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326
M. Sakr
Treatment of children and adolescents with
1.3 μg/kg/day thyroxine for 24 months was
shown in a recent study to cause signicant
reduction in thyroid size in patients with autoimmune thyroiditis, but not affect antibody levels,
or signicantly alter TSH or freeT4 [261].
When L-T4 and seleno-methionine are given
together, they reduce the release of cytokines
from monocytes and lymphocytes thus reducing
the thyroid peroxidase antibody titre and autoimmune process in HT [262].
The additional role of diet for the management
of HT is usually overlooked, and careful supplementation of possible deciencies in HT is recommended for the dietary management of these
patients. There are specic nutrients that should
be regularly taken to maintain a healthy and functional thyroid. The top nutrients are Iodine (I2),
Selenium (Se), and Zinc (Zn). A diet optimizing
these nutrients is vital to an overall recovery plan.
Diets benecial for patients with HT include
paleo diet, gluten- free diet, and vegetarian or
vegan diet. Gluten and goitrogens are the worst
foods to have in diet of patients with HT as they
can have a negative impact on the thyroid.
Surgery
Surgery is generally avoided in HT as it is unnecessary to induce hypothyroidism. Thyroidectomy
is considered in patients with cosmetic problem,
with compressive symptoms (e.g., dysphagia,
dyspnea, and dysphonia), suspicion of malignancy as PTC is commonly associated. Surgery
has also benecial effect in cases of “painful thyroiditis” [263].
Radioactive Iodine (RAI)
RAI treatment can be considered as a “last
option” in elderly patients with large goiter in
whom thyroiditis is not responding to L-T4 and
refusing surgery [263].
Prognosis
With early diagnosis, timely institution of L-T4
replacement therapy, informed patient follow-up
care, and attention to other attendant complications, the prognosis in HT is excellent, with
patients leading a normal life.
Untreated “myxedema coma” has a poor prognosis and a high mortality rate. “Transient periods of thyrotoxicosis” sometimes occur, and
rarely the illness may progress to full hyperthyroid
Graves’ disease with active orbitopathy (bulging,
inamed eyes). The increased prevalence of
“lipid disorders” in association with untreated
hypothyroidism has the potential to increase
morbidity from coronary artery disease.
The risk for “PTC” is increased in patients
with HT, though not clearly more aggressive than
other PTCs [264]. Primary thyroid “B- cell lym-
phoma” affects <1/1000 patients, and it is more
likely to affect those with long-standing autoimmune thyroiditis.
Complications of over-replacement with L-T4
include accelerated bone loss, reduction in bone
mineral density, osteoporosis, tachycardia,
increased cardiac wall thickness, and contractility, which raise the risk of cardiac arrhythmias
(especially atrial brillation), particularly in the
elderly.
12.5.15.2 Focal Lymphocytic
Thyroiditis (Focal
Autoimmune Thyroiditis)
This low-grade autoimmune thyroiditis is characterized by focal lymphocytic inltrates of <5% of
the thyroid gland and is found coincidentally in
50% of women’s and 25% of men’s autopsies,
without clinical relevance.
12.5.15.3 Postpartum Thyroiditis
Postpartum thyroiditis occurs in 2–16% of
women within 6–12 months after delivery (or
abortion) [265, 266]. It represents an exacerbation of a preceding (undiagnosed) autoimmune
thyroiditis and is classically linked to the haplotypes HLA-DR3, -DR4, and -DR5. Most patients
(85%) develop autoantibodies against TPO and
Tg, which may disappear with time. Women with
a known autoimmune thyroiditis prior to pregnancy and an elevated titer of autoantibodies
against Tg during pregnancy nearly always suffer
from a postpartum exacerbation of their autoimmune thyroiditis. Clinically, patients may show a
transient hyperthyroidism state, which rapidly
converts to hypothyroidism, and then to euthy-
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12 Benign Thyroid Disease
327
roidism within 12months. Treatment consists of
thyroid hormone replacement when required.
12.5.15.4 Subacute de Quervain’s
Thyroiditis
Synonyms include granulomatous, pseudotuberculous, or giant cell, thyroiditis. Subacute de
Quervain’s thyroiditis is a self-limiting disease
accounting for 0.5–3% of all thyroid diseases and
lasts for up to 2 months [267]. A post-viral
cytokine- mediated inammation of the thyroid is
suspected because of the seasonal frequency and
association with upper respiratory tract infection.
In 50% of patients, antibodies against mumps,
measles, inuenza, adenovirus, Coxsackie virus,
or echovirus are found. Furthermore, a genetic
predisposition exists with the haplotype
HLA-Bw35.
Women are three to six times more affected
than men, with a peak incidence between the second and fth decades of life. Symptoms include
pain in the neck that irradiates to the jaw, ear,
face, and down to the chest, fever, lassitude, and
weakness. Physical examination reveals an
exquisitely tender and enlarged gland. The erythrocyte sedimentation rate (ESR) is markedly elevated. Initially, there is transient hyperthyroidism
from destruction of the thyroid follicles by the
local inammation process. Later on, hypothyroidism emerges due to inability to cope with the
body’s demand for thyroid hormones, and nally,
as healing occurs, euthyroidism is restored.
However, permanent hypothyroidism requiring
replacement therapy may occur in 15% of
patients, and recurrence may be noted in,
although at a low rate of 4% [268].
Subacute should be differentiated from acute
suppurative thyroiditis. In de Quervain’s thyroiditis, the gland sonographically reveals irregular
hypo-perfused areas instead of hyper-perfused
tissue seen with acute suppurative thyroiditis. On
FNA, the differential diagnosis further includes
palpation thyroiditis, in addition to other granulomatous diseases such as sarcoidosis, tuberculosis
(TB), and rheumatoid diseases.
Treatment is supportive with nonsteroidal
anti-inammatory drugs (NSADs) and β-blockers
in severe cases with hyperthyroidism.
Corticosteroids are useful when the NSAD medication is not successful, and symptoms usually
improve within 2–3 days after the initiation of
treatment. However, it may take about 4 weeks
for the disappearance of the thyroid mass.
12.5.15.5 Silent (Painless) Thyroiditis
(Subacute Lymphocytic
Thyroiditis)
Patients with painless thyroiditis present with a
diffuse but mild enlargement of the thyroid gland.
Thyroid function tests reveal a transient hyperthyroidism, followed by hypothyroidism and,
nally, return to euthyroidism. Autoantibodies
against TPO and Tg are found, as well as an association with HLA-DR3 and -DR5 haplotypes.
Histological examination reveals lymphocytic
inltration with destruction of follicles (in contrast to HT) and absence of giant cell granulomas
(in contrast to subacute thyroiditis). Women are
more often affected than men with a peak of incidence in middle life and the postpartum period. It
is a self-limited disease and rarely necessitates
thyroid replacement therapy.
A signicant percentage of patients with silent
thyroiditis have personal or family history of
autoimmune thyroid disease. Most patients have
a complete remission, but some develop persistent hypothyroidism. Some patients have had
alternating episodes of typical “high-uptake” thyrotoxicosis and episodes of “transient” lowuptake thyrotoxicosis [269]. Recurrence of
disease is common in silent thyroiditis but very
rare in subacute thyroiditis.
12.5.15.6 Riedel’s Fibrosing Thyroiditis
Riedel’s thyroiditis is a rare chronic thyroiditis in
which the thyroid gland is replaced by brous tissue. The underlying etiologic mechanisms are
unclear, though an autoimmune relation is suspected, due to elevated titers of thyroid autoantibodies. It is generally considered as a part of a
multifocal bro-inammatory process also
involving other tissues such as the mediastinum,
liver, lung, retro-peritoneum, and orbit.
Women in middle to advanced ages are more
affected than men. The clinical often resembles
malignancy due to the hard consistency of the
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M. Sakr
gland. Patients usually complain of rapid indolent enlargement of the thyroid that becomes very
hard and may suffer from neck discomfort, dysphagia, hoarseness of voice, and hypoparathyroidism (due to involvement of the RLN and
parathyroid glands). Approximately, 30–40% of
patients develop overt hypothyroidism. Physical
examination, laboratory analysis, cytology, and
imaging features are not useful for differentiating
between Riedel’s thyroiditis and neoplastic diseases or the brotic variant of Hashimoto’s thyroiditis [270].
Histological examination is necessary to
establish the nal diagnosis, and so surgical
biopsy is mandatory. The differential diagnosis
further includes anaplastic carcinoma and sarcoma of the thyroid. In contrast to the brotic
variant of Hashimoto’s thyroiditis where brosis
is strictly limited to the gland, Riedel’s thyroiditis
displays a dense brotic replacement of thyroid
parenchyma that penetrates the capsule and
extends into contiguous neck structures. Once the
diagnosis is conrmed, treatment is supportive
with thyroid hormone replacement when
required.
12.5.16 Non-autoimmune Thyroiditis
Nonimmune thyroiditis consists of a heterogeneous and rare group of thyroid inammatory
diseases. Some of them are infectious while others are clearly iatrogenic, such as drug-induced
thyroiditis and post-operative necrotizing
thyroiditis.
12.5.16.1 Acute Infectious Thyroiditis
(Acute Suppurative
Thyroiditis)
Infectious thyroiditis is a rare disease of the thyroid gland caused by bacterial or fungal infection, though mycobacterial, parasitic, and viral
forms of thyroiditis have also been described,
particularly in immune-suppressed individuals.
The thyroid gland appears to be relatively resistant to infection. The protective mechanisms
include a rich vascular supply, extended lymphatic drainage, a brous capsule, fascial planes
that anatomically separate the thyroid from
other cervical structures, and the high iodine
content of the gland, which may have a bactericidal effect. Infection of the gland occurs, either
through hematogenous spread from a primary
focus or by direct extension from adjacent neck
structures, especially in children [271]. Other
less common sources of infection include neck
trauma, lymphatic spread, or rarely, surgical site
infections [272]. The most common predisposing factor for suppurative thyroiditis is immunosuppression associated with HIV, TB, old age,
or debilitating diseases. Other predisposing factors include preexisting thyroid diseases, such
as MNG, autoimmune thyroiditis, and cancer
[272–274].
Patients usually present with fever and a painful, mostly unilateral, enlargement of the thyroid,
and local inammatory signs. Thyroid function
tests are usually normal, but a slight hyper- or
hypothyroidism may occur. Laboratory tests
show leucocytosis and elevated ESR. Neck US
shows patchy hyper-perfused areas in the thyroid
with liquid content (pus) when an abscess is present. A FNAC and cultures can identify the pathogen and guide the anti-microbial treatment.
Immuno-suppressed patients tend to present with
more chronic thyroid infections, bilateral disease,
and less prominent signs and symptoms.
Diagnosis may be reached with a high index of
suspicion and aspiration biopsy.
The differential diagnosis includes de
Quervain’s thyroiditis, hemorrhage into a thyroid
nodule, infected thyroglossal or branchial cyst,
infected cystic hygroma, and cervical lymphadenitis. In addition to FNA, US helps to establish
the diagnosis, which may further be rened by
CT scan.
When an abscess is identied, surgical drainage is essential. Occasionally, complete resection
of an affected lobe is required. In patients with
recurrent acute thyroiditis, an undetected stula
must be postulated. Complete removal of the
infected stula is, therefore, required to prevent
recurrence. Injection of 0.5% methylene blue
solution through a Nélaton’s catheter into the stula usually enables the complete resection of the
tract. When the origin of the stula is difcult to
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12 Benign Thyroid Disease
329
identify, transection of the inferior pharyngeal
constrictor muscle makes intervention easier.
12.5.16.2 Drug-Induced Thyroiditis
Certain drugs have been reported to cause thyroiditis, such as chronic I2 therapy, long-term
lithium therapy, and anti-convulsants (e.g., phenytoin and carbamazepine [216]). Moreover,
patients with chronic hepatitis or cancer treated
with interferon (IFN)-α will develop painless
thyroiditis in about 1–5% of cases [275].
Elevated anti-thyroid antibodies are noted in a
higher percentage of these patients, and permanent hypothyroidism or Graves’ disease may
appear. Thus, TSH should be measured prior to
initiation of IFN-α therapy and periodically during treatment [276].
A painless thyroiditis has been reported in
about 2% of the patients treated with Interleukin-2
(IL-2), which is used for immune-modulation in
malignant melanoma, renal cell carcinoma, and
leukemia, alone or in combination with chemotherapy. Finally, the anti-arrhythmic drug amiodarone contains 35% I2 and may cause a thyrotoxic
crisis or conversely, cause hypothyroidism.
Amiodarone decreases the conversion of T4 to
the biologically active T3. If amiodarone therapy
is topped, it is not eliminated for months due to
its very long half-life [277].
12.5.16.3 Postoperative Necrotizing
Thyroiditis
Postoperative necrotizing thyroiditis is a rare surgical complication owing to the very rich vascular supply of the thyroid [278, 279]. It is related
to glandular trauma by vigorous manipulation at
surgery or through repeated FNA [280]. Such
manipulation could induce an acute thyroiditis,
which in turn may lead to thyrotoxicosis or necrotizing thyroiditis. No predictive marker or factor has been identied. Histologically, the
specimen typically shows postoperative granulomas, as found in other organs (bladder, prostate)
following surgery.
12.5.16.4 Radiation Thyroiditis
Radiation thyroiditis occurs in a dose-related
fashion after RAI or external beam radiation ther-
apy, which causes follicle destruction resulting in
a transient hyperthyroidism, followed eventually
by hypothyroidism. Neck pain and tenderness
usually develop 5–10days following treatment.
Symptoms are mild and subside spontaneously in
a week.
12.5.16.5 Other Causes ofNonImmune
Thyroiditis
Other causes of thyroiditis are related to a local
process, such as an acute hemorrhage into a thyroid cyst or nodule. “Palpation thyroiditis” refers
to mild, self-limited thyroiditis occurring after
physical examination, surgery, or trauma to the
thyroid. It is not associated with any thyroid disease. Finally, thyroiditis may be caused by systemic diseases, such as vasculitis-associated
thyroiditis (phenytoin therapy), sarcoidosis, metastatic cancer, or a globus hystericus [281].
12.5.17 Indications ofSurgery
inThyroiditis
Surgical interventions are exceptionally indicated for the management of thyroiditis, accounting for <1% of all thyroid procedures [282].
Patients with “autoimmune thyroiditis” are effectively managed with thyroid hormone replacement therapy, and surgical treatment is the
exception. Technical difculties are encountered
by the surgeon as the glands are rm, rigid, and
highly vascular and the surrounding tissues are
inamed with lymphadenopathy, rendering the
parathyroids and RLNs at risk. In the rare instance
where a large HT may develop and become
symptomatic, TT is an option [219, 282, 283].
Moreover, as thyroiditis patients bear a higher
risk of developing thyroid carcinoma, a cold nodule suspicious on FNA may indicate a thyroid
lobectomy. Similarly, the rapid growth of a
chronic lymphocytic thyroid gland is suggestive
of NHL.While TT may surgically cure a stage I
lymphoma (conned to the thyroid), most thyroid
lymphomas involve regional LNs and distant
sites and require multi-modal systemic therapy.
Open biopsy or thyroid lobectomy is sufcient in
these cases to establish the denitive diagnosis.
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M. Sakr
A subacute de Quervain’s thyroiditis exceptionally deserves thyroidectomy. This indication
is given when intractable neck pain is present in
spite of a consequent analgesic and L-thyroxin
replacement therapy over a period of 6months
[282]. The brotic variant of HT is characterized
by a rapid enlargement of a preexisting goiter
that causes suspicion of a thyroid cancer and consequently surgery. Riedel’s brosing thyroiditis
often requires an open biopsy to conrm the
diagnosis and rule out an anaplastic carcinoma,
or isthmectomy and/or lobectomy to decompress
the trachea and esophagus. However, thyroidectomy can be highly demanding because of the
dense brotic reaction extending beyond the thyroid, which puts the surrounding structures at risk
of injury. Amiodarone-induced thyrotoxicosis in
the setting of a rare patient with otherwise intractable arrhythmia is an indication for thyroidectomy. Finally, the acute suppurative thyroiditis is
a classic indication for surgical drainage followed
by antibiotic therapy, and rarely for lobectomy
when the suppurative process is necrotizing.
References
1. Policeni BA, Smoker WRK, Reede DL.Anatomy and
embryology of the thyroid and parathyroid glands.
Semin Ultrasound CT MRI. 2012;33:104–14.
2. Naidoo D, Boon JM, Mieny CJ, Becker PJ, van
Schoor AN.Relation of the external branch of the
superior laryngeal nerve to the superior pole of
the thyroid gland: an anatomical study. Clin Anat.
2007;20(5):516–20.
3. Gupta P, Bhalla AS, Thulkar S, Kumar A, Mohanti
BK, Thakar A, etal. Variations in superior thyroid
artery: a selective angiographic study. Indian J
Radiol Imaging. 2014;24(1):66–71.
4. Zada B, Anwar K, Malik SA, Niamatullah KN,
Salam F.Anatomical relationship between recurrent
laryngeal nerve and inferior thyroid artery in thyroidectomy patients. J Ayub Med Coll Abbottabad.
2014;26(3):380–3.
5. Gravante G, Delogu D, Rizzello A, Filingeri
V. The Zuckerkandl tubercle. Am J Surg.
2007;193(4):484–5.
6. Shindo ML.Considerations in surgery of the thyroid
gland. Otolaryngol Clin N Am. 1996;29(4):629–35.
7. Droulias C, Tzinas S, Harlaftis N, Akin JT Jr, Gray
SW, Skandalakis JE. The superior laryngeal nerve.
Am Surg. 1976;42(9):635–8.
8. Gray SW, Skandalakis JE, Akin JT Jr, Droulias
C, Vohman MD. Parathyroid glands. Am Surg.
1976;42(9):653–6.
9. Dozois RR, Beahrs OH.Surgical anatomy and technique of thyroid and parathyroid surgery. Surg Clin
North Am. 1977;57(4):647–61.
10. Baloch ZW, LiVolsi VA. Oncocytic lesions of
the neuroendocrine system. Semin Diagn Pathol.
1999;16(2):190–9.
11. Weiss ML, Deckart H, Pilz R, Deckart E, Kleinau E.
[Oncocytes in thyroid gland aspirates—differential
diagnostic problem: tumor/thyroiditis]. Radiobiol
Radiother (Berl). 1984;25(5):765–8.
12. Mikhailov IG, Vasil’ev NB, Smirnova
EA.Comparative quantitative electron-microscopic
study of the nucleoli of human thyroid oncocytes
and follicular cells. Arkh Patol. 1980;42(4):32–6.
13. Portulano C, Paroder-Belenitsky M, Carrasco N.The
Na+/I- symporter (NIS): mechanism and medical
impact. Endocr Rev. 2014;35(1):106–49.
14. Mullur R, Liu Y-Y, Brent GA.Thyroid hormone regulation of metabolism. Physiol Rev. 2014;94:355–82.
15. Cooper DS, Doherty GM, Haugen BR, Kloos RT,
Lee SL, Mandel SJ, etal. Revised American Thyroid
Association management guidelines for patients
with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19(11):1167–214.
16. Gharib H, Papini E, Paschke R, Duick DS, Valcavi
R, Hegedus L, et al. American Association of
Clinical Endocrinologists, Associazione Medici
Endocrinologi, and European Thyroid Association
medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. J Endocrinol
Investig. 2010;3(5 Suppl):1–6.
17. Elisei R, Bottici V, Luchetti F, Di Coscio G, Romei
C, Grasso L, etal. Impact of routine measurement
of serum calcitonin on the diagnosis and outcome
of medullary thyroid cancer: experience in 10,864
patients with nodular thyroid disorders. J Clin
Endocrinol Metab. 2004;89(1):163–8.
18. Mehanna HM, Jain A, Morton RP, Watkinson J,
Shaha A. Investigating the thyroid nodule. BMJ.
2009;338:705–9.
19. Cantisani V, Catania A, De Antoni E, Greco R,
Caruso R, Di Segni M, et al. Is pattern III as evidenced by US color-Doppler useful in predicting
thyroid nodule malignancy? Large-scale retrospective analysis. Clin Ter. 2010;161(2):e49–52.
20. Papini E, Guglielmi R, Bianchini A, Crescenzi A,
Taccogna S, Nardi F, etal. Risk of malignancy in
non-palpable thyroid nodules: predictive value
of ultrasound and color-Doppler features. J Clin
Endocrinol Metab. 2002;87(5):1941–6.
21. Fish SA, Langer JE, Mandel SJ.Sonographic imaging of thyroid nodules and cervical lymph nodes.
Endocrinol Metab Clin N Am. 2008;37(2):401–17.
22. Tan GH, Gharib H. Thyroid incidentalomas: management approaches to nonpalpable nodules dis-
t.me/Dr_Mouayyad_AlbtousH
12 Benign Thyroid Disease
331
covered incidentally on thyroid imaging. Ann
Intern Med. 1997;126(3):226–31. https://doi.
org/10.7326/0003- 4819- 126- 3- 199702010- 00009.
23. Price DC. Radioisotopic evaluation of the thyroid and the parathyroids. Radiol Clin North Am.
1993;31(5):991–1015.
24. British Thyroid Association, Royal College of
Physicians. British Thyroid Association Guidelines
for the management of thyroid cancer. 2nd ed. 2007.
25. Gharib H, Goellner JR.Fine needle aspiration biopsy
of the thyroid gland. In: Randolph surgery of the thyroid and parathyroid glands. Saunders WB; 2003.
26. Regina Castro M, Gharib H. Continuing controversies in the management of thyroid nodules. Ann
Intern Med. 2005;142:926–31.
27. Linos D, Chung WY. Minimally invasive thyroidectomy. Berlin, Heidelberg: Springer Berlin
Heidelberg; 2012. p.37–58.
28. Gharib H.Fine-needle aspiration biopsy of thyroid
nodules: advantages, limitations, and effect. Mayo
Clin Proc. 1994;69(1):44–9.
29. Baloch ZW, LiVolsi VA, Asa SL, Rosai J, Merino MJ,
Randolph G, etal. Diagnostic terminology and morphologic criteria for cytologic diagnosis of thyroid
lesions: a synopsis of the National Cancer Institute
thyroid ne-needle aspiration state of the science
conference. Diagn Cytopathol. 2008;36(6):425–37.
30. ICCIDD, UN Children’s Fund, and WHO.
Assessment of iodine deciency disorders and monitoring their elimination. 2001. http://www.who.int/
nutrition/publications/en/idd_assessment.pdf.
31. Derwahl M, Studer H. Multinodular goiter: much
more than simply iodine deciency. Baillieres
Best Pract Res Clin Endocrinol Metabol.
2000;14:577–600.
32. Polyzos SA, Kita M, Avramidis A. Thyroid nodules—stepwise diagnosis and management.
Hormones (Athens). 2007;6(2):101–19.
33. Pelizzo MR, Merante Boschin I, Toniato A, Sorgato
N, Marzola MC, Rubello D. Surgical therapeutic planning options in nodular goiter. Minerva
Endocrinol. 2010;35(3):173–85.
34. Gandol PP, Frisina A, Raffa M, Renda F, Rocchetti
O, Ruggeri C, etal. The incidence of thyroid carcinoma in multinodular goiter: retrospective analysis.
Acta Biomed. 2004;75(2):114–7.
35. Derwahl M, Studer H. Nodular goiter and goiter nodules: where iodine deciency falls short of
explaining the facts. Exp Clin Endocrinol Diabetes.
2001;109:250–60.
36. Stubner D, Gartner R, Greil W, et al. Hypertrophy
and hyperplasia during goitre growth and involution
in rats: separate bioeffects of TSH and iodine. Acta
Endocrinol. 1987;116:537–48.
37. Derwahl M, Studer H.Hyperplasia versus adenoma
in endocrine tissues: are they different? Trends
Endocrinol Metab. 2002;13:23–8.
38. Kobberling J, Hintze G.Differential indications for
thyroid gland operation. Chirurg. 1999;70:971–9.
39. Derwahl KM, Zielke A, Rothmund M. Euthyreote
knotenstruma. In: Siewert JR, Harder F, Rothmund
M, editors. Endokrine chirurgie. Berlin Heidelberg
NewYork: Springer; 2000. p.63–88.
40. Dunn JT, Semigran MJ, Delange F.The prevention
and management of iodine-induced hyperthyroidism
and its cardiac features. Thyroid. 1998;8:101–6.
41. Bischof P. Update endocrinology: thyroid sonography. Schweiz Rundsch Med Prax. 2020;93:695–700.
42. Hegedus L.Thyroid ultrasound. Endocrinol Metab
Clin N Am. 2004;30:339–60.
43. Weber AL, Randolph G, Aksoy FG.The thyroid and
parathyroid glands. CT and MR imaging and correlation with pathology and clinical ndings. Radiol
Clin North Am. 2000;38:1105–29.
44. Belmont MJ, Wax MK, DeSouza FN.The difcult
airway: cardiopulmonary bypass—the ultimate solution. Head Neck. 1998;20:266–9.
45. Rowe-Jones JM, Rosswick RP, Leighton SE.Benign
thyroid disease and vocal cord palsy. Ann R Coll
Surg Engl. 1993;75:241–4.
46. Farling PA. Thyroid disease. Br J Anaesth.
2000;85:15–28.
47. Cheung PS, Lee JM, Boey JH.Thyroxine suppressive therapy of benign solitary thyroid nodules:
a prospective randomized study. World J Surg.
1989;13:818–21.
48. Gittoes NJ, Miller MR, Daykin J, Sheppard MC,
Franklyn JA.Upper airways obstruction in 153 consecutive patients presenting with thyroid enlargement. BMJ. 1996;312:484.
49. Celani MF. Levothyroxine suppressive therapy
in the medical management of nontoxic benign
multinodular goiter. Exp Clin Endocrinol.
1993;101:326–32.
50. Gharib H, James EM, Charboneau JW, Naessens
JM, Offord KP, Gorman CA. Suppressive therapy
with levothyroxine for solitary thyroid nodules.
A double-blind controlled clinical study. N Engl J
Med. 1987;317:70–5.
51. Lima N, Knobel M, Cavaliere H, Sztejnsznajd C,
Tomimori E, Medeiros-Neto G.Levothyroxine suppressive therapy is partially effective in treating
patients with benign, solid thyroid nodules and multinodular goiters. Thyroid. 1997;7:691–7.
52. Papini E, Bacci V, Panunzi C, Pacella CM, Fabbrini
R, Bizzarri G, etal. A prospective randomized trial
of levothyroxine suppressive therapy for solitary
thyroid nodules. Clin Endocrinol. 1993;38:507–13.
53. WHO, UNICEF, and ICCIDD.Indicators for assessing iodine deciency disorders and their control programmes. 1993. http://whqlibdoc.who.int/hq/1993/
WHO_NUT_93.1.pdf.
54. Manders JMB, Corstens FHM.Radioiodine therapy
of euthyroid multinodular goiters. Eur J Nucl Med.
2002;29:S466–70.
55. Bergamaschi R, Becouarn G, Ronceray J, Arnaud
JP. Morbidity of thyroid surgery. Am J Surg.
1998;176:71–5.
t.me/Dr_Mouayyad_AlbtousH
332
M. Sakr
56. Gardiner KR, Russell CF. Thyroidectomy for large
multinodular colloid goitre. J R Coll Surg Edinb.
1995;40:367–70.
57. Gibelin H, Sierra M, Mothes D, Ingrand P, Levillain
P, Jones C, Hadjadj S, Torremocha F, Marechaud
R, Barbier J, Kraimps JL. Risk factors for recurrent nodular goiter after thyroidectomy for benign
disease: case-control study of 244 patients. World J
Surg. 2004;28:1079–82.
58. Liu Q, Djuricin G, Prinz RA.Total thyroidectomy
for benign thyroid disease. Surgery. 1998;123:2–7.
59. Marchesi M, Biffoni M, Tartaglia F, Biancari F,
Campana FP. Total versus subtotal thyroidectomy
in the management of multinodular goiter. Int Surg.
1998;83:202–4.
60. Mishra A, Agarwal A, Agarwal G, Mishra SK.Total
thyroidectomy for benign thyroid disorders in an
endemic region. World J Surg. 2001;25:307–10.
61. Muller PE, Schmid T, Spelsberg F.Total thyroidectomy in iodine-decient goiter: an effective treatment alternative? Zentralbl Chir. 1998;123:39–41.
62. Rios-Zambudio A, Rodriguez J, Riquelme J, Soria T,
Canteras M, Parrilla P.Prospective study of postoperative complications after total thyroidectomy for
multinodular goiters by surgeons with experience in
endocrine surgery. Ann Surg. 2004;240:18–25.
63. Siragusa G, Lanzara P, Di Pace G. Subtotal thyroidectomy or total thyroidectomy in the treatment
of benign thyroid disease. Our experience. Minerva
Chir. 1998;53:233–8.
64. Netterville JL, Coleman SC, Smith JC, et al.
Management of substernal goiter. Laryngoscope.
1998;108:1611–7.
65. Martin L, Delbridge L, Martin J, Poole A, Crummer
P, Reeve TS.Trainee surgery in teaching hospitals:
is there a cost? Aust N Z J Surg. 1989;59:257–60.
66. Sosa JA, Bowman HM, Tielsch JM, Powe NR,
Gordon TA, Udelsman R.The importance of surgeon
experience for clinical and economic outcomes from
thyroidectomy. Ann Surg. 1998;228(3):320–30.
67. Watkinson JC, Gaze MN, Wilson JA. Tumours of
the thyroid and parathyroid gland. Stell and Maran’s
head and neck surgery. 4th ed. Oxford: ButterworthHeinemann; 2000.
68. Lansford CD, Teknos TN.Evaluation of the thyroid
nodule. Cancer Control. 2006;13(2):89–98.
69. Buhr HJ, Mann B. Thyroidectomy and lymphadenectomy. Chirurg. 1999;70:987–98.
70. Röher HD, Goretzki PE, Hellmann P, Witte
J. Complications in thyroid surgery. Incidence and
therapy. Chirurg. 1999;70:999–1010.
71. Wagner PK. Surgical techniques for benign goiter.
Chirurg. 1999;70:980–6.
72. Pappalardo G, Guadalaxara A, Frattaroli FM,
Illomei G, Falaschi P.Total compared with subtotal
thyroidectomy in benign nodular disease: personal
series and review of published reports. Eur J Surg.
1998;164:501–6.
73. Piraneo S, Vitri P, Galimberti A, Guzzetti S,
Salvaggio A, Bastagli A. Recurrence of goitre
after operation in euthyroid patients. Eur J Surg.
1994;160:351–6.
74. Rojdmark J, Jarhult J. High long term recurrence
rate after subtotal thyroidectomy for nodular goitre.
Eur J Surg. 1995;161:725–7.
75. Delbridge L, Guinea AI, Reeve TS.Total thyroidectomy for bilateral benign multinodular goiter: effect
of changing practice. Arch Surg. 1999;134:1389–93.
76. Kann P, Jocham A, Beyer J. Hypothyroidism,
hyperthyroidism and therapy with thyroid hormones: effect on the skeletal system. Dtsch Med
Wochenschr. 1997;122:1392–7.
77. Sawin CT, Geller A, Wolf PA, Belanger AJ, Baker E,
Bacharach P, et al. Low serum thyrotropin concentrations as a risk factor for atrial brillation in older
persons. N Engl J Med. 1994;331:1249–52.
78. Muller PE, Jakoby R, Heinert G, Spelsberg
F.Surgery for recurrent goitre: its complications and
their risk factors. Eur J Surg. 2001;167:816–21.
79. Abboud B, Sleilaty G, Mallak N, Abou Zeid
H, Tabchy B. Morbidity and mortality of thyroidectomy for substernal goiter. Head Neck.
2010;32(6):744–9.
80. Katlic MR, Wang CA, Grillo HC.Substernal goiter.
Ann Thorac Surg. 1985;39(4):391–9.
81. Shin JJ, Grillo HC, Mathisen D, Katlic MR,
Zurakowski D, Kamani D, etal. The surgical management of goiter: part I. Preoperative evaluation.
Laryngoscope. 2011;121(1):60–7.
82. White ML, Doherty GM, Gauger PG. Evidencebased surgical management of substernal goiter.
World J Surg. 2008;32(7):1285–300.
83. Raffaelli M, De Crea C, Ronti S, Bellantone R,
Lombardi CP.Substernal goiters: incidence, surgical
approach, and complications in a tertiary care referral center. Head Neck. 2011;33(10):1421420–5.
84. Page C, Strunski V.Cervicothoracic goitre: an anatomical or radiological denition? Report of 223 surgical cases. J Laryngol Otol. 2007;121(11):1083–7.
85. Singh B, Lucente FE, Shaha AR. Substernal
goiter: a clinical review. Am J Otolaryngol.
1994;15(6):409–16.
86. Rios A, Rodriguez JM, Balsalobre MD, Tebar FJ,
Parrilla P.The value of various denitions of intrathoracic goiter for predicting intra- operative and postoperative complications. Surgery. 2010;147(2):233–8.
87. Newman E, Shaha A. Substernal goiter. J Surg
Oncol. 1995;60:207–12.
88. Torre G, Borgonovo G, Amato A, et al. Surgical
management of substernal goiter: analysis of 237
patients. Am Surg. 1995;61:826–31.
89. Allo MD, Thompson NW.Rationale for the operative management of substernal goiters. Surgery.
1983;94(6):969–77.
90. Sand ME, Laws HL, McElvein RB.Substernal and
intrathoracic goiter: reconsideration of surgical
approach. Am Surg. 1983;49(4):196–202.
91. Goldenberg IS, Lindskog GE.Differential diagnosis,
pathology, and treatment of substernal goiter. JAMA
J Am Med Assoc. 1957;163(7):527–9.
t.me/Dr_Mouayyad_AlbtousH
12 Benign Thyroid Disease
333
92. Vadasz P, Kotsis L. Surgical aspects of 175
mediastinal goiters. Eur J Cardiothorac Surg.
1998;14(4):393–7.
93. Wu YH, Qi YF, Tang PZ, etal. The surgical method
of retrosternal goitre. Clin J Otorhinolaryngol Head
Neck Surg. 2006;41:528–31.
94. Candela G, Varriale S, Di Libero L, Manetta F,
Giordano M, Maschio A, etal. Surgical therapy of
goiter plunged in the mediastinum. Considerations
regarding our experience with 165 patients. Chir Ital.
2007;59(6):843–51.
95. Huins CT, Georgalas C, Mehrzad H, Tolley NS. A
new classication system for retrosternal goitre
based on a systematic review of its complications
and management. Int J Surg. 2008;6(1):71–6.
96. Prinz RA. Difcult problems in thyroid surgery.
Curr Probl Surg. 2002;1:47–51.
97. Randolph GW.The importance of pre- and postoperative laryngeal examination for thyroid surgery.
Thyroid. 2010;20(5):453–8.
98. Mackle T, Meaney J, Timon C.Tracheoesophageal
compression associated with substernal goitre. Correlation of symptoms with crosssectional imaging ndings. J Laryngol Otol.
2007;21(4):58–61.
99. Mansberger AR, Wei JP.Surgical emberyology and
anatomy of the thyroid and parathyroid glands. Surg
Clin N Am. 1993;73:727–46.
100. Van Schil P, Vanmaele R, Ehlinger P, Schoofs E,
Goovaerts G.Primary intrathoracic goiter. Acta Chir
Belg. 1989;89:206–8.
101. Shen WT, Kebebew E, Duh QY, Clark OH.Predictors
of airway complications after thyroidectomy for
substernal goiter (including discussion). Arch Surg.
2004;138:656–60.
102. Rodriguez JM, Hernandez Q, Piñero A, Ortiz S,
Soria T, Ramirez P, etal. Substernal goiter: clinical
experience of 72 cases. Ann Otol Rhinol Laryngol.
1999;108(5):501–4.
103. Erbil Y, Bozbora A, Barbaros U, Ozarmagan S,
Azezli A, Molvalilar S. Surgical management of
substernal goiters: clinical experience of 170 cases.
Surg Today. 2004;34(9):732–6.
104. Mercante G, Gabrielli E, Pedroni C, Formisano D,
Bertolini L, Nicoli F, etal. CT cross-sectional imaging classication system for substernal goiter based
on risk factors for an extracervical surgical approach.
Head Neck. 2011;33(6):792–9.
105. Whiteen CR, Khan S, Munneke GJ, Grubnic S.A
diagnostic approach to mediastinal abnormalities.
Radiographics. 2007;27:657–71.
106. Tomiyama N, Honda O, Tsubamoto M, Inoue A,
Sumikawa H, Kuriyama K, Kusumoto M, Johkoh
T, Nakamura H. Anterior mediastinal tumors:
diagnostic accuracy of CT and MRI.Eur J Radiol.
2009;69:280–8.
107. Buckley JA, Stark P. Intrathoracic mediastinal
thyroid goiter: imaging manifestation. Am J Rad.
1999;173:471–5.
108. Chow TL, Chan TTF, Suen DTK, Chu DW, Lam
SH.Surgical management of substernal goitre: local
experience. Hong Kong Med J. 2005;11:360–5.
109. Michel LA, Bradpiece HA.Surgical management of
substernal goiter. Br J Surg. 1988;75:565–9.
110. Kumar A, Mohan A, Dhillon SS, Harris
K. Substernal thyroid biopsy using endobronchial
ultrasound- guided transbronchial needle aspiration.
J Vis Exp. 2014;10:e51867.
111. Laurent F, Latrabe V, Lecesne R, Zennaro H, Airaud
JY, Rauturier JF, Drouillard J.Mediastinal masses:
diagnostic approach. Eur Radiol. 1998;8:1148–59.
112. Takahashi K, Al-Janabi NJ.Computed tomography
and magnetic resonance imaging of mediastinal
tumors. J Magn Reson Imaging. 2010;32:1325–39.
113. Puderbach M, Hintze C, Ley S, Eichinger M,
Kauczor HU, Biederer J. MR imaging of the
chest: a practical approach at 1.5 T. Eur J Radiol.
2007;64:345–55.
114. Duwe BV, Sterman DH, Musani AI.Tumors of the
mediastinum. Chest. 2005;128:2893–909.
115. Wesche MF, Tiel-V Buul MM, Lips P, Smits NJ,
Wiersinga WM.A randomized trial comparing levothyroxine with radioactive iodine in the treatment of
sporadic nontoxic goiter. J Clin Endocrinol Metab.
2001;86:998–1005.
116. Gharib H, Papini E, Paschke R, Duick DS, Valcavi
R, Hegedüs L, Vitti P. American Association of
Clinical Endocrinologists, Associazione Medici
Endocrinologi, and European Thyroid Association
medical guidelines for clinical practice for the diagnosis and management of thyroid nodules: executive summary of recommendations. J Endocrinol
Investig. 2010;33:287–91.
117. Cooper DS, Doherty GM, Haugen BR, Hauger
BR, Kloos RT, Lee SL, Mandel SJ, Mazzaferri EL,
McIver B, Pacini F, Schlumberger M, Sherman SI,
Steward DL, Tuttle RM.Revised American Thyroid
Association management guidelines for patients
with thyroid nodules and differentiated thyroid cancer. Thyroid. 2009;19:1167–214.
118. McHenry CR, Piotrowski JJ. Thyroidectomy in
patients with marked thyroid enlargement: airway
management, morbidity, and outcome. Am Surg.
1994;60(8):586–91.
119. Monchik JM, Materazzi G. The necessity for a
thoracic approach in thyroid surgery. Arch Surg.
2000;135(4):467–71.
120. Huysmans AKC, Hermus RMM, Corsten HM, etal.
Large, compressive goiters treated with radioiodine.
Ann Int Med. 1994;121(10):757–62.
121. Wexler S, Yamane K, Fisher KW, Diehl JT, Hirose
H. Single-stage operation for giant substernal goiter with severe coronary artery disease. Ann Thorac
Cardiovasc Surg. 2011;17(5):524–7.
122. Hedayati N, McHenry CR. The clinical presentation and operative management of nodular and
diffuse substernal thyroid disease. Am Surg.
2002;68(3):245–51.
t.me/Dr_Mouayyad_AlbtousH
334
M. Sakr
123. Agarwal G, Aggarwal V.Is total thyroidectomy the
surgical procedure of choice for benign multinodular goiter? An evidence-based review. World J Surg.
2008;32(7):1313–24.
124. Nankee L, Chen H, Schneider DF, Sippel RS,
Elfenbein DM.Substernal goiter: when is a sternotomy required? J Surg Res. 2015;199(1):121–5.
125. Rolighed L, Rønning H, Christiansen P.Sternotomy
for substernal goiter: retrospective study of 52 operations. Langenbeck's Arch Surg. 2015;400(3):301–6.
126. Wheeler MH.Clinical dilemma. Retrosternal goitre.
Br J Surg. 1999;86:1235–6.
127. Wright CD, Mathisen DJ.Mediastinal tumors: diagnosis and treatment. World J Surg. 2001;25:204–9.
128. Tsang FH, Wan IY, Lee TW, Ng SK, Yim
AP. Management of retrosternal goitre with superior vena cava obstruction. Heart Lung Circ.
2007;16(4):312–4.
129. Shigemura N, Akashi A, Nakagiri T, Matsuda
H. VATS with a supraclavicular window for huge
substernal goiter: an alternative technique for
reventing recurrent laryngeal nerve injury. Thorac
Cardiovasc Surg. 2005;53:231–3.
130. Gupta P, Lau KKW, Rizvi I, Rathinam S,
WallerDA.Video assisted thoracoscopic thyroidectomy for retrosternal goiter. Ann R Coll Surg Engl.
2014;96(8):606–8.
131. Podgaetz E, Gharagozloo F, Najam F, Sadeghi N,
Margolis M, Tempesta BJ. A novel robot-assisted
technique for excision of a posterior mediastinal
thyroid goiter: a combined cervico-mediastinal
approach. Innovations (Phila). 2009;4:225–8.
132. Rea F, Schiavon M, Di Chiara F, Marulli G.Singleinstitution experience on robot-assisted thoracoscopic operations for mediastinal diseases.
Innovations (Phila). 2011;6:316–22.
133. Wang S, Xu S, Liu B.Resection of huge retrosternal
goiter through a novel combined cervical and robotassisted approach. Artif Organs. 2014;38:431–3.
134. Randolph GW, Shin JJ, Grillo HC, Mathisen D,
Katlic MR, Kamani D, etal. The surgical management of goiter: part II.Surgical treatment and results.
Laryngoscope. 2011;121(1):68–76.
135. Sancho JJ, Kraimps JL, Sanchez-Blanco JM, Larrad
A, Rodríguez JM, Gil P, et al. Increased mortality
and morbidity associated with thyroidectomy for
intrathoracic goiters reaching the carina tracheae.
Arch Surg. 2006;141(1):82–5.
136. Steinmuller T, Ulrich F, Rayes N, et al. Surgical
procedures and risk factors in therapy of benign
multinodular goiter. A statistical comparison of the incidence of complications. Chirurg.
2001;72:1453–7.
137. Ozbas S, Kocak S, Aydintug S, Cakmak A,
Demirkiran MA, Wishart GC. Comparison of the
complications of subtotal, near total and total thyroidectomy in the surgical management of multinodular goitre. Endocr J. 2005;52(2):199–205.
138. Pattou F, Combemale F, Fabre S, Carnaille B,
Decoulx M, Wemeau JL, et al. Hypocalcemia fol-
lowing thyroid surgery: incidence and prediction of
outcome. World J Surg. 1998;22(7):718–24.
139. Hurtado-Lopez LM, Arellano-Montano S, TorresAcosta EM, etal. Combined use of ne-needle aspiration biopsy, MIBI scans and frozen section biopsy
offers the best diagnostic accuracy in the assessment
of the hypofunctioning solitary thyroid nodule. Eur J
Nucl Med Mol Imaging. 2004;31:1273–9.
140. Baskin HJ.Ultrasound of thyroid nodules. In: Baskin
HJ, editor. Thyroid ultrasound and ultrasoundguided FNA biopsy. Boston, MA: Kluwer Academic
Publishers; 2000. p.71–86.
141. Keh SM, El-Shunnar SK, Palmer T, Ahsan
SF.Incidence of malignancy in solitary thyroid nodules. J Laryngol Otol. 2015;129(7):677–81.
142. Hanley P, Lord K, Bauer AJ.Thyroid disorders in
children and adolescents: a review. JAMA Pediatr.
2016;170(10):1008–19.
143. Hung W, Anderson KD, Chandra RS, Kapur SP,
Patterson K, Randolph JG, et al. Solitary thyroid
nodules in 71 children and adolescents. J Pediatr
Surg. 1992;27(11):1407–9.
144. Becker WF.Pioneers in thyroid surgery. Ann Surg.
1977;185(5):493–504.
145. Fowler CL, Pokorny WJ, Harberg FJ.Thyroid nodules in children: current prole of a changing disease. South Med J. 1989;82(12):1472–8.
146. Uyar O, Cetin B, Aksel B, Dogan L, Beksac K,
Akgul GG, et al. Malignancy in solitary thyroid
nodules: evaluation of risk factors. Oncol Res Treat.
2017;40(6):360–3.
147. DeAndrade MA.A review of 128 cases of posterior
mediastinal goiter. World J Surg. 1977;1(6):789–97.
148. Asteria C, Giovanardi A, Pizzocaro A, Cozzaglio L,
Morabito A, Somalvico F, et al. USelastography in
the differential diagnosis of benign and malignant
thyroid nodules. Thyroid. 2008;18:523–31.
149. Tranquart F, Bleuzen A, Pierre-Renoult P, Chabrolle
C, Sam Giao M, Lecomte P. Elastosonography
of thyroid lesions [article in French]. J Radiol.
2008;89:35–9.
150. Rago T, Santini F, Scutari M, Pinchera A, Vitti
P. Elastography: new developments in ultrasound
for predicting malignancy in thyroid nodules. J Clin
Endocrinol Metab. 2007;92:2917–22.
151. Cosgrove D. Future prospects for SonoVue and
CPS.Eur Radiol. 2004;14(Suppl 8):116–24.
152. Papini E, Bizzarri G, Pacella CM. Percutaneous
laser ablation of benign and malignant thyroid
nodules. Curr Opin Endocrinol Diabetes Obes.
2008;15:434–9.
153. Yang J, Schnadig V, Logrono R, Wasserman
PG. Fineneedle aspiration of thyroid nodules: a
study of 4703 patients with histologic and clinical
correlations. Cancer. 2007;111:306–15.
154. Danese D, Sciacchitano S, Farsetti A, Andreoli
M, Pontecorvi A. Diagnostic accuracy of conventional versus sonography-guided ne-needle
aspiration biopsy of thyroid nodules. Thyroid.
1998;8:15–21.
t.me/Dr_Mouayyad_AlbtousH
12 Benign Thyroid Disease
335
155. Kihara M, Hirokawa M, Masuoka H, Yabuta T,
Shindo H, Higashiyama T, etal. Evaluation of cytologically benign solitary thyroid nodules by ultrasonography: a retrospective analysis of 1877 cases.
Auris Nasus Larynx. 2013;40(3):308–11.
156. Vierhapper H, Raber W, Bieglmayer C, Kaserer K,
Weinhausl A, Niederle B.Routine measurement of
plasma 40 AACE/AME/ETA thyroid nodule guidelines, Endocr Pract 2010;16(Suppl 1) calcitonin in
nodular thyroid diseases. J Clin Endocrinol Metab.
1997;82:1589–93.
157. Cheung K, Roman SA, Wang TS, Walker HD, Sosa
JA.Calcitonin measurement in the evaluation of thyroid nodules in the United States: a cost- effectiveness
and decision analysis. J Clin Endocrinol Metab.
2008;93:2173–80.
158. Kotzmann H, Schmidt A, Scheuba C, Kaserer K,
Watschinger B, Söregi G, etal. Basal calcitonin levels and the response to pentagastrin stimulation in
patients after kidney transplantation or on chronic
hemodialysis as indicators of medullary carcinoma.
Thyroid. 1999;9:943–7.
159. Nagai GR, Pitts WC, Basso L, Cisco JA, McDougall
IR. Scintigraphic hot nodules and thyroid carcinoma. Clin Nucl Med. 1987;12:123–7.
160. Tan GH, Gharib H. Thyroid incidentalomas: management approaches to nonpalpable nodules discovered incidentally on thyroid imaging. Ann Intern
Med. 1997;126(3):226–31.
161. Wu CW, Dionigi G, Lee KW, Hsiao PJ, Paul Shin
MC, Tsai KB, etal. Calcications in thyroid nodules identied on preoperative computed tomography: patterns and clinical signicance. Surgery.
2011;10:12–9.
162. Deandrea M, Mormile A, Veglio M, Motta M,
Pellerito R, Gallone G, et al. Fine-needle aspiration biopsy of the thyroid: comparison between thyroid palpation and ultrasonography. Endocr Pract.
2002;8:282–6.
163. Beech P, Lavender I, Jong I, Soo G, Ramdave S,
Chong A, Nandurkar D. Ultrasound stratication of the FDG-avid thyroid nodule. Clin Radiol.
2016;71:164–9.
164. Basharat R, Bukhari MH, Saeed S, Hamid
T. Comparison of ne needle aspiration cytology
and thyroid scan in solitary thyroid nodule. Patholog
Res. 2011;2011:754041.
165. Yip L, Farris C, Kabaker AS, Hodak SP, Nikiforova
MN, McCoy KL, et al. Cost impact of molecular testing for indeterminate thyroid nodule neneedle aspiration biopsies. J Clin Endocrinol Metab.
2012;97(6):1905–12.
166. Thomusch O, Machens A, Sekulla C, Ukkat J,
Lippert H, Gastinger I, Dralle H.Multivariate analysis of risk factors for postoperative complications in
benign goiter surgery: prospective multicenter study
in Germany. World J Surg. 2000;24:1335–41.
167. Cersosimo E, Gharib H, Suman VJ, Goellner JR.
“Suspicious” thyroid cytologic ndings: outcome
in patients without immediate surgical treatment.
Mayo Clin Proc. 1993;68:343–8.
168. Gharib H, Goellner JR.Fine-needle aspiration biopsy
of thyroid nodules. Endocr Pract. 1995;1:410–7.
169. Gharib H, Goellner JR, Johnson DA. Fine-needle
aspiration cytology of the thyroid. A 12-year
experience with 11,000 biopsies. Clin Lab Med.
1993;13:699–709.
170. Renshaw AA, Pinnar N.Comparison of thyroid neneedle aspiration and core needle biopsy. Am J Clin
Pathol. 2007;128:370–4.
171. Zhang YW, Greenblatt DY, Repplinger D,
Bargren A. Factors that predict malignancy in
Hürthle cell neoplasms of the thyroid. J Surg Res.
2008;144(2):371–2.
172. Elsheikh TM, Singh HK, Silverman JF.Fine-needle
aspiration cytology versus core needle biopsy in the
evaluation of thyroid and salivary gland lesions. Path
Case Rev. 2007;12:3–9.
173. Pisani T, Bononi M, Nagar C, Angelini M, Bezzi M,
Vecchione A.Fine needle aspiration and core needle
biopsy techniques in the diagnosis of nodular thyroid pathologies. Anticancer Res. 2000;20:3843–7.
174. Datta RV, Petrelli NJ, Ramzy J.Evaluation and management of incidentally discovered thyroid nodules.
Surg Oncol. 2006;15:33–42.
175. Diamond T, Nery L, Hales I.A therapeutic dilemma:
suppressive doses of thyroxine signicantly red
measurements in both premenopausal and postmenopausal women with thyroid cancer. J Clin
Endocrinol Metab. 1991;72(6):1184–8.
176. Oertel YC, Miyahara-Felipe L, Mendoza MG, Yu
K. Value of repeated ne needle aspirations of the
thyroid: an analysis of over ten thousand FNAs.
Thyroid. 2007;17:1061–6.
177. Erdogan MF, Kamel N, Aras D, Akdogan A, Baskal
N, Erdogan G. Value of re-aspirations in benign
nodular thyroid disease. Thyroid. 1998;8:1087–90.
178. Illouz F, Rodien P, Saint-Andre JP, Triau S,
Laboureau-Soares S, Dubois S, Vielle B, Hamy A,
Rohmer V.Usefulness of repeated ne-needle cytology in the follow-up of non-operated thyroid nodules. Eur J Endocrinol. 2007;156:303–8.
179. Tee YY, Lowe AJ, Brand CA, Judson RT. Fineneedle aspiration may miss a third of all malignancy
in palpable thyroid nodules: a comprehensive literature review. Ann Surg. 2007;246:714–20.
180. Pinchot SN, Al-Wagih H, Schaefer S, Sippel R, Chen
H.Accuracy of ne-needle aspiration biopsy for predicting neoplasm or carcinoma in thyroid nodules
4cm or larger. Arch Surg. 2009;144:649–55.
181. Kuru B, Gulcelik NE, Gulcelik MA, Dincer H.The
false-negative rate of ne-needle aspiration cytology
for diagnosing thyroid carcinoma in thyroid nodules.
Langenbeck's Arch Surg. 2010;395:127–32.
182. Wharry LI, McCoy KL, Stang MT, Armstrong MJ,
LeBeau SO, Tublin ME, Sholosh B, Silbermann A,
Ohori NP, Nikiforov YE, Hodak SP, Carty SE, Yip
L. Thyroid nodules (>/ = 4 cm): can ultrasound and
t.me/Dr_Mouayyad_AlbtousH
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