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Ординатура / Хирургия / Библиотека им академика М.И. Перельмана / Книга_3608_Библиотеки_им_академика_М_И_Перельмана

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FIGURE 135 Stanford type A dissection. A, Axial multiplanar reconstruction (MPR) image. B, Coronal maximum-intensity projection (MIP). C, Three-dimensional volume-rendered (3D-VR) image shows intimal flap in ascending aorta (arrow).
and subclavian arterio-occlusive disease20 (Fig. 13-6). Rotating MIPs enable precise evaluation of the branch vessel origin without con­founding signals from overlying vessels.
CONGENITAL ANOMALIES
Congenital lesions are well depicted with MRA. Aortic coarctation appears as a discrete narrowing of the aorta distal to the left sub­clavian artery ( the stenosis, tortuosity of the aorta, and associated collateral ves-
21
sels.
Collateral flow assessment with MR velocity mapping can
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tion.
Cine-MR imaging also permits diagnosis of a concomitant
Fig. 13-7). Magnetic resonance angiography depicts
bicuspid valve and possible aortic stenosis. Magnetic resonance angiography is used after intervention to exclude complications such as stenosis or aneurysm formation.
23
Magnetic resonance angiography also can distinguish between coarctation and pseudocoarctation. Pseudocoarctation is a rare asymptomatic anomaly in the descending thoracic aorta and is characterized by an elongated redundant thoracic aorta with buckling distal to the origin of the left subclavian artery. There is no pressure gradient across the buckled segment. It is regarded as a benign condition, although several reports demonstrate that complications may occur.
24
THORACIC OUTLET SYNDROME
resonance imaging can demonstrate obstruction/compression of the fat surrounding the brachial plexus, and of the subclavian vein and artery. Magnetic resonance angiography is performed during abduction and adduction maneuvers of the arm to simulate physiological compres­sion of the veins and/or arteries to confirm the diagnosis (
Fig. 13-8).
Pulmonary Vessels
Radiofrequency ablation for atrial fibrillation has increased the role of noninvasive pulmonary vein mapping before intervention and for postprocedural surveillance for complications.
25
Magnetic resonance angiography enables comprehensive planning of elec­trophysiological procedures with respect to number, location, and size of the pulmonary veins ( erence standard for pulmonary embolism (PE),
Fig. 13-9). Multidetector CT is the ref-
26
although pul­monary MRA can be performed in patients with severe allergy to iodinated contrast media (
Fig. 13-10). Time-resolved MRA can be
used to minimize venous contamination.27 Pulmonary artery aneu­rysms and stenoses can also be characterized with MRA.
Coronary Arteries
Because of its superior soft-tissue contrast, MRI provides excel­lent cardiac morphology and function data. The coronary arter­ies, however, remain elusive because of their small caliber, motion, and tortuosity ( coronary arteries noninvasively in routine clinical practice is com­puted tomographic angiography (CTA). appropriate for coronary anomalies, purpose and can be performed with less than 1 mSv of radiation.
Fig. 13-11). The modality that can best image the
28
Coronary MRA is only
29
but CT is superior for this
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FIGURE 136 Thoracic magnetic resonance angiography (MRA). A, Coronal maximum-intensity projection (MIP). B, Three-dimensional volume-rendered (3D-VR) image shows proximal left subclavian artery occlusion (arrow) and subclavian steal syndrome.
FIGURE 137 A, Oblique sagittal maximum-intensity projection (MIP) image shows aortic coarctation (arrow). B, Three-dimensional volume-rendered (3D-VR) image shows larger field of view; extensive collaterals are evident (arrows).
Peripheral Artery Disease of the Lower and Upper Extremities
Most peripheral artery disease (PAD) is due to atherosclerosis. Other conditions altering arterial flow to the legs include periph­eral artery aneurysms, popliteal artery entrapment, cystic adven­titial disease, thromboangiitis obliterans (TAO), giant cell and Takayasu's arteritis, and (rarely) FMD.
Magnetic resonance angiography evaluation of lower-extremity PAD typically extends from the aortic bifurcation to the level of the ankle and foot ( to evaluate vascular anatomy in patients with PAD to plan revascular­ization procedures. This enables identification and characterization of all occlusive lesions, plus an evaluation of inflow and outflow vessels.
ening, thrombi, intramural hematoma, atherosclerotic plaques, and
Fig. 13-12). Magnetic resonance angiography is often used
Black-blood MRA images can assess the presence of wall thick-
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FIGURE 138 Thoracic outlet synd- rome. A, Severe compression of left
subclavian vein with arms up (arrows). B, Left subclavian vein becomes widely patent (arrows) with arms down; no evidence of thrombosis.
FIGURE 139 A, Coronal maximum­intensity projection (MIP) image. B, Posterior aspect of three-dimensional volume-rendered (3D-VR) image shows pulmonary arteries, left atrium and pulmonary veins, and separate opening of right middle lobe vein to left atrium (arrow).
FIGURE 1310 A, Coronal multiplanar reconstructed (MPR) image shows embolic filling defects in right lower lobe pulmonary artery branches (arrows). B, Coronal maximum- intensity projection (MIP) image shows whole branching pattern of pulmonary arteries but hides details. Embolic filling defects in right lower lobe pulmonary artery cannot be seen clearly.
AB
AB
FIGURE 1311 Contrast-enhanced magnetic resonance angiography (CE-MRA) of coronary arteries shows (A) normal origin of the left system (arrows)
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and (B) right coronary artery (arrow).
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FIGURE 1312 A-C, Abdominal aorta and bilateral lower-extremity runoff. Maximum-intensity projection (MIP) images show fusiform ectasia of infrarenal abdominal aorta (arrow), mild ectasia of distal external iliac artery and proximal common femoral artery (CFA) (short arrows), short-segment moderate to severe stenosis in left popliteal artery (thick arrow), and collateral vascularization. Normal three-vessel runoff is seen in each calf.
penetrating atherosclerotic ulcers.30 Black-blood MRA sequences are rarely used in current runoff protocols, largely because of long acquisition times.
The standard MR runoff uses 3D CE-MRA
6,31
for accurate and detailed assessment of the peripheral arteries. A recent meta-analysis of 32 studies from 1998 to 2009 shows a pooled sensitivity of 94.7% and specificity of 95.6% for diagnosing segmental steno- occlusive lesions in peripheral arteries.32 The fundamental challenge in peripheral CE-MRA is balancing accurate imaging throughout the length of the vascular tree against the imaging capabilities of the system. In general, the craniocaudal FOV requires acquisition from the juxtarenal abdominal aorta to the foot in three or four
overlapping stages. In one approach, the timing of the gadolinium bolus is optimized for the superior station (abdomen and pelvis), then imaging is performed as rapidly as possible to keep up with the flow of contrast material down the distal arteries. Image quality in the first stage is excellent but often suboptimal in the third stage as gadolinium enters the venous system, with resulting venous con­tamination of the image. This is especially true in patients with a short arteriovenous transit time, such as those with severely isch­emic limbs, where precise definition of the tibial arteries is critical. On average, contrast reaches the common femoral artery (CFA) in 24 seconds, with only an additional 5 and 7 seconds needed to reach the popliteal artery and ankle, respectively.
33
Contrast travel
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time to the femoral arteries correlates with increasing age, male gender, history of myocardial infarction (MI), and diabetes, and is increased in the presence of aortic aneurysm. So-called moving table technology can be used to chase a single bolus of contrast agent in its distal progression.
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Goals of peripheral MRA are higher spatial resolution to bet-
ter visualize smaller distal vessels, and faster scanning to lessen
13
the negative impact of venous enhancement. Newer acquisitions and 3-tesla (3 T) scanners provide technological advances. Parallel imaging with multichannel phased-array coils are used to reduce imaging time.35 Full-length dedicated peripheral multichannel vas­cular surface coils improve signal. Time-resolved acquisitions can be used in standard protocols and may be particularly useful in the calves. To reduce venous contamination, subsystolic midfemo­ral venous compression can be applied.
Hybrid injection protocols overcome some technical limita­tions and are more accurate for evaluating the popliteal trifurca­tion and foot vessels.
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TOF sequences are obtained to optimize prescription of the 3D slabs. The first injection is used to acquire high–spatial resolution MRA of the calf and foot to minimize venous contamination; 3D time-resolved MRA for this stage can eliminate the need for bolus timing and decrease the total contrast load. The second injection is used for acquisition of both the aortoiliac and femoral station. Complementary TOF sequences are used to assess the ankle and foot. A typical dose is 0.2 mmol/kg of gadolinium-based contrast administered at a flow rate of 1.5 to 2 mL/sec, followed by 20 mL of saline. Accurate synchronization of the peak contrast material in the vascular bed and central k-space acquisition is essential for high image quality. Timing can include a test bolus or bolus track­ing. For patients with asymmetrical flow to the legs, optimal arte­rial opacification in the more symptomatic leg (i.e., slower flow) can be challenging. Time-resolved sequences can determine peak arterial and venous enhancement of both legs so timing can be adjusted for the more symptomatic leg.
Magnetic resonance angiography can also be used to evaluate patients after endovascular intervention. gery, CE-MRA can evaluate graft location, patency, and stenosis of the proximal and distal anastomosis, even for small distal grafts. However, magnetic susceptibility created by metallic clips is prob­lematic even when source images are used for the evaluation.
34
36
Initial precontrast low-resolution axial 2D
31
39
Following bypass sur-
Blood pool contrast agents show promise to decrease gado­linium doses and provide a much longer time window for data acquisition, based on prolonged relaxivity in comparison to con­ventional gadolinium agents. loss from less pronounced T1 shortening are some challenges in blood pool MRA.
31
Newer noncontrast MRA techniques that use
acquisitions in systole and diastole to produce contrast
40
Venous contamination and SNR
41
are prom­ising for runoff exams in patients with impaired renal function. Dedicated evaluation of the pedal arteries ( rable to selective DSA.
42
Fig. 13-13) is compa-
Magnetic resonance angiography is used to evaluate patients with clinically suspected popliteal artery entrapment syndrome (
Fig. 13-14) and cystic adventitial disease. Popliteal artery entrap-
ment is an uncommon peripheral arterial disorder resulting from an anomalous relationship between the popliteal artery and the medial head of the gastrocnemius muscle. Magnetic resonance imaging defines the anatomical relationships, and MRA allows accurate evaluation of vascular compromise during provocative plantar flexion and at rest.
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Cystic adventitial disease accounts for 1 in 1200 cases of calf claudication. A mucin-containing cyst in the popliteal artery wall compromises arterial flow and causes claudication. Water signal makes the cyst appear hyperintense on T2-weighted images, and MRA reveals popliteal artery stenosis.
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Upper-extremity vascular disease affecting the subclavian artery includes stenosis, aneurysm, or compression due to thoracic outlet syndrome. Imaging of the forearm and hand may be indicated to evaluate vasculitis or ischemia secondary to trauma ( spatial resolution of MRA is inferior to DSA, although it is useful as a noninvasive technique.
46
The acquisition window is restricted to
Fig. 13-15). The
the few seconds between full enhancement of the arteries and the beginning of venous contamination. Blood pressure cuff inflation proximal to the imaged area can extend imaging time and enhance image quality of the palmar, metacarpal, and digital arteries.
47
Abdominal Vessels
Both CT and MR provide excellent imaging of the abdominal aorta and its branches. Magnetic resonance angiography is indicated to evaluate renal artery stenosis (RAS), mesenteric artery disease, and abdominal aortic aneurysm (AAA), dissection, or occlusion. Single breath-hold CE-MRA permits high contrast between vessels and
A B
FIGURE 1313 A, Time of flight (TOF) image of normal pedal arteries. B, Contrast-enhanced magnetic resonance angiography (CE-MRA) maximum intensity projection (MIP) reconstruction of pedal arteries in patient with cryoglobulinemia and small-vessel vasculitis. Arteries of pedal arch are occluded. Moderate venous enhancement is present.
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FIGURE 1314 A-B, Arterial-phase maximum-intensity projection (MIP) images of leg show left popliteal artery entrapment (arrows).
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FIGURE 1315 Contrast-enhanced magnetic resonance angiography (CE-MRA) of hand. A, Dominant ulnar supply to hand in patient with absent radial artery. B, Radial aspect of superficial palmar branch, showing stenosis (hypothenar hammer syndrome).
surrounding organs. Technical advances such as time-resolved and parallel imaging can be incorporated into clinical protocols. For detailed spatial measurements, black-blood (e.g., DIR) images are optimal for measurement of the lumen and vessel diameter and assessment of the aorta wall. Volumetric mask imaging will ensure that the 3D volume is appropriately placed. After contrast injection, at least two data sets (arterial and delayed phase) are acquired. This strategy does not significantly prolong the study and can provide valuable information, especially regarding venous struc­tures. It can also be very useful for slow flow in large aneurysms,
B
or imaging a false lumen where the initial acquisition does not provide adequate enhancement. Contrast doses of 20 mL, adminis­tered at 2 mL/s, are usually sufficient.
RENAL ARTERY IMAGING
The most common cause of RAS is atherosclerosis, which often involves the ostia or proximal 1 to 2 cm of the renal arteries. Fibromuscular dysplasia is the second most common cause of RAS and typically affects the distal two thirds of the main renal artery.
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Contrast-enhanced MR is the modality of choice for patients with hypertension and clinically suspected RAS.48 Coronal imaging is pre­scribed to minimize acquisition time (i.e., fewer phase- encoding steps). Parallel imaging can be used to minimize craniocaudal motion in the distal renal arteries. that dense calcification causes CT artifacts that obscure the lumen and
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late at or near the ostium where stenosis detection is critical. Three­dimensional CE-MRA with subtracted MIPs has less artifact at the ostium, and PC techniques can add information regarding hemody­namic significance. Secondary findings such as poststenotic dilation and delayed renal parenchymal enhancement are also important.
Magnetic resonance angiography can be used for clinically sus­pected FMD, but the presence of alternating webs and dilation may not be captured by the spatial resolution of MRA, particularly in the distal renal arteries. Thus, a negative MRA cannot entirely exclude the diagnosis.
ABDOMINAL AORTA IMAGING
Abdominal aortic aneurysms associated with atherosclerosis are typically fusiform; a saccular configuration should raise the pos­sibility of a mycotic aneurysm. Aneurysm evaluation includes the proximal and distal extent of the aneurysm, as well as its relation­ship to visceral branch vessels. Three-dimensional MRA can iden­tify the main and any supernumerary renal arteries ( mesenteric arteries.
Multidetector CT is the preferred modality for planning endo­vascular repair of AAAs and surveillance of stent grafts. Magnetic resonance angiography does not image calcification. resonance angiography is safe for nonferromagnetic stents and does not induce heating or stent deflection.
Susceptibility artifact from stents limit postprocedural studies. However, nitinol and PTFE devices have minimal MR artifact, and early data suggest that MRA can be used in patients with nitinol
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grafts.
Contrast-enhanced MRA is also accurate in the depiction of endoleaks. Time-resolved MRA is also an attractive method to characterize endoleaks because contrast passage into the aneu­rysm sac can be visualized as a cine loop.
ABDOMINAL AORTIC DISSECTION
Magnetic resonance angiography is used to detect propagation of aortic dissection into the abdominal aorta. It can identify the prox­imal and distal flap as well as involvement of the visceral branches. The celiac trunk and SMA usually arise from the true lumen, but extension of the flap into the celiac trunk, thrombosis of the false lumen, or compression of the true lumen can lead to hepatic or
49
The advantage of MRA over CT is
Fig. 13-16) and
51,52
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50
Magnetic
splenic infarcts. Magnetic resonance angiography reliably depicts the true and false lumen. For 3D acquisitions, postprocessing enables selective viewing of branch vessels. Delayed imaging can be used to characterize slow flow into the false lumen.
AORTIC OCCLUSION
MESENTERIC ARTERIES
Fig. 13-17), visceral artery dissection, vasculitides, and con-
nective tissue disorders.
Most patients do not develop symptoms of CMI unless two of the three mesenteric arteries are occluded. Magnetic resonance angiography is highly accurate for evaluating mesenteric origins, where the majority of stenoses develop (
Fig. 13-18). High accuracy
is maintained to the level of second-order branches. Qualitative and quantitative flow measurements with cine–phase contrast MRI from the SMA and vein can be performed.
55
Patients who present with severe abdominal pain and clinical suspicion for acute mesenteric ischemia require urgent imaging because of the risk of irreversible bowel damage. Major causes of acute mesenteric ischemia are SMA emboli (30%-50%), SMA throm­bosis (15%-30%), acute mesenteric vein thrombosis (5%-10%), and nonocclusive mesenteric vasoconstriction (20%-30%).56 Multidetector CT is typically used for initial imaging, since it has more widespread availability, less motion artifact in patients who are acutely ill, and the risk of bowel ischemia/infarction outweighs potential concerns for iodine-induced nephrotoxicity. However, in patients who do not require immediate intervention, MRA can be used for follow-up to characterize chronic atherosclerosis, mesen­teric occlusion, aneurysm formation, and vasculitis. Characteristics of vasculitis include findings of wall thickening and increased gad­olinium enhancement (
Fig. 13-19).
Transplantation
Magnetic resonance angiography is used in pre- and postoperative transplant patients. Detailed knowledge of vascular anatomy is essential to ensure safe and successful transplantation surgery.
FIGURE 1316 A, Coronal maximum- intensity projection (MIP) image. B, Three­dimensional volume-rendered (3D-VR) images show bilateral accessory inferior renal artery originating from left common iliac artery (CIA) (arrows).
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FIGURE 1317 Median arcuate ligament syndrome. A, Sagittal maximum- intensity projection (MIP). B, Three-dimensional volume-rendered (3D-VR) images obtained from arterial phase of contrast-enhanced magnetic resonance angiography (CE-MRA) show stenosis due to median arcuate ligament compression in origin of celiac trunk (arrow).
Magnetic resonance angiography is used in presurgical evaluation of the recipient and living donors
57,58
and in follow-up of patients after transplantation of the liver, kidney (Fig. 13-20), or pancreas, particularly in cases of suspected vascular complications.
In living donor liver transplantation, MRA provides a com­plete evaluation of the hepatic vascular anatomy in the presurgi­cal phase. It provides information regarding biliary anatomy and assessment of hepatic parenchyma for diffuse and focal abnormal-
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ities.
Magnetic resonance angiography has high sensitivity and excellent negative predictive value for detection of clinically sig­nificant vascular stenosis in liver transplantation.
60
After renal transplantation, MRA can be used for suspected vas­cular complications to identify patients who would benefit from angioplasty. and venous complications. muscle perforator arteries can also be obtained for preoperative planning of breast reconstruction.
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In pancreas transplantation, MRA identifies arterial
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Accurate maps of rectus and gluteal
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Inflammatory Diseases of the Arterial Wall
Magnetic resonance imaging is the primary technology for diagno­sis and follow-up of patients with large vessel vasculitis, based on identification of vessel wall edema and thickening that can be seen before lumen changes. Black-blood DIR imaging is preferred for wall morphology, and postcontrast imaging can be used to demon­strate mural enhancement. Other wall abnormalities seen in vasculitis include ulceration, dissection, stenosis, occlusion, and aneurysm.
FIGURE 1318 Sagittal maximum-intensity projection (MIP) image shows severe stenosis of superior mesenteric artery (SMA) (arrow).
A
B
FIGURE 1319 Axial precontrast (A) and postcontrast (B) T1-weighted images show aneurysmatic dilation, thickening, and contrast enhancement of aortic arch, consistent with aortitis (arrows) in patient with Takayasu's arteritis.
Takayasu's arteritis is an inflammatory disease that typically affects young women, and early diagnosis can be difficult because of its nonspecific symptoms and serological markers. Diagnosis and identification of disease activity with MRA is important to
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FIGURE 1322 Giant cell arteritis (GCA). Both subclavian arteries have smooth, tapered stenoses in mid- to distal segments.
FIGURE 1320 Oblique coronal maximum-intensity projection (MIP) reconstruction shows patency of renal artery anastomosis of transplanted kidney.
FIGURE 1321 Coronal maximum-intensity projection (MIP) image shows occlusion of distal abdominal aorta in region of bifurcation (arrow), intrahepatic inferior vena cava (IVC) thrombosis (short arrows), and occlusion of bilateral common iliac vein, with extensive lumbar, epigastric, and azygos collateral veins in same patient.
guide adequate therapy because severe stenoses, occlusion, or aneurysm are late irreversible manifestations. MRA findings sug­gestive of Takayasu's arteritis include stenoses of the aorta and its major branches (
Fig. 13-21). Involvement of the pulmonary
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Biomarkers are less reliable, whereas MRA shows early changes and evaluates disease activity. Findings include arterial wall thickening and enhancement in the active phase, mural thrombi, fusiform vascular dilations, and multifocal stenosis, and then thickened aortic valvular cusps in the chronic phase.
65
Giant cell arteritis (GCA) is a large-vessel inflammatory dis­ease affecting primarily older patients. Magnetic resonance angiography is used to diagnose associated thoracic aortic aneurysms and evaluates involvement of large peripheral arter­ies such as the subclavian arteries (
Fig. 13-22).
Magnetic Resonance Venography
The problems of flow-based techniques and the relatively long acquisition times are overcome by the rapid 3D sequences used for arteriography. Subtraction data sets can limit signal from arter­ies to produce high-quality venograms.
Thrombus has relatively high T1 signal from the formation of methemoglobin. Blood products have characteristic MR sig­nal changes that are used in the evaluation of very early to late hemorrhage.
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Inflammatory changes from acute deep vein thrombosis (DVT) are characteristic. After contrast enhance­ment, mural enhancement of the vessel wall is seen around an acutely thrombosed vein, appearing as a bull's eye. In conjunc­tion with the inflammatory changes and organization of the thrombus, this finding helps differentiate acute from chronic thrombosis.
Deep Vein Thrombosis
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FIGURE 1323 Axial (A-B) and coronal (C) postcontrast venous phase images show left common iliac, external iliac, and common femoral vein thromboses (arrows).
in diagnosis, although percutaneous access can be used for therapy. Computed tomography veno graphy can also be performed. Many early studies have established 2D TOF accuracy for thrombosis
68,69
in the large central veins, although contrast is beneficial for better char­acterization of more superficial and perforating veins with slow flow and retrograde flow.
70
Newer noncontrast MRA techniques have been used for DVT, but their utility requires more comprehensive studies. Magnetic resonance venography is also useful for patients with sus­pected renal vein thrombosis and can show enhancement of tumor thrombus.
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Delayed-phase MRA also provides an evaluation of the
inferior vena cava (IVC) and hepatic and portal veins.
Occlusive diseases of central thoracic veins (
Fig. 13-24) are
commonly seen in patients with malignancy or coagulopathy or long-term use of central venous catheters for hemodialysis,
hyperalimentation, or chemotherapy. Magnetic resonance venog­raphy is very helpful for vascular mapping in patients who have chronic venous occlusion but require central venous catheter placement. Magnetic resonance venography is the best modality for compression and occlusion of the abdomen and pelvis. The IVC (
Fig. 13-25) and iliac veins, lymph nodes, tumors, and large
organs can be identified. Finally, MRV delineates congenital venous anomalies and can be used to assess patency.
Vessel Wall Imaging
Sudden catastrophic adverse events such as stroke, MI, and limb ischemia do not necessarily correlate with lumen stenosis and may be better predicted by plaque characterization. Thus, vessel
FIGURE 1324 Coronal maximum-intensity projection (MIP) image shows right subclavian vein thrombotic occlusion (arrows) and patent left venous system.
FIGURE 1325 Abdominal magnetic resonance venography (MRV). Coronal maximum-intensity projection (MIP) image; large hypointense filling defect due to thrombosis seen in inferior vena cava (IVC) lumen (arrows).