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Contents
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xi
Market Overview of Herbal Medicines for Lifestyle Diseases . . . . . . . . . . . . . . . . . . . . 597
Bedanta Bhattacharjee, K. Sandhanam, Shatabdi Ghose, Dhunusmita Barman,
and Ram Kumar Sahu
Future Prospective of Herbal Medicines for Lifestyle Diseases . . . . . . . . . . . . . . . . . . . 615
Lolita Rapoliene and Vilma Matuleviciute

Editors and Contributors
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About the Editors
AmalKumarDhara, PhD has over 25years of teaching and research experience in the eld of Pharmacology
and Toxicology, especially in the eld of neuropharmacology, anti-inammatory, antiulcer, free radical scavenging activities of Indian indigenous plants. He has earned his PhD in Pharmaceutical Sciences from Jadavpur
University, Kolkata, West Bengal, India. Currently, Dr. Dhara is working as a Lecturer in Pharmacy at Contai
Polytechnic, Govt. of West Bengal, India. Dr. Dhara has also served as Production Executive at M/S Deys
Medical Stores Mfg (UP) Ltd., U.P., India, for more than 3years. To date, he has authored over 10 research and
review publications in various high-impact peer-reviewed journals, 14 book chapters, and 4 books to his credit.
Dr. Dhara has participated and presented his research work at several conferences in India and abroad. He is a
life member of the Indian Pharmaceutical Association, Indian Pharmacological Society, and is a Registered
Pharmacist.
SubhashC.Mandal, PhD is a Professor at the Division of Pharmacognosy, Department of Pharmaceutical
Technology, Jadavpur University, Kolkata, India. Professor Mandal is the recipient of prestigious awards
including Endeavour Research Award, Government of Australia; Distinguished Education & Research Award,
American Association of Indian Pharmaceutical Scientists (AAiPS), United States; Talented Scientist Award,
University of Colombo, Sri Lanka; SAARC Fellowship Award, University Grants Commission (UGC),
Bangladesh; Fast Track Young Scientist Award, Department of Science and Technology, UGC Research Award,
India; and Outstanding University Teachers’ Award, Department of Higher Education, Government of West
Bengal, India. He has supervised more than 30 doctoral and 25M.Pharm scholars and has more than 300
research publications, several patents, books, and book chapters to his credit. Professor Mandal has delivered
more than 50 research presentations around the globe, has chaired many international conferences, and successfully completed more than 10 government-funded research projects. He is a reviewer and board member of
several high-impact journals and is a recognized host scientist for many international research programmes
with developing countries sponsored by the Government of India. He has visited more than 30 countries for
various scientic deliberations, collaborations, and exchange programmes.
Contributors
Md Abubakar Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical Education and Research (NIPER)-Guwahati, Guwahati, Assam, India
Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education
and Research (NIPER)-Hajipur, Hajipur, Bihar, India
Niyati Acharya Department of Pharmacognosy, Institute of Pharmacy, Nirma University,
Ahmedabad, Gujarat, India
Priyanka Adhikari Center for GMP Extraction Facility (Department of Biotechnology),
National Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam,
India
School of Medicine, University of Maryland Marlene and Stewart Greenebaum Comprehensive
Cancer Center, Baltimore, MD, USA
BrunoDuponA.Ambamba Department of Biochemistry, Faculty of Science, University of
Yaoundé I, Yaoundé, Cameroon
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xiv
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VahidRezaAskari International UNESCO Center for Health-Related Basic Sciences and
Human Nutrition, Mashhad University of Medical Sciences, Mashhad, Iran
ArunBaidya Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West
Bengal, India
SparshaBandekar Satara College of Pharmacy, Satara, Maharashtra, India
Sugato Banerjee Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical Education and Research, Kolkata, India
TanmoyBanerjee Department of Pharmaceutical Technology, Jadavpur University, Kolkata,
West Bengal, India
JagdishS. Bankar Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj
Nagpur University, Nagpur, Maharashtra, India
Dhunusmita Barman Department of Pharmacology, NEF College of Pharmaceutical
Education and Research, Nagaon, Assam, India
SouvikBasak Dr. B.C. Roy College of Pharmacy and AHS, Durgapur, India
Ashok Behera Faculty of Pharmacy, School of Pharmaceutical and Populations Health
Informatics, DIT University, Dehradun, India
Samir Bhargava Faculty of Pharmacy, School of Pharmaceutical and Populations Health
Informatics, DIT University, Dehradun, India
Editors and Contributors
BedantaBhattacharjee Department of Pharmacology, Girijananda Chowdhury Institute of
Pharmaceutical Science, Tezpur, Assam, India
Bhavna Faculty of Pharmacy, School of Pharmaceutical and Populations Health Informatics,
DIT University, Dehradun, India
Surbhi S. Bhope Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj
Nagpur University, Nagpur, Maharashtra, India
Kajal N. Bondre Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj
Nagpur University, Nagpur, Maharashtra, India
RituparnaChaki Dr. B.C.Roy College of Pharmacy and Allied Health Sciences, Durgapur,
India
MoumitaChatterjee V.Sivaram Research Foundation, Bangalore, Karnataka, India
Sunayna Choudhary Department of Pharmacognosy, M.M. College of Pharmacy, M.M.
(Deemed to be University), Mullana, Ambala, Haryana, India
Anchal Dabas Department of Applied Chemistry, Delhi Technological University, Delhi,
India
ZoraDajić Faculty of Agriculture, University of Belgrade, Belgrade, Serbia
S.Dangat Department of Pharmacognosy and Phytochemistry, Bombay College of Pharmacy,
Mumbai, Maharashtra, India
Anish Kumar Das Department of Natural Products, National Institute of Pharmaceutical
Education and Research (NIPER) - Kolkata, Kolkata, West Bengal, India
Amal Kumar Dhara Department of Pharmacy, Contai Polytechnic, Government of West
Bengal, Contai, West Bengal, India
AmitKumarDixit Central Council for Research in Ayurvedic Sciences (CCRAS)-Central
Ayurveda Research Institute, Ministry of Ayush, Govt. of India, Kolkata, West Bengal, India

Editors and Contributors
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xv
Amit Kr. Dubey Faculty of Pharmacy, School of Pharmaceutical and Populations Health
Informatics, DIT University, Dehradun, India
Subhajit Dutta Functional Genomics and Metabolism Research Unit, Department of
Biochemistry and Molecular Biology, University of Southern Denmark, Odense, Denmark
Ronin Institute for Independent Scholarship, Montclair, NJ, USA
Sharmistha Ganguly University Department of Botany, Ranchi University, Ranchi,
Jharkhand, India
Geetanjali Department of Chemistry, Kirori Mal College, University of Delhi, Delhi, India
ShatabdiGhose Department of Pharmacology, Guwahati, Assam, India
MadhurimaGhosh Department of Pathology and Cancer Screening, Chittaranjan National
Cancer Institute, Kolkata, India
NilanjanGhosh Department of Pharmaceutical Technology, Jadavpur University, Kolkata,
West Bengal, India
Shailendra S. Gurav Department of Pharmacognosy, Goa College of Pharmacy, Goa
University, Panaji, Goa, India
AmitKumarHalder Dr. B.C. Roy College of Pharmacy and Allied Health Sciences, Dr.
Meghnad Saha Sarani, Bidhannagar, Durgapur, West Bengal, India
Md Saquib Hasnain Department of Pharmacy, Palamau Institute of Pharmacy, Chianki,
Daltonganj, Jharkhand, India
PrakashR.Itankar Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj
Nagpur University, Nagpur, Maharashtra, India
SiddhiJain Department of Pharmacology and Toxicology, National Institute of Pharmaceutical
Education and Research (NIPER), Guwahati, Assam, India
Donald Ulrich K. Kagho Department of Chemistry, Higher Teacher Training College,
University of Yaoundé I, Yaoundé, Cameroon
Sanmoy Karmakar Department of Pharmaceutical Technology, Jadavpur University,
Kolkata, West Bengal, India
Ceyda Sibel Kılıç Faculty of Pharmacy, Department of Pharmaceutical Botany, Ankara
University, Ankara, Turkey
SimeonF.Kouam Department of Chemistry, Higher Teacher Training College, University of
Yaoundé I, Yaoundé, Cameroon
Ankit Kumar Department of Pharmaceutical Technology, Jadavpur University, Kolkata,
West Bengal, India
J.Kumar University Department of Botany, Ranchi University, Ranchi, Jharkhand, India
K.JayaramKumar Department of Pharmaceutical Sciences and Technology, Birla Institute
of Technology, Mesra, Ranchi, Jharkhand, India
SonaliMaheshwari Institute of Pharmacy, Nirma University, Ahmedabad, India
JaiMalik Department of Pharmacognosy, University Institute of Pharmaceutical Sciences—
UGC Centre of Advanced Study, Panjab University, Chandigarh, India
Keya Mallick Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical Education and Research, Kolkata, India

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Subhash C. Mandal Department of Pharmacognosy and Phytochemistry, Shri Vile
ParleKelavani Mandal’s Institute of Pharmacy, Dhule, Maharashtra, India
Pharmacognosy and Phytochemistry Research Laboratory, Division of Pharmacognosy,
Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadhavpur
University, Kolkata, India
Department of Pharmacognosy, K.L.E.’s College of Pharmacy, Nehru Nagar, Belagavi,
Karnataka, India
VilmaMatuleviciute Klaipėda University, Klaipeda, Lithuania
The Excelsior School of Herbal Medicine, Belfast, Northern Ireland
MilanMilivojević Faculty of Technology and Metallurgy, University of Belgrade, Belgrade,
Serbia
JayashreeMondal Department of Pharmaceutical Technology, Jadavpur University, Kolkata,
West Bengal, India
TitusAlfredM.Msagati Institute for Nanotechnology and Water Sustainability, College of
Science, Engineering and Technology, University of South Africa, Florida Science Campus,
Johannesburg, South Africa
A.Mukne Department of Pharmacognosy and Phytochemistry, Bombay College of Pharmacy,
Mumbai, Maharashtra, India
Editors and Contributors
V. G. M. Naidu Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India
Center for GMP Extraction Facility (Department of Biotechnology), National Institute of
Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India
ParvathyG.Nair CCRAS-National Research Institute for Panchakarma, Ministry of Ayush,
Govt. of India, Thrissur, Kerala, India
PratibhaP.Nair VPSV Ayurveda College, Kottakal, Kerala, India
Ajay G. Namdeo Department of Pharmaceutical Sciences, Hemvati Nandan Bahuguna
Garhwal University (A Central University), Srinagar, Uttarakhand, India
Satheesh Kumar Nanjappan Department of Natural Products, National Institute of
Pharmaceutical Education and Research (NIPER) - Kolkata, Kolkata, West Bengal, India
Vilas D. Nasare Department of Pathology and Cancer Screening, Chittaranjan National
Cancer Institute, Kolkata, India
AnujNautiyal Department of Pharmacy, SGRR University, Dehradun, India
Amit Kumar Nayak Department of Pharmaceutics, School of Pharmaceutical Sciences,
Siksha ‘O’ Anusandhan (Deemed to be University), Bhubaneswar, Odisha, India
BathelemyNgameni Department of Pharmacognosy and Pharmaceutical Chemistry, Faculty
of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon
YvanAndersonT.Ngandjui Department of Chemistry, Higher Teacher Training College,
University of Yaoundé I, Yaoundé, Cameroon
Institute for Nanotechnology and Water Sustainability, College of Science, Engineering and
Technology, University of South Africa, Florida Science Campus, Johannesburg, South Africa
Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, Yaoundé,
Cameroon

Editors and Contributors
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xvii
SundayOritsetimenyinOtimenyin Department of Pharmacology, Faculty of Pharmaceutical
Sciences, University of Jos, Jos, Nigeria
Ivana Pajic-Lijaković Faculty of Technology and Metallurgy, University of Belgrade,
Belgrade, Serbia
Samir Ranjan Panda Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India
Jayesh S. Pande Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj
Nagpur University, Nagpur, Maharashtra, India
Shweta Parihar Department of Pharmacognosy, University Institute of Pharmaceutical
Sciences—UGC Centre of Advanced Study, Panjab University, Chandigarh, India
A.Parthiban Center for GMP Extraction Facility (Department of Biotechnology), National
Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India
KalpanaPatil Department of Pharmacognosy and Phytochemistry, Shri Vile Parle Kelavani
Mandal’s Institute of Pharmacy, Dhule, Maharashtra, India
Pharmacognosy and Phytochemistry Research Laboratory, Division of Pharmacognosy,
Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadhavpur
University, Kolkata, India
Department of Pharmacognosy, K.L.E.’s College of Pharmacy, Nehru Nagar, Belagavi,
Karnataka, India
Tiyasa Paul Department of Pharmaceutical Sciences and Technology, Birla Institute of
Technology, Mesra, Ranchi, Jharkhand, India
Arun N. Prakash Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical and Research (NIPER)-Guwahati, Guwahati, Assam, India
AabirPramanik Institute of Pharmacy, Nirma University, Ahmedabad, India
Neethu Prasad Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical and Research (NIPER)-Guwahati, Guwahati, Assam, India
SatyendraK.Prasad Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj
Nagpur University, Nagpur, Maharashtra, India
Eswara Rao Puppala School of Medicine, University of Maryland Marlene and Stewart
Greenebaum Comprehensive Cancer Center, Baltimore, MD, USA
MohamedRahamathulla Department of Pharmaceutics, College of Pharmacy, King Khalid
University, Abha, Saudi Arabia
Vafa Baradaran Rahimi Department of Cardiovascular Diseases, Faculty of Medicine,
Mashhad University of Medical Sciences, Mashhad, Iran
VimalavathiniRamesh Department of Pharmacology, College of Pharmacy, Mother Theresa
Post Graduate and Research Institute of Health Sciences, Puducherry, India
VijaySingh Rana Faculty of Pharmacy, School of Pharmaceutical and Populations Health
Informatics, DIT University, Dehradun, India
AlokRanjan Center for GMP Extraction Facility (Department of Biotechnology), National
Institute of Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India
LolitaRapoliene Klaipėda University, Klaipeda, Lithuania
Baltic Medics Port Clinic, Klaipeda, Lithuania

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SaptapadiSaha Department of Pharmaceutical Technology, Jadavpur University, Kolkata,
West Bengal, India
Ram Kumar Sahu Department of Pharmaceutical Sciences, Hemvati Nandan Bahuguna
Garhwal University (A Central University), Chauras Campus, Tehri Garhwal, Uttarakhand,
India
K.Sandhanam Department of Pharmacology, SRM College of Pharmacy, SRM Institute of
Science and Technology, Chengalpattu, Tamil Nadu, India
ShuvamSar Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West
Bengal, India
Arnab Sarkar Department of Pharmaceutical Technology, Jadavpur University, Kolkata,
West Bengal, India
SathiSarkar Department of Natural Products, National Institute of Pharmaceutical Education
and Research (NIPER) - Kolkata, Kolkata, West Bengal, India
K.Sawate Department of Pharmacognosy and Phytochemistry, Bombay College of Pharmacy,
Mumbai, Maharashtra, India
NeerajKr.Sethiya Faculty of Pharmacy, School of Pharmaceutical and Populations Health
Informatics, DIT University, Dehradun, India
Satish Shilpi Faculty of Pharmacy, School of Pharmaceutical and Populations Health
Informatics, DIT University, Dehradun, India
Editors and Contributors
P. Shirodkar Department of Pharmacognosy and Phytochemistry, Bombay College of
Pharmacy, Mumbai, Maharashtra, India
Meenakshi Singh Centre for GMP Extraction Facility, Sponsored by Department of
Biotechnology, National Institute of Pharmaceutical Education and Research (NIPER)Guwahati, Guwahati, Assam, India
RamSingh Department of Applied Chemistry, Delhi Technological University, Delhi, India
ManmohanSinghal Faculty of Pharmacy, School of Pharmaceutical and Populations Health
Informatics, DIT University, Dehradun, India
SarojSinghmura Dr. B.C. Roy College of Pharmacy and AHS, Durgapur, India
Kayalvizhie Subbarayan Department of Pharmacology, College of Pharmacy, Mother
Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India
Kavimani Subramanian Department of Pharmacology, College of Pharmacy, Mother
Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India
N. P. Syamprasad Department of Pharmacology and Toxicology, National Institute of
Pharmaceutical Education and Research (NIPER), Guwahati, Assam, India
Rostan M. Talla Department of Organic Chemistry, Faculty of Science, University of
Yaoundé I, Yaoundé, Cameroon
Joseph Tchamgoue Department of Organic Chemistry, Faculty of Science, University of
Yaoundé I, Yaoundé, Cameroon
Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, Yaoundé,
Cameroon
JeanClaudeTchouankeu Department of Organic Chemistry, Faculty of Science, University
of Yaoundé I, Yaoundé, Cameroon

Editors and Contributors
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xix
Sittarthan Viswanathan Department of Pharmacology, College of Pharmacy, Mother
Theresa Post Graduate and Research Institute of Health Sciences, Puducherry, India
RajuWadekar Department of Pharmacognosy and Phytochemistry, Shri Vile ParleKelavani
Mandal’s Institute of Pharmacy, Dhule, Maharashtra, India
Pharmacognosy and Phytochemistry Research Laboratory, Division of Pharmacognosy,
Department of Pharmaceutical Technology, Faculty of Engineering & Technology, Jadhavpur
University, Kolkata, India
Department of Pharmacognosy, K.L.E.’s College of Pharmacy, Nehru Nagar, Belagavi,
Karnataka, India
PratikshaP.Wagh Department of Pharmaceutical Sciences, Rashtrasant Tukadoji Maharaj
Nagpur University, Nagpur, Maharashtra, India
ParulYadav Department of Applied Chemistry, Delhi Technological University, Delhi, India

Introduction toLifestyle Diseases
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andRole ofHerbal Medicines
AmalKumarDhara andAmitKumarNayak
Abstract
Lifestyle diseases are medical conditions and are primar-
ily caused by unhealthy habits and practices. The differ-
ent risk factors responsible for lifestyle diseases include
poor diet, lack of physical activity, unrestricted alcohol
consumption, smoking and chronic stress, and anxiety.
Commonly occurring lifestyle diseases are type 2 diabe-
tes mellitus, obesity, chronic obstructive pulmonary dis-
ease (COPD), cardiovascular disorders, chronic liver
disease, mental illness, and lung, breast, ovarian, and
colorectal cancers. Lifestyle modication and use of
herbal medicines can help in the management of lifestyle
diseases. The current chapter briey describes the differ-
ent types of lifestyle diseases and their management par-
ticularly the role of herbal medicines.
Keywords
Lifestyle diseases · Management · Herbal medicines
1 Introduction
Lifestyle diseases are medical conditions that predominantly
arise from individuals’ everyday habits and behaviors [1, 2].
Certain practices that discourage individuals from engaging
in physical activity and instead encourage a sedentary lifestyle can contribute to various health problems, ultimately
leading to chronic non-communicable diseases (NCDs) that
may cause signicant risks to one’s life [3, 4]. There are two
types of lifestyle factors that are associated with diseases: (1)
Modiable factors, such as dietary habits, physical activity
A. K. Dhara (*)
Department of Pharmacy, Contai Polytechnic, Government of West
Bengal, Contai, West Bengal, India
A. K. Nayak
Department of Pharmaceutics, School of Pharmaceutical Sciences,
Siksha ‘O’ Anusandhan (Deemed to be University),
Bhubaneswar, Odisha, India
levels, addictive behaviors (such as smoking and drinking),
and stress levels, can be altered or adjusted, and (2) Nonmodiable factors, such as age and heredity, gender, ethnicity or race are inherently unalterable [5–8].
The progression of modern civilization has revealed a
notable trend wherein an increasing number of young individuals engage in smoking and drinking, despite knowing
the detrimental effects these behaviors have on their health
[9, 10]. The prevalence of fast food and junk food is displacing our nutritious and traditional well-balanced meals, resulting in a decline in the consumption of fresh fruits and
vegetables [11, 12]. Additionally, the preference for processed and packaged food is supplanting the inclusion of
these healthier options. Furthermore, the consumption of
soft drinks is increasingly substituting milk intake. Our inclination is to utilize transportation, such as buses or cars, rather
than engaging in pedestrian travel, even for brief distances
[13]. The development of machines to reduce physical labor
in the workplace is an increasingly prevalent trend. The
aforementioned practices have contributed to the prevalence
of overweight and obesity within our population. Obesity
refers to the condition of having a body weight that exceeds
the normal or ideal weight in relation to an individual’s
height [14]. Obesity serves as a primary contributing factor
to various lifestyle diseases, including but not limited to diabetes, hypertension, heart disease, and other related conditions [15, 16].
2 Prevention ofLifestyle Diseases
Individuals must modify their behaviors to promote a healthier lifestyle. Key practices encompass engaging in consistent
physical activity such as [17]: (1) walking, practising yoga,
participating in dance activities, performing aerobics, and
cycling; (2) Utilization of staircases in lieu of lifts or escalators; (3) Adhering to a well-rounded dietary regimen during
appropriate meal periods; (4) The consumption of processed
and packaged foods that are high in sugar, fats, salt, and calo-
© The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2023
A. K. Dhara, S. C. Mandal (eds.), Role of Herbal Medicines, https://doi.org/10.1007/978-981-99-7703-1_1
1

2
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A. K. Dhara and A. K. Nayak
ries, while lacking in ber, high-quality protein, minerals
such as iron and calcium, and vitamins, should be minimized; (5) It is recommended to consume whole grains such
as cereals (wheat, whole wheat our) and millets (sorghum,
pearl millet, nger millet, etc.), while minimizing the intake
of rened foods; (6) Consuming a daily quantity of 400–
500g of fruits and vegetables in season is recommended; (7)
It is recommended to consume an ample amount of water;
(8) Implementing yoga or meditation techniques can be benecial in mitigating stress levels in one’s daily existence. (9)
It is advisable to refrain from engaging in smoking and consuming alcohol. It is advisable to reduce the amount of time
spent engaging in sedentary activities such as watching
television, using mobile phone (WhatsApp, Facebook,
Twitter, etc.) and instead prioritize participation in outdoor
games and activities, such as gardening or playing sports like
football, cricket, or badminton.
3 History ofHerbal Medicine
Ancient Chinese and Egyptian papyrus writings mention
the therapeutic applications of plants date back to about
3000 BC, demonstrating that using plants for medicinal
purposes predates recorded history. Indigenous cultures,
including African and Native American societies, incorporated the utilization of herbs within their healing rituals. In
contrast, while other cultures adopted traditional medical
systems, such as Ayurveda and Traditional Chinese
Medicine, which prominently featured herbal therapies.
According to a recent estimation by the World Health
Organization, approximately 80% of individuals globally
depend on herbal medicines as a component of their primary health care [18, 19]. There has been a signicant rise
in the utilization of herbal supplements within the last
three decades. In the USA, herbal supplements are categorized as dietary supplements.
Scientists worldwide are diligently endeavoring to ascertain the mechanisms of action underlying herbal medications [18, 20]. In numerous instances, researchers encounter
uncertainty regarding the precise active component within a
given herb that contributes to its therapeutic efcacy in
addressing a specic medical condition. Whole plants consist of numerous components that have the potential to synergistically generate a desirable outcome. Using herbal
medicines in scientic contexts is very important due to
their potential efcacy in treating diverse conditions [18, 20,
21]. Sometimes using of whole plant may produce lesser
adverse effects than conventional pharmaceutical interventions. The assumption that herbs are inherently safe due to
their natural origin is not universally valid. Certain medical
conditions may render certain herbs inappropriate for individuals. Due to the absence of regulatory oversight, herbal
products frequently exhibit mislabeling tendencies, potentially harboring undisclosed additives and contaminants
[22–24]. Certain herbs have the potential to induce allergic
reactions or interact with conventional pharmaceuticals,
while others can be toxic when misused or administered in
excessive quantities [25, 26]. Engaging in self-medication
by consuming herbs independently poses an elevated risk,
thus emphasizing the signicance of seeking guidance from
a specialist in phytomedicines or a Pharmacist before utilization of herbal remedies. An important example of the
adverse effects associated with Evening primrose
(Oenothera biennis) involves an elevated likelihood of sei-
zures in individuals with seizure disorders, as well as an
increased risk of bleeding in individuals with bleeding disorders or those who are concurrently taking blood-thinning
medications, such as warfarin. Numerous herbal substances
possess the potential to interact with prescription medications, thereby eliciting undesirable or hazardous reactions
[27, 28]. For instance, an exceptional level of herb-drug
interaction has been observed in individuals undergoing
cancer treatment. Certain herbal supplements, particularly
those originating from Asian nations, can potentially contain elevated concentrations of heavy metals, such as mercury, lead, and cadmium which should be carefully taken
into consideration before administration for the treatment of
certain disease conditions.
Various herbal preparations can be found in the commercial market, encompassing teas, syrups, oils, liquid extracts,
tinctures, and dry extracts as pills or capsules [18]. Teas are
prepared by steeping dried herbs in hot water for a few minutes or boiling herbs in water, separating the liquid from the
solid components by straining. Syrups, derived from concentrated extracts and incorporated into sweetened formulations, are frequently employed to alleviate sore throats and
coughs. Plant-derived oils are commonly extracted and
employed as massage rubs, either in their pure form or as
constituents of ointments or creams. Tinctures and liquid
extracts are bioactive components derived from herbs solubilized in a liquid medium, typically water, alcohol, or glycerol. Tinctures are commonly prepared with a concentration
ratio of 1:5 or 1:10, indicating that one herb unit is combined
with ve to ten units (by weight) of the liquid. Liquid extracts
are characterized by a higher concentration compared to
tinctures, typically exhibiting a 1:1 concentration ratio. The
most concentrated form of an herbal product, known as a dry
extract, is generally available in the market in the form of
tablet, capsule, or lozenge, with a concentration ratio ranging
from 2:1 to 8:1. The most commonly used herbs and their
uses are mentioned in Table1.
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