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178 J. A. Salotto
vasodilator) as compared to those patients on room air (Am J Physiol Heart Circ 2005; 288: H1057–1062). A Cochrane review later examined four trials of 430 patients with confirmed STEMI or NSTEMI. They observed a two­fold increase in mortality in those treated with oxygen, but ultimately these numbers were underpowered. They concluded that evidence in support of oxygen use in ACS is sparse, and that oxygen should be used with caution given the trend towards harm (Cochrane Database of Systemic Reviews 2013; Issue 8 Art No: CD007160).
Rao et al. performed a retrospective review of over 24,000 patients in three
trials of patients with ACS. Cohorts were divided into those who received blood transfusions or not. The group undergoing transfusion had a signifi­cantly higher rate of 30-day death (8% vs. 3%), myocardial infarction (25% vs. 8%) and death or MI (29% vs. 10%). They calculated a hazard ratio for 30-day death with transfusion at 3.94, and this was statistically significant. The risk of 30-day death was higher with transfusion hematocrit triggers above 25%. (JAMA 2004; 292: 1555–1562).
Chapter 5-(viii)
Vascular Emergencies
Charles J. Fox, MD*
*Chief of Vascular Surgery, Denver Health Medical Center
Take Home Points
Early initiation of damage control resuscitation (blood in 1:1:1 ratios and
limiting crystalloid) is crucial in performing a successful simultaneous vascu­lar reconstruction without ongoing physiologic derangements.
A vascular assessment should begin in the admitting area using a handheld
continuous wave Doppler device.
A CT angiogram may be useful for cervical or truncal vascular injuries to plan
the best approach, but rarely necessary for extremity vascular injury.
Pre-hospital tourniquets should be exchanged for the pneumatic type and
removed in the operating room if the patient is unstable or if hemorrhage is expected.
Vascular repairs often require massive transfusion, therefore temporary shunt-
ing with delayed repair should be considered at remote community hospitals with limited blood banks.
Contact information: Denver Health Medical Center, University of Colorado Health Sciences Center, 777 Bannock Street, MC 0206, Denver, CO 80204; Tel.: 202-697-1456, email: Charles.fox@dhha.org
179
180 C. J. Fox
A second surgical team can save time by placing external fixation, and per-
forming saphenous vein harvests or fasciotomy.
A vein interposition graft is durable when there is adequate muscle coverage;
otherwise a longer bypass tunneled out of the zone of injury should be chosen to prevent desiccation or delayed rupture.
Veins can be ligated but repair time permitting will improve outflow.
Trust your repair. Remember, a patient in shock may not have a palpable pulse
when leaving the operating room.
Background
Traumatic vascular emergencies have special importance as injuries to major
vessels offer unique surgical challenges, and comprise the majority of poten­tially preventable deaths from penetrating injury.
In the presence of hemorrhagic shock, you will routinely perform vascular
surgery in less than optimal situations.
These situations demand early deliberate preparation to ensure successful
management of vascular wounds.
Many lessons learned during U.S. military operations continue to advance
the practice of vascular trauma surgery and now, translates into the current surgical practices which are recommended.
Common non-trauma vascular emergencies such as iatrogenic vascular access
complications, vasopressor induced ischemia and acute thromboembolism are common to the ICU setting.
Main Body
Assessment of the vascular trauma patient
 Vascular trauma usually involves extremities and is often part of the
injury complex in patients with exsanguinating hemorrhage. Optimal management requires proper planning and recognition of the essential priorities necessary to prevent immediate hemorrhagic death. Following immediate airway control, attention is directed at controlling hemorrhage and obtaining vascular access. External bleeding can often be hidden by warming blankets or transport gear. You will fi nd that direct pressure is the most effective way to control hemorrhage. A volume depleted patient may not always manifest active arterial bleeding at the time of admission. Pre-hospital tourniquets, if used, should nonetheless be inspected and
Vascular Emergencies 181
readjusted or replaced once the resuscitation restores adequate peripheral perfusion. Intravenous access may be hindered by shock, and immediate intraosseous access into the tibia or the humerus is easy and rapid. Initial laboratory studies will depict the degree of physiologic distress that is used to guide the resuscitation and early operative planning. Damage control resuscitation, a strategy of liberal blood product administration, minimal crystalloid use, should begin early in the emergency room and continue intra-operatively. The goal is to achieve hemostasis, restore normal physiology, and potentially complete a vascular reconstruction, upon arrival in the ICU. If the graft is done correctly, it should not fail because you withheld heparin or gave hemostatic agents to a coagulo­pathic patient. Blood products should be transfused within minutes of arrival with an emergency release of four units of type O packed red blood cells (PRBCs), and two units of thawed AB plasma sent from the blood bank. The blood products are best transfused through a rapid infuser system that is reserved in the admitting area. Unstable patients with a truncal injury or those with more than one mangled extremity are considered “in-extremis” and should trigger a massive transfusion pro­tocol. This involves a standardized release and transfusion of PRBCs, thawed plasma, cryoprecipitate, and platelets.
 Recognizing the need for vascular reconstruction at the time of the trauma
admission is crucial for success as indecision and progressive ischemic burden can result in ultimate graft failure and subsequent limb loss. Most of the extremity injuries involve fractures and large soft tissue wounds that can make the diagnosis, by physical exam alone, very accurate. Radiographs can provide early clues that extremity vascular injuries exist and you should take a close look at the plain fi lms as you enter the admit­ting area. For example, supracondylar femur and tibial plateau fractures are frequently associated with injuries to the distal femoral and popliteal artery. This is among the most common lower extremity vascular injury patterns that you will encounter. Deformed extremities are straightened and the onset of additional hemorrhage is controlled with direct pres­sure, gauze packing, hemostatic dressings or additional tourniquets. Alternatively, in stable patients, without active bleeding, pre-hospital tourniquets should be carefully loosened to determine the degree, if any, of vascular injury. A Doppler assessment is advised to confi rm the absence of pedal pulses and to perform an Ankle-Brachial Index when possible. A patient assessment done in concert with an orthopedic surgeon will facil­itate the necessary discussion regarding the sequence of the operation, and
182 C. J. Fox
preferred techniques for external fi xation that best aid in the anticipated vascular exposure. Important information to relay to the entire operative team should include ideal patient positioning, the plan for vein harvesting in a contralateral extremity, and the desire for a C-arm or arteriography. Special instruments located in “peel packs” can ease the apprehension of not having the favored instruments when needed quickly. The earlier you relay this information to the OR, the easier and faster your case will be.
Tips and strategies for success
 For extremity injury, a two-team practice reduces ischemic time as the
primary team may be preoccupied with thoracotomy, or laparotomy to control hemorrhage, or other damage control maneuvers. Do not hesitate to involve a second team as they can be used to apply external fi xation, perform fasciotomies, begin a peripheral vascular exposure, or harvest vein from a non-injured or amputated extremity. It is important to take some extra “careful” time when doing the vein harvest. You should always caution your assistant on the potential for injury to the saphenous vein when performing a fasciotomy. Position the patient to enable unimpeded access to another body cavity or limb in the event of unexpected deteriora­tion or need for additional vein harvesting.
 Initial control of hemorrhage is often accomplished by digital occlusion
using an assistants hand prepped directly into the bleeding wound bed with betadine spray. This is followed by a careful dissection proximal and distal to the site of injury. Balloon catheters may also tamponade hemorrhage when a tourniquet or manual pressure is not effective. Blind insertion of surgical instruments can be unproductive, or harmful, and is discouraged. Tourniquets are left in place until the anesthetist has suffi cient time to resuscitate the patient. Proximal femoral injuries are best managed by division of the inguinal ligament or a simple retroperitoneal approach and clamp control of the external iliac artery. For proximal axillo-subclavian wounds, sternotomy or left anterior thoracotomy and clamping of the subclavian artery eliminate the error of uncontrolled dissection through an expanding hematoma of the chest. You should approach distal axillary and proximal brachial arterial injuries with infraclavicular incisions, and extend across the deltopectoral region into the upper arm as needed. The medial approach is preferred for femoropopliteal injuries. The approach in relation to the knee joint is directed by the level of the wound, however total division of muscular attachments at the knee is sometimes required to
Vascular Emergencies 183
control hemorrhage of transected arteries and veins. You may fi nd that the transected end can be diffi cult to identify in the destroyed tissue. Although often thrombosed at the time, these vessels must be found and ligated because they will re-bleed later after the patient is resuscitated. Retrograde advancement of a Fogarty catheter from an uninjured distal site can also be used to locate the transected artery in a horrifi c wound that is no longer bleeding. When making a decision to amputate or salvage an extremity, you should consider the patients’ condition, extent of injury, and your willingness to commit the patient to the necessary defi nitive orthopedic care and physical rehabilitation. No one situation or scoring system can replace the surgical judgment developed by an experience team.
 A primary end-to-end repair is preferred when lateral sutures cannot repair
the injured vessel. Advantages of this repair include a single anastomosis, and use of autologous tissue. Dividing nearby branches may gain some length in non-calcifi ed vessels, but this repair should be both expedient and tensionless. A complete debridement of any disrupted tissue is an essential step of the repair, and sacrifi ces made to avoid an interposition conduit should be keenly resisted. The complexity and additional opera­tive time required for vein harvest and interposition grafting or bypass should be appreciated, and the fi nal operative plan and estimated time should be communicated early to the entire operative team. The saphen­ous vein is the preferred conduit for vascular injuries. The poor historical results of prosthetic material when used in contaminated wounds are the justifi cation for this approach. In my experience, prosthetic grafts placed in larger vessels with good muscle coverage have been used successfully. I have used prosthetic grafts for “clean” subclavian and carotid wounds, however inferior long term patency of prosthetic materials and the potential for infection in war wounds have restricted its widespread use in combat­related extremity wounds.
 High energy munitions produce large cavitary wounds, with numerous
disruption of the skin, and loss of underlying muscle that may prevent attempts to achieve suitable graft coverage. When you are confronted with this situation, a longer vein graft tunneled completely around the zone of injury should be chosen over a shorter poorly covered vein interpo­sition conduit. Appropriately applied external fi xation will take this is­sue into consideration, and this is an important subject to discuss before fasciotomy incisions are made. Devitalized tissue is excised and irrigated under low pressure, with careful evaluation of muscle tissue for viability.
184 C. J. Fox
A lengthy and meticulous debridement at the outset is not necessary as these wounds look much better in a few days after subsequent washouts and vacuum dressings.
 Ballistic trauma can transmit kinetic energy and result in intimal injury
well beyond the transected arterial segment. Therefore, perform your debridement with a great deal of concentration and focus on the qual­ity of the luminal surface and strength of the arterial infl ow relative to the patients’ hemodyanamics. When necessary, a Fogarty catheter should be carefully advanced as pre-hospital tourniquets and incomplete heparin dosing in trauma may result in thrombus accumulation proximally. A four quadrant, heel-to-toe anastomosis that is well-spatulated is the easiest re­pair method to teach and perform in diffi cult situations. Small Heifetz clips or Bulldog clamps can also minimize the chance of a clamp injury. Special precautions are worthwhile and should in particular include routine fl ushing of the graft, and native artery with heparinized saline to dislodge fi brin strands, and platelet debris.
 Upper extremity injuries should not be underestimated, and often require
massive transfusions, from ongoing blood loss and resuscitation require­ments. The arm swelling and wound expansion that can result highlights the importance of a wide tunnel for a saphenous vein graft. There has been a sustained interest in repair of venous injuries to avoid the potential for early limb loss from venous hypertension or long term disability from chronic edema. With combined injuries, arterial repair should precede venous repair to minimize further ischemic burden, unless the vein repair requires very little effort.
 The temporary use of shunts for vascular trauma is a very effective dam-
age control technique to allow for delayed reconstruction. The value of temporary shunting should be compared with the consequences of simple ligation. For example, ligation of the brachial artery after confi rming distal signals and palmar blood fl ow, allows for elective delayed reconstruction if indicated. Surgeons at smaller remote facilities may prefer shunting when rapid evacuation to places capable of matching transfusion requirements or performing emergent complex vascular repairs is necessary.
 While arteriography remains the gold standard for guiding surgical
reconstruction, static fi lm arteriography has largely been replaced with portable C-arm units capable of digital subtraction angiography. Contrast arteriography is very useful for locating the injured vascular bed when there are diffuse fragmentation wounds to the extremity. Hand injected contrast images using butterfl y needles without special wires or catheters
Vascular Emergencies 185
can be acquired quickly using the digital subtraction mode on a mobile C-arm unit. Rotating the table before the start of the case may be necessary to properly maneuver the C-arm. When all else fails, holding the feet off the end of the table may allow for the acquisition serial images to satisfac­torily complete the case. The logistics of maintaining a robust inventory in a fi eld hospital continues to limit the capability to carry out these in­terventions in combat. Completion assessments following open repair or endovascular interventions make use of a combination of physical exam, the handheld Doppler and selective arteriography.
Delayed evaluation and postoperative care
 The early postoperative period is focused on patient warming, resus-
citation, and hourly vascular checks which should be performed with a hand-held continuous wave Doppler probe. Palpable pulses and, sometimes, normal ankle-brachial ratios (>0.9) may be delayed until an appropriate resuscitation period has occurred. Patients should remain in the ICU for the at least 24 hours. In addition to ensuring overall car­diopulmonary and metabolic stability, plans for evacuation out of the war zone should take the threat of early graft failure and post-operative bleed­ing into consideration. The vascular injured patient should not be hurried unnecessarily through the chain of evacuation. External fi xators are re­adjusted based on the appearance of plain fi lm radiographs, and a wound inspection is normally performed within 24 hours. The typical patient is returned to the operating room every 48–72 hours for additional wash­outs, debridement’s, and negative pressure “vacuum” dressing changes. A careful assessment for the development of a compartment syndrome is essential, especially when the patient is transferred out of the combat zone to providers unfamiliar with the initial post-operative exam. You should always maintain a low threshold for performing a fasciotomy for patients’ with extremity vascular injury.
Non-trauma emergencies
 Pseudoaneurysm: A pseudoaneurysm can develop after a traumatic
arterial injury and, unlike a hematoma, will demonstrate arterial fl ow through a neck into a false space contained by surrounding tissue. This occurs frequently following arterial puncture and may be from inadequate compression. Pseudoaneurysms are characterized by a pulsatile mass, tenderness and in severe cases, ulceration or necrosis of the overlying skin. A Duplex ultrasound evaluation can determine the size and location. The
186 C. J. Fox
typical pulsatile echolucent sac will have a swirling “to-and-fro” fl ow pattern. Compression (10–30 mins) may avoid surgery but is often too painful and may lead to embolization or thrombosis of the native artery. Ultrasound-guided thrombin injection (1000 units/mL) is generally con­sidered a fi rst-line therapy for anatomically favorable lesions (saccular, narrow neck). The tip of a 22 gauge spinal needle is directed away from the infl ow neck to avoid distal embolization and 0.1–0.2 ml of thrombin is injected into the sac. An ultrasound performed in 24–48 hrs confi rms resolution. Direct surgical repair or endovascular interventions continue to be employed for challenging lesions. Open techniques involve tradi­tional proximal and distal control with suture or patched repair. However, directly entering the capsule and applying digital pressure is an expedi­tious approach. In the endovascular era, adjunctive balloon occlusion, coil embolization, or covered stents may simplify the approach in surgically inaccessible areas.
 Arterial-Venous Fistula: Percutaneous techniques such as central
venous cannulation and arterial catheterization have led to an increased incidence in arteriovenous fi stulae. When the adjacent artery and vein are simultaneously punctured, an abnormal connection can form. The local hemodynamic changes result in elongation and dilation of the proximal veins and the arterial circulation may be compromised distally by steal. In larger chronic fi stulas, the systemic circulation may also be affected. A thrill may be palpated over the affected site or a bruit appreciated on auscultation. The natural history is thought to be one of gradual enlarge­ment or thrombosis. Symptomatic patients require repair by open or endo­vascular techniques to restore normal perfusion and venous drainage by closing the communication. Extensive collateral circulation and friability of the artery can make the operation technically diffi cult when delayed. Therefore, most surgeons prefer to treat these cases when diagnosed. Open repairs involve either isolation of all four limbs, and quadruple ligation or ablation of the communication channel and restoration of fl ow by suture repair, patch, or interposition grafting of the two vessels. Transcatheter embolization and covered stent grafts have gained popularity particularly in surgically inaccessible areas. Endovascular interventions are particu­larly less morbid but the materials are expensive. Long-term follow-up is required to evaluate stent patency and monitor for stent migration.
 Percutaneous Closure Devices: Closure devices have permitted earlier
ambulation and discharge following diagnostic and therapeutic catheteri­zations. The incidence of complications ranges from 0.5–5% depending
Vascular Emergencies 187
on the sheath size, use of anticoagulation, and indications. Closure devices can actively or passively close the puncture site by using suture-mediated, collagen-based, or metal clip/disk-based mechanisms of action. The typical complication is device malfunction resulting in bleeding and necessitating manual compression or surgical exploration. Compression site thrombosis or vessel occlusion from the device itself may cause lower limb ischemia. It is necessary to have documentation of the baseline exam. Usually upon exploration, suture-mediated devices disrupts the back wall and dissects the artery or in the case of collagen devices, the material inadvertently advances into the lumen of the artery. Treatment options include exploration, surgical thrombectomy and primary repair.
 Vasopressor Induced Ischemia: Vasopressor agents such as norepi-
nephrine, dopamine, vasopressin, and epinephrine are often used to treat shock. Intricate mechanisms exist that modulate vasomotor tone by these vasoactive substances. The vasomotor response of vascular smooth mus­cle depends on whether an intact endoluminal endothelial layer is pre­sent or absent. When present, the endothelium responds to blood-borne substances that infl uence smooth muscle contractility. Paracrine mediators such as nitric oxide modulate the response. When endothelium is absent as in advanced peripheral arterial disease, the direct effect by vasoac­tive substances on vascular smooth muscle is often unopposed vasocon­striction. The consequences on digital blood fl ow can be signifi cant and result in gangrenous changes. Ischemic areas should be protected from additional mechanical injury which is expected given the likelihood of impaired sensation in the affected parts. Increasing ambient temperature and rewarming of any tissue not deemed to be irreversibly ischemic will improve tissue perfusion and prevent further tissue loss. Antimicrobial ointments such as silver sulfadiazine should be applied to blistered and de-epithelialized areas. Similar to a frostbite injury, the ischemic areas should be allowed to demarcate for auto-amputation in very severe cases.
 Acute Limb Ischemia: Arterial embolus produces acute limb ischemia
characterized by pulselessness, pallor, paralysis, pain and parasthesias. In comparison, thrombotic events are more gradual and associated with ath­erosclerotic disease. Most embolic events are cardiac in origin or derived from the atheroemboli of peripheral aneurysms. The specifi c level of the arterial occlusion directs the preference for catheter-directed thromboly­sis (distal small vessels) or opens surgical embolectomy (larger proximal vessels). Therapeutic unfractionated intravenous heparin should be started as soon as the diagnosis is suspected. The standard approach is a wide