- •Mistchenko V.P., Tkachenko e.V. Normal physiology
- •Dear students!
- •Lecture 1 (Introductional) Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Excitory tissues physiology. Excitive tissues functionning general features.
- •Lecture 2 Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Muscular contractions regimes.
- •Smooth muscles functional classification:
- •Lecture 3 Nervous tissue physiology (receptors, nervous fibres, synapses).
- •2 Main receptors types:
- •Receptors features:
- •Lecture 4 Different cns levels role in motor acts regulation Spine role in motor acts regulation.
- •2 Spine functions:
- •Stem role in motor functions regulation.
- •Diencephalon
- •Brain reticular formation
- •Cerebellum
- •Basal ganglions.
- •Locomotion neuronal organization.
- •Motor functions regulatory levels:
- •Lecture 5 Autonomic nervous system physiology and its role in functions regulation.
- •Lecture 6. Physiological functions humoral regulation. Interrelations between nervous and humoral mechanisms of physiological functions regulation in organism.
- •Hormones synthesis, secretion and releasing.
- •Interrelations between nervous and humoral mechanisms in physiological functions regulation.
- •Lecture 7. Sensor systems physiology (analizators and their significance for organism interrelations with surrounding external and internal environment).
- •Auditory analizator.
- •Conduction of sound from the tympanic membrane to the cochlea
- •The basilar membrane and resonance in the cochlea
- •Transmission of sound waves in the cochlea - the “travelling waves”
- •Corti organ functions
- •The auditory pathway
- •Visual analizator
- •Image formation on the retina
- •The visual pathways
- •Olfactory (smell) analizator
- •2 Main theories of smell:
- •Lecture 8 Organism integrative activity and behavioral physiological bases (the higher nervous activity, behavioral congenital and acquired forms, memory, thinking and speech).
- •Hereditary behaviour forms
- •Instincts organization
- •Acquired behavioural forms
- •Lecture 9. Human higher nervous activity peculiarities (emotions, motivations, the highest nervous activity types)
- •Stress and anger
- •Lecture 10 Waking state, sleep, dream and hypnosis.
- •Lecture 11. Blood circulation system. Heart physiology (cardiac activity phases, heart tones, electrocardiogram).
- •Complex p – atrial.
- •Lecture 12.
- •Vessels physiology. Blood pressure. Pulse. Capillary and venous circulation. Lymphatic supply. Functional vessels classification:
- •Vessels activity main indexes:
- •Pulse clinical characteristics main indexes:
- •Capillary circulation and its peculiarities
- •Venous circulation
- •3 Phlebogram waves:
- •Lymphatic circulation
- •Lecture 13 Blood circulation regulation. Heart-vascular regulation center. Blood circulation nervous and humoral regulation. Blood circulation regulation distinguishing features in separate organs.
- •Humoral-chemical regulation
- •Circulation regulation peculiarities in separate organs
- •Circulation in heart
- •Circulation in brain
- •Blood circulation in lungs
- •Lecture 14 Blood physiology – blood functions. Blood physico-chemical peculiarities. Erythrocytes and erythropoiesis.
- •Main blood functions:
- •Blood physical-chemical peculiarities and constants.
- •Erythrocytes Er (red blood cells rbc)
- •1. According to causative agent action:
- •2. According to localization:
- •Erythrocytes functions:
- •Erythropoiesis and its regulation.
- •Neural-humoral erythropoiesis regulation
- •Lecture 15. Protective blood functions connected with leucocytes. Blood groups.
- •Leucocytic formula:
- •Crossings.
- •Separate leucocytes physiology.
- •Leucopoiesis regulation.
- •Blood groups.
- •Lecture 16. Platelets (thrombocytes) physiology. Haemostasis (vascular-platelet and coagulational).
- •Platelets functions:
- •Thrombocytopoiesis regulation
- •Plasmatic blood coagulation factors.
- •Lecture 17. Anticoagulants and fibrinolysis.
- •Lecture 18.
- •Vascular-platelet haemostasis, blood coagulation and fibrinolysis regulation.
- •Lecture 19. Respiration physiology. External respiration. Gas transition and transfer by blood.
- •Oxygen transport.
- •Oxygen transfer conditions
- •Oxyhaemoglobine dissociation curve moving:
- •Carbon dioxide transport
- •Carbon dioxide forms
- •Lecture 20. Respiration regulation.
- •2) Reflexes from respiratory musculature proprioreceptors:
- •Lecture 21. Modern human being feeding (new approaches to the problem).
- •Modern feeding in childhood.
- •Lecture 22 Digestion, its types and functions. Oral cavity role in digestion.
- •Alimentary tract main functions:
- •Lecture 23 Digestion in stomach
- •Stomach secretion regulating
- •Lecture 24. Digestion in intestine. Absorbtion in alimentary tract.
- •Digestion in large intestine.
- •Lecture 25. Hunger, appetite and satiation state. Substance and energy exchange, thermoregulation.
- •Lecture 26. Excretion (separate organs and systems role). Kidneys functions.
- •Lecture 27 (Final). Healthy life style physiological bases.
- •In conclusion, telling “Good-bye” to you we would like to wish you following:
- •Content.
- •Lecture 1 (Introductional). Physiology as a science. Physiological investigations methods. Physiology chapters. Excitive tissues physiology.
- •Lecture 2. Muscular tissue physiology: sceletal, smooth and cardiac muscles activity distinguishing features.
- •Lecture 3. Nervous tissue physiology (receptors, nervous fibres, synapses).
Visual analizator
Vision organ is eye.
Eyeball levels:
fibrous layer;
vascular pigmented layer;
retina.
Fibrous layer:
sclera: posterior 5/6th opaque part – it protects eyeball;
cornea: anterior 1/6th transparent part - it allows light to enter eyeball.
Vascular pigmented layer:
chroroid: made up of outer pigmented and inner vascular layers;
ciliary body: made up of ciliary ring, ciliary processes and ciliary muscle;
iris: it is a contractile and pigmented diaphragm with central aperture, i.e. pupil – it controls size of pupil.
Retina
It is the light sensitive area of the eye.
Eyeball content:
Aqueous humour – it is a clear watery fluid that fills anterior and posterior chambers (both in front of lens). Secreted by ciliary processes.
Functions:
maintains intra-ocular pressure;
maintains eyeball shape;
it acts as refractory medium;
it supplies nutrition;
it drains metabolic end-products.
Crystalline lens – it is a transparent, elastic and biconvex lens.
Function:
It refracts light and focuses it exactly on retina.
Vitreous Body- it is a transparent gel enclosed by vitreous membrane. It fills eyeball behind lens.
Functions:
contributes to magnifying power of lens;
supports posterior surface of lens;
assists in holding neutral part of retina against pigmented part of retina.
Anterior and posterior chambers of eye
Anterior - space between cornea and iris.
Posterior- space between iris and lens.
Both chambers are filled with aqueous liquor.
Lens refractive power – lens ability to bend right rays. The more a lens bends light rays, the greater is its refractive power. This refractive power is measured in terms of diopter. Refractive power of eye lens – 15 diopters.
Image formation on the retina
In exactly the same manner that a glass lens can focus an image on a sheet of paper, the lens system of an eye can focus an image on the retina. The image is inverted and reversed with respect to the object. However, the mind perceives objects in the upright position despite the upside-down orientation on the retina because the brain is trained to consider an inverted image as the normal.
Accomodation – is eye lens adjustment for various distances.
Parasympathetic control of accomodation – the ciliary muscle is controlled almost entirely by the parasympathetic nervous system. Stimulation of the PNS contracts the ciliary muscle which relaxes the lens ligaments and increases the refractive power. With an increased refractive power the eye is capable for focusing an object nearer at hand than when the eye has less refractive power. Consequently, as a distant object moves toward the eye, the number of parasympathetic impulses on the ciliary muscle must be progressively increased for the eye to keep the object constanly in focus.
Sympathetic control. Sympathetic stimulation has a weak effect in relaxing the ciliary muscle, but this plays almost the role in the normal accomodation mechanism.
Visual acuity – is ability of human eye to discriminate between point sources of light. Normal clinical value: 20/20, that is, test chart is at 20 feet and person can see those letters clearly which he should normally be able to see at 20 feet.
Retina – is the light-sensitive portion of the eye, containing the cones, which are responsible for colour vision, and the rods, which are mainly responsible for vision in the dark. When the rods and cones are excited, signals are transmitted through successive neurons in the retina itself and finally into the optic nerve fibers and cerebral cortex.
Functions:
Vision – due to rods and cones presence, retina is responsible for photopic and scotopic vision.
Reflexes –concerned with light and accomodation reflexes.
Tone, posture and equillibrium.
Retinal impulses help to maintain tone, posture and equillibrium.
Rods and cones are photoreceptors.
Functions:
Rods are responsible for dark vision.
Cones are responsible for colour vision or daytime vision.
Photochemicals – these are light-sensitive chemicals that decompose on exposure to light and excite nerve fibers leading from eye.
Rhodopsin- photochemical present in rods. Composed of scotopsin plus 11-cis-retinal.
Iodopsin – photochemical present in cones. Composed of photopsin plus 11-cis-retinal.
Photopic vision – colour-vision or day light vision is called photopic vision.
Scotopic vision – night vision (or black and white vision).
When a person is in dark, scotopsin combines with 11-cis-retinal (derived from vitamine A) and forms rhodopsin that causes depolarization of sensory receptors which in turn excites optic nerve so the person is able to see in dark.
As soon as person comes in the light the rhodopsin splits into scotopsin and all-transretinal causing hyperpolarization which causes decreased excitation of optic nerve.
Protanopia (red blindness) – is observed due to missing of red cones.
Deuteranopia (green blindness)- due to green cones missing.
Tritanopia (due to blue cones missing).
