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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5790_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Preface
- •Acknowledgements
- •Contents
- •1: Theory and Basics
- •1.1.2.3 Reflection
- •1.1.2.4 Absorption
- •1.1.2.5 Deflection
- •1.1.2.6 Focus
- •1.1.2.7 Resolution
- •1.2 Practical Application in US Device
- •1.2.1 Emission, Transmission, Reception and Amplification
- •1.2.1.1 Emission
- •1.2.1.2 Transmission
- •1.2.1.3 Reception
- •1.2.1.4 Amplification
- •1.2.2 Signal Processing
- •1.2.2.1 Preprocessing
- •1.2.2.2 Post-processing
- •1.2.2.3 Time Gain Compensation (TGC)
- •1.2.2.4 Sound Energy = Output
- •1.2.2.5 Gain
- •1.2.2.6 Frame Rate/Persistence
- •1.2.3 Components of US Device
- •1.2.3.1 Transducers
- •Sector Transducers
- •Linear Array Transducers
- •Curved Linear Array
- •Other Transducers
- •1.2.3.2 Other Parts of US Device
- •1.3 US Methods
- •1.3.1 A (Amplitude)-Mode
- •1.3.2 (T)M-Mode (Time-Motion-Mode)
- •1.3.3 B (Brightness)-Mode
- •1.3.4 Doppler Sonography
- •1.4 Artefacts
- •1.4.1 General Remarks
- •1.1 Ultrasound (US) Physics
- •1.1.1 US Waves
- •1.1.2 Propagation and Modulation of US
- •1.1.2.1 Acoustic Impedance
- •1.1.2.2 Impedance Change
- •1.4.2 Common Artefacts
- •1.4.2.1 Side Loop Artefact
- •1.4.2.2 Bowing Artefact
- •1.4.2.3 Noise
- •1.4.2.4 Marginal Shadowing
- •1.4.2.5 Posterior Enhancement – Increased Through Transmission
- •1.4.2.6 Reverberation Artefact
- •1.4.2.7 Increment or Slice Thickness/Beam Width Artefact
- •1.4.2.8 Mirror Image Artefact
- •1.4.2.9 Shadowing
- •1.4.2.10 Refraction Artefact
- •1.4.2.11 Anisotropy
- •1.5 Biologic Effects
- •1.5.1 General Remarks
- •1.5.2 Thermal Effects
- •1.5.2.1 Tissue Heating
- •1.5.2.2 Biological Effects, Tissue Heating
- •1.5.3 Mechanical Effects and Resonance
- •1.5.3.1 Cavitation
- •Acoustic Cavitation
- •Negative Peak Pressure
- •1.5.4 Potential Risks of Diagnostic US
- •1.5.4.1 Specific Risks
- •1.5.4.2 Guidelines and Recommendations
- •1.5.5.1 Mechanical Index (MI)
- •1.5.5.2 Thermal Index (TI)
- •1.5.5.3 Display of Actual Indices
- •1.6 How to Perform Paediatric US
- •1.6.1 Requisites
- •1.6.1.1 Indications
- •1.6.1.2 Environmental Requisites
- •1.6.1.3 Specific Needs in Children
- •1.6.1.4 Specific Needs in Infants and Newborns
- •1.6.2 Positioning
- •1.6.3 Device Handling
- •1.6.4 Transducer Selection
- •1.6.4.1 General Remarks
- •1.6.4.2 Neurosonography
- •1.6.4.3 Small Part US
- •1.6.4.4 Chest US
- •1.6.4.5 Abdominal US
- •1.6.5 Course of Investigation and Measurements
- •1.6.5.1 General Remarks
- •1.6.5.2 Transducer Handling
- •1.6.5.3 Measurements
- •1.7 Documentation and Interpretation
- •1.7.1 Image Documentation
- •1.7.2 Report
- •1.7.2.1 How to Issue a Report
- •1.7.2.2 Diagnosis
- •1.7.2.3 Predefined Reports
- •1.7.2.4 Nomenclature
- •1.8 Doppler Sonography
- •1.8.1 The Doppler Phenomenon
- •1.8.2.1 Continuous Wave Doppler (CW)
- •1.8.2.2 Pulsed Wave Doppler (PW)
- •1.8.2.3 Duplex-Doppler Sonography
- •1.8.2.5 Amplitude-Coded Colour Doppler Sonography (aCDS)
- •1.8.2.6 Other Flow-Sensitive US Techniques
- •1.8.2.7 Important Parameters and Measurements (Fig. 1.16)
- •1.8.3 Artefacts in (Colour) Doppler Sonography
- •1.8.3.1 Aliasing
- •1.8.3.2 Spectral Broadening
- •1.8.3.3 Sample Volume Artefact
- •1.8.3.4 Filtering Artefacts
- •1.8.3.5 Scaling Problems
- •1.8.3.6 Gain-Induced Errors
- •1.8.3.7 Angle Correction
- •1.8.3.8 Motion Artefact
- •1.8.3.9 Twinkling Artefact
- •1.8.3.10 Others
- •1.8.4 How to Perform (Colour) Doppler Investigations
- •1.8.5 Limitations
- •1.8.6 Interpretation
- •1.9 Modern and Future US Methods and Techniques
- •1.9.1 High-Resolution US (HR-US)
- •1.9.2 Image Compounding
- •1.9.3 Harmonic Imaging (HI)
- •1.9.4 Extended Field of View US
- •1.9.5 US Texture Analysis
- •1.9.6 Sonoelastography
- •1.9.7.1 Basics
- •1.9.7.2 Applications
- •Contrast-Enhanced Voiding Urosonography (ce-VUS)
- •Other Intracavitary Use of ce-US: Sono-Genitography, Sonographic Pyelography, Etc.
- •Intravenous ce-US (CEUS)
- •Future ce-US Potential
- •1.9.8 Three- and Four-Dimensional US (3D-/4DUS)
- •1.9.8.1 Physics and Techniques
- •1.9.8.2 Typical Paediatric 3DUS Applications
- •Neonatal Neurosonography
- •3DUS of the Kidney
- •Urinary Bladder 3DUS
- •3DUS of the Paediatric (Female) Genitalia
- •Musculoskeletal 3DUS Applications
- •Small Part 3DUS Applications
- •Other Potential 3D-/4DUS Applications
- •1.9.8.3 Benefits of 3D-/4DUS
- •1.9.8.4 Restrictions of 3D-/4DUS
- •2: Ultrasound-Guided Interventions
- •2.1 General Aspects
- •2.1.1 Requisites
- •2.1.1.1 Other Important Needs
- •2.1.2 Precautions and Preparations
- •2.2 US-Guided Filling of Structures for Diagnostic or Therapeutic Purpose
- •2.2.2 Diagnostic Sonographic Enema
- •2.2.3 Therapeutic Sonographic Enema
- •2.2.4 US Genitography
- •2.2.5 Contrast-Enhanced Voiding Urosonography (ce-VUS)
- •2.2.6 Other Intracavitary Contrast Applications
- •2.2.7 Intravenous ce-US
- •2.3 Biopsies and Punctures
- •2.4 Drainage
- •2.5 Vascular Access
- •2.6 Lumbar Puncture
- •2.7 Foreign Body Removal
- •3: Neurosonography in Neonates, Infants and Children
- •3.1 Requisites
- •3.1.1 Equipment and Transducer Needs
- •3.1.2 Indications for Brain US
- •3.1.3 How to Investigate
- •3.2 Normal Findings
- •3.2.1 Transfontanellar Access
- •3.2.2 Alternate Access Findings
- •3.2.3 Colour Doppler Sonography (CDS)
- •3.2.4 Normal Variances in Preterm Babies
- •3.2.4.1 Periventricular Echogenicities
- •3.2.4.2 Ventricular Asymmetry
- •3.2.4.3 Ventriculomegaly
- •3.2.4.4 Cisterna Magna
- •3.2.4.5 Vascular Variations
- •3.3 Pathologic Findings
- •3.3.1 Neural Tube Defects
- •3.3.1.1 Anencephaly
- •3.3.1.2 Meningomyelocele and Encephalocele
- •3.3.1.3 Arnold Chiari Malformation
- •3.3.1.4 Dandy-Walker Malformations
- •3.3.1.5 Corpus Callosum Malformations
- •3.3.1.6 Lipoma
- •3.3.2 Migration and Gyration Alterations and Disturbances
- •3.3.2.2 Megalencephaly
- •3.3.2.3 Schizencephaly
- •3.3.2.4 Holoprosencephaly
- •3.3.2.5 Hydranencephaly
- •3.3.3 Phakomatoses
- •3.3.4 Cerebral Cysts
- •3.3.5 Ischemic Encephalopathy
- •3.3.5.1 Preterm Infant
- •3.3.5.2 Global or Diffuse Brain Oedema
- •3.3.5.3 Focal Hypoxemia and Ischemia
- •3.3.5.4 (C)DS in Brain Hypoxia
- •3.3.6 Inflammation
- •3.3.6.1 Prenatal Intrauterine Infections and Residuals
- •3.3.6.2 Postnatal Inflammation
- •3.3.7 Dilatation of CSF Spaces: Hydrocephalus
- •3.3.8 Cerebral Haemorrhage
- •3.3.8.2 Haemorrhage in Term Infants
- •3.3.8.3 Role of CDS in Neonatal Haemorrhage
- •3.3.8.4 Haemorrhage in Infants and Older Children
- •3.3.9 Tumours and Space-Occupying Lesions
- •3.3.9.1 Vascular Malformations
- •3.3.10 Cerebral Calcifications
- •3.4 Ultrasound of the Skull
- •3.4.1 Introduction
- •3.4.2 Haematoma
- •3.4.3 Space-Occupying Lesions and Tumours
- •3.4.4 Skull Fracture
- •3.5 Additional Imaging
- •3.5.1 Plain Film
- •3.5.2 CT
- •3.5.3 MRI
- •3.5.4 Catheter Angiography
- •3.5.5 Additional Supporting Procedures
- •3.6 Ultrasound of the Eye and the Orbit
- •3.6.1 Introduction
- •3.6.2 Normal Findings
- •3.6.3 Sonographically Depictable Pathology
- •3.7 Ultrasound of the Spinal Canal
- •3.7.1 Requisites
- •3.7.2 Transducers and Technique
- •3.7.3 Indications
- •3.7.4 Normal Findings
- •3.7.5 Pathologic Findings of the Spinal Cord
- •3.7.5.1 Dysraphism
- •3.7.5.2 Other Associated Pathology
- •3.7.5.3 Other “Occult” Dysraphisms
- •3.7.6 Trauma
- •3.7.7 Tumours
- •3.7.8 Other Spinal and Vertebral Pathology
- •3.7.9 Additional Imaging
- •3.7.10 Value of US
- •4: Ultrasound of the Neck
- •4.1 Indications, Requisites and Techniques
- •4.1.1 Transducers
- •4.1.2 Positioning and Handling
- •4.1.3 Typical Examinations
- •4.1.3.1 Cervical Lymph Nodes
- •4.1.3.2 Glands
- •4.1.3.3 Cervical Arteries
- •4.1.3.4 Cervical Veins
- •4.1.3.5 Intervention
- •4.2 Normal Findings
- •4.2.1 Lymph Nodes
- •4.2.2 Cervical Glands
- •4.2.2.1 Thyroid Gland
- •4.2.2.2 Parotid, Submandibular and Sublingual Glands
- •4.2.3 Other Cervical Soft Tissues
- •4.2.3.1 Muscles
- •4.2.3.2 Tonsils
- •4.2.3.3 Tongue
- •4.2.3.4 Para- and Retropharyngeal Spaces
- •4.2.3.5 Larynx
- •4.2.4 Cervical Vessels
- •4.3 Pathologic Findings
- •4.3.1 Lymph Nodes
- •4.3.2 Pathology of Cervical Soft Tissue
- •4.3.2.1 Malformations
- •Cervical Cyst
- •Dermoid Cyst
- •Duplication Cysts
- •Thymic Cyst
- •Cervical Ectopic Thymus
- •4.3.2.2 Tumours
- •Haemangioma
- •Lymphatic Malformation
- •Other Mesenchymal Tumours
- •Neuroblastoma, (Ganglio-)Neuroma, Neurofibroma and Other Nerve (Sheath) Tumours
- •Teratoma
- •Other Malignant Tumours
- •Role of US
- •4.3.2.3 Abscess Formations
- •4.3.2.4 Traumatic Changes
- •Haematoma (Including Sternocleidomastoid Muscle “Haematoma”)
- •4.3.3 Thyroid Gland
- •4.3.3.1 Cystic Changes
- •4.3.3.2 Malformations
- •4.3.3.3 Inflammation
- •4.3.3.4 Other Conditions
- •Hypothyroidism/Struma Diffusa/Colloides (Fig. 4.17)
- •Nodular Goitre
- •Amyloid Goitre
- •Adenoma/Carcinoma
- •4.3.4.1 Inflammation
- •4.3.4.2 Cysts
- •4.3.4.3 Calcifications/Sialolithiasis
- •4.3.4.4 Tumours
- •4.3.5 Cervical Vessels
- •4.3.5.1 Arteriosclerosis
- •4.3.5.2 Dissection
- •4.3.5.3 Stenosis
- •4.3.5.4 Other Vascular Anomalies
- •4.3.5.5 Thrombosis and Occlusion
- •5: Basics of Paediatric Echocardiography
- •5.1 Introduction
- •5.2 Equipment Needs and Specific Considerations
- •5.2.1 Transducers
- •5.2.2 Standard US Techniques
- •5.2.3 Patient Position
- •5.2.4 Sedation
- •5.3 Standard Planes and Standardised Course of Examination
- •5.4 Normal 2D Echocardiogram Findings
- •5.4.1 Parasternal Views
- •5.4.1.1 Parasternal Long Axis View (Fig. 5.2)
- •5.4.1.2 Parasternal Short Axis Views (Figs. 5.3 and 5.4)
- •5.4.2 Apical Views
- •5.4.3 Subcostal Views
- •5.4.3.1 Sagittal Subcostal View
- •5.4.3.2 Subcostal Four-Chamber View (Fig. 5.6)
- •5.4.4 Suprasternal View (Fig. 5.7)
- •5.5 Other Techniques
- •5.5.1 M (Motion)-Mode Echocardiography
- •5.5.2 Doppler Sonography
- •5.5.2.1 CDS with 2DUS
- •5.5.2.2 PW- and CW-Doppler
- •5.5.2.3 Calculation of Pressure ( P) Gradients ( P 1 Minus P 2)
- •5.5.3 Other Calculations and Functional Parameters
- •5.6 Special Echocardiographic Techniques
- •5.6.1 Transoesophageal Echocardiography (TEE)
- •5.6.2 Three-Dimensional (3D) Echocardiography
- •5.6.3 Tissue Doppler Imaging (TDI)
- •5.6.4 Contrast-Enhanced US
- •5.7 Normal Values
- •5.8 Pathologic Findings
- •5.8.1 Congenital Heart Defects with Left-to-Right Shunt
- •5.8.1.1 Atrial Septal Defect (ASD)
- •5.8.1.2 Atrioventricular Septal Defects (AVSD)
- •5.8.1.3 Ventricular Septal Defects (VSD)
- •5.8.1.4 Patent Ductus Arteriosus of Botalli (PDA)
- •5.8.1.5 Persistent Truncus Arteriosus (Truncus Arteriosus Communis)
- •5.8.2 Obstructions of Left Ventricular Outflow
- •5.8.2.1 Aortic Valve Stenosis (AS)
- •5.8.2.2 Subaortic Stenosis (Sub AS)
- •5.8.2.3 Supravalvular Aortic Stenosis
- •5.8.2.4 Aortic Coarctation (CoA)
- •5.8.2.5 Interrupted Aortic Arch
- •5.8.3 Obstructions of the Right Ventricular Outflow
- •5.8.3.1 Isolated Pulmonary Valve Stenosis (PS)
- •5.8.3.2 Subvalvular Pulmonary Stenosis
- •5.8.3.3 Supravalvular Pulmonary Stenosis
- •5.8.4 Miscellaneous Congenital Heart Defects
- •5.8.4.1 Transposition of Great Arteries (TGA)
- •5.8.4.2 Total Anomalous Pulmonary Venous Return (TAPVR)
- •5.8.4.3 Univentricular Heart (UVH)
- •5.8.4.4 Double Outlet Right Ventricle (DORV)
- •5.8.4.5 Ebstein Anomaly
- •5.8.4.6 Cor Triatriatum
- •5.9 Acquired Paediatric Heart Diseases
- •5.9.1 Cardiomyopathies (CMP)
- •5.9.1.1 Hypertrophic CMP
- •5.9.1.2 Hypertrophic Obstructive CMP (HOCMP)
- •5.9.1.3 Dilated (Congestive) CMP
- •5.9.1.4 Restrictive CMP
- •5.9.2 Acute Myocarditis
- •5.9.3 Acute (Infective) Endocarditis
- •5.9.4 Pericarditis/Pericardial Effusion
- •5.9.5 Kawasaki Disease
- •5.9.6 Intracardiac Thrombi
- •5.9.7 Cardiac Tumours
- •5.10 Complementing Investigations
- •5.10.1 Cardiac Catherisation and Angiography
- •5.10.2 Cardiac MRI and CT
- •5.11 When to Do What
- •5.11.1 Imaging in Typical Clinical Scenarios
- •5.11.1.1 Typical Orientating Examination
- •5.11.1.2 Typical Clinical Queries
- •5.11.2 Trauma and Emergency
- •6: Ultrasound of the Chest
- •6.1 Requisites
- •6.1.1 Transducers
- •6.1.2 Positioning
- •6.1.3 Indications
- •6.1.4 How to Perform Chest US
- •6.2 Normal Findings
- •6.2.1 Chest Wall
- •6.2.2 Breast
- •6.2.3 Pleural Space
- •6.2.4 Diaphragm
- •6.2.5 Lung
- •6.2.6 Mediastinum
- •6.2.6.1 Anterior Mediastinum/Thymus
- •6.2.6.2 Middle Mediastinum
- •6.2.6.3 Posterior Mediastinum
- •6.2.7 CDS
- •6.3 Pathology of Chest Wall
- •6.3.1 Aplasia, Variations of Ribs
- •6.3.2 Congenital Malformations
- •6.3.3 Traumatic Changes
- •6.3.4 Chest Wall Tumours
- •6.3.4.1 Lymphangioma (veno-lymphatic vascular malformation)
- •6.3.4.2 Lipoma
- •6.3.4.3 Fibroma/Neurofibroma
- •6.3.4.4 Other Tumours
- •6.3.5 Breast
- •6.3.6 Role of US and Additional Imaging
- •6.4 Pathology of Pleural Space
- •6.4.1 Pleural Effusion
- •6.4.2 Empyema
- •6.4.3 Other Pleural Pathology
- •6.4.4 Role of Imaging
- •6.5 Pathology of Diaphragm
- •6.5.1 Diaphragmatic Hernia
- •6.5.2 Diaphragmatic Motion Disturbance
- •6.5.3 Role and Potential of Imaging
- •6.6 Lung Pathology
- •6.6.1 Pneumonia
- •6.6.2 Lung Abscess
- •6.6.3 Atelectasis
- •6.6.5 Sequestration
- •6.6.6 Congenital Cystic Adenomatoid Malformation (CCAM)
- •6.6.7 Cysts
- •6.6.8 Infarction
- •6.6.9 Tumours and Space-Occupying Lesions
- •6.7 Other Miscellaneous and Rare Applications
- •Many More Partially Rare Applications Reported: Most Relevant Ones
- •6.7.1 US for Interstitial Lung Disease
- •6.7.2 US for Pneumothorax
- •6.8 Additional Imaging
- •7: Liver and Bile System
- •7.1 Requisites and Investigation
- •7.1.1 Preparation
- •7.1.2 Positioning
- •7.1.3 Transducers
- •7.1.4 Course of Investigation
- •7.1.5 Standard Planes
- •7.2 Normal Findings
- •7.2.1 Structure
- •7.2.2 Ligaments
- •7.2.3 Hepatic Veins (HV)
- •7.2.4 Portal Vein (PV)
- •7.2.5 Hepatic Artery (HA)
- •7.2.6 Gall Bladder
- •7.2.8 Intrahepatic Bile Ducts
- •7.2.9 Doppler Findings
- •7.2.9.1 Hepatic Veins (HV)
- •7.2.9.2 Portal Vein (PV)
- •7.2.9.3 Hepatic Artery (HA)
- •7.2.10 Special Aspects of Newborns and Infants
- •7.3 Pathology of the Liver
- •7.3.1 Congenital Changes and Normal Variance
- •7.3.1.1 Situs Inversus (Abdominalis)
- •7.3.1.2 Butterfly or Midline Liver
- •7.3.1.3 Hypoplasia/Atrophy of Left Liver Lobe and Other Variations
- •7.3.2 Inflammatory Conditions
- •7.3.2.1 Hepatitis
- •7.3.2.2 Liver Abscess
- •7.3.2.3 Granulomatous Disease
- •7.3.2.4 Role of US
- •7.3.3 Other Parenchymal Liver Disease
- •7.3.3.1 Hepatopathy
- •Fatty Liver/Steatosis
- •Liver Congestion
- •7.3.3.2 Liver Fibrosis
- •7.3.3.3 Cirrhotic Liver
- •7.3.3.4 Liver Involvement in Systemic Disease
- •Cystic fibrosis
- •Glycogen storage disease
- •Tyrosinaemia
- •Wilson disease
- •α1-antitrypsin deficiency
- •Haemosiderosis
- •7.3.3.5 Role of US
- •7.3.4 Portal Hypertension and Vascular Problems
- •7.3.4.1 Portal Hypertension
- •7.3.4.2 Vascular Malformations
- •7.3.4.3 Portal vein and hepatic artery stenosis
- •7.3.4.5 Hepatic vein thrombosis/occlusion/stenosis
- •Budd-Chiari syndrome
- •Veno-occlusive disease (VOD)
- •Increased right atrial/intrathoracic pressure
- •7.3.4.6 Portosystemic Shunts
- •7.3.5 Liver Trauma
- •7.3.5.1 Liver Haematoma
- •7.3.5.2 Contusion
- •7.3.5.3 Laceration
- •7.3.5.4 Haemobilia
- •7.3.5.5 Associated Diaphragmatic Injury
- •7.3.5.6 Liver Infarction
- •7.3.5.7 Role of US in Liver Trauma
- •7.3.5.8 Additional Imaging
- •7.3.6 Space-Occupying Liver Lesions
- •7.3.6.1 Simple Cysts
- •7.3.6.2 Complicated Cysts
- •7.3.6.3 Liver Calcifications
- •7.3.6.4 Intrahepatic Gas
- •7.3.6.5 Haemangioma
- •7.3.6.6 Mesenchymal Hamartoma
- •7.3.6.7 Focal Nodular Hyperplasia (FNH)
- •7.3.6.8 Hepatic Adenoma
- •7.3.6.9 Fatty Tumours
- •7.3.6.10 Hepatoblastoma
- •7.3.6.11 Hepatocellular Carcinoma
- •7.3.6.12 Hepatic Sarcomas
- •Embryonal Cell Sarcoma
- •Rhabdomyosarcoma
- •Angiosarcoma
- •Hepatic Leiomyosarcoma
- •7.3.6.13 Metastasis
- •7.3.6.14 Proliferative Disorders
- •7.3.6.15 Role of US
- •7.3.6.16 Additional Imaging
- •7.4 Biliary Tract and Gall Bladder
- •7.4.1 General Findings
- •7.4.2 Congenital Conditions and Normal Variants of Biliary Tract
- •7.4.2.1 Intrahepatic Gall Bladder
- •7.4.2.3 Choledochal cyst
- •7.4.3 Biliary Tract Diseases
- •7.4.3.1 Aerobilia
- •7.4.3.2 Cholestatic Changes/Inspissated Bile/Gall \stone
- •7.4.3.3 Sclerosing cholangitis
- •7.4.3.4 Other Forms of Cholangitis and Cholecystitis
- •7.4.4 Tumour-Like Conditions
- •7.4.4.1 Polyps
- •7.4.4.2 Tumours
- •Cholangiocellular Tumours
- •Granular Cell Tumour
- •7.4.5 Role of US
- •7.4.5.1 Cholestasis and Jaundice
- •7.4.5.2 Malformations
- •7.4.5.3 Trauma
- •7.4.5.4 Postoperative Conditions
- •7.4.5.5 Metabolic Disease
- •7.4.7 Additional Imaging
- •7.5 US in Liver Transplantation
- •7.5.1 Pretransplant US
- •7.5.1.1 Recipient Evaluation
- •7.5.2 Intraoperative US
- •7.5.3 Postoperative Assessment
- •7.5.4 Typical Complications
- •8: Spleen and Pancreas
- •8.1 Spleen
- •8.1.1 Requisites
- •8.1.2 Positioning
- •8.1.3 Indications
- •8.1.4 Course of Investigation
- •8.1.5 Normal Anatomy
- •8.1.6 Normal Variants
- •8.1.6.1 Splenunculus (Accessory Spleen)
- •8.1.6.2 Splenic Lobulations and Clefts
- •8.1.7 Malformations
- •8.1.7.1 Asplenia
- •8.1.7.2 Polysplenia Syndrome
- •8.1.7.3 Wandering Spleen
- •8.1.8 Splenomegaly
- •8.1.9 Trauma
- •8.1.10 Splenic Infarction
- •8.1.11 Space-Occupying Lesions of the Spleen
- •8.1.11.1 Cysts
- •8.1.11.2 Abscess
- •8.1.11.3 Tumours and Space-Occupying Lesions
- •8.1.11.4 Role of US
- •8.2 Pancreas
- •8.2.1 Requisites
- •8.2.2 Indication
- •8.2.3 Course of Investigation
- •8.2.4 Normal Findings
- •8.2.5 Variations and Malformations
- •8.2.5.1 Annular Pancreas
- •8.2.5.2 Pancreas Divisum
- •8.2.6 Inflammation: Pancreatitis
- •8.2.6.1 Oedematous or Reactive Pancreatitis
- •8.2.6.2 Haemorrhagic or Necrotising Pancreatitis
- •8.2.6.3 Chronic Pancreatitis
- •8.2.7 Trauma
- •8.2.8 Space-Occupying Lesions
- •8.2.8.1 Cysts/Pseudocysts
- •8.2.8.2 Tumours
- •8.2.9 Role of US
- •8.2.10 Additional Imaging
- •8.3.1 Abdominal Vessels
- •8.3.1.1 Positioning
- •8.3.1.2 Transducers
- •8.3.1.3 How to Investigate
- •8.3.1.4 US Findings
- •8.3.1.5 Important Variants and Malformations
- •8.3.2 Vascular Pathology
- •8.3.2.1 Thrombosis/Occlusion
- •8.3.2.2 Pelvic Congestion Syndrome
- •8.3.2.3 Mid-aortic Syndrome
- •8.3.2.4 Retroaortic Left Renal Vein: Nutcracker Syndrome (see Chap. 10)
- •8.3.2.6 Arteriosclerotic Changes and Aneurysms
- •8.3.2.7 Embolic Thrombus to Abdominal Aorta
- •8.3.2.8 Role of US
- •8.3.2.9 Complementing Imaging
- •8.3.3 Mesentery
- •8.3.3.1 Mesenteric (Peritoneal) Masses
- •Cyst
- •Lymphatic Vascular Malformation and Other Tumours
- •8.3.3.2 Abscesses
- •8.3.3.3 Twisted Appendices Epiploica
- •8.3.4 Mesenteric Lymph Nodes
- •8.3.5 Free Intraperitoneal Air
- •8.3.6 Free Intraperitoneal Fluid: Ascites
- •8.3.7 Retroperitoneal Soft Tissues
- •8.3.7.1 Lymph Nodes
- •8.3.7.2 Retroperitoneal Tumours
- •8.3.8 Abdominal Wall
- •9: US of the Gastrointestinal (GI) Tract
- •9.1 Stomach
- •9.1.1 Requisites
- •9.1.2 How to Investigate
- •9.1.2.1 Access
- •9.1.2.2 Functional Assessment of Bowel and Stomach
- •9.1.3 Normal Findings
- •9.1.4 Normal Variants
- •9.1.5 Malformations
- •9.1.5.1 Microgastria
- •9.1.5.2 Pyloric Atresia
- •9.1.5.3 Congenital Hiatal Hernia
- •9.1.6 Pathologic Findings
- •9.1.6.1 Gastro-Oesophageal Reflux (GOER)
- •9.1.6.2 Hypertrophic Pyloric Stenosis (HPS)
- •9.1.6.3 Other Stomach Conditions
- •Gastritis/Ulcers
- •Bezoars and Foreign Bodies
- •Hyperplastic Gastric Mucosa
- •Menetrier’s Disease: Giant Hypertrophy of Gastric Mucosa
- •Eosinophilic Gastr(oenter)itis
- •Gastric Perforation
- •Granulomatous Disease
- •Duplication Cysts
- •Teratoma
- •Focal Foveolar Hyperplasia
- •Inflammatory Pseudotumour
- •Other Benign Tumours
- •Malignant Masses
- •9.1.7 Role of US
- •9.2 Bowel
- •9.2.1 Preparation and Requisites
- •9.2.2 Course of Investigation
- •9.2.3 Normal US Findings
- •9.2.4 Pathology
- •9.2.4.1 Congenital Anomalies
- •Atresia
- •Malrotation
- •Volvulus
- •Hirschsprung Disease/Neuronal Intestinal Dysplasia (NID)
- •Duplication/Diverticula
- •Meckel’s Diverticulum
- •9.2.5 Acquired Obstructive Pathology
- •9.2.5.1 Meconium Ileus
- •9.2.5.2 Midgut Volvulus
- •9.2.5.3 Sigma Volvulus
- •9.2.5.4 Hernia
- •9.2.5.5 Intussusception
- •9.2.5.6 Tumours
- •9.2.6 Inflammatory Conditions
- •9.2.6.1 Necrotising Enterocolitis (NEC)
- •9.2.6.2 Gastroenteritis
- •9.2.6.3 Henoch-Schönlein Purpura
- •9.2.6.4 Appendicitis
- •9.2.6.5 Crohn’s Disease
- •9.2.6.6 Colitis
- •9.2.6.7 Other Inflammatory Bowel Conditions
- •9.2.6.8 Bowel Trauma
- •10: Ultrasound of the Urogenital Tract
- •10.1 Requisites
- •10.1.1 Indications
- •10.1.2 Preparation
- •10.1.3 Transducers
- •10.1.4 Positioning
- •10.1.5 How to Investigate
- •10.1.5.1 Diuretic US
- •10.2 Normal Findings
- •10.2.1 Bladder
- •10.2.2 Kidney
- •10.2.2.1 Normal Variants
- •Duplex Kidney
- •Ectopic Kidneys
- •Renal Agenesis
- •Fusion Anomalies and Other Rare Findings
- •10.3 Pathology of the Kidney
- •10.3.1 Congenital Conditions
- •10.3.1.1 Dysplasia/Hypoplasia
- •10.3.1.2 Cystic Renal Disease
- •Inherited/Congenital Cystic Disease
- •Acquired Cystic Kidney Disease
- •10.3.1.3 Alteration of Urinary Drainage
- •Hydronephrosis (HN)
- •Ureteropelvic Junction Obstruction (UPJO)
- •Uretero-Vesical Junction Obstruction (UVJO)/Obstructive Megaureter (POM/MU)
- •Posterior Urethral Valve (PUV)
- •Vesico-Ureteric Reflux (VUR)
- •Secondary Obstruction
- •10.3.2 Inflammatory Renal Parenchymal Conditions
- •10.3.2.1 Pyelitis
- •10.3.2.2 Acute Pyelonephritis (aPN)/Interstitial Nephritis
- •10.3.2.3 Necrosis and Abscess Formation
- •10.3.2.4 Scarring
- •10.3.2.5 Tuberculosis
- •10.3.2.6 Xanthogranulomatous Pyelonephritis
- •10.3.2.7 Glomerulonephritis/Nephrotic Syndrome
- •10.3.3 Vascular Conditions
- •10.3.3.1 Renal Artery Stenosis
- •10.3.3.2 Arteriovenous Fistula (AVF)
- •10.3.3.3 Infarction
- •10.3.3.4 Renal Vein Thrombosis
- •10.3.4 Nephrocalcinosis
- •10.3.5 Urolithiasis
- •10.3.6 Other Important Renal Parenchymal Disease
- •10.3.6.1 Haemolytic Uremic Syndrome (HUS)
- •10.3.6.2 Glomerulonephritis/Nephrotic Syndrome
- •10.3.6.3 Scars, Cirrhotic Kidney
- •10.3.7 Renal Failure (RF)
- •10.3.8 Renal/Urinary Tract Trauma
- •10.3.9 Renal Tumours
- •10.3.9.1 Benign Tumours
- •10.3.9.2 Pre- or Semimalignant Tumours
- •10.3.9.3 Malignant Tumours
- •10.4 Renal Biopsy and Interventions
- •10.4.1 Renal Biopsy
- •10.4.2 Drainage/Nephrostomy
- •10.4.3 Postoperative Imaging
- •10.4.3.1 After VUR Treatment
- •Cystoscopic Treatment
- •Antireflux Surgery
- •10.4.3.2 Findings After Pyeloplasty
- •10.4.3.3 After Various Interventions
- •10.5 Renal Transplant
- •10.5.1 Normal US Findings in Renal Transplant
- •10.5.2 Pathologic US Findings
- •10.6 Adrenal Glands and Pararenal Space
- •10.6.1 General Remarks
- •10.6.2 Typical Normal US Finding
- •10.6.3 Pathologic Findings
- •10.6.3.1 Adrenal Gland Haemorrhage
- •10.6.3.2 Inflammatory Condition
- •10.6.3.3 Tumours
- •Adrenal Cysts
- •Adrenal Adenoma
- •Neuroblastoma
- •Ganglioneuroma
- •Phaeochromocytoma
- •Adrenal Carcinoma
- •Role of US
- •10.7 US of Urinary Bladder
- •10.7.1 Requisites
- •10.7.2 Pathologic Findings
- •10.7.2.1 Atypical Shape (Neurogenic Bladder, “Valve Bladder”)
- •10.7.2.2 Polyps
- •10.7.2.3 Bladder Tumours
- •10.7.2.4 Calcification in/of Bladder
- •10.7.2.5 Ureterocele
- •10.7.2.6 Persisting Urachus
- •10.7.2.7 Megaureter
- •10.7.2.8 Infravesical Obstruction
- •10.7.2.9 Inflammation
- •10.7.2.10 Traumatic Changes
- •10.7.2.11 Vesico-ureteric Reflux
- •10.7.3 Paravesical Changes
- •10.7.3.1 Abscess Formations
- •10.7.3.2 Tumours of Paravesical Region
- •10.7.3.3 Cystic Perivesical Structures
- •10.7.4 Role of US
- •10.8 US of Male Genitals
- •10.8.1 US Technique
- •10.8.2 Normal Findings
- •10.8.3 Common Pathologic Findings
- •10.8.3.1 Hydrocele
- •10.8.3.2 Undescended Testes
- •10.8.3.3 Varicocele
- •10.8.3.4 Cystic Dysplasia of Rete Testis and Seminal Vesicles
- •10.8.3.6 Microlithiasis
- •10.8.4 Inflammation – Orchitis, Ependymitis
- •10.8.5 Scrotal Trauma
- •10.8.6 Torsion
- •10.8.6.1 Torsion of Appendages
- •10.8.6.2 Inguinal Hernia
- •10.8.7 Testicular Tumours
- •10.8.8 Role of US and Additional Imaging
- •10.9 Female Genitals
- •10.9.1 Indications
- •10.9.2 Requisites
- •10.9.3 Transducers
- •10.9.4 How to Perform Investigation
- •10.9.5 Normal Findings
- •10.9.5.1 Sonogenitography
- •10.9.6 Pathologic Findings
- •10.9.6.1 Congenital Malformations
- •Vaginal Septum and Duplications
- •Vaginal Atresia
- •Vaginal Fistula
- •Other Vaginal Malformations
- •Vaginal Aplasia
- •Uterine Malformations
- •Ovarian Malformations
- •10.9.6.2 Inflammatory Conditions of Female Genitalia
- •10.9.6.3 Genital Tumours and Space-Occupying Lesions
- •Cysts
- •Teratoma
- •Other Genital Tumours
- •Rhabdomyosarcoma
- •10.9.6.4 Traumatic Changes
- •Ovarian Torsion
- •Pregnancy
- •10.9.6.6 Role of US/Additional Investigations
- •11: Small Part and Hip Ultrasound
- •11.1 Hip US
- •11.1.1 General Remarks
- •11.1.2 Examination Technique
- •11.1.2.1 Hip US According to Graf
- •11.1.2.2 Modified Graf Classification (Rosendahl)
- •11.1.2.3 Hip US According to Harcke
- •11.1.3 Normal Anatomy
- •11.1.3.1 US Criteria in Graf
- •11.1.3.2 Rosendahl Modification
- •11.1.3.3 Normal Findings During Harcke Investigation
- •11.1.3.5 Hip US in Older Children
- •11.1.4 Pathologic Findings
- •11.1.4.1 Developmental Dysplasia of the Hip (DDH)
- •11.2 Other Conditions of Hip Joint
- •11.2.1 Arthritis and Inflammation of Hip Joint
- •11.2.1.1 Capsular Thickening
- •11.2.1.2 Joint Fluid/Effusion
- •11.2.1.3 Hip Osteoarthritis
- •11.2.3 Perthes Disease
- •11.3 Investigation of Bones, Joints, Tendons
- •11.3.1 Requisites and Technique
- •11.3.2 Typical Normal Findings
- •11.3.3 Pathologic Findings
- •11.3.3.1 Fracture
- •11.3.3.2 Joint Effusion
- •Simple Effusion
- •Complicated Effusion
- •11.3.3.3 Arthritis
- •11.3.3.4 Trauma
- •Haematoma
- •Rupture of Tendon
- •11.3.3.5 Cysts
- •11.3.3.6 Inflammation
- •Myositis
- •Cellulitis
- •Fasciitis
- •Tendinitis – Tendovaginitis/Synovitis
- •Osteomyelitis, Soft Tissue Abscess
- •11.3.3.7 Neoplasia
- •11.3.3.8 Foreign Bodies
- •11.3.3.9 Peripheral Nerves
- •11.4 US for Peripheral Vessels
- •11.5 US-Guided Interventions
- •Index

7.3 Pathology of the Liver
Alternatively, ce-US after IV US-CM administration signifi cantly improves US
potential to diagnose injuries early, with similar sensitivity as CT and may even
visualise active bleeding (BUT: at present US-CMs in paediatrics are off-label
only).
7.3.5.1 Liver Haematoma
Simple haematoma or subcapsular haemorrhage is usually less threatening, may
become more serious if liver capsule is ruptured and signifi cant free peritoneal fl uid
seen (potentially with more or less sedimentation depending on time of
investigation).
NOTE : Free peritoneal fl uid/blood appearing like complicated ascites can be found
anywhere in abdomen and does not necessarily correlate with site of injury, as fl uid
redistributes depending on positioning and other phenomena.
US Findings
Initially same echogenicity as liver parenchyma, potentially disruption of other
structures such as vessels or outer contour can aid diagnosis (Fig. 7.13a ). Thereafter
appear hyperechoic, eventually turns hypoechoic with more or less complex appearance. Persisting hypoechoic posttraumatic lesions indicate seroma/cyst or even
biloma (the latter particularly when growing) (Fig. 7.13d ).
a
bc
235
d
Fig. 7.13 Liver trauma: ( a ) Large subcapsular liver haematoma (+ +), reactive ascites and pleural
effusion. ( b ) Liver laceration – initial baseline US scan. ( c ) IV ce-US (CEUS) (same patient as in
b ) clearly delineates the liver laceration in early phase. ( d ) Cystic transformation of old liver hae-
matoma (seroma – diffi cult to differentiate from biloma)

236
7 Liver and Bile System
7.3.5.2 Contusion
More diffi cult to diagnose, often triangular in shape, located in subcapsular.
US and CDS fi ndings
Initially diffi cult to see, echogenicity changes from hyperechoic to hypoechoic.
(a)CDS may improve detection of contusions by focal disruption of normal vascular architecture with regional rarefaction of vessel colour signals.
7.3.5.3 Laceration
Defi nition
Disruption of liver parenchyma and capsule.
US Findings
Discontinuity of contour may be primary fi nding – despicable even in early stages.
IV ce-US (CEUS) will aid early diagnosis (Fig. 7.13b, c ). Often appears hypoechoic,
whereas surrounding tissue inhomogenously patchy, with more or less echogenic
areas. Local haematoma will coexist (see above).
NOTE : Pay particular attention to involvement of major structures such as major
bile ducts, central PV or involvement of HVs (may develop occlusion and thrombosis causing necrosis of respective liver segment). If extrahepatic hypoechoic collections persist after liver trauma, consider bile leakage and biloma.
7.3.5.4 Haemobilia
Haemorrhage into bile ducts – sludge-like echoes in bile ducts/gall bladder.
7.3.5.5 Associated Diaphragmatic Injury
Rarely diaphragm can be involved. Detectable commonly just by reactive palsy with
high position of upper liver border + subphrenic haematoma + reactive pleural effusion (common).
If diaphragm ruptured, US may be able to demonstrate herniation of liver or
haematoma into thorax.
NOTE : Reliable assessment of integrity and continuity of entire diaphragm is
impossible by US, particularly on left side.
7.3.5.6 Liver Infarction
Rare traumatic fi nding due to dual blood supply, more common after transplantation
or surgery and more common in HA than PV, usually branch occlusion. Potentially
also more diffuse after severe shock with diffuse hypoperfusion and hypooxygenation of liver. Other causes are systemic vascular or haemolytic disease.
US and CDS fi ndings
Typically wedge shaped, round to oval hypoechoic area with indistinct margins and
peripheral distribution reaching to subcapsular area. Secondary necrosis with cystic
structures or even hyperechoic foci representing gas, secondary calcifi cation and
bile lakes. CDS – lack of perfusion in affected vessel.
7.3.5.7 Role of US in Liver Trauma
First imaging modality in moderate blunt abdominal trauma – need to perform more
than just FAST (“focused abdominal US for trauma”, as performed in emergency

7.3 Pathology of the Liver
237
room for detection of free fl uid). Detailed study in any stable patient can help to
reduce need for (or for tailoring) CT. US follow-up after 6–24 h is essential. Ce-US
improves lesion detection, particularly in early phase (see Fig. 7.13 ).
NOTE : Ce-CT is mandatory (after FAST ) in severe and multiple trauma – US may
additionally miss signifi cant injuries of retroperitoneal structures, bowel and spine,
as well as chest involvement – US fi ndings may serve as indicator injury.
7.3.5.8 Additional Imaging
Acute setting/severe trauma: Ce-trauma-CT mandatory.
For assessing equivocal lesions in stable patient/follow-up: dynamic ce-CT
increasingly replaced by ce-MR for radiation protection; consider ce-US if
available.
Abdominal plain fi lm – no utility.
Chest fi lm – usually performed in multiple trauma in ER.
7.3.6 Space-Occupying Liver Lesions
7.3.6.1 Simple Cysts
Commonly congenital, usually an incidental fi nding, rarely asymptomatic.
Other causes: posttraumatic, after (displaced) umbilical vein catheter, after
abscess, after surgery, bile leakage and biloma, infectious, biliary malformations/
cysts, cystic/necrotic part of tumour.
US Findings
Anechoic fl uid, spherical, thin and smooth wall, no parenchymal nodules (Fig. 7.14 ).
NOTE : As soon as there are septae, parenchymal areas or thick wall-like membranes, other entities such as abscesses, hydatid cyst, epidermoid cyst (potentially
with complex content) must be considered (see Fig. 7.15 ).
7.3.6.2 Complicated Cysts
Different causes, postinfectious/posttraumatic/postsurgical or hematogenous/
ascending infl ammatory disease and cystic tumours
Fig. 7.14 Cystic liver lesions. Huge, but otherwise
simple liver cyst

238
ab c d
Fig. 7.15 Complicated liver cysts: ( a ) Complicated liver cyst with sedimentation – probably post-
traumatic. ( b ) Complicated liver cyst after a liver abscess. ( c ) Complicated liver cyst with split wall
and septations – a hydatid cyst ( d ) Complex cystiform lesion (+ +) after surgery that proved to be
a biloma
7 Liver and Bile System
US and CDS fi ndings
Similar to simple cysts, but additionally fl oating echoes, septae, thick wall or parenchymal nodules (Fig. 7.15 ). Need at least follow-up or additional diagnostic efforts.
Sometimes resected/punctured, particularly in suspicion of tumour or for (sclerosing) therapy.
CDS may fi nd vascularisation of wall, septae or parenchymal nodules.
7.3.6.3 Liver Calcifications
Variety of causes such as after haemorrhage, abscess, bile duct concretion, cholangitis,
Caroli syndrome, cystic fi brosis, infl ammatory (viral, particularly fetal infections) and
meconium peritonitis (capsular calcifi cations). US usually cannot defi ne aetiology.
US and CDS fi ndings
• Echogenic spots of varying size with dorsal shadowing, depending on amount of
calcium/size (Fig. 7.16 )
• May (must not!) twinkle on CDS
• Single or multiple
7.3.6.4 Intrahepatic Gas
Either in vasculature or bile ducts:
• In biliary system: usually ascends from duodenum (e.g. due to distal obstruction,
associated with bile duct pathology), may be associated with infection + second-
ary calcifi cations, may also be transient without any sequelae
• In vessels: gas bubbles commonly within PV system, derive from some condi-
tion in GI tract, (e.g. necrotising entocolitis, severe gaseous distention); may also
be idiopathic
US and CDS fi ndings
Most commonly air/gas gathers in dependent areas (highest parts of liver – upper
ventral areas in supine position). Seen as echogenic foci (with comet-tail-like reverberation echoes), sometimes fl oating echogenic foci visualised in central PV
(Fig.
7.17 ).

7.3 Pathology of the Liver
239
ab
Fig. 7.16 Liver calcifi cation: ( a ) Superfi cial liver calcifi cation with shadowing. ( b ) CDS shows
some twinkling artefact of subcapsular calcifi cation
abc
Fig. 7.17 Liver/portal venous gas: ( a ) Intrahepatic bright spots – in this case due to air in bile
ducts. ( b ) Air spikes in portal liver fl ow spectra (due to NEC). ( c ) Bidirectional “Doppler noise” on
spectral analysis – obviously not in portal vein branches – thus aerobilia has to be suggested (note
arterial hyperaemia)
CDS (Fig. 7.17b, c ): multidirectional colour signals, similar to twinkling arte-
fact. Typical bidirectional spikes on spectral trace, helpful for DDx biliary versus
vascular air – intravascular if found within portal vein.
NOTE : US – most sensitive method for detecting air, long before visualised on
plain fi lm. If found, should prompt thorough US investigation of GI tract.
7.3.6.5 Haemangioma
Not a single entity, different ages of manifestation, different tendencies for spontaneous regression:
• The classical small haemangioma (adult type, “cavernous” haemangioma; –
remeber new classifi cation = venous vascular malformation) – benign condition.
Rarer in childhood, often starting from puberty. Really a venous malformation.

240
ab
7 Liver and Bile System
dc
Fig. 7.18 Liver haemangioma: ( a ) Adult-type echogenic small liver haemangioma (+ +). ( b , c )
Haemangioendothelioma/giant infantile haemangioma (RICH) – see also Fig.
Central calcifi cation ( arrow , d )
1.25 (CE-US).
• The neonatal or infantile haemangioendothelioma/“infantile/congenital haeman-
gioma (CH)” (GLUT1 positive or negative). May be small or large, may disap-
pear (RICH – rapidly involuting CH) or stay/grow (NICH – non-involuting CH).
In large CH α-fetoprotein may be elevated, but usually normal. Rarely malignant
transformation into angiosarcoma may occur. New clasifi cation: infantile/con-
genital hepaitc arterio-venous vascular malformation.
US Findings
Adult cavernous haemangioma – usually homogenous hyperechoic mass with welldefi ned margins (Fig. 7.18a ). Larger lesions may be more complex, contain calcifi -
cations or central fi brosis, thrombosis, necrosis and degeneration. Sometimes
peripheral hypoechoic halo and acoustic enhancement.
Infantile type haemangioma – usually small hypoechoic nodules, single or multiple, of varying size arise and grow after birth. CH = congenital hemangioma are
present at birth. May change size and echotexture, may even vanish (RICH). The
GLUT1 negative form is more consistent with a vascular malformation (not a true
congenital haemangioma), usually larger and more complex in appearance (often
called haemangioendothelioma – Fig. 7.18b–d ).

7.3 Pathology of the Liver
241
CDS
Cavernous adult haemangioma: slow blood fl ow, some peripheral vascularisation
may be depictable, particularly using aCDS and Ce-US.
Neonatal CH/haemangioendothelioma/haemangioendotheliomatosis (multiple/
numerous lesions throughout liver): high-blood fl ow with signifi cant shunt and
hypervascularity in periphery of lesions – large HA, tapering of abdominal aorta
distal to coeliac trunk. Large shunt may cause cardiac failure. Spectral analysis –
high-fl ow velocities with high-diastolic fl ow + low RI, potentially arterialisation or
signifi cantly increased fl ow in affected draining HV. Depending on size and vascularity, may demonstrate central vascularity, particularly using aCDS and ce-US.
Ce-US: typical Iris-phenomena of slow centripetal enhancement, with sustained
enhancement in portal phase, as in CT or MRI (see Fig. 1.25 ).
7.3.6.6 Mesenchymal Hamartoma
Benign tumour, commonly in younger children. May have arteriovenous shunts,
may be pedunculated and secondarily undergo torsion. May be cystic, sometimes
similarities to complex vascular/veno-lymphatic malformations.
Rare malignant transformation, may spontaneously regress.
US and CDS fi ndings
Typically well-circumscribed multilocular mass with smooth well-defi ned borders,
anechoic and cystic spaces and echogenic septae – very mixed US appearance. US
is useful for depicting tumours and follow-up; specifi c diagnosis diffi cult. Diagnosis
made by dynamic MRI, potentially biopsy/resection.
CDS shows vascularisation and reveals arteriovenous shunting if large feeding/
draining vessels (always confi rm by spectral analysis).
DDx: Lymphangioma, fi broadenoma, etc.
7.3.6.7 Focal Nodular Hyperplasia (FNH)
Rare in childhood, more commonly during puberty. Associated with oral contraceptive use, myelo- and lympho-proliferative syndromes, immune disorders, long-term
medication (particularly steroids and antineoplastic agents), rarely sporadic, additionally in Abernethy malformations, in children with hereditary haemorrhagic telangiectasia, etc.
Regenerative lesions in noncirrhotic liver.
US Findings
• Commonly multiple, well-defi ned, iso-, hypo- or even hyperechoic nodules
within normal parenchyma. Spherical to polygonal nodular structure of varying
size without capsule. Behaves like tumour/space occupying lesion, may com-
press surrounding liver tissue causing pseudocapsule. May not be distinguish-
able from other masses
• Central large vascular pedicle leading to central fi brous “scar”
• Echogenicity: iso- or hypoechoic to liver, more easily seen by mass effect than
by its echogenicity (often subscapular – focal bump in liver surface) or in altered
liver parenchymal echotecture (e.g. fatty liver)

242
7 Liver and Bile System
CDS
May reveal central scar, more readily appreciated by aCDS.
Ce-US: typical central spoke wheel pattern in early arterial phase by radial vessels, no
portal/late phase enhancement (no enhancement of parenchyma in late phase).
7.3.6.8 Hepatic Adenoma
Associated with glycogen-storage disease, Fanconi anaemia, galactosaemia, steroids, after chemotherapy.
US Findings
Usually solitary mass, well circumscribed, encapsulated, iso- to hypoechoic, rarely
hyperechoic – with heterogeneous features in haemorrhage, glycogen or fat- storage.
Never contains central “vascular” scar.
CDS
May show peripheral, central or combined fl ow – with random stippled pattern.
Ce-US: better differentiation (by excluding FNH-typical central scar appearance),
demonstration of homogenous arterial phase enhancement with absence of portal
phase enhancement.
7.3.6.9 Fatty Tumours
Angiomyolipoma (in tuberous sclerosis), lipoma
US fi ndings
Hyperechoic mass, varying degree of acoustic shadowing (Fig. 7.19 ). Without clini-
cal history or other imaging (e.g. chemical shift MRI) not to be differentiated from
adult type haemangioma.
7.3.6.10 Hepatoblastoma
Most common malignant liver tumour in childhood – different microscopic entities.
Variable US appearance.
Associated with Beckwith-Wiedemann syndrome, hemihypertrophy
syndromes, etc.
Commonly metastasises to lung, brain and skeleton. Often large and asymptomatic at presentation, elevated α-fetoprotein levels. Vascular invasion common.
Fig. 7.19 Liver angiomyolipoma. Echoic liver
tumour in child with tuberous sclerosis, consistent
with a liver angiomyolipoma

7.3 Pathology of the Liver
ab
Fig. 7.20 Liver tumours: ( a ) Liver tumour (+ +) in a 3-year-old that was proven to be a hepato-
blastoma. Bicolour mode used to improve visualisation of subtle echogenicity differences even in
diffi cult scanning conditions. ( b ) Complex, partially cystic liver tumour in 9-year-old girl that
proved to be a liver sarcoma
US and CDS fi ndings
Commonly large space-occupying lesion with inhomogenous echogenicity without
specifi c criteria (Fig. 7.20a ). Secondary regressive changes, haemorrhage, necrosis
and potentially calcifi cations. Tend to compress surrounding structures. PV thrombosis and/or invasion of HV.
CDS nonspecifi c, commonly some large vessels with high-velocity fl ow.
Ce-US: marked early arterial enhancement (similarly to carcinoma) with quick
washout and no PV enhancement. Vascular invasion, disruption and irregular vascular architecture readily appreciated.
243
7.3.6.11 Hepatocellular Carcinoma
Second most common liver malignancy, usually in older children, associated with
pre-existing liver disease (hepatitis B, glycogen-storage disease, tyrosinaemia, haemochromatosis, Wilson, α1-antitripsin-defi ciency, other forms of liver cirrhosis).
Elevated α-fetoprotein levels; rarely multifocal.
US and CDS fi ndings
Similar to hepatoblastoma. Typically a large mass, hyperechoic to normal liver –
with heterogeneous appearance, calcifi cations or necrosis, even with hypoechoic
areas. Fibrous capsule causing hypoechoic rim may be present.
CDS similar to hepatoblastoma. Hypervascularity with high fl ow may be depicted.
Ce-US: marked early arterial enhancement (similarly to hepatoblastoma) with quick
washout and no PV-phase enhancement. Vascular invasion, disruption and irregular
vascular architecture readily appreciated.
• Fibrolamillar carcinoma (subtype): normal α-fetoprotein levels, usually solitary.
Otherwise nonspecifi c US fi ndings, not differentiable from classic hepatocellular
carcinoma or hepatoblastoma by US. US-guided biopsy may aid diagnosis.

244
7 Liver and Bile System
7.3.6.12 Hepatic Sarcomas
Embryonal Cell Sarcoma
Undifferentiated, usually large tumour, also called malignant mesenchymoma or
hepatic mesenchymal sarcoma. Commonly in school age children. α-fetoprotein
normal.
US and CDS fi ndings : unspecifi c, large, with cystic spaces + solid areas (Fig. 7.20b ).
NOTE : Particularly large tumours with complex cystic spaces and septations must
raise suspicion.
Rhabdomyosarcoma
Rare tumour arising from muscle cells (bile ducts, etc.), commonly situated centrally (see also Sect. 7.4 ).
US and CDS fi ndings unspecifi c. Large, usually hypoechoic, causing early secondary cholestasis due to its position. No other specifi c signs.
CDS is helpful to differentiate vessels from dilated bile ducts with potential intraductal tumour growth and invasion.
Angiosarcoma
Rare vascular tumour arising from endothelial cells.
US fi ndings: multiple small nodules are more common than large mass, with satellite nodules. Otherwise nonspecifi c US fi ndings with heterogeneous mass containing cystic and solid components.
Hepatic Leiomyosarcoma
Malignant mesenchymal tumour. Poor prognosis and early metastases.
US fi ndings: Predominantly solid mass with potential secondary haemorrhage, otherwise nonspecifi c. CDS does not aid diagnosis.
7.3.6.13 Metastasis
Various malignancies may cause liver metastases, particularly neuroblastoma (stage
IV or IV), Wilms tumour and lymphoma. Rare metastases from other primaries (e.g.
carcinoid/gonadal tumours).
US and CDS fi ndings
Either solitary or multiple, large or small nodules. May be hyper-, iso- and
hypoechoic. Potentially show target-like appearance. Cysts/degenerative changes
may be present. CDS of little value, except for demonstrating patency of adjacent
compressed vessels.
Ce-US will aid differentiation from other liver lesions by showing typical US-CM
enhancement dynamics - as known from CT and MR (see Table 1.4 ).
7.3.6.14 Proliferative Disorders
Particularly after transplantation – hepatic involvement in posttransplantation lymphoproliferative disease and lymphoma common.
US Findings
Single or multiple hyperechoic masses with commonly homogenous echotexture,
well-defi ned margins. In very small and diffuse involvement – widespread nodular
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