- •Pathophysiology tasks:
- •General doctrine of disease. Basic concepts of general pathology: norm, health. Definition by who. Disease.
- •Disease.
- •Conception of pathological process, pathological state, pathological reaction. Definition of typical pathological processes.
- •Typical pathological processes are the processes which are developed by similar laws, independently on reasons, localization, animals type and organism individual peculiarities.
- •Disease difference from health
- •3 Points of view:
- •Disease, biological and social factors are actual because human being is first of all social creature
- •4 Levels of diseases prescription:
- •5. Diseases classification principles:
- •8. Collapse. Comparative characteristics with shock. Aethiology and pathogenesis. Role of nervous and humoral mechanisms
- •9. Crash-syndrome -
- •10. Coma -
- •11. Informational aspects of cell injury. Pathology of signalization.
- •13. Programmed cell death (pcd)
- •3 Apoptosis phases:
- •14. Outcomes of apoptosis inhibiting and activation.
- •Classification.
- •4 Main types.
- •Classification.
- •16. The concept of primary and secondary alteration. Molecular mechanisms of cell injury. Lipid mechanisms role in alteration pathogenesis.
- •17. Free radicals and their role in pathological processes development.
- •19. Antioxidant mechanisms of cells. Antioxidant insufficiency.
- •19. Apoptosis and necrosis comparative characteristics.
- •20. Reactivity. Types. Dependence on sex.
- •23. Resistance. Passive and active resistance. Resistance and reactivity relationship.
- •25. Constitution, role in pathology, types classification.
- •26. Diatheses.
- •27. Stress, general adaptation syndrome.
- •28. Stress-inducing and stress-limiting systems. Diseases of adaptation.
- •29. Concept of “local microcirculatory disorders”. Some mechanisms.
- •30. Arterial hyperemia
- •2 Subtypes:
- •31. Venous hyperemia
- •32. Ishemia
- •33. Reperfusion syndrome
- •34. Stasis.
- •Variants:
- •35. Thrombosis and embolism. Thrombosis characteristics.
- •3 Main factors encouraging thrombi formation (Wirhow’s triad):
- •36. Embolism.
- •37. Embolism of pulmonary, systemic and portal circulation.
- •38. Microcirculation disorders typical forms:
- •39. Intravascular circulation disorders: rheological changings and changings of blood flow.
- •41. Microvascular tone disorders.
- •42. Extravascular disorders.
- •43. Concept of inflammation. Aethiology.
- •44. Inflammation stages, main signs and types.
- •Inflammation types (continuation).
- •45. Primary and secondary alteration.
- •46. Mediators and antimediators.
- •47. Circulatory changings during inflammation.
- •48. Fever aethiology. Pyrogens classification.
- •49. Fever stages. Fever reactions types.
- •50. Fever comparative characteristics with exogenous overheating and hyperthermia other forms.
- •50. Edemas. Classification. Oncotic and hydrostatic mechanism.
- •58. Anaemias. Erythrocytes regenerative and degenerative forms. Cells of pathological regeneration.
- •54. Anisocytosis, poikylocytosis, price-jonce’ curve movements on the right and on the left.
- •55. Blood loss.
- •56. Acute and chronic posthaemorrhagic anaemias.
- •57. Hereditary hemolytic anaemias.
- •3 Groups:
- •58. Acquired haemolytic anaemias.
- •59. Dyserythropoietic anaemias.
- •60. Aplastic and hypoplastic anaemias. Metaplastic anaemia. Myelophthysis.
- •2 Groups of factors:
- •2 Main pathogenetic mechanisms:
- •61. Cardiac arrhythmias.
- •62. Concept of arterial hypo- and hypertension.
- •63. Primary arterial hypertension.
- •2 Pathogenetical conceptions:
- •64. Secondary arterial hypertension.
- •65. Cardiac insufficiency.
- •2 Overloads types:
- •66.Heart failure myocardial form.
- •67. Coronary cirulation disorders. Reperfusion syndrome. Calcium paradox. Oxygen paradox.
- •68. Respiratory failure.
- •Probes which allow to determine one or another disorders type:
- •69. External respiratory failure. Dyspnea.
- •70. Hypoxies.
- •71. Appetite disturbance.
- •2 Main mechanisms:
- •72. Caries.
- •73. Periodontitis and parodontosis.
- •74. Hypo- and hypertonic gastric dyskinesias.
- •75. Heartburn, eructation, nausea, vomiting.
- •76. Hepatic failure. Classification. Functional hepatic tests.
- •77. Hepatic failure hepatic-vascular form.
- •78. Liver excretory function disorders. Jaundices. Liver functions
- •Proteinic exchange
- •Carbohydrates metabolism
- •Lipid metabolism
- •Pigment metabolism
- •Jaundices differentiated diagnosis
- •79. Haemolytic jaundice.
- •80. Hepato-cellular or parenchymatous jaundice.
- •81. Hepato-portal hypertension. Ascitis.
- •82. Urine amount qualitative and quantitative changings.
- •Urine relative density (weight) (in morning portion)
- •83. Urine pathological components. Protein
- •Leucocytes:
- •Cylinders
- •84. Proteinuria.
- •85. Renal acid-alkaline balance disorders
- •86. Adrenal glands pathology. Cortex acute and chronic insuffieiency.
- •87. Thyroid hypofunction.
- •88. Hypothyroidism.
- •89. General regularities in occurrence and development cns disorders. Pathological processes classification.
- •90. Pathological excitement and inhibiting in nervous centers.
- •I. Of pathological excitement:
- •II. Of pathological inhibiting:
- •91. Ephaptic effects.
- •92. Pain.
61. Cardiac arrhythmias.
Cardiac arthythmias – disorders of rate, rhythm, co-ordination and consequences of heart contractions.
Classification:
Delt with automatism disorders:
nomotopic – impulses generation like under normal conditions occurs in sinus-atrial node:
sinus tachycardy – cardiac contractions rate increasing; R-R are shortened;
sinus bradycardy - cardiac contractions rate decreasing; R-R is prolonged;
sinus (respiratory) arrhythmia – tachypnoe in inspiration and bradypnoe in expiration; R-R are alternated;
heterotopic – sinus-atrial node weakening syndrome – pace-maker of Ist order is not sinus node but other structures of heart conductive system:
atrial slow rhythm – pace-maker is in left atrium, contractions rate is less than 70 beatings per 1 min;
atrio-ventriular rhythm – pace-maker is superior part (rate is 70-60), intermediate (60-50) or inferior part (50-40) of atrio-ventricular node;
idio-ventricular ventricular rhythm – Giss’ fascicle or its arms are pace-makers (contraction rate is less than 40 in 1 min).
Delt with excitability disturbances:
Extrasystols – additional contractions of all heart or only ventricles; such contractions names are extrasystols:
sinus – is appeared due to premature contractions of sinus-atrial node cells part; interval T-P is shortened;
atrial – ectopic excitement locus is in atria different parts; P is decreased, 2-phased, negative; T-P is prolonged (incomplete compensatory pause);
atrial-ventricular – at ectopic impulse occurrence in atrio-ventricular node; excitement wave is spread in 2 dimensions: in normal in ventricles and in retrograde (up from below) in atria; negative P can interfere with QRS; simultaneous atria and ventricles contractions also can take place;
ventricular – is characterized by complete compensatory pause after premature contraction;
allorhythmia – extrasystoles alternation with normal systolic cycles;
bigeminy – if one normal cycle and one extrasystole is alternated;
trigeminy – if 1 extrasystole is alternated with 2 normal cycles;
quadrigeminy – if 1 extrasystole is observed after 3 normal cycles.
Paroxysmal tachycardia – rapidly repeated extrasystols despite physiological rhythm; rate is 140-250 contractions per 1 min; fit duration is different:
a) atrial – is the mostly widely spread.
Connected with conductance disturbances:
blockades – arrhythmias caused by retardation or complete stoppage of impulses conduction through conductive system; possible reason is conductive easy injury:
intraatrial – at impulses distribution retardation through atrial conductive system; it is observed at mitral stenosis at left atrium dilation, more seldom at myocardial infarction, myocardites et al; P duration is increased more than 0,11 sec and P is decomposed (P-mitrale);
atrio-ventricular – impulses conduction is disturbed from atria to ventricles:
of Ist degree – is determined by impulses conduction retardation – interval P-Q is prolonged more than 0,20 sec;
of 2nd degree – periodically QRS-complexes disappearance due to impulses conductance progressive disorders from atria to ventricles; it is known as Samoilov-Venkebah’s periods – progressing interval P-Q increasing up to one of excitements (usually 8th or 10th) is not conducted; then P-Q is gradually restored and prolonged;
of 3rd degree – every second-third contraction is failed or on the contrary only they are conducted;
complete atrial-ventricular blockade – atria and ventricles are contracted independently one from another, every one - in its own rhythm: atria with 70, ventricles – about 35 contractions per 1 min (idio-ventricular rhythm);
intraventricular:
- one-fascicled blockades of Giss’ fascicle: of right arm – M-shaped dilated QRS more than 0,12 sec in V1-V2, seldom in III and aVF; of left arm – if such R is in V5-V6 (specialists must differentiate blockade of left anterior arm and left posterior arm);
2-fascisled blockades: of both rami of left arm; of right arm and left anterior ramus; of right arm and left posterior ramus;
3-fascicled: simultaneous blockade of all 3 rami of Giss’ fascicle at which complete a/v blockade is developed.
2) Impulses accelerated conductance – Wolf-Parkinson-Wite’s syndrom – premature ventricles contraction, P-Q size is decreased; reason – additional conductance ways (in mitral and tricuspidal rings – Paladino-Kent’s fascicle, between Giss’ fascicle superior part and ventricles – Mahaim’s fascicle, between atria and atrio-ventricular node inferior part or Giss’ fascicle – James’ fascicle).
Linked with excitability and conductance combined disorders:
1) Twinkled arrhythmia:
Atrial trembling (palpitation) – atria contraction rate is 250-400 per 1 min; main pathogenetic link is so-called re-entry mechanism when impulses are going round and round (often round cava veins and enter the heart; prognosis is more favourable comparatively to atrial fibrillation; EKG: frequent (250-350 in min) regular, similar atrial F-waves; non-changed ventricular QRS complexes (1 normal QRS after 2-3-4 F-waves).
Atria twinkling or fibrillation – impulses rate occuring in atria is 400-600 per 1 min; it is chaotic excitement without any order and atria muscular fibers separate groups contractions; such fibers are pathological impulsation origin; many ectopic focuses are generated in atrial myocardium; EKG: P-denses are absent; f-waves are registered in duration of all cardiac cycle; QRS complexes are not-changed but they are registered after different intervals (R-R are different); it is complication of such diseases as mitral stenosis, cardiosclerosis, thyreotoxicosis, myocardites, myocardial infarction; first fits are temporary, then they become constant;
Ventricles trembling – ventricles are contracted with rate equal to 150-300 per 1 min; sinusoid curve on EKG with frequent similar waves.
Ventricles twinkling (fibrillation) – impulses rate is 300-500 impulses in ventricles, heart is not contracted; none blood comes to aorta; different-shaped, with various altitude, chaotic and irregular waves, denses are not registered; electrical defibrillation should be applied.
