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24. Carbonell A, Kercher K, Matthews B, Sing R, Cobb W, Heniford T.The laparoscopic repair of
suprapubic ventral hernias. Surg Endosc Other Intervent Tech. 2005;19(2):174–7.
25. Losanoff J, Basson M, Laker S, Weiner M, Webber J, Gruber A.Subxiphoid incisional hernias
after median sternotomy. Hernia. 2007;11(6):473–9.
26. Hirasa T, Pickleman J, Shayani V. Laparoscopic repair of parapubic hernia. Arch Surg.
2001;136:1314–7.
27. Losanoff J, Collier A, Wagner-Mann C, Richman B, Huff H, Hsieh F, Diaz-Arias A, Jones
J.Biomechanical comparison of median sternotomy closures. Ann Thorac Surg. 2004;77:203–9.
28. Hope W, Hooks W.Atypical hernias. Surg Clin North Am. 2013;93(5):1135–62.
29. Blair L, Cox T, Huntington C, Ross S, Kneisl J, Augenstein V, Heniford B.Bone anchor xa-
tion in abdominal wall reconstruction: a useful adjunct in suprapubic and para-iliac hernia repair. Am Surg. 2015;81(7):693–7.
30. Awad Z, Miedema B.Subxiphoid incisional hernias after median sternotomy. J Am Coll Surg.
2006;202(2):386–7.
31. Landau O, Raziel A, Matz A, Kyzer S, Haruzi I.Laparoscopic repair of poststernotomy subxi-
phoid epigastric hernia. Surg Endosc. 2001;15:1313–4.
32. Ghanem O, Zahiri H, Devlin S, Sibia U, Park A, Belyansky I.Laparoscopic subxiphoid hernia
repair with intracorporeal suturing of mesh to the diaphragm as a means to decrease recur­rence. J Laparoendosc Adv Surg Tech. 2016;26(2):129–32.
P. Dolan and G. Dakin
Recurrent Ventral Hernia Repair
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26
CharlotteHorne andAjitaPrabhu
Introduction
Recurrent ventral hernias pose many technical challenges to a general surgeon. Each year over three billion US dollars are spent on approximately 350,000 ventral hernia repairs [1]. Reducing recurrence rates by as little as 1% could result in 3.2 million dollars in savings [1, 2]. Although a signicant effort has been put forth to delineate both patient factors and technical factors that increase likelihood of recurrence, recurrence still represents a signicant cause of morbidity postopera­tively. Risk of recurrence has decreased signicantly with the routine use of pros­thetic mesh reinforcement; however, recurrence rates remain high with reported recurrence rates of 25–44% after second and third repair, respectively [3, 4]. Recurrent hernia repairs are technically difcult operations for many reasons: there is potential for dense adhesions to the abdominal wall, often mesh has been placed and anatomical planes have been disturbed by previous dissection, and there may be device-related complications such as mesh infection or mesh-related pain. Additionally, there may be concerns for loss of domain and/or potential for difculty achieving soft tissue coverage of the hernia repair if the overlying skin is compromised due to infection or ulceration. It is imperative to understand why possible previous hernia repairs have failed and address any patient factors preop­eratively that put patients at increased risk for recurrence. Herein, we present an algorithm for the workup and management of these complicated patients (Fig.
26.1).
C. Horne, MD · A. Prabhu, MD (*) Department of General Surgery, Cleveland Clinic, Cleveland, OH, USA e-mail: PRABHUA@ccf.org
© Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) 2019 S. S. Davis Jr. et al. (eds.), The SAGES Manual of Hernia Surgery,
https://doi.org/10.1007/978-3-319-78411-3_26
359
360
Approach to Recurrent Ventral Hernia Repair
polypropylene mesh
Laparoscopic
C. Horne and A. Prabhu
• Obtain previous operative reports
• Pre-operative CT
Recurrent Ventral Hernia
Identify Special Considerations
• Contaminated
Defect > 7cm
• Identify modifiable co-morbidities
Yes
• Loss of Domain
• Extensive soft tissue reapsir required
No
BMI <35
Loss of Domain
Pre-op weight counseling
tissue repair
Contaminated Extensive soft
TAR
Posterior
component
separation or
ACS
Open
retrorectus
approach with
Retrorectus bridged
Plastics involvement
or
Immediate
Staged Repair
repair
Heavy weight
repair
Defect </= 7cm
Onlay
• Non-Diabetic
• Non smoker
• BMI <30
approach
Lap-assisted
approach
Fig. 26.1 Algorithm for ventral hernia approach. ACS (anterior component separation). TAR (transversus abdominis release). Posterior component separation
or TARs should not be performed with concurrent anterior component separation as this may destabilize the lateral abdominal wall, resulting in a ank hernia
26 Recurrent Ventral Hernia Repair
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361
Approach tothePatient
When evaluating a patient for recurrent ventral hernia repair, it is important to determine any modiable risk factors that can increase likelihood of recurrence. Often, such factors have not been addressed at prior operations and may be responsible in part for recurrences. Postoperative surgical site infection is one potentially preventable occurrence that is closely linked to increased risk of recur­rence [5]. Potential patient factors that increase likelihood of postoperative infec­tion include obesity with BMI >40, diabetes, COPD, active smoking, and immunosuppression [6]. Efforts to optimize modiable factors prior to elective hernia repair should be pursued to ensure a successful subsequent repair. Furthermore, preventable comorbidities such as smoking, diabetes, and obesity are also known to directly increase hospital charges, and modication of these factors preoperatively may therefore help to offset costs of care of these compli­cated patients [2].
Smoking
Active smoking is known to compromise healing due to peripheral vasoconstriction as well as reduced cutaneous blood ow [7]. Active smokers have an approximately
2.5 times increase in relative risk of wound complications when compared to non­smokers [7]. Grade A evidence exists supporting the avoidance of elective hernia repair in active smokers [8]. Patients should stop smoking at least 4weeks prior to undergoing elective surgery as this has been shown to decrease postoperative com­plications [9]. Because there is reasonable data to suggest that the wound healing problems associated with smoking are likely related to the contents of cigarette smoke and not the nicotine itself, the authors allow nicotine replacement therapy with either nicotine gum or patches, but not e-cigarettes as the contents are not stan­dardized. Urine nicotine metabolite testing has the ability to distinguish between active smoking and nicotine replacement therapy and therefore is the test of choice used by the authors to ensure smoking cessation compliance. In our practice, smok­ing cessation is discussed in the ofce as an imperative prior to surgery for complex abdominal wall reconstruction (it is discussed but not necessarily required for mini­mally invasive hernia repair). Patients are informed that urine nicotine testing will be performed if they are active smokers at the time of the ofce visit. Patients are tested 4weeks prior to their planned surgery dates to allow time for cancellation of cases in the case of non-compliance.
Diabetes
Diabetes is a common comorbidity that may lend itself to postoperative surgical site infection in patients with uncontrolled blood glucose undergoing ventral hernia repair. Specically, a hemoglobin A1C >7 has been found to be associated with
362
C. Horne and A. Prabhu
increased risk of wound infection [10]. Therefore, the authors routinely check Hgb A1c preoperatively in all patients undergoing recurrent ventral hernia repair, with the goal of achieving a value of 7 or less. When Hgb A1c is greater than 7, the authors usually engage the primary care physician and/or an endocrinologist to assist with improving blood glucose control prior to surgery. In the postoperative period, hyperglycemia with blood glucose level >140mg/dL has also been found to be associated with increased risk of surgical site infection [11]. Still, meticulous glycemic control postoperatively may be complicated by hypoglycemia and is therefore discouraged as the risk outweighs the potential benets [12]. Some authors suggest that 140–160mg/dL may be the optimal range for postoperative blood glu­cose in diabetic patients [13].
Obesity
Addressing weight in the preoperative setting can be a challenging discussion for both surgeons and patients. Nevertheless, weight loss should be discussed with obese patients undergoing recurrent ventral hernia repair as obesity is associated with increased risk of surgical site infection, prolonged hospital stays, and increased risk of recurrence [1417]. Obesity increases technical difculty, leads to increased operative time, and causes increased intra-abdominal pressure and decreased tissue healing [2]. The best approach to preoperative weight reduction is still yet to be determined. Some series suggest that a multidisciplinary approach to weight loss results in sustained weight loss; however, other data suggest that this weight loss is not durable in the long term [17, 18]. An optimal BMI prior to surgical intervention has not been established, but it is well known that increasing BMI correlates with increasing risk of postoperative morbidity [19]. Pernar etal. set out to determine a BMI threshold at which there was a signicant increase in postoperative complications. They demonstrated that 16.5% of patients with BMI >40 that underwent open ventral hernia repair had a postoperative complication compared to 5.6% in patients with BMI <25. They also showed that when con­trolled for other medical comorbidities, BMI >40 alone increases odds of postop­erative complication 3.4 times [19].
Increased risk of complications is not limited to open repair exclusively, as patients with BMI >40 have a fourfold increased risk of recurrence when under­going laparoscopic hernia repair [20]. Bariatric surgery either prior to denitive recurrent repair or concurrent with laparoscopic hernia repair has been evaluated. Currently the data is limited to small, single institution retrospective analyses. There have been promising results in patients who underwent bariatric surgery prior to complex ventral hernia repair [21]. A study by Newcomb etal. showed no recurrence at 2–50 months postoperatively, and patients also had a signicant decrease in BMI from an average of 51kg/m hernia repair [21]. Although this study showed effective weight loss after bariatric surgery, patients undergoing concomitant bariatric surgery and ventral hernia repair are known to have increased 30-day unplanned reoperation, unplanned
2
preoperatively to 33kg/m2 prior to
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363
readmission, and 30-day postoperative complications [22]. Although studies sug­gest that concomitant laparoscopic ventral hernia repair during bariatric surgery is safe, the authors prefer to avoid placement of intraperitoneal barrier coated mesh at the time of a clean-contaminated case as it has been suggested that barrier coat­ing may harbor infection and potentially result in wound complications [23]. Some patients with complex surgical histories and multiply recurrent hernias may not be candidates for a laparoscopic bariatric intervention. Additionally, adequate preoperative evaluation with a multidisciplinary team prior to bariatric surgery is essential, and patients with a recurrent ventral hernia and obstructive symptoms may not be able to complete the process prior to requiring surgical intervention for their hernia. Still, in patients that are candidates for bariatric surgery, it is rec­ommended that they undergo bariatric surgery prior to ventral hernia repair when possible.
Other options for preoperative weight loss for patients who are not candidates for bariatric surgery include guided lifestyle modication, diet and exercise programs that may be commercially available, or medical weight loss programs such as the protein-sparing modied fast [18]. The authors prefer the latter when patients are able to enroll in the program, as it can be very successful when the patient is engaged and participating. Protein-sparing modied fast can also allow for a relatively quick weight loss which may be benecial in patients who are very symptomatic from their hernias. This may also be an effective weight loss method in patients who are unable to exercise, often due to joint or back pain caused by obesity. BMI <30kg/ m2 is associated with overall improved outcomes and decreased hernia recurrence [2, 15, 20]. In the setting of elective recurrent ventral hernia repair, it is essential to encourage weight loss in patients with BMI >30kg/m2, and it may be reasonable to defer patients with BMI >50kg/m2 from an operative intervention due to the high risk of morbidity [2, 7].
The authors feel strongly that to maintain the investment of both the patient and the surgeon in the weight loss process and preparation for surgery, it is best to dis­cuss the plan for weight loss, document the goal for weight loss including the expected time frame, and see patients back in the ofce 3 months after setting weight loss goals. While many patients are not yet ready to schedule surgery at that point due to remaining excess weight that must be lost, often this signals an ongoing investment by the surgeon in the patient’s care and can help patients ultimately reach their weight loss goal.
Choice ofApproach toHernia Repair
When approaching recurrent ventral hernia repair, numerous patient and technical factors should be considered. Size of defect, location of previous mesh placement, presence of chronic infection or stulas, and medical comorbidities and BMI all play roles in determining the best surgical approach. Obtaining previous operative reports assists in determining what previous prosthetic was utilized and its location and help to guide operative intervention. CT scan imaging of the abdomen and
364
C. Horne and A. Prabhu
pelvis is also very useful in determining the characteristics of the hernia defect and the surrounding anatomy and is routinely obtained in our practice for evaluation of recurrent ventral hernias [24].
Laparoscopic Recurrent Ventral Hernia Repair
A laparoscopic approach to the repair of a recurrent ventral hernia has many advan­tages. Laparoscopic ventral hernia repair has been shown to have decreased wound events, decreased postoperative pain, and overall decreased length of stay when compared to an open approach [20, 25]. Data also reports low recurrence rates (3.5–
5.7% at 41months), and, even the setting of multiply recurrent hernias, a higher risk of recurrence has not been shown after laparoscopic hernia repair [2628]. Obese patients may benet from laparoscopic ventral hernia repair over open when man­aging a recurrent hernia as there is a decreased risk of postoperative wound compli­cations and the ability to recognize smaller fascial defects not previously appreciated in patients with BMI >30kg/m
These hernia repairs can be completed in an entirely laparoscopic fashion or in a hybrid open and laparoscopic fashion (lap-assisted hernia repair) where the hernia contents are reduced through a small laparotomy incision and the mesh is placed laparoscopically. Regardless of approach, it is imperative that previous operations, mesh placements, and location of the abdominal wall defect are delineated as these factors will determine optimal trocar placement.
In patients with signicant intra-abdominal adhesions, a combined laparoscopic and open approach (hybrid/laparoscopic assisted) may be considered. Laparoscopic­assisted approach is similar to laparoscopic approach in that much of the operation is performed through small incisions. In addition, a small laparotomy incision can facilitate adhesiolysis and closure of fascial defects with substantial mesh overlap of the defects while obviating the need for a generous laparotomy incision that might otherwise be required for an open approach. Advantages to completing the hernia repair via a hybrid or lap-assisted approach include the ability to perform adhesioly­sis in an open fashion which reduces the risk for missed enterotomy as well as the ability to close the fascial defect [29]. Additionally, this allows the surgeon to place a mesh with signicant overlap of the defect without making a large laparotomy incision, which may contribute to wound morbidity and longer recovery time.
The current practice of closure of the fascial defect during laparoscopic hernia repair is often dependent on the operating surgeon’s routine preference. The benets of routine closure potentially include an improved cosmetic outcome as well as potential decreased risk of postoperative seroma formation [3032]. A meta- analysis and literature review by Yanaga etal. was conducted which showed fascial closure (IPOM plus) was associated with decreased risk of recurrence, 0–7.7% risk com­pared to 4.4–29%, and decreased risk of seroma formation, 0.5–78% compared to 0–11.43% [30]. However, more recent studies showed that there was no signicant difference in postoperative surgical site infection, hernia recurrence, or seroma for­mation between a bridged repair or repair with fascial closure [31, 32]. Currently, in
2
[24].
26 Recurrent Ventral Hernia Repair
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365
the author’s practice, routine closure of the fascial defect is performed when techni­cally feasible.
One main limitation to laparoscopic hernia repair for recurrent hernias is defect size. Heniford et al. and Hauters et al. demonstrated that hernia defect size was associated with increased risk of recurrence after laparoscopic ventral hernia repair [20, 26]. Hauters etal. found that despite having more than 5cm overlap, when the mesh size to defect size ratio was less than 8, this was associated with a 70% risk of recurrence [26]. As defect size increases, laparoscopic bridge repair may result in mesh eventration, or pseudohernia occurrence, over time, which can be both dis­satisfying to patients and ineffective as a long-term repair. Although laparoscopic repair has been successful with defects that are larger, recurrence rates increase signicantly as the width of the hernia defect increases [26, 28]. While there is cur­rently no upper limit of defect size that can be approached laparoscopically, we currently recommend laparoscopic intraperitoneal onlay mesh repair for defects 7cm in greatest width.
Open Recurrent Ventral Hernia Repair
Factors that lead to multiply recurrent hernias often necessitate an open repair. For instance, patients with large or multiple defects, signicant intra-abdominal adhe­sions, or compromise of the overlying skin integrity may require open approach. Patients with recurrent hernias and chronically draining sinus tracts, infected mesh, or enterocutaneous stulas are frequently considered for staged open repairs in the authors’ practice, as the initial goal of the operation is typically source control for contamination and infection, with subsequent denitive abdominal wall reconstruc­tion once eradication of infection has been accomplished. There is some recent lit­erature to suggest that permanent synthetic mesh repair may be safe and effective in clean-contaminated and contaminated cases [33]; however, this has not yet been widely adopted as standard of care in the United States. Further studies are ongoing to determine the safety of permanent mesh repair in clean-contaminated and con­taminated elds. For patients undergoing denitive abdominal wall reconstruction, important preoperative considerations prior to attempted repair include location and type of mesh previously used and presence of concurrent chronically draining sinus tracts or enterocutaneous stulas as these will determine operative approach and mesh selection. When performing denitive reconstruction in clean-contaminated and contaminated cases, the authors use macroporous, midweight polypropylene mesh for repair.
The goal of an open ventral hernia repair, whether primary or recurrent, is to optimize patient factors, prepare the wound by taking down adhesions or stulas, reapproximate midline, and obtain adequate coverage with appropriate reinforce­ment [34]. Reapproximating the midline should be the goal when safe and feasible in repairing recurrent ventral hernias. Compared to a bridging technique, fascial closure has been shown to have a decreased risk of recurrence as well as surgical site occurrence when compared to bridging the defect [35, 36]. A review of the
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current open surgical procedures for incisional hernia showed that recurrence rates were not statistically different between the mesh placement in a sublay and onlay position; however, both methods were superior to a bridged or primary closure after component separation for giant hernia repairs [35]. In the practice of the authors, onlay mesh repair is generally reserved for small- to medium-sized defects and clean cases in nonobese, non-smoker, nondiabetic patients. In these cases, a modi­ed Chevrel approach, described by Stoikes etal., is preferred [37]. Bridged intra­peritoneal repair is not preferred because the mesh is exposed to both the intra-abdominal contents and the subcutaneous tissue as well as decreased abdomi­nal wall functionality due to the lack of restoration of normal abdominal wall anat­omy [36]. When performing a sublay repair, the authors prefer to place the mesh in a retrorectus position, which was initially described by Rives in 1973 [38]. This allows the mesh to be placed in a well-vascularized plane and increases mesh cover­age with muscle and soft tissue, which is protective against mesh infections.
To reapproximate the midline and restore the linea alba, a component separation is sometimes necessary. The rst components separation, external oblique release, was introduced by Ramirez etal. in 1990 as a method to perform functional transfer of muscular components of the abdominal wall to close large hernia defects [39]. Other approaches to component separation have been described, including endo­scopic, perforator sparing, and posterior. A well-known drawback of anterior com­ponent separation is the creation of large subcutaneous aps which have been shown to result in signicant wound morbidity [40, 41]. Still, this technique can be particu­larly useful when the hernia sac has dissected into the subcutaneous space, and the ventral surface of the rectus abdominis is therefore exposed, lending itself to approaching the external oblique muscle without additional wound morbidity.
Although the Rives-Stoppa repair is an effective method of herniorrhaphy for many situations, this technique may provide insufcient release in larger hernia defects [42, 43]. The Rives-Stoppa technique takes advantage of the space in the preperitoneal plane below the umbilicus. Dissection here allows for signicant mobilization and midline reapproximation but also creates a space capable of incor­porating a sizeable piece of mesh to provide adequate coverage of large ventral hernias [44]. In addition, posterior component separation with transversus abdomi­nis muscle release allows for even further advancement of the rectus fascia, pre­serves neurovascular innervation, and provides a space that will accommodate a sizeable piece of mesh [43]. The authors generally prefer to use a midweight bare polypropylene mesh for this repair. This technique is becoming increasingly popu­lar due to the ability to create a large space for adequate prosthetic coverage, a pre­viously unviolated anatomical plane even in multiply recurrent hernia repairs, as well as placing the mesh in the sublay position theoretically decreases risk of post­operative surgical site occurrence and infection. This technical approach to recur­rent ventral hernias has many technical advantages as the open approach facilitates adhesiolysis in complex abdomen, wound morbidity is not increased as with exter­nal oblique release, and the space created can accommodate an appropriately sized mesh for giant ventral hernias which helps to minimize recurrence, and it allows for placement of mesh in the sublay position [43, 45].
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Special Considerations
Contaminated Fields
As surgical site infections are a well-known factor associated with increased her­nia recurrence, it is likely that potential contamination will have to be managed when repairing a recurrent hernia [15, 20]. The type of reinforcement material utilized in these repairs must be carefully considered to minimize surgical site infection as well as repeat recurrence. Traditionally, biologic mesh was favored in contaminated situations due to the high incidence of postoperative wound morbid­ity. Recommendations from the Ventral Hernia Working Group suggest against synthetic mesh in both grade 3 (contamination of the wound or suspicion of con­tamination) or grade 4 (frankly infected wounds) as using biologic mesh in these situations does not require mesh resection even in the face of active infection [34]. Data in repair of grade 3 and 4 hernia repairs with biologic mesh demonstrates recurrence rates of approximately 12% and surgical site infection rates of 15–36% [46, 47]. There is data that supports the safety of using synthetic material in a contaminated eld. Lopez et al. evaluated placement of synthetic and biologic meshes in contaminated elds and saw no difference in surgical site infections (SSI) between the two groups but a 35% recurrence rate in situations when bio­logical cases were used compared to 8.3% when synthetic mesh was used [48]. Introduction of biosynthetic mesh provides another potential option in the repair of contaminated hernias. One example of biosynthetic mesh, Gore BioA, is com­posed of an absorbable copolymer that is gradually absorbed by the body in approximately 6–7months. A multicenter, prospective trial evaluated the use of this synthetic material in grade 2 and grade 3 [34] hernia repairs. Postoperative wound events occurred in 28% of patients, and recurrence occurred in 17% of repairs at 2years [49]. This represents a signicant decrease in surgical site occur­rence as well as hernia recurrence when compared to repair with non-cross-linked porcine dermis [ thetic mesh in contaminated elds, caution must be used in performing repairs with absorbable materials and should be saved for select circumstances. Additional biosynthetic meshes have subsequently been developed, however thus far there is insufcient literature available to comment on their performance in contaminated hernia repairs.
Multiple reinforcement techniques have been utilized for contaminated/grade 3 hernia repairs. In these situations, the choice of mesh is at the discretion of the sur­geon with knowledge that there is an increased likelihood of recurrence if biologic mesh is used [34, 47, 48, 50]. When performing recurrent ventral hernia repair in contaminated elds, it is necessary to be meticulous about decreasing infectious burden. This includes debridement and/or removal of infected skin and soft tissue and removal of all infected mesh. Primary repair with staged reconstruction once infectious burden is eradicated should be strongly considered. Use of prosthesis in repair should be carefully considered. Synthetic or biosynthetic mesh use in grade 3 hernia repairs is likely safe and has decreased recurrence rates without signicant
50]. Still, given the somewhat high recurrence rates using biosyn-
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