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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_2593_Библиотеки_им_академика_М_И_Перельмана
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Applied
Therapeutics
Anniversary
Edition
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V O L U M E O N E
APPLIED THERAPEUTICS
The Clinical Use of Drugs
T W E L F T H E d i t i o n
V O L U M E O N E
APPLIED THERAPEUTICS
The Clinical Use of Drugs
T W E L F T H E d i t i o n
CAROLINE S. ZEIND, PHARMD
Vice President for Academic Affairs/Provost
Professor of Pharmacy Practice
Academic Affairs
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
MICHAEL G. CARVALHO, BS, PHARMD, BCPP
Professor Emeritus of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
JUDY W. CHENG, PHARMD, MPH, BCPS, FCCP
Professor and Chair
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
KATHY ZAIKEN, PHARMD
Professor of Pharmacy Practice
Director, International Pharmacy Residency Program
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
TRISHA LAPOINTE, PHARMD, BCPS, FASHP
Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Acquisitions Editor: Matt Hauber
Development Editors: Kelly Horvath/Deborah Bordeaux
Editorial Coordinator: Venugopal Loganathan
Editorial Assistant: Parisa Saranj
Marketing Manager: Phyllis Hitner
Production Project Manager: Catherine Ott
Manager of Graphic Arts and Design: Steve Druding
Art Director: Jennifer Clements
Manufacturing Coordinator: Margie Orzech
Prepress Vendor: S4Carlisle Publishing Services
Twelfth Edition
Copyright © 2024 Wolters Kluwer.
Copyright © 2018, 2013, 2009, 2005 by Lippincott Williams & Wilkins, a Wolters
Kluwer business. All rights reserved. This book is protected by copyright. No part
of this book may be reproduced or transmitted in any form or by any means,
including as photocopies or scanned-in or other electronic copies, or utilized by
any information storage and retrieval system without written permission from the
copyright owner, except for brief quotations embodied in critical articles and
reviews. Materials appearing in this book prepared by individuals as part of their
official duties as U.S. government employees are not covered by the abovementioned copyright. To request permission, please contact Wolters Kluwer at Two
Commerce Square, 2001 Market Street, Philadelphia, PA 19103, via email at
permissions@lww.com, or via our website at shop.lww.com (products and
services).
9 8 7 6 5 4 3 2 1
Printed in Mexico
Library of Congress Cataloging-in-Publication Data
ISBN-13: 978-1-975167-09-7
Cataloging in Publication data available on request from publisher.
This work is provided “as is,” and the publisher disclaims any and all warranties,
express or implied, including any warranties as to accuracy, comprehensiveness,
or currency of the content of this work.
This work is no substitute for individual patient assessment based upon healthcare
professionals’ examination of each patient and consideration of, among other
things, age, weight, gender, current or prior medical conditions, medication history,
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laboratory data and other factors unique to the patient. The publisher does not
provide medical advice or guidance and this work is merely a reference tool.
Healthcare professionals, and not the publisher, are solely responsible for the use
of this work including all medical judgments and for any resulting diagnosis and
treatments.
Given continuous, rapid advances in medical science and health information,
independent professional verification of medical diagnoses, indications,
appropriate pharmaceutical selections and dosages, and treatment options should
be made and healthcare professionals should consult a variety of sources. When
prescribing medication, healthcare professionals are advised to consult the
product information sheet (the manufacturer’s package insert) accompanying each
drug to verify, among other things, conditions of use, warnings and side effects and
identify any changes in dosage schedule or contraindications, particularly if the
medication to be administered is new, infrequently used or has a narrow
therapeutic range. To the maximum extent permitted under applicable law, no
responsibility is assumed by the publisher for any injury and/or damage to persons
or property, as a matter of products liability, negligence law or otherwise, or from
any reference to or use by any person of this work.
shop.lww.com
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Dedication
As we near the 50th anniversary of Applied
Therapeutics, the editors wish to honor Dr.
Mary Anne Koda-Kimble and Dr. Lloyd Young
who created Applied Therapeutics, the gold
standard textbook used in the teaching of
patient-centered drug therapeutics. Their
vision and legendary contributions have
advanced health professions education for
generations of healthcare students who are
making a difference in the lives of their
patients and the communities in which they
serve.
After embarking on the twelfth edition of
Applied Therapeutics, the COVID-19
pandemic brought forward unexpected
challenges to a dedicated team of over 200
contributors for this edition. Many of our
contributors served in dual roles as health
professions educators and as healthcare
providers on the front lines managing the
pandemic. We dedicate this twelfth edition to
them, as well as the health professions
students who demonstrated resilience to
advance their education and training during
the pandemic. Finally, we wish to thank our
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families for their patience and unwavering
support as we navigated through the winding
roads of this journey and completed this
twelfth edition of the textbook.
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Preface
Health professions education was significantly affected by the
COVID-19 pandemic, as there was a significant need to adapt the
delivery of clinical education. Many health professions programs
redesigned curriculum to incorporate virtual educational tools with
enhancements to online education. The pandemic has shown us
more than ever the importance of educating students who are able to
think critically and to utilize problem-solving skills to address
healthcare challenges. Approximately five decades later, the
founding principle for this textbook—a patient-centric, case-based
approach to learning—remains the cornerstone of health professions
education. Our authors present approximately 900 patient cases that
stimulate the reader to integrate and apply therapeutic principles in
the context of specific clinical situations. Health professions students
and practitioners gain a glimpse into the minds of expert clinicians as
they work to assess and solve therapeutic problems and develop
their own critical thinking and problem-solving skills.
Readers familiar with past editions of the book will notice that the
overall design of the book is consistent with the eleventh edition,
which incorporates a Core Principles section at the beginning of
each chapter, providing the most important “take home” information
from the chapter. Each Core Principle is mapped to specific cases
within the chapter where the principle is discussed in detail. Key
references and websites are listed at the end of each chapter,
whereas the full reference lists for each chapter have been moved
online.
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Building upon the excellent foundation of case-based learning
provided in previous editions, the twelfth edition has incorporated
changes to meet the evolving educational needs of health
professions educators and students across the globe. The editors
and contributors have utilized the five Institute of Medicine (IOM)
core competencies as a broad framework for proposing case studies
and questions within the textbook: patient-centered care,
interprofessional teams, evidence-based practice, quality
improvement, and informatics. In addition, the Accreditation Council
for Pharmacy Education (ACPE) Accreditation Standards 2016, the
Center for the Advancement of Pharmacy Education (CAPE)
Educational Outcomes, and the North American Pharmacist
Licensure Examination (NAPLEX) revised competency statements
have served as road maps for the editorial team and contributors in
designing the twelfth edition.
Featuring contributions from more than 200 experienced health
professions educators, every chapter has been revised and updated
to reflect our ever-changing knowledge of drugs and the application
of this knowledge to the individualized therapy of patients. Given the
importance of incorporating Interprofessional Practice and Education
(IPE) within health professions curricula, we have dedicated a
chapter on IPE, as well as an array of IPE case studies prepared by
contributors that are representative of various sections of the
textbook. These IPE cases, along with answer guides, will be
available for instructors on the textbook’s website (see the
“Additional Resources” section).
We welcome your feedback as we undertake planning for the next
edition. The authors have drawn on information from the literature,
current standards, and their own clinical experiences to share the
process involved in making sound and thoughtful therapeutic
decisions. However, it remains the responsibility of every practitioner
to evaluate the appropriateness of a particular opinion in the context
of the actual clinical situation, bearing in mind any recent
developments in the field. We strongly urge students and
practitioners to consult several appropriate information sources when
working with new and unfamiliar drugs.
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