- •Pathophysiology tasks:
- •General doctrine of disease. Basic concepts of general pathology: norm, health. Definition by who. Disease.
- •Disease.
- •Conception of pathological process, pathological state, pathological reaction. Definition of typical pathological processes.
- •Typical pathological processes are the processes which are developed by similar laws, independently on reasons, localization, animals type and organism individual peculiarities.
- •Disease difference from health
- •3 Points of view:
- •Disease, biological and social factors are actual because human being is first of all social creature
- •4 Levels of diseases prescription:
- •5. Diseases classification principles:
- •8. Collapse. Comparative characteristics with shock. Aethiology and pathogenesis. Role of nervous and humoral mechanisms
- •9. Crash-syndrome -
- •10. Coma -
- •11. Informational aspects of cell injury. Pathology of signalization.
- •13. Programmed cell death (pcd)
- •3 Apoptosis phases:
- •14. Outcomes of apoptosis inhibiting and activation.
- •Classification.
- •4 Main types.
- •Classification.
- •16. The concept of primary and secondary alteration. Molecular mechanisms of cell injury. Lipid mechanisms role in alteration pathogenesis.
- •17. Free radicals and their role in pathological processes development.
- •19. Antioxidant mechanisms of cells. Antioxidant insufficiency.
- •19. Apoptosis and necrosis comparative characteristics.
- •20. Reactivity. Types. Dependence on sex.
- •23. Resistance. Passive and active resistance. Resistance and reactivity relationship.
- •25. Constitution, role in pathology, types classification.
- •26. Diatheses.
- •27. Stress, general adaptation syndrome.
- •28. Stress-inducing and stress-limiting systems. Diseases of adaptation.
- •29. Concept of “local microcirculatory disorders”. Some mechanisms.
- •30. Arterial hyperemia
- •2 Subtypes:
- •31. Venous hyperemia
- •32. Ishemia
- •33. Reperfusion syndrome
- •34. Stasis.
- •Variants:
- •35. Thrombosis and embolism. Thrombosis characteristics.
- •3 Main factors encouraging thrombi formation (Wirhow’s triad):
- •36. Embolism.
- •37. Embolism of pulmonary, systemic and portal circulation.
- •38. Microcirculation disorders typical forms:
- •39. Intravascular circulation disorders: rheological changings and changings of blood flow.
- •41. Microvascular tone disorders.
- •42. Extravascular disorders.
- •43. Concept of inflammation. Aethiology.
- •44. Inflammation stages, main signs and types.
- •Inflammation types (continuation).
- •45. Primary and secondary alteration.
- •46. Mediators and antimediators.
- •47. Circulatory changings during inflammation.
- •48. Fever aethiology. Pyrogens classification.
- •49. Fever stages. Fever reactions types.
- •50. Fever comparative characteristics with exogenous overheating and hyperthermia other forms.
- •50. Edemas. Classification. Oncotic and hydrostatic mechanism.
- •58. Anaemias. Erythrocytes regenerative and degenerative forms. Cells of pathological regeneration.
- •54. Anisocytosis, poikylocytosis, price-jonce’ curve movements on the right and on the left.
- •55. Blood loss.
- •56. Acute and chronic posthaemorrhagic anaemias.
- •57. Hereditary hemolytic anaemias.
- •3 Groups:
- •58. Acquired haemolytic anaemias.
- •59. Dyserythropoietic anaemias.
- •60. Aplastic and hypoplastic anaemias. Metaplastic anaemia. Myelophthysis.
- •2 Groups of factors:
- •2 Main pathogenetic mechanisms:
- •61. Cardiac arrhythmias.
- •62. Concept of arterial hypo- and hypertension.
- •63. Primary arterial hypertension.
- •2 Pathogenetical conceptions:
- •64. Secondary arterial hypertension.
- •65. Cardiac insufficiency.
- •2 Overloads types:
- •66.Heart failure myocardial form.
- •67. Coronary cirulation disorders. Reperfusion syndrome. Calcium paradox. Oxygen paradox.
- •68. Respiratory failure.
- •Probes which allow to determine one or another disorders type:
- •69. External respiratory failure. Dyspnea.
- •70. Hypoxies.
- •71. Appetite disturbance.
- •2 Main mechanisms:
- •72. Caries.
- •73. Periodontitis and parodontosis.
- •74. Hypo- and hypertonic gastric dyskinesias.
- •75. Heartburn, eructation, nausea, vomiting.
- •76. Hepatic failure. Classification. Functional hepatic tests.
- •77. Hepatic failure hepatic-vascular form.
- •78. Liver excretory function disorders. Jaundices. Liver functions
- •Proteinic exchange
- •Carbohydrates metabolism
- •Lipid metabolism
- •Pigment metabolism
- •Jaundices differentiated diagnosis
- •79. Haemolytic jaundice.
- •80. Hepato-cellular or parenchymatous jaundice.
- •81. Hepato-portal hypertension. Ascitis.
- •82. Urine amount qualitative and quantitative changings.
- •Urine relative density (weight) (in morning portion)
- •83. Urine pathological components. Protein
- •Leucocytes:
- •Cylinders
- •84. Proteinuria.
- •85. Renal acid-alkaline balance disorders
- •86. Adrenal glands pathology. Cortex acute and chronic insuffieiency.
- •87. Thyroid hypofunction.
- •88. Hypothyroidism.
- •89. General regularities in occurrence and development cns disorders. Pathological processes classification.
- •90. Pathological excitement and inhibiting in nervous centers.
- •I. Of pathological excitement:
- •II. Of pathological inhibiting:
- •91. Ephaptic effects.
- •92. Pain.
82. Urine amount qualitative and quantitative changings.
Diuresis – urine releasing for the time unit. One can differentiate several diuresis types:
for 24 hours;
daily (from 9.00 till 21.00);
night or nocturnal (from 21.00 till 9.00);
hour-long et al.
Daily diuresis correlation with night one is equal to 3:1. Urine quantity in morning portion is equal to 100…300 ml.
Anuria – (complete uroreleasing stoppage or when 24-houred diuresis is 0-100 ml):
unreal or postrenal, or excretory – obstacle existence to uroreleasing due to urinary ways obturation with stones, tumors, particularly prostatic adenoma; prerenal unreal anuria is delt with renal circulation disorders for example due to heart-vascular insufficiency;
real or secretory – kidneys uroreleasing injure due to acute renal insufficiency, hard acute glomerulonephritis forms.
Ishuria – uroreleasing lack when patient can not empty his urinary vesicle; this case can be observed particularly at spine injure, in unconscious state, at stress, problems in urinary vesicle, after surgical operations.
Nycturia – night diuresis dominance over daily one; it can be connected with enuresis, chronic renal insufficiency, heart activity disorders. Physiological nycturia can be present in children up to 3 years (term of ending spine lumbal and sacral parts maturation).
Pollakyuria – urination freaquening (more than 6 times in 24 hours). Usually it is accompanied by polyuria.
Dolakyuria – freaquent urination with small portions.
Dysuria – all urination disorders total designation.
Stranguria – painful urination.
Polyuria – state when urine quantity is more than 1800 ml/24 hour. Main reasons:
Liquids big quantities usage:
nervous excitement,
hypothalamus diseases.
Osmotic polyuria:
diabetes mellitus;
sodium chloridum excessive usage;
aminoacids excessive usage;
glucose excessive usage;
urea excessive usage;
mannite excessive usage;
parenteral feeding;
chronic renal insufficiency.
Diabetes unmellitus:
central – hypophysis diseases;
nephrogenic – kidneys diseases.
Nephropathy:
after narcosis;
pregnancy second half;
after courses (cleanings, menstrual bleedings);
primary alderosteronism;
hyperparathyreoidism.
At oedemas liquidation:
acute pyelonephritis;
chronic renal insufficiency.
At diuretics taking.
Paraproteinaemias:
amyloidosis;
sarcoidosis;
myelomic disease.
Renal artery stenosis.
Kidney transplantation.
Acute channel necrosis diuretic (polyuretic) phase.
Some drugs action results:
caffeine;
digitalis drugs;
ethanol;
acetylsalicylic acid;
lithium;
drugs with hypoglycaemic action.
Olyguria –urine 100-500 ml/24 hours:
1. Physiological:
drinking regimen limit;
excessive sweating in a hot weather.
2. Kidney diseases:
nephrites;
nephroses;
inflammatory processes in renal parenchyma.
3. Enforced liquid loss:
diarrhea;
vomiting;
bleeding;
spread burnings;
oedemas formation;
abdomen traumas;
intestinal obturation (impermeability).
4. Nephrotoxic substances action:
Pb;
As;
Vi;
ethylenglycol;
drugs.
5. Urine outflow injure:
stones;
tumor and others.
