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tone of the lower esophageal sphincter (LES) when pH is >4 [9]. Calcium carbonate absorbs primarily in the duodenum and changes with age (60% for infants, 28% for prepubertal children, 34% for pubertal children, and 25% for adults). It is important to note that absorption doubles during pregnancy [9]. Solubility of calcium carbonate increases with increasing acidity [9]. Constipation, diarrhea, nausea, vomiting, and hypophosphatemia are common side effects of antacid use [9]. Drug interactions with antacids are common and may involve interactions with medications such as levo­thyroxine, fluoroquinolones, tetracyclines, iron supplements, and salicylates. These interactions typically result in decreased absorption of the aforementioned medica­tions and can affect therapy [9]. In order to minimize the effects of antacids on the absorption of other medications, the recommendation is to administer the medica­tions 2hours before or up to 6hours after taking antacids [9]. Historically, antacids were the first-line medication for the treatment of peptic ulcer disease (PUD) prior to the introduction of PPIs [9]. Due to their familiarity and low cost, antacids are still very commonly used to treat heartburn. When used for the treatment of heartburn, patients are recommended to consult their physician if symptoms persist after 14days of use. Antacids represent a low-cost, relatively safe option for patients with intermit­tent GERD symptoms but have the potential to mask more serious problems, which is why long-term unsupervised use is not recommended [9].