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Textbook for medical schools
Team of authors
Internal illnesses. Volume 1
"SpetsLit"
2015
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UDC 615 616
Team of authors
Internal illnesses. Volume 1 / Team of authors - "SpetsLit", 2015 - (Textbook for medical universities)
ISBN 978-5-299-00474-5
The textbook was written by leading specialists of therapeutic clinics of medical universities in St. Petersburg. The first volume of the publication is devoted to diseases of the cardiovascular and
digestive systems, diseases of the kidneys and respiratory organs. The second volume contains chapters that deal with diseases of the blood system, endocrine glands, systemic lesions of the connective tissue and joint diseases, immunodeficiencies, chronic fatigue syndrome, pharmacotherapy in geriatric practice, and allergic diseases. The presentation is built according to the traditional plan with a description of the etiology and pathogenesis, modern classification, clinical manifestations, methods for diagnosing and treating diseases of internal
organs. Each section provides examples of the formulation of diagnoses, describes the most common complications of diseases and methods for their prevention. The textbook complies with the program approved by
the Ministry of Health of the Russian Federation, and is intended for students of the 4
UDC 615 616
ISBN 978-5-299-00474-5 |
© Team of authors, |
|
2015 © SpecLit, 2015 |
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. The team of authors. "Internal illnesses. Volume 1"
Content
CONVENTIONAL ABBREVIATIONS |
7 |
FOREWORD Chapter 1 |
12 |
|
thirteen |
1.1. RISK FACTORS FOR CARDIOVASCULAR |
thirteen |
DISEASES |
|
1.2. ATHEROSCLEROSIS |
sixteen |
1.3. HYPERTENSION 1.4. ISCHEMIC |
28 |
HEART DISEASE 1.4.1. Angina pectoris (angina |
59 |
pectoris) 1.4.2. Myocardial infarction 1.5. |
60 |
INFECTIOUS ENDOCARDITIS 1.6. |
75 |
MYOCARDITIS 1.7. PERICARDITIS 1.8. HEART |
97 |
DEFECTS 1.8.1. Congenital heart defects 1.8.2. |
108 |
Acquired heart defects 1.9. CARDIOMYOPATHY |
116 |
1.9.1. Hypertrophic cardiomyopathy 1.9.2. |
124 |
Dilated cardiomyopathy 1.9.3. Restrictive |
124 |
cardiomyopathy 1.9.4. Arrhythmogenic |
129 |
dysplasia of the right ventricle 1.9.5. |
146 |
Unclassifiable cardiomyopathies 1.10. |
146 |
TUMORS OF THE HEART 1.10.1. Myxoma |
150 |
1.10.2. Non-myxomatous benign tumors |
153 |
1.10.3. Sarcomas 1.10.4. Secondary malignant tumors |
156 |
|
158 |
|
160 |
|
160 |
|
161 |
|
161 |
|
162 |
1.11. HEART FAILURE |
163 |
1.11.1. Acute heart failure 1.11.2. Pulmonary |
163 |
edema 1.11.3. Cardiogenic shock 1.11.4. |
163 |
Chronic heart failure |
166 |
|
170 |
1.12. HEART RHYTHM AND CONDUCTIVITY DISORDERS 1.12.1. |
198 |
Anatomy and physiology of the conduction system |
199 |
hearts. Mechanisms of formation of arrhythmias |
|
1.12.2. The main methods of examination of patients with |
200 |
arrhythmias |
|
1.12.3. Supraventricular arrhythmias |
205 |
1.12.4. Ventricular arrhythmias |
217 |
1.12.5. Violations of the function of the sinus |
227 |
node 1.12.6. Conduction disorders (blockade) of the |
231 |
heart 1.13. TREATMENT OF ARRHYTHMIAS QUESTIONS |
238 |
TESTS ANSWERS TO QUESTIONS ANSWERS TO TESTS |
247 |
|
249 |
|
254 |
|
256 |
4
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. The team of authors. "Internal illnesses. Volume 1" |
|
Chapter |
258 |
2 2.1. DEFECTS AND HEREDITARY |
258 |
CONDITIONED RESPIRATORY DISEASES |
|
2.1.1. Lung malformations 2.1.2. |
258 |
hereditary lung diseases |
261 |
2.2. ACUTE RESPIRATORY DISEASES 2.3. ACUTE |
267 |
BRONCHITIS 2.4. PNEUMONIA 2.5. CHRONIC BRONCHITIS |
271 |
2.6. PULMONARY EMPHYSEMA 2.7. BRONCHIAL |
274 |
ASTHMA 2.8. CHRONIC OBSTRUCTIVE PULMONARY |
286 |
DISEASE 2.9. BRONCHIOECTATIC DISEASE 2.10. |
297 |
INFECTIOUS DESTRUCTIONS OF THE LUNGS 2.11. |
299 |
DISEASES OF THE PLEURA |
318 |
|
327 |
|
333 |
|
341 |
2.11.1. Pleurisy |
341 |
2.11.2. Spontaneous pneumothorax |
355 |
2.12. SARCOIDOSIS OF THE RESPIRATORY |
360 |
ORGANS 2.13. INTERSTITIAL LUNG DISEASES 2.13.1. Idiopathic |
366 |
fibrosing alveolitis |
366 |
(Hammen-Rich disease) |
|
2.13.2. Exogenous allergic alveolitis |
371 |
2.14. PNEUMOCONIOSIS |
376 |
2.15. PULMONARY EMBOLISM |
384 |
2.16. LUNG CANCER TASKS |
392 |
TESTS ANSWERS TO TESTS |
401 |
ANSWERS TO TESTS Chapter 3 |
407 |
|
415 |
|
417 |
|
418 |
3.1. DISEASES OF THE ESOPHAGUS |
418 |
3.1.1. Gastroesophageal reflux disease 3.1.2. |
418 |
Achalasia of the cardia 3.1.3. Cancer of the |
427 |
esophagus 3.2. DISEASES OF THE STOMACH 3.2.1. |
429 |
Acute gastritis 3.2.2. Chronic gastritis 3.2.3. Peptic ulcer |
432 |
3.2.4. Cancer of the stomach 3.3. DISEASES OF THE |
432 |
SMALL INTESTINE 3.3.1. Malabsorption syndrome |
435 |
3.3.2. Celiac disease (gluten disease) 3.3.3. Whipple's |
446 |
disease 3.4. DISEASES OF THE COLON 3.4.1. |
474 |
Inflammatory bowel disease - ulcerative |
478 |
|
478 |
|
484 |
|
490 |
|
494 |
|
494 |
colitis and Crohn'sdisease |
|
3.4.2. Irritable bowel syndrome 3.4.3. colorectal |
503 |
cancer |
515 |
5
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. The team of authors. "Internal illnesses. Volume 1"
3.5. DISEASES OF THE LIVER AND BILIOLOGY |
519 |
WAYS |
|
3.5.1. Pigmentary hepatoses |
519 |
3.5.2. Fatty degeneration of the liver (the first stage of fatty |
522 |
liver disease) |
525 |
3.5.3. Chronic hepatitis 3.5.4. |
|
Cirrhosis of the liver 3.5.5. |
544 |
Idiopathic hemochromatosis 3.5.6. |
557 |
Liver tumors 3.5.7. Dysfunctional |
559 |
biliary disorders |
564 |
tract |
|
3.5.8. Gallstone disease 3.5.9. |
569 |
Postcholecystectomy syndrome 3.5.10. |
579 |
Chronic acalculous cholecystitis 3.5.11. |
581 |
Tumors of the biliary system 3.6. DISEASES |
582 |
OF THE PANCREAS 3.6.1. Chronic pancreatitis 3.6.2. |
586 |
Tumors of the pancreas QUESTIONS AND TESTS |
586 |
Chapter 4 4.1. CLASSIFICATION OF KIDNEY |
596 |
DISEASES 4.2. AMYLOIDOSIS 4.3. GLOMERULONEPHRITIS |
603 |
|
615 |
|
616 |
|
619 |
|
626 |
4.3.1. Acute endocapillary diffuse |
627 |
proliferative glomerulonephritis |
638 |
4.3.2. Chronic glomerulonephritis |
|
4.4. DIABETIC NEPHROPATHY 4.5. |
659 |
pyelonephritis 4.5.1. Acute pyelonephritis |
682 |
4.5.2. Chronic pyelonephritis 4.6. |
683 |
RENAL FAILURE |
686 |
|
694 |
4.6.1. Acute renal failure 4.6.2. Chronic |
694 |
renal failure QUESTIONS |
697 |
|
713 |
6
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. The team of authors. "Internal illnesses. Volume 1"
Internal illnesses. Volume 1
CONVENTIONAL ABBREVIATIONS
5-NAA - 5-nucleotidase
AAP - antiarrhythmic drugs AV - atrioventricular (th, - th, - th) AH - arterial hypertension AHA - antigliadin antibodies BP - blood pressure ADA - adenosine deaminase ADP - adenosine diphosphate AIH - autoimmune chronic hepatitis AK - calcium antagonists ACTH - associated clinical conditions ACTH - adrenocorticotropic hormone
ALG - antilymphocyte globulin ALT - alanine aminotransferase ANA - antinuclear antibodies ANF - antinuclear factor APTT - activated partial thromboplastin time ACE - angiotensin converting enzyme APC - antigen-presenting cells ARC - branched
chain amino acids AST - ROS aspartate – reactive oxygen species BA – bronchial asthma BAB – beta-adrenergic blockers BAS – biologically active substances CD – Crohn'sdisease LSD – basal acid production LBBB – left bundle branch block BM – basement membranes ARB – angiotensin II receptor blockers BTK – tyr blockers osine kinase BU - Whipple'sdisease VBCP - secondary biliary cirrhosis IBD - inflammatory bowel disease VIP - vasoactive intestinal peptide WHO - World Health Organization – hypertension GBM – glomerular basement membranes GGTP – gamma-glutamyl transpeptidase GC – glucocorticoids
7
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. The team of authors. "Internal illnesses. Volume 1"
GCS - glucocorticosteroids
GM-CSF - granulocyte-macrophage colony-stimulating factor GP receptors - glycoprotein receptors GPGA - glucocorticoid suppressed hyperaldosteronism dichlorodiphenyltrichloroethane DN – diabetic nephropathy DNA – deoxyribonucleic acid DPP – dipeptidyl peptidase VC – lung vital capacity GSD – cholelithiasis GIT – gastrointestinal tract VT – ventricular tachycardia ACE inhibitor – angiotensinconverting enzyme inhibitor CHD – coronary heart disease interstitial lung disease IC - immune complex ICD - implantable cardioverterdefibrillator, implantable cardioverter-defibrillator IL - see IL MI - myocardial infarction BMI - body mass index IMF - idiopathic PI - polycythemia vera PPI - proton pump inhibitors ISAH - isolated systolic arterial hypertension ELISA - idiopathic fibrosing alveolitis hormone CRC - colorectal cancer CSF - colony stimulating factors CT - computed tomography CPK - creatine phosphokinase KSh - coronary bypass grafting LAP - leucine aminopeptidase LH - luteinizing hormone LDH - lactate dehydrogenase HDL - high density lipoproteins LDL - low density lipoproteins VLDL - very low density lipoproteins
eight
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. The team of authors. "Internal illnesses. Volume 1"
LIPP - intermediate density lipoproteins MA - microalbuminuria MAC - membrane attack
complex UA - uric acid INR - international normalized ratio MRD - minimal residual
disease MPGN - membranous proliferative glomerulonephritis MP therapy - melphalan and
prednisolone therapy MRI - magnetic resonance imaging resonance cholangiopancreatography MS - metabolic syndrome NADP - nicotinamide dinucleotide phosphate NAFLD - non-alcoholic fatty liver disease NASH - non-alcoholic steatohepatitis LMWH - low molecular weight heparins NSAIDs - non-steroidal
anti-inflammatory drugs NES - lower esophageal sphincter NS - nephrotic syndrome UFH -
unfractionated heparin NERD - non-erosive reflux disease OAF - osteoclast activating factor OH - acute gastritis AGN - acute glomerulonephritis TL - total lung capacity OL - residual lung volume OB - lifestyle APGN - acute poststreptococcal glomerulonephritis AKI - acute renal failure t ARI - acute respiratory diseases FEV1 - forced expiratory volume in the first second PBCP - primary biliary cirrhosis of the liver PDF - fibrin degradation product PEP - end plate potential PNH - paroxysmal nocturnal hemoglobinuria POM - target organ damage PRL - prolactin PSV - peak expiratory flow PSM – sulfonylurea drugs PTH – parathyroid hormone PCT – polychemotherapy PCR
– polymerase chain reaction PET – positron emission tomography PAM – pathogen-associated molecular structures GC – gastric cancer RNHA – indirect hemagglutination reaction RNA – ribonucleic acid RP
– esophageal cancer RS-virus – respiratory -syncytial virus RSK - complement fixation reaction
nine
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. The team of authors. "Internal illnesses. Volume 1"
HI - hemagglutination inhibition reaction RE - reflux esophagitis SBP - systolic blood pressure DM - diabetes mellitus FFA - free fatty acids EFR - stimulated acid production GFR - glomerular filtration rate CM - malabsorption syndrome HF - heart failure ESR - erythrocyte sedimentation rate SR - sinus rhythm CRP
–C-reactive protein IBS – irritable bowel syndrome SSS – sick sinus syndrome SU
–sinus node FNA – fine needle aspiration biopsy TBCA – transluminal balloon coronary angioplasty TBM – tubular basement membranes TG – triglycerides TLT – thrombolytic therapy TNF – tumor necrotic factor TSH – thyroid-stimulating
hormone PE – pulmonary embolism Ultrasound – ultrasound EF – von Willebrand factor FVD – respiratory function FDC – follicular dendritic cell FC – functional class TNF-a (TNF-a) – tumor necrosis factor-á AF – atrial fibrillation FR – risk factor FSH - follicle stimulating hormone FEGDS - fibroesophagogastroduodenoscopy CKD - chronic kidney disease CG - chronic gastritis CGN - chronic glomerulonephritis CKD - chronic kidney disease CM - chylomicrons COPD - chronic obstructive pulmonary disease CP - chronic pancreatitis CPB - chronic kidney disease CKD - chronic renal failure cholesterol cAMP - cyclic adenosine monophosphate CNS - central nervous system RR - respiratory rate PR - pelvicalyceal complex HR - heart rate AP - alkaline phosphatase
ten