LOcal anestetics, adsorbing, covering, irritative drugs

1. Agents, affecting the afferent innervation

1. A driver felt sharp pain in the eye. He was delivered to the hospital. What local anesthetic may be applied for removal of a foreign body from the eye?

A.* Dicainum

B. Novocainum

C. Lidocainum

D. Trimecainum

E. Sovcainum

2. As a result of the influence of terminal anesthesia which part of the skin and mucus membranes are affected.

A. * Sensory nerve endings

B. Epiderm

C. Subcutaneous fatty tissue

D. Walls of capillaries

E. Dermis

3. Indicate the principle of action of covering drugs.

A. *Creation of protective layer on the mucous membranes.

B. Blockade of mucous membranes receptors.

C. Coagulation of proteins of superficial layer of mucous membrane.

D. Formation of complexes with toxic agents.

E. Stimulation of regenerative processes.

4. Indicate the mechanism of action of local anesthetics.

A. *Block sodium channels.

B. Create albuminates with plasma proteins

C. Block M-cholinoreceptors

D. Inhibit nonspecific activating systems of the CNS.

E. Block alpha adrenoreceptors.

5. Why not used Novocaine is terminal anesthesia?

A. *Is poorly absorbed through normal skin surface and mucous membrane

B. Doesn't cause covering action.

C. Is rapidly absorbed and inhibits the CNS.

D. Irritates mucous membrane.

E. Activates m-cholinoreceptors.

6. Indicate main effect of the local anesthetics.

A. *Eliminate all kinds of sensibility due to blockade of action potential creation

B. Selective relieve ot pain sensibility in local action.

C. Decrease of excitability of nerve endings

D. Decrease of excitability and conductivity of the afferent

E. Eliminates all kinds of sensibility due to paralysis of the CNS.

7. Indicate the mechanism of action of local anesthetics.

A. *Blockade of Na-channels

B. Formation of albuminates with tissue’s proteins

C. Blockade of M-cholinoceptors

D. Inhibition of non-specific excitatory systems of CNS

E. Blockade ot alfa-adrenoceptors

8. What morphological elements of skin and mucous membranes are involved in interaction with the drug in terminal anesthesia?

A. *Sensitive nervous endings

B. Epidermis

C. Fatty tissue

D. Capillary wall

E. Derma

9. The patient needs an operation on soft palate. What method of anesthesia is the most appropriate?

A. *Infiltrative anesthesia

B. Local cooling

C. Conductive anesthesia

D. General anesthesia

E. Psychotherapy

10. The patient needs Vishnevsky paranephric blockade. What concentra­tion of novocainum (procaine) solution should to be used?

A. *0,25-0,5%

В. 1-2%

C. 2-4%

D. 4-5%

E. 0.5-1%

11. What drugs from the group of local anesthetics are not used together with sulfonamides?

A. *Novocainum (procaine)

B. Sovcainum

C. Lidocaine

D. Trimecaine

E. Ultracaine

12. Determine the drug which is used for all type of anesthesia.

A. *Lidocaine

B. Anesthesinum (benzocaine)

C. Novocainum (procaine)

D. Trimecaine

E. Dicainum (tetracaine)

13. Injection of a local anesthetic has to be given to a patient for tooth extraction. What drug from listed below is to be chosen?

A. *Lidocaine

B. Dicainum (tetracaine)

C. Anesthezinum (benzocaine)

D. Cocaine

E. Ketamine

14. This agent is poorly soluble in water, so it is used for superficial anesthesia only in the form of ointment, paste and powder. What is this drug?

A. *Anesthezinum (benzocaine)

B. Novocainum (procaine)

C. Pyromecaine

D. Trimecaine

E Sovcainum

15. What drug has to be added to lidocaine solution to prolong its action?

A. *Adrenaline

B. Coffeinum

C. Analginum (methamizole)

D. Atropine

E. Anaprilinum (propranolol)

16. What is the mechanism of anti-inflammatory action of astringent drugs?

A. *They form albumin film which decreases irritation of receptors

B. They inhibit excitability of membrane of the nerve fibers

C. They are able to form colloid solutions

D. They block prostaglandine synthase

E. They inhibit phosphorylase

17. What is the mechanism of action of covering drugs?

A. Blockade of receptors of mucous membrane

B. Coagulation of proteins of superficial layer of mucous membrane

C. Binding to toxic substances with complexes formation

D. *Formation of protective layer on mucous membranes

E. Stimulation of regenrative processes

18. What is the main indication for adsorbing drugs use?

A. *Intoxication

B. Hvpoacidic gastritis

C. Decrease in trypsin activity

D. Decrease in bile secretion

E. Diarrhea

19. A nurse used mustard plaster with water of more than 60oC temperature and applied it on patient's back. In 30 minutes she found that patient's skin under the (sinapism, mustard poultice) mustard plaster did not get red. What is the reason for absence of (sinapism, mustard poultice) mustard plaster effect?

A. *Inactivation of mirosine

B. Inactivation of choline estherase

C. Activation of mirosine

D. Inactivation of monoaminooxydase

E. Activation of methyltranspherase