manual resuscitator (> 20 L/M of O
flow). The goal is to identify an airway occlusion that must be reversed immediately. Difficult bagging is suggestive and further addressed by passage of a
section catheter. Inability to pass the catheter pin points to the problem which
must be rectified without delay. Artificial airway leaks while problematic can
usually be troubled-shot by an experienced therapist, thereby preventing unnecessary reintubation. Clearly, if the patient responds to bagging with an increase in
oxygen saturation then attention should be turned to the ventilator looking for
circuit or settings that are inappropriate. Once the airway is eliminated as a
primary concern (this should take < 60 seconds) and the patient remains unstable,
tension pneumothorax must be considered. When in doubt and in the face of lifethreatening hypoxemia, the chest should be vent prior to obtaining a chest X-ray.
Once oxygenation has stabilized but the etiology remains unclear, performance of
the secondary survey should commence. Clearly, a recent intervention i.e. new
medication, transport etc. may have been responsible. Likewise, complications
from procedures must be recognized as well as the possibility for progression of
the underlying disease process. A common mistake is to attribute an acute hypoxic
event to a pulmonary embolism when a portable chest X-ray reveals a new infiltrative or collapse. The last place you want to be is in a dark, cold radiology room
at two in the morning with a hypoxic patient who more likely has a much more
common problem like mucous plugging or atelectasis!
2

Mechanical Ventilation 223
Practical Algorithm(s)/ Diagrams
Fig. 1. Algorithm for initial management of acute hypoxic events.

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Chapter 6-(iv)
Liberation from Mechanical Ventilation
Fredric M. Pieracci, MD* James Haenel, RRT †
and Michael Sawyer, MD
*Acute Care Surgeon, Denver Health Medical Center
†
Surgical Critical Care Specialist, Denver Health Medical Center
‡
Associate Professor of Anaesthesia, University of Colorado School of Medicine
‡
Take Home Points
• Mechanical ventilation is hazardous to all organ systems and the appropriateness
for liberation from it should be assessed at least daily.
• The term “ weaning from the ventilator” refers to a gradual increase in
patient work of breathing after a prolonged (days to weeks) period of
mechanical ventilation that has resulted in both gas exchange and respiratory
muscle embarrassment. This clinical scenario applies only to the minority of
critically ill surgical patients. Rather, most surgical ICU patients may be
rapidly liberated from mechanical ventilation without a prolonged wean.
Therefore, the term “liberation from mechanical ventilation” is preferred to
“weaning.”
Contact information: Denver Health Medical Center, 777 Bannock Street, MC 0206, A388,
Denver, CO 80206; Email: Fredric.pieracci@dhha.org; James.Haenel@dhha.org; Michael.
Sawyer@dhha.org
225

226 F. M. Pieracci, J. Haenel and M. Sawyer
• The surgical intensivist must distinguish appropriateness for ventilator libera-
tion from appropriateness for extubation. The former refers specifically to the
contribution of the ventilator to work of breathing. The latter includes more
general issues such as mental status and upper airway patency.
• Certain predisposing factors and injury patterns can predict early the need for
prolonged ventilator support via tracheostomy.
• General contraindications to transitioning a patient from a full support mode
of ventilation (e.g., assist control) to a partial support mode (e.g., pressure
support ventilation) include any condition that significantly either depresses
or elevates minute ventilation. Recent neuromuscular paralysis is a common
example of the former; shock is a common example of the latter.
• Appropriateness for extubation may be assessed using the pneumonic
“SOAP”
{ Secretions
{ Oxygenation
{ Airway/Alertness
{ Parameters
• The most studied and useful parameter for predicting successful extubation
is the rapid shallow breathing index (RSBI, A.K.A. the Toben Index), defined
as the respiratory rate divided by the spontaneous tidal volume (L). Assuming
all other aspects of the SOAP pneumonic are favorable, a RSBI < 100 suggests
a high likelihood of successful extubation.
• Most patients who fail extubation do so within the first hour. Be ready to
emergently re-intubate your patient before you extubate them. Identify potentially difficult airways [Chapter 6-(i)] prior to extubation and muster the
appropriate resources.
• If you are unsure whether your patient needs to be re-intubated, then your
patient probably needs to be re-intubated. You will regret a missed opportunity to re-intubate far more than a potentially unnecessary re-intubation.
Background
• Mechanical ventilation is a necessary evil. Although it is life-saving for
patients with respiratory failure, it is fraught with complications, including
atelectasis, baro and volutrauma, pneumonia, respiratory muscle atrophy,
agitation, and delirium.
• Surgical ICU patients differ from medical ICU patients in several ways that
are pertinent to liberation from mechanical ventilation. In general, surgical

Liberation from Mechanical Ventilation 227
ICU patients are younger, more likely to have a rapidly reversible pathology,
and less likely to have chronic pulmonary disease. These conditions combine
to make rapid liberation from mechanical ventilation more appropriate for the
surgical, as compared to the medical ICU patient.
• Normal minute ventilation (V
) is 6–10 L/min; multiple pathologies may be
e
operating to either decrease or increase Ve in the surgical ICU patient.
Main Body
Predicting the need for prolonged mechanical ventilation early
• Early and safe extubation should be the goal for every ventilated patient.
• However, certain factors increase significantly the likelihood that a patient
will require prolonged mechanical ventilation, and thus inform the decision to
perform a trachesotomy early in the patient’s course (Chapter 19). This strategy will allow the patient early exposure to the benefits of trachesotomy,
including:
{ Ability to minimize both analgesic and sedative infusions
{ Improved pulmonary toilet
{ Improved comfort
{ Improved communication with the patient
{ Decreased risk of inadvertant extubation
{ Decreased airway resistance
{ Possible decreased risk of VAP
• These risk factors may be divided into two categories: (1) pre-existing conditions
and (2) injury patterns.
{ Injury patterns
Severe traumatic brain injury
Severe facial fractures
Laryngotracheal trauma
{ Pre-existing conditions:
Age > 70 years
Psychiatric illness
Substance abuse, particularly alcohol abuse
Chronic obstructive pulmonary disease
Morbid obesity
Prior need for trachestomy
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