- •Mistchenko V.P., Tkachenko e.V. Normal physiology
- •Dear students!
- •Lecture 1 (Introductional) Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Excitory tissues physiology. Excitive tissues functionning general features.
- •Lecture 2 Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Muscular contractions regimes.
- •Smooth muscles functional classification:
- •Lecture 3 Nervous tissue physiology (receptors, nervous fibres, synapses).
- •2 Main receptors types:
- •Receptors features:
- •Lecture 4 Different cns levels role in motor acts regulation Spine role in motor acts regulation.
- •2 Spine functions:
- •Stem role in motor functions regulation.
- •Diencephalon
- •Brain reticular formation
- •Cerebellum
- •Basal ganglions.
- •Locomotion neuronal organization.
- •Motor functions regulatory levels:
- •Lecture 5 Autonomic nervous system physiology and its role in functions regulation.
- •Lecture 6. Physiological functions humoral regulation. Interrelations between nervous and humoral mechanisms of physiological functions regulation in organism.
- •Hormones synthesis, secretion and releasing.
- •Interrelations between nervous and humoral mechanisms in physiological functions regulation.
- •Lecture 7. Sensor systems physiology (analizators and their significance for organism interrelations with surrounding external and internal environment).
- •Auditory analizator.
- •Conduction of sound from the tympanic membrane to the cochlea
- •The basilar membrane and resonance in the cochlea
- •Transmission of sound waves in the cochlea - the “travelling waves”
- •Corti organ functions
- •The auditory pathway
- •Visual analizator
- •Image formation on the retina
- •The visual pathways
- •Olfactory (smell) analizator
- •2 Main theories of smell:
- •Lecture 8 Organism integrative activity and behavioral physiological bases (the higher nervous activity, behavioral congenital and acquired forms, memory, thinking and speech).
- •Hereditary behaviour forms
- •Instincts organization
- •Acquired behavioural forms
- •Lecture 9. Human higher nervous activity peculiarities (emotions, motivations, the highest nervous activity types)
- •Stress and anger
- •Lecture 10 Waking state, sleep, dream and hypnosis.
- •Lecture 11. Blood circulation system. Heart physiology (cardiac activity phases, heart tones, electrocardiogram).
- •Complex p – atrial.
- •Lecture 12.
- •Vessels physiology. Blood pressure. Pulse. Capillary and venous circulation. Lymphatic supply. Functional vessels classification:
- •Vessels activity main indexes:
- •Pulse clinical characteristics main indexes:
- •Capillary circulation and its peculiarities
- •Venous circulation
- •3 Phlebogram waves:
- •Lymphatic circulation
- •Lecture 13 Blood circulation regulation. Heart-vascular regulation center. Blood circulation nervous and humoral regulation. Blood circulation regulation distinguishing features in separate organs.
- •Humoral-chemical regulation
- •Circulation regulation peculiarities in separate organs
- •Circulation in heart
- •Circulation in brain
- •Blood circulation in lungs
- •Lecture 14 Blood physiology – blood functions. Blood physico-chemical peculiarities. Erythrocytes and erythropoiesis.
- •Main blood functions:
- •Blood physical-chemical peculiarities and constants.
- •Erythrocytes Er (red blood cells rbc)
- •1. According to causative agent action:
- •2. According to localization:
- •Erythrocytes functions:
- •Erythropoiesis and its regulation.
- •Neural-humoral erythropoiesis regulation
- •Lecture 15. Protective blood functions connected with leucocytes. Blood groups.
- •Leucocytic formula:
- •Crossings.
- •Separate leucocytes physiology.
- •Leucopoiesis regulation.
- •Blood groups.
- •Lecture 16. Platelets (thrombocytes) physiology. Haemostasis (vascular-platelet and coagulational).
- •Platelets functions:
- •Thrombocytopoiesis regulation
- •Plasmatic blood coagulation factors.
- •Lecture 17. Anticoagulants and fibrinolysis.
- •Lecture 18.
- •Vascular-platelet haemostasis, blood coagulation and fibrinolysis regulation.
- •Lecture 19. Respiration physiology. External respiration. Gas transition and transfer by blood.
- •Oxygen transport.
- •Oxygen transfer conditions
- •Oxyhaemoglobine dissociation curve moving:
- •Carbon dioxide transport
- •Carbon dioxide forms
- •Lecture 20. Respiration regulation.
- •2) Reflexes from respiratory musculature proprioreceptors:
- •Lecture 21. Modern human being feeding (new approaches to the problem).
- •Modern feeding in childhood.
- •Lecture 22 Digestion, its types and functions. Oral cavity role in digestion.
- •Alimentary tract main functions:
- •Lecture 23 Digestion in stomach
- •Stomach secretion regulating
- •Lecture 24. Digestion in intestine. Absorbtion in alimentary tract.
- •Digestion in large intestine.
- •Lecture 25. Hunger, appetite and satiation state. Substance and energy exchange, thermoregulation.
- •Lecture 26. Excretion (separate organs and systems role). Kidneys functions.
- •Lecture 27 (Final). Healthy life style physiological bases.
- •In conclusion, telling “Good-bye” to you we would like to wish you following:
- •Content.
- •Lecture 1 (Introductional). Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Lecture 2. Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Lecture 3. Nervous tissue physiology (receptors, nervous fibres, synapses).
Stress and anger
Every day you read in newspapers, books and magazines that it is important to avoid stress. Stress can kill, they say. Stay calm. Be relaxed. Slow down. Don’t worry so much and don’t work so hard. Unfortunately, this is difficult. There are always many problems in our everyday life. Our cities are full of traffic and noise. Stressful situations seem to be everywhere.
When people are under stress they react in different ways. Signs of stress you can quickly recognize include poor sleep, over-eating or drinking, repetitive mannerism like nail-biting or pencil-tapping. Some people find it difficult to stay calm and often become tense. Little things, like a baby crying, can make them irritated. They get very annoyed if they have to wait just a few minutes too long – in a shop, stop or restaurant. These people are usually very moody. One minute they are fine and the next they can be really angry- absolutely furious. Other people seem to stay calm almost all the time, and rarely get angry. For example, if they are caught in bad traffic, they don’t get frustrated. They sit calmly in their cars, telling themselves that there is nothing they can do about the situation. These people are not moody at all. They don’t change from moment to moment, but always seem to be in control of their emotions.
Some doctors give names to these 2 personality types. Type A people and type B people. Type A people work very hard, worry a lot and are often bad-tempered. Type B people are the opposite. They don’t worry. Work is not so important to them and they don’t get angry easily. They like to relax a lot and have fun. These doctors say it is better for your health and your heart if you are a type B person.
Stress can be alleviated by mental discipline, conscious relaxation and the right kind of food. First of all, it’s necessary to try to get rid of the feeling of worry that often make us tense. Before going to bed, aid to empty your mind of worries. Take paper and pencil and dreg them out into the open, writing down every nag in your mind. Having written them down, study them carefully. Can you do anything about this one, for example? No? Then take your pencil and strike it out. The very act of putting your pencil through it will get it off your mind. This worries now? You can do something about that!
Well, write down just what you can do and resolve to do it on such and such a date. Do this every night, clearing your mind of worried feelings and watch your stress symptoms disappear.
Stress stages:
adaptive – it increases organism internal reserves and we can perform one kind of work;
sthenic negative- with tension growth in course of activity all organism reserves are used and “vegetative storm” occurs – blood pressure and heart beats increasing, fury et al.
asthenic negative- energetic and intellectual abilities are inhibited leading to fear, horror, boredom, anguish;
neurosis- highest nervous activity disruption and diseases possible development.
How to be at emotional tension development and not to lead youself to the 3rd and moreover to its 4th stage? The best discharging – physical loading, communication with interesting people, sometimes – falling in love.
“Emotional” brain:
reticular formation;
hypothalamus;
limbic system;
cortex.
One can tell about emotional hemispheres asymmetry. Temporary left hemisphere switching off (in everyday life and in clinics) is accompanied by movement towards negative emotions (bad mood, pessimism); right one – good mood, irresponsibility, complacency, carelessness. Thus, right hemisphere is responsible for negative emotions, left one – for positive. Interhemispherical interrelations are usually disturbed at shizophrenia, maniac-depressive psychosis, brain traumas. There exists so-called lateral therapy which allows to release suffering of such patients by selective switching injured hemisphere off and thus by changing the profile of their interhemispherical asymmetry.
Sense organs are significant for emotions formation. First place has vision organ (up to 90 per cent of all emotional states are connected with it), then auditory organ and others. Vision gives us the presentation about colour, environment changings and subjects dysposition. It provides corresponding emotional state to us (red colour- excitement; blue – grief). Remember your state when sun is shining or it is raining. Hearing – high sounds excite, low- cause fear, monotonous – inhibit all the emotions; rock-music intensive hearing leads to mental abilities decreasing; classical one – one the contrary; it also may be used at different diseases (music-therapy, art-therapy). Smell also forms different emotional states (for example, smell of chocolate increases immunity, stinking or smelly – decrease it). It is well-known that 40 minutes of everyday listenting to the lovely music is a brilliant anti-stressful therapy.
Emotions are essential for work reproductiveness. Positive emotions and sthenic part of negative emotions increase it; negative emotions in their asthenic stage – decrease it.
There are interrelations between emotional state and morbidity. Fear emotions cause heart diseases, wrath – liver, anguish – stomach.
Keeping healthy life style, we create all conditions for emotional tension relaxing.
Emotions depend on individual (typologic) subject features. People under one and same situations have different behaviour. But one can differentiate common behaviour schemas or types despite all multiple reactions.
This phenomenon was seen long long ago. It was the base of Greek medicine according to which there were 4 elements (air, water, fire and earth) or matters (blood, lymph, bile and black bile). Combination of them determines temperamentum of behaviour. Theses data were the base of Hippocrate’s temperaments classification. He considers that human availability level depends on correlation of all these liquids (fluids) in organism. These fluids mixture (taking into account translating from Greek into Latin the word “mixture” sounds as “temperamentum”) and defines individual peculiariry of any person. According to this learning, one can differentiate:
sanguine person – with blood (sanguis predominance in this mixture);
choleric – with bile (chole) predominance in this mixture;
melancholic – with black bile (chole) predominance in this mixture;
phlegmatic- with mucus (phlegma) predominance in this mixture.
These names are actual till nowadays.
I.P.Pavlov (1910-1935) connects temperamentum’s types with such nervous system features as force, stediness and motility. People are divided into strong and weak types according to force. Strong type – acts to the irritation according to the law of force interrelations; weak – doesn’t act according to it. According to steadiness – steady and unsteady. Steady – person in which excitement and inhibition processes are equal (in equillibrium). Unsteady – if excitement process predominates over inhibition. According to motility – agile and inert (sluggish). Agile type – excitement and inhibition processes changing occurs quickly. Inert type – if inhibition is predominant comparatively to excitement.
According to these data next combinations were done:
Sanguine person – strong, steady, agile.
Choleric – strong, unsteady, agile.
Phlegmatic – strong, steady, inert.
Melancholic – weak type.
One can also differentiate properly human types of the highest nervous activity:
Artist – first sygnal system (and right brain hemisphere) is dominant.
Mental – second sygnal system (and left brain hemisphere) is dominant.
Mixed – without any dominance.
There are many new classifications during last years:
Extraverts: people with orientation to environment – sanguine person (stable) and choleric (unstable).
Intraverts: people with orientation to their internal world – phlegmatic (stable) and melancholic (unstable).
Of course, to determine human type finally is rather difficult. Moreover, every human being, depending on the situation, can express the features of all mentioned 4 types. In addition, every person in course of his or her life comes through age and temperamentum periods: childdhood – sanguine person, adolescence – melancholic, adulthood – choleric, elderness – phlegmatic. Children can express individual typologic peculiarities from 6 months of their life but especially brightly in 5-6 years. Children are different according to excitement and inhibiting processes force, steadiness and motility signs. But they are changed in course of human ageing. One can see similar regularity due to seasons changing: spring - choleric, summer – melancholic, autumn – sanguine person, winter – phlegmatic. Human biorhythms are also essential for this. Our behaviour depends on biorhythms in big extent. Biorhythms – are harmony, phenomena periodically repeated. Biorhythms types:
High-freaquened – from msec till 30 min:
breathing,
heart activity et al.
Middle-freaquened:
ultradian – up to 20 hours;
circadian – 20-28 hours;
infradian – more than 28 hours;
circaseptan – up to 7 days.
Examples:
sleep and waking state;
metabolism changes near 24 hours;
hormonal changes near 24 hours et al.
Low-freaquened- up to months, years:
seasonal;
year;
sunny et al.
There are several important terms in medicine delt with biorhythms – chronogram and chronotherapy. Organism, its separate organs and systems activity chronogram is essential at patients diagnosis. Chronotherapy should be taken into account at medicines application.
Learning about highest nervous activity types is very important for doctor from different aspects. At diagnosis statement, patients location in a ward, therapy. But it is also of great significance in other spheres of our life: marriage, people groups creation, interrelation head-subordinate and so on.
