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360 G. Perdikaris, A. Pefanis, E. Giamarellou

antibiotic prophylaxis) did not show a decreased incidence in the group that was administered an antibiotic, we cannot recommend their administration. Some studies showed that the prophylactic administration of antibiotics resulted in fewer, noninfectious complications, such as trismus, pain, edema, and fibrinolytic alveolitis (dry socket). Even so, some of these studies presented methodological planning problems. Two recent reviews do not recommend routine prophylactic administration of antibiotics for surgical extraction of the impacted third molar, concluding that their administration is justified only in very difficult cases, for example when impaction is deep and a large amount of bone has to be removed. Also, according to the recommendations of the British Society for Antimicrobial Chemotherapy (1992) administration of prophylaxis is not recommended for this surgical procedure.

To conclude, it must be emphasized that the administration of antibiotics for a period greater than 24–

48 h after the operation is not considered prophylaxis but therapy. Indications for therapy are limited and include: (a) the presence of edema with pain or sensitivity that suggests cellulitis or an abscess that must absolutely be drained, (b) presence of trismus, unless it is secondary to postoperative edema, hematoma, trauma, (c) presence of purulent exudate, unless the cause was removed and the focal site of infection is far from the airway passages, (d) no improvement of symptoms

48 h later or worsening 36 h or more after surgical procedure, and (e) tachycardia (>100 beats per min) and fever (>38 °C). Fever is not necessarily a symptom of infection, especially in elderly people in whom severe infection may occur without fever.

In conclusion and according to recent data, prophylaxis with antibiotics is recommended for few dental procedures. In these limited cases the antibiotic must be administered shortly before the operation. A second dose is recommended only in the case of extensive and prolonged surgery.

16.3 Osteomyelitis

Osteomyelitis is a rare complication of odontogenic infections. In most cases it is the result of spread of infection from a dentoalveolar or periodontal abscess, or from the paranasal sinuses, by way of continuity through tissue spaces and planes. It occasionally occurs as a complication of jaw fractures, or as a result of abusive manipulations during surgical procedures. It is classified as acute or chronic osteomyelitis.

In the acute form, which, though rarely, may also be of hematogenous origin, the infection begins in the medullary cavity of the bone. The resulting increase of intrabony pressure leads to a decreased blood supply and spread of the infection, by way of the Haversian canals, to the cortical bone and periosteum. This aggravates the ischemia, resulting in necrosis of the bone. Predisposing factors include compromised host defenses due to compromised local blood supply (Paget’s disease, radiotherapy, bone malignancy, etc.), or systemic disease (e.g., alcoholism, diabetes mellitus, leukemia, AIDS, etc.), and infection from microorganisms with great virulence. In such cases even a periapical abscess may be implicated in osteomyelitis. The mandible, due to decreased vascularity, is involved 6 times more often than the maxilla. The main pathogens are streptococci, Klebsiella spp., Bacteroides spp., and other anaerobic bacteria. Piercing, deep, and constant pain predominates in the clinical presentation in adults, while low or moderate fever, cellulitis, lymphadenitis, or even trismus may also be noted. In the mandible, paresthesia or dysesthesia of the lower lip may accompany the disease. When the disease spreads to the periosteum and the surrounding soft tissues, a firm painful edema of the region is observed, while the tooth becomes loose and there is discharge of pus from the periodontium. Radiographic examination reveals osteolytic or radiolucent regions (Figs. 16.1, 16.2), which sometimes surround a portion of dense bone (sequestrum). Therapy entails combined surgical (incision, drainage, extraction of the tooth, and removal of sequestrum) and pharmaceutical treatment with antibiotics. Antibiotics must be administered intravenously, in large doses, for at least 3–4 days after the fever ceases. Treatment may then continue orally for another 2–4 weeks, depending on the extent of the disease, the causative pathogen, and the clinical response. The antibiotic of choice is penicillin (3 =106 units every 4 hours, i.v.), and in the case of allergy to penicillin, clindamycin is administered (600 mg every 6 h, i.v.). If staphylococcus or another

“difficult” to treat microorganism develops, consultation with an infectious diseases specialist is recommended. In the case of fracture of the mandible, which has occurred over 48 h previously, the possibility of osteomyelitis is great. The patient should be administered antibiotic therapy intravenously as soon as possible, particularly in cases of compound fractures of the mandible.

Chronic osteomyelitis is characterized by a clinical course lasting over a month. It may occur after the acute phase, or it may be a complication of odontogenic infection without a preceding acute phase. The clinical

Chapter 16 Prophylactic and Therapeutic Use of Antibiotics in Dentistry

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Fig. 16.1. Pathologic (spontaneous) fracture at premolar region of the right side of the mandible as a result of previous osteomyelitis

Fig. 16.2. Chronic osteomyelitis at the molar region and region of first premolar of the left side of the mandible

presentation is milder, with painful exacerbations and discharge of pus, or sinus tracts (Fig. 16.3). Diagnosis is often difficult to make, while scintigraphy with 99mTc helps to reveal latent sites. Generally treatment is the same as that for the acute form, but it lasts a much longer period of time. Hyperbaric oxygen has been used to successfully treat difficult cases. Squamous cell carcinoma is a remote complication of chronic osteomyelitis (incidence ranging from 0.2% to 1.5%).

16.3.1

Sclerosing Osteomyelitis

Other rarer types of osteomyelitis are the chronic focal and chronic diffuse sclerosing osteomyelitis.

The focal type represents an unusual bone reaction, with normal defense mechanisms, to an infection caused by microorganisms of low virulence. It occurs in persons under 20 years old with significant carious lesions, especially the first molar (Fig. 16.4). Either endodontic therapy or extraction of the tooth is required.

The diffuse form mainly occurs in elderly people, and is exhibited in edentulous areas of the mandible. The symptoms are mild, and include episodes of recurrent pain, edema, and/or trismus. Upon radiographic examination, depending on the phase of the disease, osteolytic or diffuse sclerosing zones at the posterior region of the mandible are observed.

Treatment consists of muscle relaxants, nonsteroidal anti-inflammatory drugs, antibiotics, diazepam, etc., though with questionable results.

Fig. 16.3. Cutaneous sinus secondary to osteomyelitis of the mandible

Fig. 16.4. Periapical radiograph of a case of chronic focal sclerosing osteomyelitis at apical region of the mandibular first molar

362 G. Perdikaris, A. Pefanis, E. Giamarellou

Fig. 16.5. Radiograph of a case of proliferative periostitis in a child, showing localized expansion of the periosteum (onion skin appearance) with peripheral reactive formation of bone

16.3.2

Proliferative Periostitis

Chronic osteomyelitis with proliferative periostitis, formerly known as Garré’s osteomyelitis, is characterized by the formation of new bone beneath the periosteum at the surface of the cortex, which covers an inflammatory area of spongiosa (Fig. 16.5). Common pathogens include staphylococci and streptococci. The lesion is seen in persons less than 30 years of age, usually children, and is characterized by nontender swelling at the inferior border of the mandible. The skin as well as the mucosa has a normal appearance.

Treatment consists of extraction of the tooth, while the administration of antibiotics is a subject of controversy. Remission of the lesion is expected within 2–6 months.

16.3.3 Osteoradionecrosis

Osteoradionecrosis is regarded as a severe disease that is observed after high radiation doses resulting in ischemia of the bone, which leads to necrosis in the case of infection. The cardinal cause of the disease is tooth extraction a short while after the radiotherapy, a period during which the body cannot achieve satisfactory healing. The clinical presentation includes odontalgia and rapid spread of the lesion to a large part of the bone.

Fig. 16.6. Clinical photograph showing actinomycosis. Note draining sinus tracts

Management consists of combined surgical and pharmaceutical treatment, while the use of hyperbaric oxygen is beneficial.

16.4 Actinomycosis

Actinomycosis is usually a chronic bacterial infection, caused by the Gram-positive, anaerobic bacteria Actinomyces israelii. This microorganism lies dormant in the oral cavity and may become activated under certain circumstances. Portals of entry include root canals of infected teeth, postextraction sockets, etc. A hard, slightly painful lesion characterizes the clinical presentation, with reddish overlying skin, on which sinus tracts are often observed (Fig. 16.6). Sulfur granules are found in the pus discharged from the sinus tracts, which are composed of colonies of the microorganism. Either the skin alone or the bone as well may be involved in the infection.

Treatment consists of surgical incision and drainage with excision of sinus tracts, and administration of penicillin for several months (up to a year), depending on the severity of the disease.

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