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480
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R. R. Colon et al.
References
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2. Carty MJ, Bueno EM, Lehmann LS, Pomahac B.A position paper in support of face transplantation in the blind. Plast Reconstr Surg. 2012;130(2):319–24.
3. Hendrickx H, Blondeel PN, Van Parys H, Roche NA, Peeters PC, Vermeersch HF, etal. Facing
a new face: an interpretative phenomenological analysis of the experiences of a blind face
transplant patient and his partner. J Craniofac Surg. 2018;29(4):826–31.
4. Lemmens GM, Poppe C, Hendrickx H, Roche NA, Peeters PC, Vermeersch HF, etal. Facial
transplantation in a blind patient: psychologic, marital, and family outcomes at 15 months
follow-up. Psychosomatics. 2015;56(4):362–70.
5. Kantar RS, Alfonso AR, Diep GK, Berman ZP, Rifkin WJ, Diaz-Siso JR, etal. Facial transplantation: principles and evolving concepts. Plast Reconstr Surg. 2021;147(6):1022e–38e.
6. Petruzzo P, Kanitakis J, Testelin S, Pialat JB, Buron F, Badet L, etal. Clinicopathological
ndings of chronic rejection in a face grafted patient. Transplantation. 2015;99(12):2644–50.
7. Rifkin WJ, David JA, Plana NM, Kantar RS, Diaz-Siso JR, Gelb BE, etal. Achievements and
challenges in facial transplantation. Ann Surg. 2018;268(2):260–70.
8. Kollar B, Pomahac B, Riella LV. Novel immunological and clinical insights in vascularized
composite allotransplantation. Curr Opin Organ Transplant. 2019;24(1):42–8.
9. Rifkin WJ, Manjunath AK, Kantar RS, Jacoby A, Kimberly LL, Gelb BE, etal. A comparison of immunosuppression regimens in hand, face, and kidney transplantation. J Surg Res.
2021;258:17–22.
10. Ramly EP, Kantar RS, Diaz-Siso JR, Alfonso AR, Shetye PR, Rodriguez ED.Outcomes after
tooth-bearing Maxillomandibular facial transplantation: insights and lessons learned. J Oral
Maxillofac Surg. 2019;77(10):2085–103.
11. Sosin M, Ceradini DJ, Levine JP, Hazen A, Staffenberg DA, Saadeh PB, etal. Total face, eyelids, ears, scalp, and skeletal subunit transplant: a reconstructive solution for the full face and
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12. Tasigiorgos S, Kollar B, Turk M, Perry B, Alhefzi M, Kiwanuka H, etal. Five-year follow-up
after face transplantation. N Engl J Med. 2019;380(26):2579–81.
13. Khalian S, Brazio PS, Mohan R, Shaffer C, Brandacher G, Barth RN, etal. Facial transplantation: the rst 9 years. Lancet. 2014;384(9960):2153–63.
14. Krezdorn N, Lian CG, Wells M, Wo L, Tasigiorgos S, Xu S, etal. Chronic rejection of human
face allografts. Am J Transplant. 2019;19(4):1168–77.
15. Cendales LC, Kanitakis J, Schneeberger S, Burns C, Ruiz P, Landin L, et al. The Banff
2007 working classication of skin-containing composite tissue allograft pathology. Am J
Transplant. 2008;8(7):1396–400.
16. Frautschi R, Rampazzo A, Bernard S, Djohan R, Papay F, Gharb BB.Management of the salivary glands and facial nerve in face transplantation. Plast Reconstr Surg. 2016;137(6):1887–97.
17. Krezdorn N, Alhefzi M, Perry B, Aycart MA, Tasigiorgos S, Bueno EM, etal. Trismus in face
transplantation following ballistic trauma. J Craniofac Surg. 2018;29(4):843–7.
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Reconstr Aesthet Surg. 2021;74(2):327–35.

Index
https://t.me/medicina_free
A
ACell, 379
Acellular nerve allografts, 448
Additive manufacturing (AM), 293
Adenosine, 296
Adjuvant therapy, 135
Allen’s test, 148
AlloDerm, 376
Alveolar bone grafting, 44
Ameloblastoma, 258, 259
American Academy of Facial Plastic
Reconstructive Surgery
(AAFPRS), 462
American Board of Facial Plastic
Reconstructive Surgery
(ABFPRS), 462
AmnioFix, 383
Anastomotic coupler systems, 175–177
Anatomic (AI) and functional/molecular
imaging (FMI)
ASBO, 80, 81
CBTs, 84–86
NPCA, 82, 84
parathyroid adenoma, 90, 91
PTC, 89
SCC with PTS, 87–89
Anterior nasal spine (ANS), 113
Anterolateral thigh ap (ALT), 226
Anterolateral thigh free ap (ALT),
149–151
Anti-inammatory interleukins, 369
Apert syndrome, 3
Articial intelligence (AI), 131
Atypical skull base osteomyelitis
(ASBO), 80, 81
Augmented reality (AR), 418
Autologous nanofat graft, 283
Axonotmesis, 335
B
Bardach aps, 37
Bicoronal synostosis, 10
Binocular microscopy, 64, 74
Blepharoplasty, 280
Bone grafting, 43
Bone grafts, 311
Bone marrow aspirate concentrate
(BMAC), 314
Bone osteotomy, 431
Bone tissue engineering, 302
Buccal myomucosal aps (BMMF), 39, 42
C
Cable grafting, 446, 448
Cable repair, 446
Calcium phosphate, 293
Carnoy’s solution, 265, 267, 268
Carotid body tumors (CBTs), 84–86
CDN immunotherapies, 58
Central nervous system (CNS), 336
Cetuximab, 56
Chemoradiation (chemoRT), 50
Circulating tumor cells (CTC’s), 55
Cisplatin, 56
© The Editor(s) (if applicable) and The Author(s), under exclusive license to
Springer Nature Switzerland AG 2023
J. C. Melville et al. (eds.), Advancements and Innovations in OMFS, ENT, and
Facial Plastic Surgery, https://doi.org/10.1007/978-3-031-32099-6
481

482
https://t.me/medicina_free
Index
Cleft care
alveolar bone grafting, 43–44
BMMFs, 42
buccal myomucosal aps, 39
complications and prevention, 38
current standard, 37
ERAS protocols, 45
hard palate closure timing, 42
modied Von Langenbeck approach, 41
nasal aps and nasal oor closure, 40–41
Cleft palate, 292
Cold Ablation Robot-guided Laser Osteotome
(CARLO®), 432–435, 437–439
Colonic interposition, 154–156
Color Doppler ultrasonography, 170
Color duplex ultrasound (CDU), 173–174
Compound muscle action potential (CMAP),
342, 343
Computed tomography angiography
(CTA), 170
Computer aided design (CAD), 295
Computer-aided design and computer-aided
manufacturing (CADCAM), 267
Computer assisted surgical simulation
(CASS), 249
Computer tomography angiography
(CTA), 171–172
Cone beam computerized tomography
(CBCT), 193, 210, 228, 244
Contemporary operative microscopes, 177
Craniofacial dysostosis, 9
Craniofacial surgery
craniosynostosis, 2–6
HFM and TCS, 21–23, 28
midface advancement, 9–16
Pierre Robin sequence, 15, 18–20
Craniomaxillofacial (CMF), 292
bioactive molecules, 295, 296
materials and methods, 293
skeletally immature translational mode,
300, 302
skeletally mature translational
models, 300
tissue engineering strategies, 297
Craniosynostosis, 2–6
Cross-facial nerve graft (CFNG), 451
Crouzon syndrome, 3
Cryosurgery, 268
Cultured epidermal autografts (CEA), 369
Custom facial implants, 28
Cutaneous perforator, 172
D
Da Vinci Si, 414, 415
Deep inferior epigastric perforator (DIEP)
aps, 172, 174
De-escalation therapy, 424, 426, 427
Deltopectoral (DP) ap, 141, 142
Dermal substitutes, 368, 369, 372, 373, 384
ACell, 379, 382
AlloDerm, 376–378
AmnioFix, 383, 384
integra postoperative management, 376
integra recommended protocol, 374
integra wound matrix system, 373, 374
Dexmedetomidine, 401–404
Diffusion tensor imaging (DTI), 396
Digital imaging and communications in
medicine (DICOM)
encapsulation, 193
Dihydropyrimidine dehydrogenase (DPD)
deciency, 269
Dipyridamole (DIPY), 296–298
Distraction osteogenesis maxillary expansion
(DOME), 100
DNA methylation, 54, 56
Donor selection, 472
Dynamic infrared thermography (DIRT), 174
E
Elective neck dissection (END), 50
Electrolarynx, 158–159
En-bloc resection, 266
Endoscopic ear surgery
advantages, 71
angled endoscopy, 66
disadvantages, 71
disadvantages of, 70–71
extracorporeal video microscopy, 73
future of, 73
into practice, 72–73
postauricular incision, 65
postauricular tympanomastoidectomy, 64
resident training and teaching, 70
set up and safety, 71–72
transmastoid endoscopic ear surgery, 67
underwater endoscopic ear surgery, 67–70
zero degree endoscopy, 66
Endoscopic sterilization, 65
Enhanced recovery after surgery (ERAS)
protocols, 45
Enucleation, 266

Index
https://t.me/medicina_free
483
Epidermal growth factor (EGF), 369
Epidermal growth factor receptor (EGFR), 56
Esophageal speech, 159
Exoscopes, 73, 178
Exoscopic ear surgery, 74
External handheld Doppler systems, 183
Extracellular matrix (ECM), 336, 369
F
Facial feminization surgery, 355, 357
Facial grading scale (FGS), 456
Facial palsy (FP), 441
cable repair, 446
cross-facial nerve graft, 452
facial nerve rehabilitation, 456
factors affecting reconstruction, 443, 444
nerve transfer, 449, 451
primary repair, 445
timing of repair, 442, 443
Facial plastics
blepharoplasty, 280
facial rejuvenation, 282–285
nasoseptal reconstruction, 277
rhinoplasty, 276, 277
upper lip lift, 278, 279
Facial reanimation, 444, 445
Facial rejuvenation, 282, 283, 285
Facial skeletal and soft tissue differences,
353, 355–357
Facial transplantation, 469
donor selection, 472
immunosuppression therapy, 473
indications and contraindications, 471
patient selection, 470
patient-specic planning, 471
post-operative considerations, 477, 478
preparation and planning, 473, 474
surgical considerations, 474, 475
Facial trauma
assessment of facial fracture, 253
CASS, 249, 250
ICT, 252
PSI, 253
surgical navigation, 250
Fibroblast growth factor (FGF), 342
Fibula free ap (FFF), 226
Fibula segments, 216
Follicular unit extraction (FUE), 287
Follicular unit transplantation (FUT), 287
Forearm free aps, 146–149
Free bula ap (FFF), 225
Free gracilis muscle transfer
(FGMT), 453–456
Functional sensory recovery (FSR), 325
G
Gadolinium contrast-enhanced MRA
imaging, 172
Gallium-67 citrate (Ga-67), 81
Gastric conduit, 151–154
Genioglossus advancement (GGA), 108–111
Genioplasty, 361, 362
Global positioning system (GPS), 250
Gonial angle reduction, 360
Granulocyte colony-stimulating factor
(G-CSF), 369
Great auricular nerves (GAN), 329, 448
H
Hair loss affects, 287
Handheld IRT devices, 174
HBO-resistant ORN, 234
Head and neck squamous cell
carcinoma (HNSCC)
advances in immunotherapy, 57
advances in OSCC biomarker, 53–54
advances in treatment, 56–58
immunosuppressive TIME, 51
immunotherapy, 50
non-invasive biopsy techniques, 54–56
OSCC, 50
Head and neck surgery (HNS), 466
Hemifacial microsomia (HFM),
21–23, 28, 292
Human papilloma virus (HPV), 50
Hyaluronic acid, 364
Hyperbaric oxygen therapy (HBO), 234
Hypoglossal nerve stimulation
(HGNS), 104–107
Hypoglossal nerve transfer, 450, 451
Hypophyarynx, 421
I
Immediate dental implant
history of, 208–209
in free tissue transfer, 209–210
intraoperative technique, 216–217
osseous free aps, 208
post-operative digital workow, 217–221
temporary prosthesis design, 210, 212, 213

484
https://t.me/medicina_free
Index
Immediate dental rehabilitation, 208
Immune-related adverse events (irAEs), 51
Immunotherapy, 50
Implantable Doppler probe systems, 184
Indocyanine green angiography (ICGA),
180, 182
Inferior alveolar nerve (IAN), 324–327, 329,
337, 390
Infrared (IR) radiation, 174
Infrared thermography (IRT), 174
Injectable medicines, 364
Integra wound matrix system, 373, 374
Internal mammary artery perforator (IMAP)
ap, 141
Intraoperative computed tomography
(ICT), 252
Intra-pleural route, 158
Isolated sagittal synostosis, 6
J
Jejunal aps, 146
K
Ketamine, 404
L
Laryngopharyngeal anatomy, 137
Laryngopharyngeal reconstruction, 147
Larynx, 421, 422
Lateral cephalometry, 97
LeFort I osteotomies, 99, 103
LeFort III osteotomy, 10
Light based detection systems, 127
Lip lift, 363
Liquid nitrogen, 268–269
Locoregional aps, 141
Locoregional reconstruction, 142
Lymphovascular invasion (LVI), 50, 54
M
Magnetic resonance angiography (MRA), 172
Magnetic resonance neurography, 389
classication, 392, 394, 395
imaging, 394–396
principles and justication, 390, 391
Malignant transformation, 130
Mandibular distraction, 18
Mandibular distraction osteogenesis
(MDO), 18
Mandibular reconstruction, 435–437
Masseteric nerve transfer, 449, 450
Maxillary-mandibular hypoplasia, 104
Maxillofacial benign tumors and cysts
adjunct therapy, 267
ameloblastoma, 258, 259
BCNS, 263–264
Carnoy’s solution, 268
cryosurgery, 268
En-bloc resection, 266
enucleation, 266
5-FU, 269–271
marsupialization and decompression, 265
OKC, 263–265
peripheral ostectomy, 267
PTCH1 gene, 263
PTCH1 mutation, 263–264
Sonic Hedgehog pathway, 263
Maxillofacial CT, 210
Maxillofacial reconstruction, 309, 310, 324
current methods, 313, 315
growth factors, 312, 313
matrix, 319, 320
signal, 319
traditional non-vascular bone grafts,
311, 312
Maxillofacial reconstructive surgery, 207
Maxillomandibular advancement (MMA),
98, 111–116
Medication-related osteonecrosis of the jaws
(MRONJ), 223
en bloc segmental resection, 237
extent of disease, 242–245
free ap reconstruction, 237
healing, 242
malignancy, 238–242
mandible with draining stula, 238
VSP planning, 239
MedPor, 28
Mental component score (MCS), 326
Mental nerve (MN), 337
Mesenchymal stem cells (MSC), 317
Mesoporous silica rod (MSR)-based
biomaterial vaccines, 57
Meticulous technique, 138
Micro-needling, 283
Microvascular, 463–465
Microvascular free tissue transfer (MVFTT),
137, 146–151
Microvascular surgery
anastomotic coupler systems, 175–177
CDU, 173
CTA, 171

Index
https://t.me/medicina_free
485
intraoperative ap assessment, 182
intraoperative techniques, 175–180
MRA, 172
operative microscope, 177–179
postoperative ap monitoring, 183–185
preoperative donor site assessment, 170
Midface advancement, 9–16
MINI-DOME approach, 102
Modied Carnoy’s solution, 268
Modied Von Langenbeck approach, 41
Motor nerve reconstruction, 442
Muenke syndrome, 3
Multi-angular osteotomies, 19
Multidetector-row computed tomography
(MDCT), 182
MultiDomain peptide (MDP), 57
Musculocutaneous free aps, 169
Myocutaneous (PMMC) aps, 141
N
Nager syndrome, 24
Nasal oor closure, 41
Nasal obstruction symptom evaluation
(NOSE), 101
Nasal surgeries, 99
Nasopharyngeal carcinoma (NPCA), 82–84
Nasopharynx, 423
National quality improvement project
(NSQIP), 465
Near-infrared spectroscopy (NIRS), 185
Nerve, 324, 325
graft, 335
reconstruction, 337
repair, 328–330
Neural stem cells (NSCs), 342
Neurotmesis, 335
Nuclear medicine imaging, 80
O
Obstructive sleep apnea (OSA)
GGA, 108–111
HGNS, 104–107
maxillomandibular advancement, 111–116
nasal surgeries, 99
rhinognathic surgery, 99–104
UPPP, 107–108
Odontogenic cysts classication, 257
Odontogenic keratocyst (OKC), 263–265
Odontogenic tumors (OTs), 258
Ofce-based anesthesia, 399
Operative microscope, 177–179
Optical coherence tomography (OCT), 438
Optical scanning, 194
Oral dysplasia
detection and diagnosis, 126–128
grading and classication, 124–126
OPMDs, 122, 123
risk of malignant transformation, 130–131
treatment and surveillance, 128–129
WHO classication, 125, 126
Oral epithelial dysplasia (OED), 122
Oral health impact questionnaire (OHIP), 326
Oral leukoplakia, 123
Oral maxillofacial surgery (OMFS), 463–466
Oral potentially malignant disorders
(OPMDs), 121–124
Oral squamous cell carcinoma
(OSCC), 49, 122
Oral surgery, 325
Oronasal palatal stula, 43
Oropharyngeal cancer, 49, 413
augmented reality, 418–420
de-escalation therapy, 424–427
retractor systems, 417, 418
robotic surgery
Da Vinci Si, 414, 415
Da Vinci SP, 416
Da Vinci Xi, 415, 416
Orthognathic surgery, 434, 435
Osteocutaneous free aps, 169
Osteoprogenitor cells (OPC), 317
Osteoradionecrosis (ORN), 195
Osteoradionecrosis of the jaws (ORN), 223
extent of disease, 234–236
multi-stage surgical approach, 225
perioperative management, 236
radiation therapy, 225
tissue quality and healing, 233–234
vasculature, 227–233
Osteotomes, 103
Otoendoscopy, 64
Otolaryngology head and neck surgery
(OHNS), 465
P
Palatal stulas, 39
Palatopharyngeus muscle, 108
Papillary thyroid cancer (PTC), 89
Parathyroid adenoma, 90, 91
Parotid, 422, 423
Particularly pharyngocutaneous stula
(PCF), 136
Patient specic implant (PSI), 253

486
https://t.me/medicina_free
Index
Pectoralis major (PM) ap, 143, 144
Pectoralis major myofascial (PMMF), 141
PENTO protocol, 237
Percutaneous endoscopic gastrostomy (PEG)
tubes, 237
Perineural invasion (PNI), 50
Perineural tumor spread (PTS), 87–89
Peripheral nerve damage, 335
Peripheral nerves, 389, 390, 392
Peripheral trigeminal neuropathies (PTNs), 392
Pfeiffer syndrome, 3
Pharyngoesophageal reconstruction
electrolarynx, 158–159
enteric conduit options for
colonic interposition, 154–156
gastric conduit, 151–154
route of conduit, 157
supercharged jejunal interposition,
156, 157
esophageal speech, 159
MVFTT, 146–151
outcomes, 160–161
pedicled ap reconstruction
DP ap, 142
IMAP ap, 143
locoregional reconstruction, 142
pectoralis major ap, 143
PM ap, 143, 144
SCAIF, 145
primary closure, 137–140
survive adjuvant therapy, 136
tracheoesophageal puncture, 159–160
voice rehabilitation, 158
Pharyngoscopy, 97
Physical component score (PCS), 326
Pierre Robin sequence, 15, 18–20
Pittsburgh classication system, 38
Placement in osseous free aps, 208
Placental growth factor (PlGF), 369
Platelet-derived growth factor, 369
Point-of-care 3-dimensional (3D) printing, 202
Polydioxanone (PDO), 285
Polyetheretherketone (PEEK), 28
Polymethylmethacrylate (PMMA)
milling, 210
Polysomnography (PSG), 97, 101
Positive predictive value (PPV), 172
Posterior nasal spine (PNS), 113
Postoperative dysphagia, 161
Potentially premalignant oral epithelial lesion
(PPOEL), 121
Powell-Riley protocol, 97
Pre-cancer, 121
Precancerous lesions, 121
Precursor lesion, 121
Pre-malignancy, 121
Primary closure, 137–140
Procedural sedation, 399, 405, 408
Programmed cell death protein 1 (PD-1), 56
Propofol, 404–406
Proteocyte AI, 131
R
Radial forearm free ap (RFFF), 146
Radiation (RT), 50
Reconstructive ladder, 137
Remifentanil, 400, 401, 405
Remimazolam, 407, 408
Revision surgery, 479
Rhinognathic surgery, 99–104
Rhinoplasty, 276, 277
Rhytidectomy, 284
Robin sequence (RS), 15
Robotic microscope, 179–180
Robotic surgery, 417–420, 424
S
Selective laser melting (SLM), 195, 253
Sensory disturbances, 334
Several exoscopes, 178
Skeletally mature translational models,
298, 300
Skin grafts, 368
Skull base osteomyelitis (SBO), 80
Sleep surgery, 97
Solid free form fabrication (SFFF), 293
Squamous cell carcinoma (SCC), 87–89
Stanford sleep surgery protocol, 98
Stereoelectroencephalography (sEEG), 439
Stereolithographic models, 19
Sternocleidomastoid muscle (SCM), 145
STINGel, 57, 58
Subcutaneous route, 158
Substernal route, 157
Sunnybrook facial grading system
(SFGS), 445
Supraclavicular artery island ap
(SCAIF), 141, 145
Sural nerve, 447
Surgical intervention, 328
Surgical navigation (SN), 250
Syndromic craniosynostosis, 3
SynerGel, 58
Synthetic cyclic dinucleotides (CDNs), 57

Index
https://t.me/medicina_free
487
T
Targeted molecular therapy, 260–262
Technetium Tc99m methylene diphosphonate
(Tc99m MDP), 81
Temporomandibular Joint (TMJ), 437
3D printing (3DP), 293, 295
Thyroid, 422
Tissue autouorescence, 127
Tissue engineering, 297, 310, 341
Tissue spectroscopy, 184
Titanium, 28
Titanium Milling, 195
TMJ prosthesis, 28
Tongue-lip adhesion (TLA), 18
Tooth-borne oating prosthesis, 213
Total laryngectomy, 136
Tracheal shave, 358–360
Tracheoesophageal (TE) speech, 158
Tracheoesophageal puncture (TEP), 159–160
Traditional microscopic surgery, 74
Transcanal endoscopic ear surgery, 65
Transgender
epidemiology, 350, 351
gender afrming care, 352
terminology, 350
Transmastoid endoscopic ear surgery, 67
Transverse maxillary hypoplasia (TMH), 99
Treacher Collins syndrome (TCS), 21–23, 28
Trigeminal nerve, 325, 329, 389, 392
Trigeminal nerve reconstruction, 334
historical perspective, 334
infraorbital nerve, 340
measuring outcomes, 340
peripheral nerve damage, 335
Tumor immune microenvironment (TIME), 51
Underwater endoscopic ear surgery, 67–70
Unenhanced CT, 80
Upper airway resistance syndrome
(UARS), 101
Upper airway stimulation (UAS), 97
Upper airway surgery, 97
Upper lip lift, 278
Urinary bladder mucosa (UBM), 378
Uvulopalato-preservation pharyngoplasty
(UPPP), 107–108
V
Vascular anastomosis, 169
Vascular endothelial growth factor
(VEGF), 369
Velocardiofacial syndrome, 17
VELscope, 127
Venous anastomosis, 176
Vertical dimension of occlusion
(VDO), 216
Virchow’s Law, 2
Virtual surgical planning (VSP), 101,
113, 208
data acquisition, 194
imaging modalities, 193
maxillofacial reconstructions, 192
oncologic resection and reconstruction,
195, 197–200
orthognathic surgery planning, 194
Visceral aps, 146
Visible light spectroscopy (VLS), 184
Voice rehabilitation, 158
Von Langenbeck bipedicle aps, 37
V2 paresthesia, 103
U
Ulnar artery perforator free ap (UAPFF), 148
W
Wookey ap, 142
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