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Acknowledgments
We are deeply indebted to the many dedicated people who have
given of themselves to complete the twelfth edition of Applied
Therapeutics: The Clinical Use of Drugs. We are grateful to our
contributing authors who have worked tirelessly and with resolve to
provide the highest quality of work, while providing vital services to
patients during the pandemic, along with numerous responsibilities
as educators, clinicians, and researchers. We are grateful for the
exceptional work of our 28 section editors, who provided critical
feedback necessary both in the organizational structure of the
textbook and in the individual editing of chapters; without their
dedication and support, this edition would not have been possible.
We sincerely thank the past editorial team of Applied Therapeutics,
with special thanks to Dr. B. Joseph Guglielmo for his guidance and
support and contributions to this textbook.
The team from Wolters Kluwer, Matt Hauber, Deborah Bordeaux,
Kelly Horvath, Venugopal Loganathan, Sean Hanrahan, and Susan
Thomas, deserves special recognition for their efforts. Their
exceptional patience, attention to detail, and guidance have been
critical to the success of this project. We sincerely thank Catherine
Ott (project management) and Subhash Nataraj (production) for their
assistance in completing this edition. Most importantly, we wish to
acknowledge the love, understanding, and unwavering support of
our spouses and families. They selflessly gave to us early mornings,
late nights, weekends, and vacation time that we spent writing and
editing.
https://t.me/medicina_free

Consistent with past editions, we continue to dedicate our work to
our students who inspire us and to the many patients we have been
privileged to care for and who have taught us invaluable lessons. We
also dedicate the twelfth edition to those health professions
educators and clinicians who have served as pioneering leaders and
role models in the delivery of patient-centered care using teambased approaches.
https://t.me/medicina_free

Additional Resources
The twelfth edition of Applied Therapeutics: The Clinical Use of
Drugs includes additional resources for both instructors and
students, available on the book’s companion website at
http://thepoint.lww.com/AT12e.
STUDENT RESOURCES
Students who have purchased Applied Therapeutics: The Clinical
Use of Drugs, Twelfth Edition, have access to the following additional
resources for each chapter:
A full online reference list for that chapter
INSTRUCTOR RESOURCES
Approved adopting instructors will be given access to the following
additional resources:
Interprofessional Education (IPE) Case Studies and Answer
Guides
Each chapter will map which NAPLEX competency statements are
addressed within it, which will be a helpful resource for instructors.
https://t.me/medicina_free

Section Editors
Mary G. Amato, PharmD, MPH, FCCP, BCPS
Professor Emerita of Pharmacy Practice
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Michael C. Angelini, PharmD, MA, BCPP
Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Judith L. Beizer, PharmD, CGP, FASCP
Clinical Professor
Department of Clinical Pharmacy Practice
College of Pharmacy & Allied Health Professions
St. John’s University
Jamaica, New York
Snehal H. Bhatt, PharmD, BCPS
Associate Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
https://t.me/medicina_free

Clinical Pharmacist
Beth Israel Deaconess Medical Center
Boston, Massachusetts
Michael G. Carvalho, BS, PharmD, BCPP
Professor Emeritus of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Judy W. Cheng, PharmD, MPH, BCPS, FCCP
Professor and Chair
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
R. Rebecca Couris, PhD, RPh
Professor of Nutrition Science and Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Elizabeth Anne Farrington, PharmD, FCCP, FCCM,
FPPA, BCPS, BCNSP, BCPPS
Clinical Pharmacist–Pediatrics
Department of Pharmacy
Novant Health New Hanover Regional Medical Center
Wilmington, North Carolina
Steven Gabardi, PharmD, BCPS, FAST, FCCP
https://t.me/medicina_free

Abdominal Organ Transplant Clinical Specialist
Brigham and Women’s Hospital
Assistant Professor of Medicine
Harvard Medical School
Mass General Brigham
Boston, Massachusetts
Jennifer D. Goldman, PharmD, CDCES, BC-ADM,
FCCP
Professor of Pharmacy Practice
Clinical Pharmacist, Well Life
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Christy S. Harris, PharmD, BCOP, FHOPA
Associate Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Timothy R. Hudd, BS, PharmD, AE-C
Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Susan Jacobson, MS, EdD, RPh
Associate Professor of Pharmacy Practice
School of Pharmacy—Boston
https://t.me/medicina_free

Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Katie Kiser, PharmD, BCACP
Associate Professor of Pharmacy Practice
Director, Interprofessional Education
Ambulatory Care Clinical Specialist–NHC Farragut
South College School of Pharmacy
Knoxville, Tennessee
Maria Kostka-Rokosz, PharmD, RPh
Assistant Dean of Academic Affairs
Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Susan A. Krikorian, MS, PharmD
Professor Emerita of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Trisha LaPointe, PharmD, BCPS, FASHP
Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Michele Matthews, PharmD, BCACP, CPE, FASHP
https://t.me/medicina_free

Professor and Vice Chair
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Susan L. Mayhew, PharmD
Dean and Professor
Pharmacy Practice
Appalachian College of Pharmacy
Oakwood, Virginia
Oussayma Moukhachen, PharmD, BCPS, BCCCP
Associate Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Kamala M. Nola, PharmD, MS, FAPhA
Associate Dean of Academic Affairs and Professor
Department of Pharmacy Practice
Lipscomb University College of Pharmacy
Nashville, Tennessee
Dorothea Rudorf, PharmD, MS (Germany), RPh
Professor of Pharmacy Practice
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
David Schnee, PharmD, BCACP
https://t.me/medicina_free

Professor and Vice Chair
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
Carrie A. Sincak, PharmD, BCPS, FASHP
Associate Dean for Clinical Affairs
Professor of Pharmacy Practice
Midwestern University Chicago College of Pharmacy
Downers Grove, Illinois
Adrian Wong, PharmD, MPH, FCCM, BCCCP
Adjunct Associate Professor
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
G. Christopher Wood, PharmD, FCCP, FCCM,
BCCCP
Professor
Department of Clinical Pharmacy and Translational Science
College of Pharmacy
University of Tennessee Health Science Center
Memphis, Tennessee
Kathy Zaiken, PharmD
Professor of Pharmacy Practice
Director, International Pharmacy Residency Program
School of Pharmacy—Boston
Massachusetts College of Pharmacy and Health Sciences
https://t.me/medicina_free

Boston, Massachusetts
Caroline S. Zeind, PharmD
Vice President for Academic Affairs/Provost
Professor of Pharmacy Practice
Academic Affairs
Massachusetts College of Pharmacy and Health Sciences
Boston, Massachusetts
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