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spread of tumour, as well as additional prognostic features is challenging. Especially in adenoid cystic carcinomas and invasive thyroid malig­nancy, MRI has been shown to provide additional information regarding extent of invasion of the tracheal wall. Despite these advantages, MRI has not been specically been shown to confer any signicant additional diagnostic benet.
10.7.1.4 Positron-Emission Tomography (PET)
Fluorine 18-uorodeoxyglucose (FDG) positron­emission tomography (PET) and fused PET/CT images can be helpful in distinguishing between malignant and benign tumours. Benign tumours typically exhibit minimal or no standardised uptake values (SUV), whereas malignant lesions often demonstrate high SUVs. It can also be helpful in establishing whether disease has metastasised to regionally to lymph nodes, or to distant sites. This modality can also help assess response to adjuvant treatment and determine the presence of residual or recurrent disease, with follow-up PET scans typically performed at 8weeks post adjuvant radiotherapy.
10.7.1.5 Ultrasonography
Whilst not utilised to diagnose tracheal malig­nancies, the use of ultrasonography and ultraso­nographically guided biopsies of lymph nodes can be a useful adjunct in assessing progression of disease.
nary function testing can be utilised to track progress, with peak ows easily self- administered to detect subtle early changes.
10.7.3 Endoscopic Evaluation andBiopsy
Bronchoscopy and biopsy is the gold-standard for diagnosing tracheal tumours and is a critical step in the workup of these masses. Initial exi­ble bronchoscopy can be performed to visualise the lesion. In patients with non-obstructing distal lesions, biopsies can be taken via the exible bronchoscope. Despite both exible and rigid bronchoscopy allowing for visualisation of the trachea down to the level of the carina and biopsy, the simplest way to evaluate tracheal lesions is via microlaryngoscopy and a rigid endoscope whilst the patient is either spontaneously breath­ing, or being oxygenated via jet ventilation or THRIVE.Any lesions can then be biopsied, and if necessary, the surgeon can debulk the tumour with laser or coblation and/or perform airway dilatations. Another advantage rigid bronchos­copy offers is the ability to apply pressure in the event of bleeding from the tumour or biopsy sites.
10.8 Management ofTracheal Malignancy
10.7.2 Pulmonary Function Testing
Pulmonary function testing (PFTs) has a limited role in the diagnosis of tracheal malignancies. They can suggest upper airway obstruction with attening of the inspiratory and/or expiratory ow-volume loops. This can differentiate between both proximal and distal airway disease as well as intratracheal or extratracheal compres­sion. The presence of these ndings does not diagnose a tracheal tumour, and their absence does not preclude one; further investigation with imaging and endoscopy is required. Following treatment of tracheal malignancies, serial pulmo-
The management of tracheal malignancies is complex and necessitates multidisciplinary approach with detailed input from surgeons (ENT, Head and Neck, Thoracic), physicians (respiratory and intensivists) and anaesthetics for management of the shared airway, radiolo­gists, pathologists, medical and radiation oncologists. Given the scarcity of these tumours, there are no randomised controlled trials to suggest the most effective treatment approach. Treatment regimens are based on basic oncologic principles and contingent on the surgical resectability of the tumour, with adjuvant therapy determined by histopathologi­cal subtype and other high-risk factors includ-
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ing positive margins, perineural invasion, lymphovascular invasion and extracaspsular spread.
10.8.1 Endoscopic Assessment andManagement
If examination under anaesthesia via microlaryn­goscopy and rigid endoscopy has not been per­formed previously, it should be done immediately prior to resection. This allows the surgeon to comprehensively assess the lesion and airway, plan the exact nature of the approach to the lesion and precise location of incisions. Depending on disease progression and patient suitability for surgery, tracheal lesions may be debulked to improve the airway with either coblation or laser, avoiding a long-term tracheostomy whilst enabling denitive, curative treatment via radiotherapy.
10.8.2 Surgical Resection
Surgical resection is the core treatment modality in tracheal malignancy, with tumour resectability a key factor in long-term survival.
The three governing surgical principles in tra-
cheal surgery for malignancy are:
1. Ensuring all tumour is resected with adequate
margins to optimise outcomes.
2. Limiting lymph node dissection and excessive
tracheal mobilisation to preserve arterial sup­ply, minimising risk of tracheal ischaemia, necrosis and stenosis.
3. Achieving a tension-free anastomosis.
10.8.3 Airway Management during Tracheal Surgery
The management of the airway during tracheal surgery requires clear communication between a surgical and anaesthetic team, with experience in managing these complex cases. The initial estab­lishment of an airway, followed by maintenance
of an airway after tracheal resection are the two main challenges. Ideally, the airway is stabilised prior to denitive surgical resection with debulk­ing; however, it is not uncommon to have patients in respiratory distress. In these cases, slow induc­tion with inhalational gases, avoidance of paraly­sis and the maintenance of spontaneous ventilation may be required. A tracheostomy is generally only utilised in patients with proximal tracheal lesions, as it may hinder subsequent tra­cheal anastomosis.
During resection, the nature of the lesion and type of resection will dictate the manner in which the airway is managed. For simple window resec­tions, the endotracheal tube can often be left in situ (or advanced beyond), with care taken to avoid puncturing the cuff. Where segmental tra­cheal resection is required, ventilation via an on table endotracheal tube needs to be planned (so­called ‘cross-eld’ ventilation). Generally, the distal incision is made rst, with the distal tra­cheal stump intubated directly from the surgical bed. This is done under apnoea. A silk suture can be placed through Murphy’s Eye of the original endotracheal tube to allow for easy retrieval at the end of the procedure. The on table tube is then secured and the orotracheal tube is left in the larynx and out of the way of the resection. Once the resection is complete, the posterior anasta­motic sutures are placed. The existing endotra­cheal tube is then advanced beyond the transection, allowing for the anterior anastamotic sutures to be placed and the anastomosis to be completed. Typically, all sutures are interrupted with the knot placed on the external surface of the trachea.
Depending on the location of the tumour, other methods such as passing a small jet venti­lation catheter into the distal airway, or for more distal lesions, intubating the right and left main bronchi directly are possible. Jet ventila­tion needs to be utilised with caution, as the constant insufation of air can cause baro­trauma due through progressive lung hyperin­ation and increased ventilating pressures. Cardiopulmonary bypass remains an option; however, it comes with signicant thrombotic risk and is rarely required.
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10.8.4 Approach
Different incisions can be utilised to provide access to allow for resection and reconstruction, depending on the size and location of the primary tumour. Upper and mid-tracheal lesions can be accessed with a low cervical collar incision, with the option of a further vertical limb or partial/full median sternotomy providing access inferiorly. For more distal tracheal lesions, access may be gained through a right posterolateral thoracot­omy through the fourth intercostal space. When using a cervical incision, the patient is positioned with the neck in a fully extended position with the assistance of a shoulder roll. In a similar fash­ion to a tracheostomy, the subplatysmal plane is developed and the trachea is exposed by separa­tion of the strap muscles at the midline. Major mediastinal vasculature, especially the innomi­nate artery, need to be identied and protected.
Mobilisation of the trachea depends on the extent of resection required and additional procedures such as thyroidectomy and or lymph node dissection. In general, the trachea should be mobilised only on its anterior surface to the level of the carina. At the point of resection, dissection should remain close to the trachea to protect the recurrent laryngeal nerves. Alternatively, these can be fully dissected and formally identied after removal of the thyroid gland and associated lymphatic tissue. Should resection of the cricoid cartilage be necessary, it is important to stay deep to its external perichondrium in order to avoid the recurrent laryngeal nerve at the level of Berry’s Ligament and the criocothryoid joint, whilst pre­serving vascularity.
10.8.5 Extent ofResection
10.8.5.1 Tracheal Shave
This is the simplest method of tracheal excision, typically performed in patients with thyroid can­cer. A margin is shaved off the surface of the tra­chea, with postoperative radioactive iodine relied upon to control and residual tumour should it be
present. Despite this method perhaps being sim­pler and initially effective, the tumour is more predisposed to recur, especially if the trachea shave demonstrated disease involvement.
10.8.5.2 Simple Segmental Tracheal Resection
This is the most common type of tracheal resec­tion, where a tracheal segment with disease/ tumour involvement is resected. Important ana­tomical structures and landmarks such as the thy­roid isthmus, cricoid, trachea and innominate artery are identied (Fig.10.1a). The trachea is then mobilised on its anterior surface only to the level of the carina, ensuring dissection remains close to the trachea itself, and that superior medi­astinal structures are avoided (Fig.10.1b). Based on the extent of disease and accounting for mar­gins, the superior and inferior limits of resection are then identied (Fig. 10.1c). The trachea is then mobilised circumferentially at the level of the resection, along the trachea-oesophageal groove; taking care to protect the recurrent laryn­geal nerves bilaterally (Fig.10.1d).
After the excised segment is mobilised, the inferior cut can be made. The endotracheal tube is withdrawn slightly if required, allowing the distal tracheal stump to be directly intubated via the surgical bed with a exible, sterile endotra­cheal tube (Fig.10.1e, f). When the airway has been established, the resection is completed with the superior cut and division of the trachealis muscle posteriorly.
Silk stay sutures are placed laterally around the superior and inferior tracheal rings and are brought together, allowing the surgeon to assess the level of tension of the anastomosis (Fig. 10.1h). Generally, a monolament suture such as PDS is used, and the neck is placed in exion to further reduce tension. The posterior sutures are placed rst in a continuous manner, with the knot of the suture on the external surface of the trachea. The endotracheal tube may be intermittently inserted and removed, balancing the need for ventilation with repair of the poste­rior tracheal wall (Fig.10.1i). The anastomosis is
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completed anteriorly with the placement of inter­rupted sutures around the adjacent anterior tra­cheal rings (Fig.10.1j). Once the anastomosis is almost complete, the original endotracheal tube is pushed back down, distal to the anastomosis to facilitate normal ventilation. A ‘reminder’ or ‘guardian’ chin-to-chest suture is placed to pre­vent hyperextension (Fig. 10.1k). The patient should be extubated postoperatively.
10.8.5.3 Window Resection andRepair
This type of resection most encountered during thyroid surgery, where there is evidence of tumour adherence to the tracheal wall. A horizon­tal cervical incision is made to expose the thyroid isthmus, allowing the cricoid and trachea to be identied (Fig.10.2a). The trachea is mobilised, and the window to be excised is delineated (Fig.10.2b). Care must be taken to avoid inad­vertent injury to the recurrent laryngeal nerves. The area is excised and the tracheal lumen is entered (Fig. 10.2c). Following resection, there are a number of methods by which the defect can be addressed. Should the defect be mainly ante­rior, a tracheostomy tube can be inserted, and the window can be allowed to heal via secondary intention after decannulation.
For small non-circumferential defects, a local ap is a simple option for immediate repair; with the sternocleidomastoid located nearby (Fig.10.2d). The sternocleidomastoid can either be divided superior (Fig.10.2e) and rotated medially to cover the defect (Fig.10.2f) or mobilised inferior with the periosteum of the clavicle (Fig.10.2g) and rotated medially to cover the defect (Fig.10.2h). When suturing in the muscle, tension of the muscle is required to prevent collapse of the muscle into the trachea during inspiration.
10.8.5.4 Cricotracheal Resection
andThyrotracheal Anastomosis
This method involves resection of the cricoid, with subsequent thyrotracheal anastomosis achieved in either a sliding or step-wise fashion.
Slide
The area to be resected is exposed, including the thyroid isthmus, anterior arch of the cricoid carti­lage and tracheal rings below (Fig.10.3a). The thyroid isthmus is divided and the thyroid lobes are dissected off the lateral tracheal walls with care taken to avoid injury to the recurrent laryn­geal nerves (Fig.10.3b).
The anterior arch of the cricoid is mobilised from above and removed. The cricotracheal liga­ment laterally is also mobilised, staying deep/ inside the external perichondrium, protecting the recurrent laryngeal nerves which run outside this layer. The internal cricoid perichondrium is mobilised posteriorly in continuity with the trachealis muscle, allowing detachment of the trachea from the remaining posterior cricoid lam­ina. The trachea can then be mobilised off the oesophagus (Fig.10.3c).
The inferior cut is made, and the distal stump of the trachea is directly intubated through the surgical bed with a exible sterile endotracheal tube. The oro-endotracheal tube is withdrawn to facilitate this, but not removed as it will be required after anastomosis (Fig.10.3d). The exci­sion is completed with the superior cut, with care taken to avoid inadvertent injury to the oesopha­gus posteriorly (Fig.10.3e).
Stay sutures are placed laterally, bringing the segments together in a tension-free fashion. The trachea inferiorly will telescope into the cricoid and approximate the thyroid cartilage (Fig.10.3f). The posterior wall is repaired rst by placing sutures through the subglottic mucosa and part of the posterior cricoid lamina using a monola­ment continuous suture (PDS).
The oro-endotracheal tube is retrieved back into the distal airway, and the anterior wall of the trachea is repaired with interrupted sutures placed around the thyroid cartilage superiorly and tra­cheal ring inferiorly. Soft drains are placed, the wound is closed in layers and a chin-to-chest reminder suture preventing hyperextension is placed. Extubation is preferred; however, a small tracheostomy tube can be placed if there are air­way concerns (Fig.10.3g).
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Fig. 10.1 (a) The thyroid isthmus is exposed, with important anatomical landmarks (cricoid, trachea and innominate artery inferiorly) identied. (Key: red thy­roid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves). (b) The trachea is mobilised bluntly on its anterior surface only to the level of the carina, taking care to avoid injury to superior mediastinal vascular contents. (Key: red thy­roid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves). (c) The superior and inferior extent of resection are identi­ed. (Key: red thyroid, green tumour, light blue endotra­cheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black line superior and inferior margins of resection). (d) Circumferentially mobilise the trachea at the level of resection, avoiding injury to the oesophagus by separating the trachea-oesophageal groove region. (Key: red trachea-oesophageal groove,
green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black line superior and inferior margins of resection). (e) The
trachea is entered via the inferior cut, the endotracheal tube is withdrawn and the distal stump is intubated via a separate endotracheal tube, through the operative eld. (Key: red thyroid, green tumour, light blue endotracheal tube, dark blue intubation of distal tracheal stump, grey trachea, thin black lines recurrent laryngeal nerves, thick black line superior and inferior margins of resection). (f) The trachea is entered via the inferior cut, the endotra­cheal tube is withdrawn, and the distal stump is intubated via a separate endotracheal tube, through the operative eld. (Key: red thyroid, green tumour, light blue new endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black line superior and inferior margins of resection). (g) The resection is completed by
making the superior cut and dividing the trachealis poste­riorly. (Key: red thyroid, green tumour, light blue endo­tracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, orange defect). (h) Silk stay sutures are placed laterally around the superior and inferior tracheal rings and test bringing the segments together in a tension­free manner. You may need to remove the shoulder roll and place the neck in slight exion to reduce tension. (Key: red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black line stay silk sutures, orange defect). (i) Commence your repair by placing sutures posteriorly rst. You might use a monolament (PDS) in a continu­ous manner. Utilise the stay sutures to bring the posterior wall together to facilitate a tension-free repair. Endotracheal tube may be intermittently inserted and removed intermittently to facilitate oxygenation, or to expose the posterior wall fully. (Key: red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black line sutures, orange defect). (j) The anastomosis is completed anteriorly by placing sutures around the adjacent tracheal rings using interrupted sutures (PDS). (Key: red thyroid,
green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black line sutures, orange defect). (k) Once the repair is nearly
complete, push the endotracheal tube back down to facil­itate normal ventilation. Insert soft drains to prevent sub­cutaneous emphysema and close the wound in layers. Place a ‘reminder stitch’ between the mentum and the sternum to prevent inadvertent hyperextension. Aim to extubate the patient at the end of the procedure. (Key: red thyroid, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black line sutures, orange defect)
Step-Wise
This technique is ideally suited to tumours located at the level of the cricotracheal groove and Berry’s Ligament, with sacrice of the recur­rent laryngeal nerve potentially necessary. The trachea is rst mobilised on its anterior surface to the level of the carina (Fig.10.4a). The tumour is then excised with sections of the cricoid cartilage and adjacent tracheal rings. If possible, dissec­tion should stay inside or deep to the external perichondrium of the cricoid, protecting the recurrent laryngeal nerves. (Fig.10.4b). A step­wise cut is fashioned in the distal trachea, with the corresponding segment removed (Fig.10.4c). The distal segment is advanced into the superior resection margin, with stay sutures helpful in
bringing the segments together (Fig.10.4d). The posterior wall is repaired rst, and then the ante­rior walls are brought together with interrupted monolament sutures (PDS). The repair can be completed while the endotracheal tube remains in situ taking care to avoid injury to the cuff (Fig.10.4e).
10.8.6 Principles ofAnastomosis
Following resection, the patient’s neck is restored to a exed position to allow for anastomosis. Depending on the segment excised, anastomoses can be performed in an end-to-end, end-to-side or sliding fashion utilising continuous sutures inter-
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Fig. 10.2 (a) Expose trachea via a horizontal cervical inci- sion. Identify cricoid above and trachea below the thyroid isthmus. (Key: red thyroid, green tumour, light blue endo­tracheal tube, grey trachea, thin black lines recurrent laryn­geal nerves). (b) The trachea is carefully mobilised, with the window to be excised delineated. Care is taken to avoid injury to the recurrent laryngeal nerve. (Key: red thyroid,
green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black lines
window resection). (c) The area is excised, the tracheal lumen is entered and tumour removed. (Key: red thyroid,
green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves). (d) The adja­cent sternocleidomastoid muscle is ideally located. (Key: light red thyroid, dark red sternocleidomastoid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, yellow clavicle, blue
periosteum of clavicle). (e) Option 1—The sternocleido­mastoid muscle is partially divided superiorly, taking care to avoid injury to the accessory nerve and underlying carotid sheath. (Key: light red thyroid, dark red sternoclei­domastoid, green tumour, light blue endotracheal tube, grey
trachea, thin black lines recurrent laryngeal nerves, yellow clavicle, blue periosteum of clavicle). (f) Option 1—The superior portion of the sternocleidomastoid is rotated into the defect medially. This is sutured into the edge of the defect ensuring adequate tension to avoid collapse into the tracheal lumen during respiration. (Key: light red thyroid, dark red sternocleidomastoid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, yellow clavicle, blue periosteum of clavi­cle). (g) Option 2—The sternocleidomastoid muscle can be mobilised inferiorly together with periosteum of the clavi­cle below. (Key: light red thyroid, dark red sternocleido­mastoid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, yellow clavicle, blue periosteum of clavicle). (h) Option 2—The inferior mobilised muscle is rotated medially and sutured to the edges of the tracheal defect, ensuring some degree of tension in order to avoid collapse into the tracheal lumen. (Key: light red thyroid, dark red sternocleidomastoid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, yellow clavicle, blue periosteum of clavicle)
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Fig. 10.3 (a) Expose the area to resected which includes the anterior arch of the cricoid cartilage and the tracheal rings below. (Key: light red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves). (b) The thyroid isthmus is divided, and the thyroid lobes are mobilised off the lateral tracheal walls, taking care to avoid injury to the recurrent laryngeal nerves. (Key: light red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black lines superior and inferior limit of resection). (c) The anterior arch of the cricoid is mobilised from above and removed. The cri­cotracheal ligament laterally is also mobilised, staying deep/inside the external perichondrium, protecting the recurrent laryngeal nerves which run outside this layer. The internal cricoid perichondrium is mobilised posteri­orly in continuity with the trachealis muscle, allowing detachment of the trachea from the remaining posterior cricoid lamina. The trachea can then be mobilised off the oesophagus. (Key: light red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black lines superior and inferior limit of resection). (d) The inferior cut is made, and the distal stump of the trachea is directly intubated through the surgical bed. The oro-endotracheal tube is withdrawn to facilitate this, but not removed as it will be required after anastomosis. A silk suture may be placed through Murphy’s Eye in order to allow retrieval after anastomosis. (Key: light red thyroid, green tumour, light
blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black lines superior and inferior limit of resection). (e) The resection is completed following the superior excision, taking care to avoid injury to the oesophagus posteriorly. (Key: light red thy­roid, green tumour, light blue endotracheal tube, grey tra­chea, thin black lines recurrent laryngeal nerves, orange defect). (f) Stay sutures are placed laterally, bringing the segments together in a tension-free fashion. The trachea inferiorly will telescope into the cricoid and approximate the thyroid cartilage. The posterior wall is repaired rst by placing sutures through the subglottic mucosa and part of the posterior cricoid lamina using a monolament con­tinuous suture (PDS). (Key: light red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black lines sutures, orange defect). (g) The orotracheal tube is brought back into the distal airway and the repair of the anterior wall is completed using interrupted sutures placed around the thyroid cartilage superiorly and the tracheal ring inferiorly. Soft drains are placed and the wound is closed in layers. A ‘reminder stitch’ preventing neck hyperextension is placed. Extubation is preferable, but placement of a small tracheostomy tube is appropriate where there are airway concerns. (Key: light red thyroid, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves, thick black lines sutures, orange defect)
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Fig. 10.4 (a) Mobilise the trachea on its anterior surface only to the level of the carina. (Key: red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin
black lines recurrent laryngeal nerves, dotted thick black line limit of resection). (b) The tumour is excised with
sections of the cricoid cartilage and adjacent tracheal rings. If possible, dissection should stay within the exter­nal perichondrium of the cricoid cartilage to protect the recurrent laryngeal nerves. Avoid injury to the oesophagus posteriorly. (Key: red thyroid, green tumour, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves). (c) A step-wise cut is created and the corresponding segment of the trachea is removed. (Key: red thyroid, light blue endotracheal tube, grey trachea,
rupted or a combination of both, with the goal of creating a tension-free join. If following the required resection, there is still an unacceptable tension on the potential anastomosis, release manoeuvres can be performed to further mobilise
thin black lines recurrent laryngeal nerves, dotted thick black line step-wise tracheal cut). (d) The distal segment
is mobilised into the superior resection margin. Stay sutures laterally are helpful and bringing the segments together. (Key: red thyroid, light blue endotracheal tube, grey trachea, thin black lines recurrent laryngeal nerves). (e) The posterior wall is repaired rst, and then the ante­rior walls are brought together with interrupted monola­ment sutures (PDS). The repair can be completed while the endotracheal tube remains in situ taking care to avoid injury to the cuff. (Key: red thyroid, light blue endotra­cheal tube, grey trachea, thin black lines recurrent laryn­geal nerves, thick black lines sutures)
the trachea. Supra-laryngeal release procedures allow further mobilisation of the tracheal inferi­orly, with the suprahyoid and/or infrahyoid release potentially generating an additional 1–2 cm of movement inferiorly each. Infra-
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laryngeal release procedures such as hilar release, pretracheal dissection and incision of the annular ligaments provide an additional 1–2cm of move­ment superiorly each. These manoeuvres are not without their own challenges and complica­tions– with supra-laryngeal release manoeuvres placing the patient at a high risk of signicant dysphagia, and infra-laryngeal release proce­dures requiring input from thoracic surgeons.
Following anastomosis, a local, regional, or free ap can be utilised to ‘cover’ the anasto­motic site, especially if there has been previous irradiation. In the neck, the strap musculature or a pedicled sternocleidomastoid muscle may be used, whereas in the chest pericardial fat, pedi­cled chest wall muscle, or omental aps may be used. A soft drain (such as an open penrose drain) is placed at the anastomotic site to reduce subcu­taneous emphysema and a chin-to-chest ‘guard­ian’ or ‘reminder’ suture (otherwise, eponomyously known as the Grillo suture) is often placed from the submental skin to the sternal skin to hold the neck in exion for 7days, preventing neck extension and rupture of the anastomosis.
Following resection and anastomosis, it is imperative that mechanical ventilation is avoided, secretions are controlled, and prophylactic anti­biotics are administered to prevent wound break­down. If the patient requires re-intubation, a small endotracheal tube should be placed under rigid endoscopic vision ideally distal to the anas­tomotic junction. High ventilation pressures should be avoided where possible.
Table 10.6 Comparison of early and late complications following tracheal surgery
Early complications Late complications Airway obstruction
(from oedema) Bleeding Development of granulation
Infection Tracheomalacia Anastomotic leak,
dehiscence or rupture
Subcutaneous emphysema
Dysphonia (laryngeal oedema/ RLN injury)
Tracheal stenosis
tissue
Fistula (tracheoesophageal, tracheo-inominate, tracheopulmonary)
Dehiscence of anastomosis.
Dysphagia
bleeding, aspiration and anastomotic dehiscence or rupture. With larger and recurrent resections, or patients who are immunocompromised or have previously received radiotherapy to the area, there is an increased risk of anastomotic compli­cation. Pulmonary complications such as retained secretions, aspiration (especially after suprahy­oid release manoeuvres or recurrent laryngeal nerve injury) is also common and may require management with antibiotics and swallow rehabilitation.
Later complications can include stenosis of the anastomotic junction requiring bronchoscopy and dilatation, development of granulation tissue, dysphagia, dehiscence of the anastomosis and s­tula to surrounding viscera or vessels. See Table
10.6 for a breakdown of early and late complica-
tions from tracheal surgery.
10.8.7 Risks andComplications
Tracheal surgery is complex, and as such it has signicant intraoperative risk and postoperative complications, which can be life-threatening in nature through imminent loss of the airway. Intraoperative risks include bleeding, damage to surrounding vasculature, damage to nearby struc­tures and injury to the recurrent laryngeal nerves.
Early complications can include airway
obstruction from postoperative oedema and
10.9 Non-Surgical andAdjuvant
Management
10.9.1 Radiotherapy
Radiotherapy can be utilised with curative intent as an adjuvant following surgical resection in patients with histopathologically aggressive dis­ease. The presence of positive or close surgical margins, perineural or lymphovascular invasion indicates the use of adjuvant radiotherapy and has been shown to increase median survival times