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Файл:Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_5510_Библиотеки_им_академика_М_И_Перельмана.pdf
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- •Preface
- •Essays
- •Viva questions
- •Dedication
- •Acknowledgement
- •1 Evidence-based practice
- •Overview
- •1.1 Decision-making
- •Evidence-based medicine
- •Best research evidence
- •Clinical expertise
- •Using this book
- •Patient values
- •Benefits and limitations of evidence-based medicine
- •1.2 Randomised controlled trials
- •Components of the randomised controlled trial
- •Randomisation and allocation concealment
- •Philosophy of the book
- •Layout and contents
- •Approaching assessment
- •The main types of assessment
- •Multiple choice questions
- •Single best answer questions
- •Short notes
- •Blinding
- •Completeness of follow-up
- •Sample size calculation
- •Inclusion and exclusion criteria
- •Estimate of effect
- •Different types of randomised controlled trial
- •Phase I, II and III trials
- •Parallel, cross-over, and split-mouth design
- •Bias and assessment of randomised controlled trials
- •Bias
- •Assessing the quality of randomised controlled trials
- •1.3 Other research methods
- •Cohort studies
- •Case-control studies
- •Cross-sectional surveys
- •Case reports
- •1.4 Systematic reviews
- •1.5 How to read a paper
- •Appraisal questions
- •Consort
- •1.6 Clinical practice guidelines
- •Implementation of guidelines
- •Problems with guidelines
- •2 Assessing patients
- •Overview
- •2.1 History
- •The complaint
- •History of the complaint
- •Past dental history
- •Social and family history
- •Medical history
- •2.2 Extra-oral examination
- •Lymph node examination
- •Temporomandibular joint
- •Salivary glands
- •Problem-specific examination
- •Swelling/lump
- •Paraesthesia/anaesthesia
- •Paralysis/motor disturbance
- •2.3 Intra-oral examination
- •2.4 Special investigations
- •Chairside laboratory investigations
- •Evidence-based laboratory medicine
- •Microbiology
- •Viruses
- •Bacteria
- •Fungi
- •Aspiration biopsy
- •Incisional/excisional biopsy
- •Excisional biopsy
- •Incisional biopsy
- •Haematology
- •Biochemistry
- •Immunology
- •Imaging
- •Conventional radiography
- •Contrast investigations
- •Computed tomography
- •Cone beam computed tomography
- •Diagnostic ultrasound
- •Radioisotope imaging
- •Magnetic resonance imaging
- •2.5 Writing a referral letter
- •3 Human disease and patient care
- •Overview
- •3.1 Medical assessment
- •Medical history
- •Physical examination
- •Cardiac failure
- •Management
- •Arrhythmias
- •Management
- •Angina and myocardial infarction
- •Management
- •The respiratory system
- •The upper airway
- •Chronic obstructive pulmonary disease
- •Management
- •Asthma
- •Management
- •Other respiratory diseases
- •Upper or lower respiratory tract infections
- •Cystic fibrosis
- •Pulmonary tuberculosis
- •Haematological disorders
- •Anaemia
- •Management
- •Sickle cell anaemia
- •Leukaemia
- •Management
- •Lymphoma
- •Management
- •Bleeding disorders
- •Management
- •Thrombocytopenia
- •Emergency management of a bleeding patient
- •Anticoagulant therapy
- •Management
- •Antiplatelet therapy
- •Endocrine disease
- •Diabetes mellitus
- •Management
- •Hypothyroidism and hyperthyroidism
- •Management
- •Hypoparathyroidism and hyperparathyroidism
- •Hypoparathyroidism
- •Hyperparathyroidism
- •Hepatic disease
- •Clotting dysfunction
- •Drugs
- •Cross-infection
- •Renal disease
- •Gastrointestinal disease
- •Bone disease
- •Radiotherapy
- •HIV/AIDs
- •Management
- •Cross-infection
- •Neurological disorders
- •Epilepsy
- •Management
- •Psychiatric disorders
- •Organic pathology
- •Psychological origin
- •The psychoses
- •The neuroses
- •Personality disorders
- •Other psychiatric disorders
- •Medications
- •Routine medication
- •Steroid drugs
- •Contraceptive pill
- •Allergies
- •Pregnancy
- •Treatment
- •3.3 Medical emergencies
- •Emergency drugs and equipment
- •Common medical emergencies
- •Syncope
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Further management
- •Hyperventilation
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Postural hypotension
- •Signs and symptoms
- •Causes
- •Principles of treatment
- •Choking and aspiration
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Further management
- •Diabetic emergencies: Hypoglycaemia
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Further management
- •Epileptic seizure
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Further management
- •Signs and symptoms
- •Cause
- •Hospital setting
- •Medical risk assessment
- •3.2 Dental relevance of the medical condition
- •The cardiovascular system
- •Congenital and rheumatic heart disease
- •Hypertension
- •Management
- •Principles of management
- •Further management
- •Acute asthma
- •Signs and symptoms of acute severe asthma
- •Signs and symptoms of life-threatening asthma
- •Cause
- •Principles of treatment
- •Further management
- •Anaphylaxis
- •Signs and symptoms
- •Principles of treatment
- •Further management
- •Stroke
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Further management
- •Benzodiazepine overdose
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Further management
- •Psychiatric emergencies
- •Signs and symptoms
- •Cause
- •Principles of treatment
- •Angina and myocardial infarction
- •Signs and symptoms
- •Angina
- •Myocardial infarction
- •Cause
- •Principles of treatment
- •Further management for severe angina or myocardial infarction
- •Cardiorespiratory arrest
- •Signs and symptoms
- •Causes
- •Principles of treatment
- •Further management
- •ALS for cardiac arrest
- •Advanced airway management
- •Adrenaline (epinephrine)
- •Hospital transfer
- •3.4 Drug delivery
- •Self-assessment questions
- •True/false
- •Case history question
- •Oral examination questions
- •Self-assessment answers
- •True/false
- •Case history answer
- •Oral examination answers
- •4 Control of pain and anxiety
- •Overview
- •4.1 Systemic analgesia
- •Nociception and pain
- •Nociception
- •Pain
- •The pain system
- •Acute pain
- •Chronic pain
- •Pain control
- •Dental pain and pain after surgery
- •Dosing schedules
- •Preemptive analgesia
- •Preoperative patient preparation
- •Patient-controlled analgesia
- •Route of drug administration
- •Pain and the mind
- •4.2 Local anaesthesia
- •Mechanism of action
- •Amino-esters
- •Amino-amides
- •Potency
- •Speed of onset
- •Duration of action
- •Metabolism and excretion
- •Failure of anaesthesia
- •Complications
- •General complications
- •Psychogenic
- •Toxic
- •Allergic
- •Local complications
- •Soft-tissue trauma
- •Nerve trauma
- •Intravascular injection
- •Complications of inferior alveolar nerve block
- •Types of LA drugs
- •Topical LAs
- •Intraoral
- •Skin
- •Application method
- •Vasoconstrictors
- •Adrenaline (epinephrine)
- •Felypressin (octapressin)
- •Common drugs in dentistry
- •Lidocaine (lignocaine)
- •Prilocaine
- •Articaine
- •Bupivacaine
- •Drug dose for safety
- •4.3 Conscious sedation
- •Assessment for conscious sedation
- •Dental indications
- •Medical and behavioural indications
- •Dental contraindications
- •Medical contraindications
- •Allergy
- •Systemic disease
- •Respiratory disease
- •Pregnancy
- •Liver and kidney disease
- •Muscle disease
- •Obesity
- •Psychiatric disorders
- •Drug interactions
- •Physical status
- •Indicator of sedation need
- •Sedative drugs
- •Nitrous oxide
- •Elimination
- •Undesirable effects
- •Teratogenicity
- •Nausea or vomiting
- •Increased pressure in gas-containing body spaces
- •Benzodiazepines
- •Mechanism of action
- •Undesirable effects
- •Respiratory depression
- •The elderly
- •Elimination
- •Diazepam
- •Midazolam
- •Temazepam
- •Legal status
- •Flumazenil
- •Sedation techniques
- •Oral sedation
- •Inhalation sedation
- •Intravenous sedation
- •Dosage
- •Venous access
- •Amnesia
- •Analgesia
- •Discharge
- •Preoperative starvation
- •Intranasal sedation
- •Monitoring sedated patients
- •4.4 General anaesthesia
- •Patient assessment
- •Social history
- •Smoking
- •Alcohol
- •Home circumstances
- •Drug abuse
- •Previous anaesthetic history
- •Hereditary problems
- •Porphyria
- •Malignant hyperpyrexia
- •Suxamethonium apnoea
- •Physical examination
- •Special investigations
- •Haemoglobin concentration
- •Urinalysis
- •Sickle test
- •Urea and electrolyte (U&E) concentrations
- •Blood glucose concentration
- •Liver function tests (LFTs)
- •Clotting studies
- •Chest X-ray
- •Cervical spine X-ray
- •Electrocardiogram (ECG)
- •Pulmonary function tests
- •Weight
- •Risk assessment
- •Grading of physical status
- •Cardiovascular disease
- •Hypertension
- •Respiratory disease
- •Preoperative medication
- •Preoperative starvation
- •GA technique
- •Maintenance
- •Recovery
- •Monitoring during anaesthesia
- •Cardiovascular system
- •Respiratory system
- •Neuromuscular junction
- •Body temperature
- •Depth of anaesthesia
- •Self assessment questions
- •True/false
- •Single best questions
- •Case histories questions
- •Case history 1
- •Case history 2
- •Self assessment answers
- •True/false
- •Single best answers
- •Case histories answers
- •Case history 1
- •Case history 2
- •Overview
- •5.1 Pulpitis
- •Acute pulpitis
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Chronic pulpitis
- •Clinical eatures
- •Radiology
- •Pathology
- •Management
- •Acute periapical periodontitis
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Chronic periapical periodontitis (periapical granuloma)
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Pathoses associated with periapical inflammation
- •Hypercementosis
- •External resorption
- •5.4 Soft tissue infections of the face
- •Infection sited at a tooth
- •Acute alveolar abscess
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Spread of infection to facial tissues
- •Lymphatic spread of infection
- •Spread of infection through tissue spaces
- •Floor-of-mouth tissue spaces
- •Other tissue spaces of importance
- •Buccal spaces
- •Pharyngeal tissue spaces
- •Hard palate area
- •Types of facial infection
- •Maxillary infections
- •Mandibular infections
- •Cellulitis
- •Cavernous sinus thrombosis
- •Management of infections about the face
- •Drainage
- •Chronic infection
- •Actinomycosis
- •Clinical features
- •Pathology
- •Management
- •Osteomyelitis
- •Acute osteomyelitis
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Chronic osteomyelitis
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Osteoradionecrosis
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Medication related osteonecrosis of the jaw (MRONJ)
- •Clinical features
- •Radiology
- •Pathology
- •Management
- •Periostitis
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 4
- •Clinical features
- •Radiology
- •Likely diagnosis
- •Viva answers
- •6 Removal of teeth and surgical implantology
- •Overview
- •6.1 Dental extractions
- •Assessment for extraction
- •Indications for dental extraction
- •History and clinical examination
- •Radiographic examination
- •Treatment planning
- •Consent
- •Infection control
- •Reducing risk of errors in surgery
- •Surgical removal of teeth
- •Surgical flap design
- •Postoperative care
- •Complications of dental extractions
- •Postoperative pain
- •Postoperative swelling
- •Trismus
- •Fracture of teeth
- •Excessive bleeding
- •History
- •Examination
- •Achieve haemostasis
- •Postoperative infection
- •Osteomyelitis
- •Damage to soft tissues
- •Damage to nerves
- •Opening of the maxillary sinus
- •Loss of tooth
- •Loss of tooth fragment
- •Fracture of the maxillary tuberosity
- •Fracture of jaw
- •Dislocation of the mandible
- •Displacement of tooth into the airway
- •Surgical emphysema
- •6.2 Impacted and ectopic teeth
- •Assessment
- •Third molars
- •Impacted maxillary canines
- •Impacted lower second premolars
- •History and clinical examination
- •Radiological examination
- •Diagnosis
- •Treatment options
- •Indications for removal of third molars
- •Surgical techniques
- •Lower third molar surgery
- •Upper third molar surgery
- •Maxillary canines
- •Mandibular second premolars
- •Supernumerary teeth
- •Complications of treatment of impacted and ectopic teeth
- •6.3 Preprosthetic surgery
- •Retained teeth/roots removal
- •Denture irritation hyperplasia
- •Tori
- •Muscle attachments
- •Alveolar ridge augmentation
- •Sulcus deepening
- •Nerve repositioning
- •6.4 Dental implant surgery
- •Assessment
- •Indications for implant treatment
- •Assessment for oral implant surgery
- •Clinical examination
- •Presurgical investigations
- •Imaging
- •Periapical view
- •Panoramic view
- •Lateral cephalometric radiograph
- •Cone beam computed tomography (CBCT)
- •Surgical techniques
- •Bone augmentation
- •Autogenous bone
- •Alloplastic materials
- •Ceramics
- •Allografts
- •Xenografts
- •Bone grafting techniques
- •Onlay grafting
- •Interpositional grafting
- •Sinus elevation or lift
- •Stimulation of bone regeneration
- •Guided bone regeneration (GBR)
- •Distraction osteogenesis
- •Implant placement
- •Implant exposure
- •Immediate loading of implants
- •Postoperative care
- •Soft tissue surgery
- •Timing of implant placement
- •Immediate implant placement
- •Delayed immediate implants
- •Zygoma implants
- •Implant success
- •Self-assessment questions
- •True/false
- •Case history questions
- •Case history 1
- •Case history 2
- •Viva questions
- •Self-assessment answers
- •True/false
- •Case history answers
- •Case history 1
- •Case history 2
- •Viva answers
- •7 Diseases of bone and the maxillary sinus
- •Overview
- •7.1 Diseases of bone
- •Normal jaw skeleton
- •Benign fibro-osseous lesions
- •Fibrous dysplasia
- •Clinical features
- •Pathology
- •Radiology
- •Management
- •Cemento-ossifying fibroma
- •Clinical features
- •Pathology
- •Radiology
- •Management
- •Paget’s disease of bone
- •Cemento-osseous dysplasias
- •Giant-cell granuloma (central giant-cell granuloma)
- •Osteoporosis
- •Hyperparathyroidism
- •Genetic disorders
- •Bone tumours
- •7.2 Diseases of the maxillary sinus
- •Anatomy
- •Histology
- •Anomalies
- •Inflammation (“sinusitis”)
- •Chronic maxillary sinusitis
- •Acute maxillary sinusitis
- •Mucosal cysts of the antrum
- •Benign tumours
- •Osteoma
- •Odontogenic cysts and benign tumours
- •Malignancy
- •Antral response to inflammation of dental origin (odontogenic sinusitis)
- •Displacement of roots into the sinus
- •Oro-antral communication
- •Fracture of the maxillary tuberosity
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Case history 5
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Case history 5
- •Viva answers
- •Overview
- •8.1 Assessment of the injured patient
- •Primary survey
- •Airway
- •Breathing
- •Circulation
- •Disability
- •Exposure and environmental control
- •Radiographic examination
- •Secondary survey
- •Documentation
- •Children
- •Adult domestic violence and abuse
- •8.2 Dental injuries
- •Management
- •8.3 Facial soft tissue injuries
- •Aetiology
- •Clinical presentation
- •Radiology
- •Surgical management of lacerations
- •Surgical management of burns
- •8.4 Facial fractures
- •Aetiology
- •Clinical presentation
- •Radiological examination
- •Principles of facial fracture management
- •Dento-alveolar fractures
- •Mandibular fractures
- •Zygoma (or malar) fractures
- •Orbital fractures
- •Maxillary fractures
- •Nasal/nasoethmoidal fractures
- •Techniques for facial fracture management
- •Closed reduction and indirect fixation in the mandible
- •Acrylic splints
- •Disadvantages of IMF fixation
- •Peralveolar and circumandibular wiring
- •Gunning-type splints
- •Closed reduction and indirect fixation in the maxilla
- •Suspension wires
- •Extraoral craniomandibular fixation
- •Open reduction and direct fixation in the mandible and maxilla
- •Plating with mini- and micro-plating systems
- •Titanium mesh
- •Biodegradable plates and screws
- •Transosseous and intraosseous wiring
- •Bone screws
- •8.5 Gunshot wounds
- •Weapons
- •Management
- •Initial
- •Imaging
- •Soft tissues
- •Hard tissues
- •8.6 Dislocation of the mandible
- •8.7 Complications of facial injury
- •Complications of dental injury
- •Primary teeth
- •Permanent teeth
- •Complications of facial soft tissue injury
- •Complications of facial fractures
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Viva answers
- •9 Dentofacial and craniofacial anomalies
- •Overview
- •9.1 Congenital anomalies
- •Aetiology and types
- •Clinical management
- •History
- •Clinical examination
- •Investigations
- •Imaging
- •Cephalometric analysis
- •Diagnosis
- •Treatment planning
- •9.2 Orthognathic surgery
- •Preoperative stage
- •Preoperative planning
- •Preoperative care
- •Treatment
- •Mandibular surgery
- •Genioplasty
- •Maxillary surgery
- •Postoperative care
- •Airway management
- •Analgesia
- •Follow-up
- •9.3 Cleft lip and palate surgery
- •9.4 Craniofacial surgery and osteodistraction
- •Osteodistraction techniques
- •Technique
- •9.5 Cosmetic facial surgery
- •Self-assessment questions
- •True/false
- •Single best questions
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Viva answers
- •10 Cysts and odontogenic tumours
- •Overview
- •10.1 General features
- •Cyst growth
- •Classification of cysts
- •Other cysts
- •Odontogenic cysts
- •10.2 Examination
- •General clinical features
- •Radiological examination: General principles
- •Maxilla
- •Mandible
- •Radiological signs
- •Margins
- •Shape
- •Locularity
- •Effects on adjacent structures
- •Effect on unerupted teeth
- •Radicular cyst
- •Radiology
- •Pathology
- •Residual radicular cyst
- •Radiology
- •Pathology
- •Inflammatory collateral cysts
- •Radiology
- •Pathology
- •Dentigerous cyst
- •Radiology
- •Pathology
- •Eruption cyst
- •Radiology
- •Pathology
- •Odontogenic keratocyst
- •Radiology
- •Pathology
- •Lateral periodontal and botryoid cysts
- •Radiology
- •Pathology
- •Gingival cysts
- •Glandular odontogenic cyst
- •Radiology
- •Pathology
- •Calcifying odontogenic cyst
- •Radiology
- •Pathology
- •Orthokeratinising odontgenic cyst
- •Radiology
- •Pathology
- •Nasopalatine cyst
- •Radiology
- •Pathology
- •Nasolabial cyst
- •Radiology
- •Pathology
- •Solitary bone cyst
- •Radiology
- •Pathology
- •Aneurysmal bone cyst
- •Radiology
- •Pathology
- •10.4 Surgical management of cysts
- •Enucleation
- •Marsupialisation
- •Surgical management of particular cysts
- •Radicular cysts
- •Odontogenic keratocyst
- •Eruption cysts
- •Solitary bone cyst
- •Aneurysmal bone cyst
- •Malignant odontogenic tumours
- •Ameloblastoma
- •Odontomes
- •Mesenchymal odontogenic tumours
- •10.7 Surgical management of odontogenic tumours
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history 2
- •Case history 3
- •Short note questions
- •Essay questions
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Short note answers
- •Essay question answers
- •Viva answers
- •11 Mucosal diseases
- •Overview
- •11.1 Normal oral mucosa
- •Normal structures
- •Leukoedema
- •11.2 Conditions related to friction or trauma
- •Smoker’s palatal keratosis
- •Fibrous hyperplasia and neoplasia
- •Fibroepithelial polyp
- •Denture irritation hyperplasia
- •Connective tissue neoplasms
- •11.3 Ulceration
- •Traumatic ulceration
- •Drug-related ulceration
- •Recurrent aphthous stomatitis: Aphthous ulceration
- •Aetiology
- •Diagnosis
- •Management
- •11.4 Infections
- •Bacterial infections
- •Viral infections
- •Herpes simplex
- •Primary herpetic gingivostomatitis
- •Herpes labialis (cold sores)
- •Herpes zoster
- •Coxsackievirus
- •Epstein–barr virus
- •Human papillomavirus
- •Kaposi’s sarcoma
- •Hairy leukoplakia
- •Erythematous candidiasis
- •HIV-related gingivitis
- •HIV-related periodontitis
- •Other mucosal manifestations in HIV infection
- •Fungal infections
- •Angular cheilitis
- •Chronic hyperplastic candidiasis
- •Clinical features
- •Histopathological features (fig. 11.12)
- •Median rhomboid glossitis
- •11.5 Lichen planus
- •Clinical features
- •Oral lesions
- •Skin lesions
- •Lichenoid mucositis
- •Histopathological features
- •Aetiology
- •Management
- •11.6 Pigmented lesions
- •Black hairy tongue
- •Amalgam tattoos
- •Melanotic lesions
- •Discrete melanin-pigmented lesions
- •Malignant melanoma
- •Diffuse oral melanosis
- •Other lesions
- •11.7 Vesiculo-bullous lesions
- •Immune-mediated conditions
- •Mucous membrane pemphigoid
- •Pemphigus vulgaris
- •Other autoimmune conditions
- •Erythema multiforme
- •Genetic disorders
- •Angina bullosa haemorrhagica
- •11.8 Granulomatous disorders
- •Causes of granulomas
- •Foreign body
- •Orofacial granulomatosis
- •Crohn’s disease
- •Sarcoidosis
- •11.9 Other mucosal conditions
- •White sponge naevus
- •Diagnosis
- •Management
- •Geographic tongue
- •Diagnosis
- •Management
- •Epulides
- •Fibrous epulis
- •Vascular epulis
- •Giant-cell epulis (peripheral giant-cell granuloma)
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Case history 5
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Case history 5
- •Viva answers
- •12 Oral potentially malignant disorders and oral cancer
- •Overview
- •12.1 Oral potentially malignant disorders
- •Leukoplakia
- •Erythoplakia
- •Oral lichen planus
- •Oral lichenoid reactions
- •Oral lesions of graft-versus-host disease
- •Oral lupus erythematosus
- •Chronic hyperplastic candidosis and candidal leukoplakia
- •Proliferative verrucous leukoplakia (PVL)
- •Types of oral cancer
- •Minor salivary gland cancers
- •Malignant melanoma
- •Malignant lymphoma
- •Leukaemia
- •Metastatic deposits
- •Rare neoplasms
- •Squamous cell carcinoma
- •Aetiology
- •Smoking
- •Paan and other tobacco use
- •Alcohol
- •Ultraviolet light
- •Diet
- •Viruses
- •Clinical features
- •The lip
- •Intra-oral surfaces
- •Head and neck
- •Pathology
- •Histopathological features
- •Bone invasion
- •Metastasis
- •Grading and staging
- •Histological grading: Prognostic features
- •Imaging of oral squamous cell carcinoma
- •Treatment
- •Exophytic verrucous hyperplasia
- •Oral submucous fibrosis
- •Palatal lesions in reverse smokers
- •Genetic mucosal lesions
- •Clinically normal susceptible mucosa
- •12.2 Pathology, dysplasia grading and management
- •Epithelial dysplasia
- •Grading of dysplasia
- •Molecular pathology of opmds
- •12.3 Management of opmds
- •12.4 Oral cancers
- •Epidemiology
- •Global incidence and trends
- •Morbidity and mortality
- •Surgery
- •Radiotherapy
- •Chemotherapy
- •12.5 Role of the dentist in prevention, detection and treatment
- •Prevention
- •Early diagnosis and screening
- •Referral
- •Dental care prior to radiotherapy
- •Post-treatment care
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 2
- •Case history 4
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Viva answers
- •13 Facial skin and neck
- •Overview
- •13.1 Facial skin lesions
- •Non-melanoma skin cancer
- •Malignant melanoma
- •13.2 Neck swellings
- •Lymphadenopathy
- •Examination and investigation of lymph nodes
- •Bacterial infections
- •Viral infections
- •Fungal and protozoal infections
- •Sarcoidosis
- •Haematological malignancy
- •Secondary malignancy
- •Other causes of lymphadenopathy
- •Cysts of the neck
- •Self-assessment questions
- •True/false
- •Case history questions
- •Case history 1
- •Case history 2
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •14 Salivary gland disease
- •Overview
- •14.1 Anatomy
- •Minor salivary glands
- •Submandibular gland
- •Parotid gland
- •14.2 Investigations
- •History and clinical examination
- •Sialometry
- •Radiology
- •Is there a calculus present?
- •Plain radiographs, or ultrasound
- •Parotid glands
- •Submandibular gland
- •Ultrasound
- •Is there an obstruction in the duct system? What is the condition of the duct system?
- •Sialography
- •Sialoendoscopy
- •Is there a mass present?
- •Ultrasound
- •Is there an abnormality of gland function?
- •Radio-isotope imaging
- •Biopsy
- •14.3 Salivary gland disorders
- •Obstructive salivary disorders
- •Extra-ductal obstruction
- •Duct wall thickening
- •Intra-ductal obstruction
- •Acute sialadenitis
- •Viral sialadenitis
- •Bacterial sialadenitis
- •Chronic sialadenitis
- •Bacterial sialadenitis
- •Relapsing parotitis
- •Radiation sialadenitis
- •Chronic sclerosing sialadenitis
- •Sarcoidosis
- •Sialosis
- •Sjögren’s syndrome
- •Diagnosis
- •Management
- •Systemic disorders and salivary function
- •Salivary gland tumours
- •Benign tumours
- •Pleomorphic adenoma
- •Warthin’s tumour
- •Other adenomas
- •Soft tissue salivary tumours
- •Malignant tumours
- •Adenoid cystic carcinoma
- •Mucoepidermoid carcinoma
- •Acinic-cell carcinoma
- •Secretory carcinoma
- •Polymorphous adenocarcinoma
- •Carcinoma arising in pleomorphic adenoma
- •Other carcinomas
- •Other malignant tumours
- •Molecular pathology of salivary glands
- •Salivary gland cysts
- •Mucous extravasation mucocoele
- •Mucous retention mucocoele
- •Ranula
- •14.4 Surgery
- •Minor salivary glands
- •Submandibular salivary gland
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 3
- •Case history 4
- •Case history 5
- •Case history 6
- •Viva questions
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Case history 5
- •Case history 6
- •Viva answers
- •15 Facial pain
- •Overview
- •15.1 Assessment of a patient suffering from orofacial pain
- •Social history
- •Trigeminal neuralgia
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating factors
- •Associated signs and symptoms
- •Special investigations
- •Medical management
- •Surgical management
- •Painful trigeminal neuropathies
- •Painful trigeminal neuropathy attributed to herpes zoster (preherpetic neuralgia)
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Associated signs and symptoms
- •Special investigations
- •Medical management
- •Trigeminal postherpetic neuralgia
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Accompanying signs and symptoms
- •Special investigations
- •Medical management
- •Surgical management
- •Glossopharyngeal neuralgia
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating factors
- •Associated signs and symptoms
- •Special investigations
- •Medical management
- •Surgical management
- •15.3 Primary and secondary headaches
- •Migraine
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating factors
- •Associated signs and symptoms
- •Special investigations
- •Medical management
- •Tension type headache
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating factors
- •Associated signs and symptoms
- •Special investigations
- •Medical management
- •Trigeminal autonomic cephalalgias
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating factors
- •Associated signs and symptoms
- •Special investigations
- •Medical management
- •Secondary headaches
- •Giant-cell arteritis (cranial arteritis, temporal arteritis)
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating factors
- •Associated signs and symptoms
- •Special investigations
- •Medical management
- •15.4 Idiopathic orofacial pain
- •Persistent idiopathic facial pain (PIFP)
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating/ameliorating factors
- •Associated signs and symptoms
- •Clinical examination
- •Medical history
- •Social history
- •Special investigations
- •Medical management
- •Persistent idiopathic dentoalveolar pain (atypical odontalgia)
- •Burning mouth syndrome
- •Clinical presentation
- •Nature
- •Duration
- •Site
- •Initiating/ameliorating factors
- •Associated symptoms
- •Clinical examination
- •Special investigations
- •Medical management
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Essay question
- •Self-assessment answers
- •True/false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Case history 5
- •Essay answer
- •16 Disorders of the temporomandibular joint
- •Overview
- •16.1 Anatomy and examination
- •Anatomy
- •Components
- •The mandibular condyle
- •The mandibular (glenoid) fossa
- •Interarticular disc (meniscus)
- •Capsule
- •Ligaments
- •Joint movement
- •Examination
- •Clinical examination
- •Joint examination
- •Movement
- •Pain on palpation
- •Auscultation
- •Muscle examination
- •Radiology
- •Arthroscopy
- •16.2 Temporomandibular joint disorders (TMDs)
- •What are TMDs?
- •Clinical features
- •Radiology
- •Management
- •Internal derangement
- •Disc displacement with reduction
- •Clinical features
- •Radiology
- •Management
- •Disc displacement without reduction
- •Clinical features
- •Radiology
- •Management
- •Surgical treatment of internal derangement
- •16.3 Other conditions affecting the joint
- •Degenerative joint disease
- •Clinical features
- •Radiology
- •Management
- •Rheumatoid arthritis
- •Clinical features
- •Radiology
- •Management
- •Juvenile idiopathic arthritis (juvenile chronic arthritis)
- •Malignancy mimicking a TMD
- •Rare disorders of the TMJ
- •Trauma
- •Effusion
- •Clinical features
- •Radiology
- •Management
- •Dislocation
- •Clinical features
- •Radiology
- •Management
- •Ankylosis
- •Self-assessment questions
- •True/false
- •Single best questions
- •Case history questions
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Viva questions
- •Self-assessment answers
- •True / false
- •Single best answers
- •Case history answers
- •Case history 1
- •Case history 2
- •Case history 3
- •Case history 4
- •Viva answers
- •17 Radiation protection
- •Overview
- •17.1 Ionising radiation and its effects
- •Interaction with matter
- •Somatic and genetic effects of X-rays
- •Doses and risks in dental radiography
- •17.2 Radiation protection
- •Protection of patients
- •Selection of bitewing radiographs
- •Selection of periapical radiographs
- •Selection of panoramic radiographs
- •Selection of cone beam CT examinations
- •Dose limitation
- •Quality assurance
- •Protection of staff
- •Position
- •Workload
- •Local rules
- •‘Good practice’ guidelines
- •Administration of radiation protection
- •Employer (legal person)
- •Registration
- •Referrer
- •Practitioner
- •Operator
- •Radiation protection supervisor
- •Radiation protection adviser (RPA)
- •Medical physics expert (MPE)
- •Self-assessment questions
- •True/ false
- •Single best questions
- •Essays
- •Viva questions
- •Self-assessment answers
- •True /false
- •Single best answers
- •Essay plans
- •Viva answers
- •Index

2.3 Intra-Oral Examination
LEARNING OBJECTIVES
You should:
• be able to differentiate dental and non-dental sources of
symptoms.
• understand the significance of features of ulcers such
as form, site and pain.
• be able to examine for motor and sensory nerve
dysfunction.
• know how to examine a tooth and supporting tissues.
Again, a systematic approach is essential to avoid being
distracted by the first unusual finding you encounter. The examination must include lips, cheeks, parotid gland orifices,
buccal gingivae, lingual gingivae and alveolar ridges in edentulous areas, hard palate, soft palate, dorsal surface of the
tongue, ventral surface of the tongue, floor of mouth, submandibular gland orifices and, finally, the teeth. Different clinicians will have their own sequence of examination, but it is
the thoroughness of the examination that is important, not
the order in which the regions of the mouth are examined.
Once the general intra-oral examination is complete, a
problem-specific examination can proceed. This is tailored
to the clinical problem.
Swelling/Lump
The examination of an intra-oral swelling or lump is essentially the same as that described above as part of the extraoral examination. Most oral swellings are inflammatory,
caused by periapical or periodontal infections. However, the
minority of oral swellings and lumps that are nondental
encompasses a wide range of conditions, the details of
which form a significant part of this book.
Ulcer
Examination of an ulcer should include assessment of eight
important characteristics:
n
site
n
single/multiple
n
size
n
shape
n
base of the ulcer
n
edge
n
pain
n
time period.
Visual inspection is essential but palpation is also an important part of the examination of an ulcer. Gloves must be
worn for palpation and the texture of the ulcer base, margin and surrounding tissues should be ascertained by gentle pressure. Malignant neoplasms tend to ulcerate, and
these often feel firm, hard or even fixed to deeper tissues. A
raised margin is a suspicious finding, as is the presence of
necrotic, friable tissue in the ulcer base and bleeding on
lightly pressing (Fig. 2.4). Healing traumatic ulcers tend to
be painful on palpation, and they feel soft and gelatinous.
The finding of an ulcer on examination may necessitate
taking additional history; for example, if a traumatic ulcer
is suspected, direct questioning may prompt the patient to
2 • Assessing Patients
Fig. 2.4 Clinical photograph of a squamous cell carcinoma of the
tongue. Note the raised edges and necrotic centre.
13
recall the injury (Fig. 2.5). If multiple ulcers are detected,
this may lead to further enquiries about any previous history of recurrent oral ulceration or specific gastrointestinal
diseases. It is surprising how often ulceration is discovered
that the patient is not aware of. When an ulcer is found, it
is vital that a detailed record of the history and examination findings is made. Any oral mucosal ulcer that does not
heal within 3 weeks should be considered as possibly malignant and urgent referral must be arranged.
Certain ulcers have a tendency to occur in particular
oral sites; for example, squamous cell carcinomas are most
common on the lower lip, on the floor of the mouth and on
the lateral border of the tongue. On the other hand, traumatic ulcers are most common on the lateral border of the
tongue and buccal mucosa in the occlusal plane. Ulceration
on the lower lip is also a common site for traumatic ulceration, particularly following administration of an inferior
dental block or after a sports injury. Site is also important in
diagnosis; for example, minor aphthae are restricted to
Fig. 2.5 Clinical photograph of a traumatic ulcer of the lingual mucosa.
Note the superficial nature of the ulcer. Its base is covered by fibrous
exudates and the surrounding area is inflamed.

14
Master Dentistry
lining mucosa and can be ruled out if ulceration is occurring on the hard palate or gingivae.
Size and shape can also be helpful; for example, linear
fissure-type ulcers may be seen in Crohn’s disease, though
aphthae are more usual. The shape of a traumatic ulcer
may reveal the cause; for example, semicircular ulcers are
sometimes caused by the patient’s fingernail. Bizarre persistent ulceration is sometimes a result of deliberate selfharm, unusual habits or taking recreational drugs; in such
cases, diagnosis can be difficult as the patient may deny
knowledge of the causation. Minor aphthae have characteristic size and site features, which can distinguish them
from major and herpetiform aphthae (see Chapter 11).
Pain, as mentioned above, is a feature of inflammatory and
traumatic ulcers, while in the early stages a malignant ulcer is
often painless. Advanced malignant ulcers eventually tend to
become painful as a result of infection and involvement of
adjacent nerves. Presentation with a painful traumatic ulcer is
common in dentistry. The cause should be eliminated if possible (e.g., smoothing or replacement of an adjacent fractured
restoration), symptomatic treatment such as analgesic mouthwash prescribed, and most importantly, review arranged to
ensure that healing has occurred.
Other Mucosal Abnormalities
The eight important characteristics listed earlier for the
examination of an ulcer can be modified and applied to
other mucosal abnormalities such as white/red patches,
oral mucosal pigmentation, vesicles, and bullae.
Paraesthesia/Anaesthesia
The principles of examination are those described above for
extra-oral examination. Once again, you need good anatomical knowledge of the nerves supplying different parts
of the oral cavity to interpret the possible site of the underlying pathological process (Fig. 2.6).
Paralysis/Motor Disturbance
Within the oral cavity, motor disturbance is seen in the
tongue (owing to damage to the function of the hypoglossal
nerve) and the soft palate (owing to lesions affecting the
vagus nerve). With hypoglossal nerve lesions, there is deviation of the tongue towards the affected side when attempting protrusion. There is also a problem with speech, with
“lingual” sounds such as “l,” “t,” and “d” affected.
Tooth Problems
Tooth problems are, of course, the commonest problems
facing the dentist. The context is usually pain or swelling. A
standard method of examination helps in reaching a diagnosis. You should not simply hammer the suspect tooth
with the mirror handle and take a radiograph as your
method of assessment! Indeed, careful examination may
establish a diagnosis and thus avoid any need for radiography or other special tests. Examination will involve:
n
visual
n
probing restorations
n
assessing mobility
(greater
(branch of
V
2
infraorbital nerve)
(nasopalatine)
V
2
V
(ASA)
2
(PSA)
V
2
(buccal)
V
3
V
(lesser palatine)
2
IX (glossopharyngeal nerve)
(mental)
V
3
V
(lingual)
3
ASA = Anterior superior alveolar nerve
PSA = Posterior superior alveolar nerve
Fig. 2.6 Sensory innervation of the oral cavity is principally from the trigeminal nerve (V) while the glossopharyngeal nerve (IX) supplies the posterior
third of the tongue. NB: Taste sensation in the anterior two-thirds of the tongue is provided by fibres of VII nerve origin passing through the
lingual nerve.
V
2
palatine)

n
periodontal probing
n
thermal tests
n
pressure tests.
Visual examination will reveal gross caries, the presence
of restorations, signs of tooth wear and gingivitis. A probe
will allow tactile assessment of restoration margins.
Mobility should be assessed manually. Periodontal probing should be carried out to assess pocketing, the presence
of calculus/overhangs and, ultimately, bone loss.
A basic test of vitality should always be performed, using
a cotton wool pledget soaked with ethyl chloride (cold
stimulus) and sometimes heated gutta-percha (hot stimulus). While these are usually sufficient to reveal a hypersensitive tooth with pulpitis, an electrical pulp test can be used
to assess vitality in some cases.
Pressure sensitivity should be assessed using direct finger
pressure and, when this does not evoke a response, can be
supplemented by percussion using a dental mirror handle.
This will assess whether periodontitis is present or not.
However, if a single cusp is tender to percussion, this may
be indicative of cracked cusp syndrome.
2.4 Special Investigations
LEARNING OBJECTIVES
You should:
• understand what samples can be taken for tests, how to
take and treat these materials, and what tests are available.
• know how to interpret the results that are returned.
• know when imaging techniques would be informative
and which type of imaging to choose.
2 • Assessing Patients
15
Most laboratories can advise on current codes of practice
relating to the above issues and may give reference ranges
and advice, for example about a particular biopsy result.
Most laboratories now have a website and notification of
sample submission electronically is often preferred. Sending pathological material through the post is potentially
hazardous and current regulations must be followed.
It should be remembered that laboratory tests require
considered interpretation in conjunction with the patient’s
history. Some tests have low sensitivities, for example certain cytology tests, and a negative result cannot be relied
upon to exclude disease. The test may need to be repeated,
or an alternative test with a higher sensitivity used. Other
tests have low specificity and a positive result does not necessarily indicate that disease is present. Examples include
low-titre autoantibodies, which may be detected in the
serum but which can be of no clinical significance. The
receiver–operator curve (ROC) for any laboratory test can
be plotted to guide clinical use. Use of resources is also
important, particularly when expensive reagents or complex procedures are required.
Microbiology
Diagnosis of infection and determination of sensitivity of
the infectious agent to pharmacotherapeutic agents are the
principal requirements for microbiology tests in dentistry.
Viruses
Most often a clinical diagnosis is adequate for acute or
recurrent viral oral infections such as herpes simplex. A
viral swab can be used to collect virus from fresh vesicles
and must be forwarded in special transport medium to the
virology laboratory. Other virus infections such as glandular fever can be detected by looking for a rising titre of antibodies in the patient’s serum.
CHAIRSIDE LABORATORY INVESTIGATIONS
Evidence-Based Laboratory Medicine
Whenever special tests are undertaken, it is important to
consider medicolegal issues, informed consent, appropriateness of the test, and the evidence base for the use of any
particular laboratory investigation. It is always necessary to
have a differential clinical diagnosis in mind when requesting an investigation. When requesting a test, it is vital to
possess the knowledge and skills so that the result can be
acted upon appropriately. In some situations, for example
suspected oral cancer, it may be wise to refer the patient
directly to a specialist for a biopsy. Other important considerations when considering laboratory testing are:
n
obtaining a representative/appropriate sample
n
collecting in the right specimen container and fluid if
appropriate
n
completing the information required by the laboratory
correctly
n
having systems that avoid mixing up specimens;
labelling the specimen container with patient details
n
organising the correct packaging and transport to the
laboratory
n
reading reports and acting on them; filling in patient records
n
interpretation: sensitivity and specificity.
Bacteria
Bacterial infections in the oral cavity, jaws, and salivary
glands may be identified by forwarding a swab or specimen
of pus to the laboratory, with a request for culture and antibiotic sensitivity.
Fungi
Candida species are the most common organisms to cause
oral fungal infection. Often clinical diagnosis is adequate; for
example, in denture-related stomatitis, the clinical history
and appearance of the mucosa may be sufficient. Direct
smears from the infected mucosa and the denture-fitting
surface can be stained by the periodic acid-Schiff or Gram’s
method. The presence of typical hyphae indicates Candida
proliferation consistent with infection. Swabs or oral rinses
can be used to discriminate the various Candida species and
heavy growth suggests infection rather than carriage.
Aspiration Biopsy
Fluid from suspected cysts can be collected with a standard
gauge needle and syringe: radicular cysts contain brown
shimmering fluid because of the presence of the cholesterol
crystals, whereas odontogenic keratocysts contain pale
greasy fluid, which may include keratotic squames. Infection after aspiration biopsy can be a problem and indeed the
technique tends to be restricted to atypical cystic lesions

16
Master Dentistry
where neoplasia is suspected. Fine needle aspiration cytology (FNAC) can be used to obtain a sample of cells from a
solid tumour and is a hospital procedure. In most specialist
centres (ENT, maxillofacial, or dental), localization using
ultrasound guidance is now routinely used for FNAC of extra-oral lesions and occasionally for intra-oral ones.
Incisional/Excisional Biopsy
Mucosal biopsy is one of the more common investigations
used by dentists in primary and secondary care. Tissue is removed under local or general anaesthesia using sharp dissection to avoid crushing the specimen. It is fixed in at least 10
times its volume of 10% neutral buffered formalin or similar
fixative. It is then forwarded to the cellular pathology or specialist oral and maxillofacial pathology laboratory.
Excisional biopsy
The entire lesion is removed and submitted for diagnosis. It
is suitable for benign polyps, papillomas, mucocoeles, epulides, and other small reactive lesions.
Incisional biopsy
A representative sample of a larger lesion is taken for diagnosis prior to treatment. This is a specialist procedure requiring some expertise and experience. It is used for generalised
mucosal disorders such as lichen planus or for the diagnosis
of other red and white patches. An important consideration
is obtaining a sample from an appropriate area. Non-healing
ulcers are often investigated by incisional biopsy; here it is
important to include the margin of the ulcer with some
normal tissue and to obtain a sufficiently large sample (normally 10 mm 3 10 mm) to identify or exclude cancer. For
red and white patches, there is no requirement to include
the margin and including it may under-represent the disease. Biopsy should be targeted at the most suspicious or
most representative areas and multiple sites of large mucosal lesions may be sampled in some situations. Punch biopsies are often used for mucosal biopsy. Needle core biopsies
are increasingly used by specialists to biopsy swellings such
as enlarged lymph nodes and salivary tumours. Sometimes
fresh tissue is required for diagnosis, for instance in the vesiculo-bullous diseases where immunofluorescence is needed.
Special arrangements must be made with the laboratory
when such tests are planned.
Haematology
Patients presenting with oral manifestations of haematological disease are normally referred for specialist opinion. Full
blood count and assay of haematinics is an important investigation for patients presenting with lingual papillary atrophy or
recurrent oral ulceration, for example. Coagulation studies
and platelet counts may be required when excessive bleeding is
encountered. Patients taking coumarin based anticoagulant
therapy (e.g., warfarin) should have their INR (international
normalised ratio) checked before any surgical procedure is
undertaken. New oral anticoagulants such as dabigatran have
more predictable peak concentration times and therefore
monitoring of INR is not required when they are used.
The Sickledex test may be used to screen for sickle cell
anaemia prior to giving general anaesthesia in situations
of urgency. The blood sample should be subjected to haemoglobin electrophoresis.
Haematological parameters of importance in dentistry
are described in Table 2.1.
Biochemistry
Biochemical investigations are used principally in specialist clinics to investigate patients presenting with oral manifestations of
systemic disease, for example estimation of alkaline phosphatase
in Paget’s disease of bone, serum calcium to exclude hyperparathyroidism when a giant cell granuloma is diagnosed, and glycosylated haemoglobin when diabetes is suspected. Biochemical
estimation of cyst fluid for protein content is sometimes undertaken as part of the diagnosis of an odontogenic keratocyst.
Immunology
Advances in knowledge and methods in immunology have
resulted in a large number of laboratory immunological
investigations, available in specialist laboratories. Sometimes diagnostic arrays of tests are offered by the laboratory. Examples of tests in dentistry include detection of antibodies against extractable nuclear antigens, including Ro/
SS-A for the diagnosis of Sjögren’s syndrome and autoantibodies in vesiculo-bullous diseases.
Dentists must be able to recognise the oral manifestations
of immunodeficiency states and arrange proper referral.
Imaging
Imaging is an important special test in dentistry and
oral and maxillofacial surgery. It can be used for diagnostic
purposes or treatment planning. Because x-ray exposure
Table 2.1 Important Haematological Values in Dentistry
Unit of
Measure
Haemoglobin (Hb)
Male
Female
Red cell count (RBC)
Male
Female
Haematocrit (HCT)
Male
Female
Mean cell volume, adults
(MCV)
Mean cell haemoglobin, adults
(MCH)
Mean cell haemoglobin
concentration, adults (MCHC)
White cell count, adults
(leucocytes; WBC)
Neutrophils
Lymphocytes
Monocytes
Eosinophils 3 109/L 0.04–0.40
Basophils 3 109/L 0.00–0.10
Platelets, adults (PLT)
Erythrocyte sedimentation
rate, adults (ESR)
C-Reactive Protein
g/L 130–180
3 1012/L 4.5–6.5
Ratio 0.40–0.54
fl 80–101
pg 27–32
g/L 320–365
9
/L 4.0–11.0
3 10
3 109/L 2.0–7.5
3 109/L 1.5–4.0
3 109/L 0.2–1.2
9
3 10
/L 150–400
mm/h 0–8
mg/L 0.3–5
Reference
Range
115–165
3.8–5.8
0.37–0.47

carries a quantifiable risk (see Chapter 17), x-ray examinations should be appropriately chosen, according to specific
selection (referral) criteria. Other imaging investigations
not using ionising radiations (ultrasound and magnetic
resonance imaging) have their place and should be used in
preference to x-ray techniques (radiography, computed tomography [CT], and cone beam computed tomography
[CBCT]) when they can provide the same or better diagnostic information. Selection criteria should be based upon the
diagnostic efficacy of the technique for the disease process
being examined. For example, approximal caries diagnosis
is best aided by bitewing rather than other radiographs.
There are a large number of imaging techniques available,
and these are summarised later in the chapter. Details of
the specific uses of these techniques are given where appropriate in subsequent chapters.
Imaging findings should always be recorded in the pa-
tients notes.
Conventional Radiography
This is familiar to every dentist and student in the forms of
bitewing, periapical, occlusal, panoramic, and cephalometric radiography, and these techniques are covered in more
detail in the companion volume to this book (Dentistry II).
Other maxillofacial radiographs should be used in addition to the traditional “dental” techniques when appropriate. While detailed prescription of radiographs depends on
the particular needs of each patient, some general guidelines are useful and are given in Table 2.2.
2 • Assessing Patients
17
A
Contrast Investigations
Some radiological techniques use radio-opaque contrast
media injected into parts of the body. In the maxillofacial
Table 2.2 Guidelines on Plain Radiographic Projections
Available for Maxillofacial Uses
Anatomical Site
to be Examined Radiographic Projections
Anterior mandible Periapical, oblique, and true occlusal
Body of mandible Periapical, true occlusal, panoramic
Third molar region, angle
and ramus of mandible
Condyle
temporomandibular joint
Anterior maxilla Periapical and oblique occlusal
Posterior maxilla Periapical, oblique occlusal,
Maxillary sinus Periapical, oblique occlusal,
Parotid gland (for calculi) Intra-oral soft tissue view of parotid
Submandibular gland
(for calculi)
views
(or lateral oblique) views.
Periapical and true occlusal (third
molar region only). Panoramic (or
lateral oblique) view.
Panoramic (or lateral oblique) view.
Transcranial views (open/closed).
views.
panoramic (or lateral oblique) views.
panoramic (or lateral oblique) views.
Occipitomental view.
papilla region. Localised posteroanterior/antero-posterior of face with
cheek blown out.
True occlusal of floor of mouth. Modified
oblique occlusal for submandibular gland.
B
Fig. 2.7 (A) A typical axial contrast enhanced computed tomographic
image. (B) A coronal reformat of Fig. 2.7A.
region, they are most commonly used for sialography
(Chapter 14). Arthrography of the TMJ (Chapter 16) is of
largely historical interest.
Computed Tomography
CT (Fig. 2.7A) provides primarily axial cross-sectional images and uses x-rays. These can be reformatted during post
processing into different planes (Fig. 2.7B). The computer
calculates the x-ray absorption (and thus indirectly the
density) of each unit volume (voxel) of tissue and then assembles the information into an image made up of many
pixels (picture elements). Each pixel is given a grey-scale
value according to its density (Hounsfield scale). Dense
bone is white, most soft tissues are mid-grey, fat is dark grey
and air is black. Metals are beyond the comprehension of
the computer software, so dental fillings cause artefacts.
Contrast can be introduced intravenously to demonstrate
blood vessels and also tissues with an increased blood flow
when inflamed or neoplastic.

18
Master Dentistry
Clinical maxillofacial applications include:
n
large maxillary cysts/benign tumours
n
malignancy arising in the antrum
n
soft tissue masses
n
oral carcinoma.
Images can be reconstructed in two or three dimensions.
In maxillofacial work, reconstructions are invaluable for
implantology and useful in major facial trauma and orthognathic surgical treatment planning.
CT is associated with a relatively high dose of radiation.
Generally, the thinner the sections (and the better the fine
detail), the higher the dose.
Cone Beam Computed Tomography
This technique (also known as digital volumetric tomography) has come to prominence in the last decade as a relatively low-cost method of producing cross-sectional images,
usually with lower radiation dose than conventional CT.
CBCT equipment still uses x-rays, but uses a cone-shaped
beam instead of the fan-shaped beam used in CT. This results in a volume of image data that can be used to provide
images of equivalent quality in any desired plane (Fig. 2.8).
Voxel sizes are smaller than with CT, so they can give better
image resolution. Soft tissue contrast is very limited compared with CT, however, so that CBCT only gives useful images of hard tissues, with all soft tissues having a similar
grey-scale value. Furthermore, Hounsfield’s scale is generally not applicable to CBCT.
Equipment is substantially cheaper than CT, so is a feasible purchase for dentists in large practices. Some CBCT
equipment (“dento-alveolar”) can only produce localized
volumetric images of the jaws which are ideal for the typical dentist and which generally have lower radiation doses.
Other CBCT systems (“craniofacial”) can image large
fields of view in a single scan and are only appropriate for
hospital or specialist practice.
The volume data can be used with specialist software
for surgical planning, creation of surgical stents, and 3D
printing.
Diagnostic Ultrasound
Ultrasound uses the principle that high-frequency (2–18 MHz)
sound waves can pass through soft tissue but will be
Fig. 2.8 Cone beam computed tomography (CBCT) imaging. The data are displayed in four windows, representing (clockwise from lower left) axial,
coronal, sagittal, and volume-rendered (“3D”) images.

2 • Assessing Patients
19
reflected back from tissue interfaces. The echoes can be detected to produce an image. The sound is transmitted and
detected by the same hand-held transducer. Imaging is
“real-time,” which permits its use in conjunction with needle biopsy techniques.
Clinical maxillofacial applications include:
n
soft tissue lumps in the neck (e.g., lymph nodes) and the
salivary glands
n
detection of salivary calculi and demonstration of inflammatory or obstructive disease of the salivary glands.
Radioisotope Imaging
Radioisotope imaging is also known as nuclear medicine
(Fig. 2.9). The technique uses radioisotopes (usually
gamma ray emitters) tagged on to pharmaceuticals, which
are usually injected into the bloodstream. By choosing the
radiopharmaceutical appropriately, particular organs or
types of tissues will become radioactive. The patient is
placed in front of a gamma camera, which detects the
emitted radiation to give an image of physiological activity. It is not an anatomical imaging modality. Positron
emission tomography (PET) is usually linked to CT for
more accurate localization.
Clinical maxillofacial applications include:
n
bone scanning (for bone tumours, metastatic disease,
Paget’s disease, arthritis and condylar hyperplasia): uses
technetium-99 m-labelled methylene disphosphonate
n
salivary scanning (particularly in Sjögren’s syndrome):
using sodium pertechnetate-99 m. is largely of historical
interest
n
PET (for detection of unknown primary malignancy and
distinguishing recurrence of malignancy from posttreatment changes): uses fluorodeoxyglucose (18F).
Magnetic Resonance Imaging
Magnetic resonance imaging is also known as MR, MRI or
NMR. In this technique, patients are placed into an intense
magnetic field, forcing their hydrogen nuclei (principally in
water molecules) to align in the field. Radiofrequency waves
are pulsed into the patient, the hydrogen nuclei “wobble,”
producing an alteration in the magnetic field. This induces an
electric current in coils placed around the patient. The computer is capable of reading this and, because different tissues
contain different amounts of hydrogen (in water), of producing an image that, superficially, is like a CT scan. However,
imaging can be in any plane (axial, sagittal or coronal). Images from MR examinations can look very different from each
other according to which of several “sequences” have been
used. These sequences are selected according to the particular
clinical situation. Two basic sequences are T1- and T2weighted MR. On the former, fat appears bright, while water
containing tissues are dark, while on the latter the reverse is
the case. Other commonly used sequences include fat-saturated MR and FLAIR (fluid attenuated inversion recovery).
Clinical maxillofacial applications include:
n
almost anything CT can do (but no ionising radiation)
n
imaging of the TMJ
n
sialography if the patient is allergic to contrast agent.
Problems are twofold: the high cost of MR and, second,
patients with some metallic implants (e.g., intracranial vascular clips, cardiac pacemakers) are not eligible for the
technique. Fixed orthodontic appliances may, depending on
the material from which components are made, need to be
removed before MR imaging.
2.5 Writing a Referral Letter
Fig. 2.9 Radioisotope scan of the salivary glands. Frontal view. Foci of
activity are visible in the four major salivary glands, in the mouth and
at the bottom of the image, the thyroid gland.
LEARNING OBJECTIVES
You should:
• know when to refer a patient
• be able to write a competent referral letter
• know how to keep good records of the referral
However good your diagnostic abilities are and however
skilled you are as a clinician, there will come a time when
you need to refer a patient on to a colleague. The letter
should be thorough, providing the second clinician with a
detailed history and the results of your examination. It is
reprehensible to write a “Dear Sir, please see and treat,
yours sincerely” letter. The referral must include:
n
name, address, date of birth of the patient
n
description of the patient’s problem/symptoms
n
a history of the problem
n
the results of your examination
n
the results of any special tests you have performed
n
your provisional diagnosis, if any
n
the medical history
n
any special factors, such as difficulty in attending
n
all relevant radiographs or investigations.
The letter should be word-processed wherever possible,
rather than hand-written, to ensure accuracy. A model

20
Master Dentistry
The Dental Practice
1, High Street
Anytown
Dr A Smith
Consultant Oral and Maxillofacial Surgeon
Anytown General Hospital
Anytown
2 January 2021
Dear Dr Smith,
Urgent Referral: Mr John Doe, 24 Green Lane, Anytown.
Date of birth: 25.12.40 Tel: 0123 456789
I would be grateful if you would see this 60-year-old man. He presented today complaining
of a ‘growth’ from a recent extraction socket in his upper jaw. He said that this had appeared
after an extraction I carried out two weeks ago and was getting slowly bigger. He also
complains of a numb feeling on the left cheek. I had extracted /6 two weeks ago at the
request of the patient because it was loose.
Examination revealed a palpable left cervical lymph node. There was reduced sensation to
touch on the left upper lip and cheek. Intra-orally there was a mass on the left maxillary
alveolus in /6 region, about 2 by 1 cm. The mass has an irregular surface, feels indurated,
bleeds easily on palpation and looks necrotic in places. I have taken a periapical radiograph,
which shows some bone destruction at the site of the socket (enclosed).
I am worried that this might be maxillary sinus malignancy and I would appreciate your
urgent opinion and management.
Mr Doe has a history of mild hypertension for which he takes a bendrofluazide tablet (2.5mg)
in the morning. Otherwise there is no other medical history of note. He is a nervous patient
generally and will probably be accompanied by his wife. Mr Doe is a non-smoker and drinks
7-8 units of alcohol per week. He can attend at any time.
Yours sincerely,
Mrs B Jones BDS
Fig. 2.10 An example of a referral letter.
letter is shown in Fig. 2.10. It is important to remember
that patients tend to open and read referral letters and that
they become ultimately part of the hospital medical record.
Such records are available to patients and their legal advisers. The example in Fig. 2.10 demonstrates that the dentist
acted promptly and exercised a high standard of care and
consideration for the patient. A copy of the referral letter
should be kept with the patient’s records. Original, or copy,
radiographs which may be of relevance to the current problem should be supplied with the referral letter, as these may
avoid the need for further imaging. However, received images
must be diagnostically acceptable, with adequate contrast
and resolution, and patient and side identifiers. Original conventional hard copy images, or digital images on CD, printed
on photographic paper or uploaded to a secure portal are acceptable. Data protection guidelines must be followed scrupulously. Clinical photographs of the lesion(s) in question
can be particularly helpful during triaging of referrals.
It is good practice to establish a working relationship
between primary and secondary carers. In the situation

2 • Assessing Patients
21
described in Fig. 2.10, when an oral cancer is suspected, it
can be helpful for the primary care dentist to telephone the
oral and maxillofacial department for advice. Sometimes an
early appointment can be offered. A letter should still be
forwarded, for the reasons given above. However, it is not
helpful to telephone or send patients with non-urgent
conditions to hospital with an expectation of being seen
immediately. It is better for all concerned to write a
letter and advise the patient of likely waiting times, often
obtainable from hospital intranet links. Guidelines for referral have been produced by national and local authorities,
such as the NHS England, National Institute for Clinical
Excellence (NICE) and the Royal Colleges. These should be
consulted whenever possible, as inappropriate referrals
should be avoided. Electronic referral systems are being
used increasingly in the UK. Proformas can be configured to
meet the needs of the various specialist dental services and
digital radiographs/images attached.

3
Human Disease and Patient Care
CHAPTER OUTLINE
Overview‚ 22
3.1 Medical Assessment‚ 22
3.2 Dental Relevance of the Medical
Condition‚ 23
Overview
This chapter discusses the assessment of a patient with a
preexisting medical condition that might affect dental treatment. Particular aspects are the effects that anaesthetic
drugs might have on these conditions and the potential for
drug interactions. Medical emergencies are described in
terms of their signs and symptoms. The immediate first-line
treatment is listed and subsequent management steps outlined. The technique for resuscitation of a patient is clearly
described. Finally, the methods of administration of drugs
are described and their relative merits in dentistry.
3.1 Medical Assessment
LEARNING OBJECTIVES
You should:
• know how to obtain information on relevant medical
problems.
• be able to assess a patient’s fitness for treatment.
• know when a patient should be referred for treatment
in a hospital setting.
Today, many patients with a life-threatening disease
survive as a result of advances in medical and surgical
treatment and may present for dental treatment looking
deceptively fit and well. The medical assessment:
n
is important to establish the suitability of the patient to
undergo dental treatment and may significantly affect
the dental management
n
may prompt examination for particular oral manifestations
n
may be particularly relevant when a sedation technique
or general anaesthesia (GA) is being considered
n
may give prior warning of a possible medical emergency.
MEDICAL HISTORY
As a full medical examination of the patient is generally
not feasible or appropriate, the medical history should be
comprehensive. This will include questions about previous
serious illness and operations, present drug history and
3.3 Medical Emergencies‚ 30
3.4 Drug Delivery‚ 39
Self-Assessment: Questions‚ 40
Self-Assessment: Answers‚ 41
known allergies and the possibility of pregnancy. Information may then be obtained concerning the individual
systems by relevant questions depending on the age of the
patient, the dental treatment necessary and the anticipated
type of anaesthesia.
Questions should refer to known medical problems, past
history and present general fitness. The answers can give
an indication of severity and so provide an American Society of Anesthesiologists’ (ASA) grade (Table 3.1) that can
be helpful in predicting perioperative risks.
PHYSICAL EXAMINATION
Sufficient information can usually be obtained by
obtaining a thorough history, so that a physical examination is unnecessary outside the hospital setting. However, if a sedation technique is being considered, then it
may be appropriate to undertake a limited examination
as follows.
Observe the Patient in General
Is the patient clinically well or are there any obvious generalised clinical signs, such as cyanosis, pallor, or jaundice? Is
the patient unusually anxious? Are they talking continuously? Do they appear calm but have sweaty palms? Weigh
the patient and also take note of any excessive fat under the
chin, particularly in a retrognathic mandible as this may
indicate a less than ideal airway.
Check the Cardiovascular System
The radial pulse should be checked for rate, rhythm, volume and character. The arterial blood pressure may be
measured using a sphygmomanometer on the upper arm
of the patient while they are sitting. This limited examination is the minimum that should be carried out
for adult patients, for whom intravenous sedation is
proposed.
Social History
Social factors also affect the patient’s ability to cope with
treatment. The patient’s age, the distance they have to
travel for treatment and the availability of an escort if considering sedation or GA should be determined.
22
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