Добавил:
kiopkiopkiop18@yandex.ru t.me/Prokururor I Вовсе не секретарь, но почту проверяю Опубликованный материал нарушает ваши авторские права? Сообщите нам.
Вуз: Предмет: Файл:
Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_885_Библиотеки_им_академика_М_И_Перельмана.pdf
Скачиваний:
0
Добавлен:
31.08.2026
Размер:
34 Мб
Скачать
218 J. Haenel
{ Based on the breath types and phases used to initiate a ventilator breath
conventional ventilators today offer only five basic breath types:
Volume-Controlled: time-triggered, flow-targeted and volume-cycled Volume-Assisted: effort-triggered, flow-targeted and volume cycled Pressure-Controlled: time-triggered, pressure-targeted and time-cycled Pressure-Assisted: effort-triggered, pressure-targeted and time-cycled Pressure-Support: effort-triggered, pressure-targeted and flow-cycled
{ Once the mode, breath type, respiratory rate and FIO
are selected then
2
the clinician will then set a peak inspiratory flow rate in liters/minute in Volume-Control or a % inspiratory time in seconds or fraction thereof in Pressure-Control.
Fundamentally, the peak flow setting (in L/M) is what fine tunes the
I:E ratio. In volume ventilation, the I:E ratio is generated by a combi­nation of the Vt, RR and peak inspiratory flow setting. The flow wave selection (generally either a square wave or decelerating waveform) will also impact the I:E ratio.
The peak inspiratory flow rate delivered in the volume modes is a
fixed or flow-targeted setting. This means that if the patients demand for ventilation increases for any reason and the RR increases then the I:E ratio will decrease. Conversely, with pressure-targeted breaths, the flow will adjust to maintain the pressure target. An inadequate deliv­ered flow of gas is a common reason for ventilator asynchrony and must be addressed.
Positive-end expiratory pressure
all deal with manipulation of inspiration. Conversely PEEP is the manage­ment of end-expiratory pressure above atmospheric pressure. There are two primary indications for PEEP:
{ To recruit lung volume and attempt to return the functional residual capac-
ity (FRC) towards normal and thus improve or reverse hypoxemia.
{ To reduce or minimize the inspiratory work of breathing associated with
severe acute restrictive lung disease or that associated with dynamic hyperinflation and Auto-PEEP.
By recruiting and stabilizing collapsed small airways and alveoli PEEP may increase the respiratory system compliance and thus the FRC, and
Mechanical Ventilation 219
therefore mitigate the effects of intrapulmonary shunting associated with acute lung injury.
{ Much controversy still exists regarding how to select the optimal PEEP/
FIO2 levels. Whether PEEP should be titrated to optimize compliance, minimize the intrapulmonary shunt fraction, prevent dorsal alveolar col­lapse from hydrostatic imposed pressures or minimize ventilator induced lung injury from atelectatrauma or stretch induced over-inflation from high tidal volumes remains to be determined.
{ First and foremost, there is no compelling evidence for a low versus high
PEEP setting nor is there strong evidence that performance of pressure­volume curves used to identify the lower or upper inflection points is necessary to optimize an individual PEEP setting.
The vast majority of patients have been satisfactorily managed with PEEP values of 5–15 cm H2O.
{ The ARDS Network titration table for determining PEEP/FIO
has been
2
available for over a decade and has performed well in thousands of patients enrolled in various ARDS Network trials.
{ Arguments against the PEEP/FIO
titration table are that it is “cook book”
2
and that not all ARDS are the same. ARDS may be classified as either Pulmonary ARDS or Extrapulmonary ARDS. It has been noted that the main difference between the two types of ARDS is that chest wall compliance is normal in Pulmonary ARDS but significantly lower in Extrapulmonary ARDS thus the response to PEEP may be dramatically different.
{ To account for the differences in types of ARDS as well as different
patient’s body habitus, potential for mixed obstructive defects complicat­ing the acute restrictive defects an individual approach may be needed.
{ Recruitment maneuver(s) to identify optimal PEEP:
Use Pressure-control mode Set RR to 10/min Adjust I”E ratio to 1:1 Set peak inspiratory pressure to 20 cm H
O
2
Increase baseline PEEP to 20–40 cm H2O for 1–2 minutes
experienced a sudden decline in oxygenation while on their baseline ventila­tor settings. Recruitments should be performed while closely monitoring the
220 J. Haenel
patient’s hemodynamic response. It is not unusual to see a decrease in blood pressure or even saturation during the maneuver. Changes greater than 20% may require stopping the maneuver. Certainly any decrease in heart rate necessitates immediate discontinuation. The recruitment maneuver should be repeated in response to new or continued desaturation events and the baseline PEEP increased by 2.5–5.0 cm H2O following each recruitment until oxygenation has improved or there is no further positive response.
{ Adverse effects of PEEP
Elevation of PEEP levels will necessarily increase both end-inspiratory
as well as the mean airway pressures. The potential exists for a fall in cardiac output as a result of decreased venous return to the right side of the heart. In lieu of a decrease in cardiac function, any increase in PaO2 will be negated based on the principal of oxygen delivery (DO2 = CaO2 [Hb × 1.36 × SPO2]). Strong consideration of monitoring cardiac out­put should be made when PEEP levels > 15 cm H2O are used. Also, any unexplained tachycardia or the need for inotropic agents would suggest the need for monitoring of cardiac output.
Ventilator asynchrony
Ventilator synchrony requires a perfect matching of the patient’s inspiratory effort to be in concert with the ventilators ability to provide both flow and pressure. There are three crucial periods where this relationship between patient and ventilator may become uncoupled: during triggering, flow delivery or at breath termination. Failure of the ventilator to respond at the appointed time may result in the patient experiencing excessive muscle loads, compromised alveolar venti­lation, ventilator induced injury or excessive periods of dyspnea resulting in use of excess sedation. Evidence for asynchrony includes new respiratory distress, diaphoresis, tachycardia and anxiety.
During trigger phase
{ Ineffective triggering — missed triggers
Auto-PEEP
{ Autocycling { Double triggering { Triggering delay
Mechanical Ventilation 221
During flow delivery phase
{ Inadequate set peak flow in volume mode { Excessive set peak flow/excessive I:E ratios
During cycling phase
{ Increased neural inspiratory demand { Prolonged machine inspiratory time
Ventilator asynchrony has been reported to occur in upwards to 25%
of patients receiving positive pressure ventilation. Interestingly, the adverse effects of patient-ventilator asynchrony remain unknown in terms of duration of ventilator days or increase length of weaning times.
{ Approach to management of Ventilator Asynchrony
During breath triggering
Delayed or miss triggers are common in the presence of Auto-PEEP. First and foremost, treat Auto-PEEP. Try adding set PEEP to offset Auto-PEEP. Change from pressure trigger to flow trigger.
Autocycling occurs when sensitivity is set inappropriately low i.e. “Hair Trigger.” Decrease sensitivity. Extra triggers may be caused by chest tube nega­tive pressure in setting of a bronchopleural fistula (BPF) and will respond to decreasing pressure trigger sensitivity. To and fro motion from excessive water in vent circuits is not uncommon and easily addressed. Cardiac oscillations may occur in the hyperdynamic heart when sensitivity is overly low.
{ During flow delivery
Increase set peak inspiratory flow until patient appears comfortable (in volume modes).
Switch from volume mode to pressure mode for variable flow rates.
If plateau pressures are not excessive, increase set tidal volume.
Decrease flow or pressure if patient is actively making expiratory efforts to terminate breath.
{ During cycling phase
If secondary to altered neural inspiratory times are greater than machine inspiratory times, then lengthening of cycle criteria may help (volume, time, flow).
If secondary to prolonged machine inspiratory time compared to neu­ral inspiratory time, then decreasing cycle variables may result in a better match.
222 J. Haenel
Acute hypoxic events during mechanical ventilation
Nothing is more stressful for the patient’s cardiopulmonary and neurologic system, not to mention the stress put on the responsible bedside staff, than having to respond to a serious life-threatening acute hypoxic event. Acute hypoxemia is a frequent ICU event and has been reported to occur in up to 25% of patients receiving mechanical ventilation, that is 1 out of every 4! As a result, it is incum­bent upon all critical care personnel to be capable of an immediate and cogent response to identify and reverse this potentially life-threatening situation.
Over two decades ago, we developed a bedside algorithm that specifically addresses both the immediate response required to address life-threatening hypoxemia in the ventilated patient as well as the steps to identify the primary etiologic cause. See Fig.1.
The algorithm is divided into a primary and secondary survey. The thought behind this was that immediate threats to life must be identified and managed within minutes. Once an acute hypoxic event is identified, the patient should instantly be hand ventilated with a high flow manual resuscitator (> 20 L/M of O flow). The goal is to identify an airway occlusion that must be reversed immedi­ately. Difficult bagging is suggestive and further addressed by passage of a section catheter. Inability to pass the catheter pin points to the problem which must be rectified without delay. Artificial airway leaks while problematic can usually be troubled-shot by an experienced therapist, thereby preventing unneces­sary reintubation. Clearly, if the patient responds to bagging with an increase in oxygen saturation then attention should be turned to the ventilator looking for circuit or settings that are inappropriate. Once the airway is eliminated as a primary concern (this should take < 60 seconds) and the patient remains unstable, tension pneumothorax must be considered. When in doubt and in the face of life­threatening hypoxemia, the chest should be vent prior to obtaining a chest X-ray. Once oxygenation has stabilized but the etiology remains unclear, performance of the secondary survey should commence. Clearly, a recent intervention i.e. new medication, transport etc. may have been responsible. Likewise, complications from procedures must be recognized as well as the possibility for progression of the underlying disease process. A common mistake is to attribute an acute hypoxic event to a pulmonary embolism when a portable chest X-ray reveals a new infil­trative or collapse. The last place you want to be is in a dark, cold radiology room at two in the morning with a hypoxic patient who more likely has a much more common problem like mucous plugging or atelectasis!
2
Mechanical Ventilation 223
Practical Algorithm(s)/ Diagrams
Fig. 1. Algorithm for initial management of acute hypoxic events.
This page intentionally left blankThis page intentionally left blank
Chapter 6-(iv)
Liberation from Mechanical Ventilation
Fredric M. Pieracci, MD* James Haenel, RRT
and Michael Sawyer, MD
*Acute Care Surgeon, Denver Health Medical Center
Surgical Critical Care Specialist, Denver Health Medical Center
Associate Professor of Anaesthesia, University of Colorado School of Medicine
Take Home Points
Mechanical ventilation is hazardous to all organ systems and the appropriateness
for liberation from it should be assessed at least daily.
The term “ weaning from the ventilator” refers to a gradual increase in
patient work of breathing after a prolonged (days to weeks) period of mechanical ventilation that has resulted in both gas exchange and respiratory muscle embarrassment. This clinical scenario applies only to the minority of critically ill surgical patients. Rather, most surgical ICU patients may be rapidly liberated from mechanical ventilation without a prolonged wean. Therefore, the term “liberation from mechanical ventilation” is preferred to “weaning.”
Contact information: Denver Health Medical Center, 777 Bannock Street, MC 0206, A388, Denver, CO 80206; Email: Fredric.pieracci@dhha.org; James.Haenel@dhha.org; Michael. Sawyer@dhha.org
225
226 F. M. Pieracci, J. Haenel and M. Sawyer
The surgical intensivist must distinguish appropriateness for ventilator libera-
tion from appropriateness for extubation. The former refers specifically to the contribution of the ventilator to work of breathing. The latter includes more general issues such as mental status and upper airway patency.
Certain predisposing factors and injury patterns can predict early the need for
prolonged ventilator support via tracheostomy.
General contraindications to transitioning a patient from a full support mode
of ventilation (e.g., assist control) to a partial support mode (e.g., pressure support ventilation) include any condition that significantly either depresses or elevates minute ventilation. Recent neuromuscular paralysis is a common example of the former; shock is a common example of the latter.
Appropriateness for extubation may be assessed using the pneumonic
“SOAP”
{ Secretions { Oxygenation { Airway/Alertness { Parameters
The most studied and useful parameter for predicting successful extubation
is the rapid shallow breathing index (RSBI, A.K.A. the Toben Index), defined as the respiratory rate divided by the spontaneous tidal volume (L). Assuming all other aspects of the SOAP pneumonic are favorable, a RSBI < 100 suggests a high likelihood of successful extubation.
Most patients who fail extubation do so within the first hour. Be ready to
emergently re-intubate your patient before you extubate them. Identify poten­tially difficult airways [Chapter 6-(i)] prior to extubation and muster the appropriate resources.
If you are unsure whether your patient needs to be re-intubated, then your
patient probably needs to be re-intubated. You will regret a missed opportu­nity to re-intubate far more than a potentially unnecessary re-intubation.
Background
Mechanical ventilation is a necessary evil. Although it is life-saving for
patients with respiratory failure, it is fraught with complications, including atelectasis, baro and volutrauma, pneumonia, respiratory muscle atrophy, agitation, and delirium.
Surgical ICU patients differ from medical ICU patients in several ways that
are pertinent to liberation from mechanical ventilation. In general, surgical
Liberation from Mechanical Ventilation 227
ICU patients are younger, more likely to have a rapidly reversible pathology, and less likely to have chronic pulmonary disease. These conditions combine to make rapid liberation from mechanical ventilation more appropriate for the surgical, as compared to the medical ICU patient.
Normal minute ventilation (V
) is 6–10 L/min; multiple pathologies may be
e
operating to either decrease or increase Ve in the surgical ICU patient.
Main Body
Predicting the need for prolonged mechanical ventilation early
Early and safe extubation should be the goal for every ventilated patient.
However, certain factors increase significantly the likelihood that a patient
will require prolonged mechanical ventilation, and thus inform the decision to perform a trachesotomy early in the patient’s course (Chapter 19). This strat­egy will allow the patient early exposure to the benefits of trachesotomy, including:
{ Ability to minimize both analgesic and sedative infusions { Improved pulmonary toilet { Improved comfort { Improved communication with the patient { Decreased risk of inadvertant extubation { Decreased airway resistance { Possible decreased risk of VAP
These risk factors may be divided into two categories: (1) pre-existing conditions
and (2) injury patterns.
{ Injury patterns
Severe traumatic brain injury Severe facial fractures Laryngotracheal trauma
{ Pre-existing conditions:
Age > 70 years Psychiatric illness Substance abuse, particularly alcohol abuse Chronic obstructive pulmonary disease Morbid obesity Prior need for trachestomy