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Examples of Krok 1 tests

88. By consumption of fresh milk in kid developed disorders of digestive tract. Consumption of other sugar-containing food-stuffs did not cause similar disorders. Genetically determined insufficiency of what enzyme can be considered in this case?

  1. Lactase

  2. Phosphoglucomutase

  3. Glycogen synthetase

  4. Hexokinase

  5. Glucose-6 phosphate isomerase

89. In a patient was detected disorder in digestion of protein in stomach and small intestines. What group of enzymes may cause this disorder?

А. Proteinases

В. Amylase

С. Lipase

D. Lyases

Е. Aminotransferases

90. In dietology in cases of children milk intolerance a milk is used in which lactose content is diminished enzymatically. What enzyme is used for this purpose?

  1. -galactosidase

  2. –amylase

  3. –glucosidase

  4. –amylase

  5. –glucosidasde

91. Ethylene glycol, the major ingredient in antifreeze, is occasionally consumed by alcoholics as a substitute of true alcohol beverages. In metabolism of ethylene glycol a highly toxic aldehyde is produced, much more toxic than acetaldehyde, produced from ethanol. Ethanol is often administered as a treatment in cases of ethylene glycol poisoning. What is the most likely reason that ethanol is an effective treatment for ethylene glycol poisoning?

  1. Alcohol dehydrogenase (ADH) exhibits a much lower Michaelis constant (Km) for ethanol than for ethylene glycol

  2. Ethanol is an allosteric effector of ADH in addition to being a substrate

  3. Ethanol combines with a toxic product formed by the reaction of ADH with ethylene glycol and converts it to a harmless product

  4. Acetaldehyde, which is produced by the reaction of ADH with ethanol, is of therapeutic value

  5. Ethanol induces another enzyme which effectively metabolize ethylene glycol

92. In a treatement of some infections diseases, sulfanilamide drugs are used, which inhibit the growth of bacteria. What is the mechanism of their action?

  1. They are structural analogs of p-aminobenzoic acid, needed for biosynthesis of folic acid

  2. Allosteric inhibition of bacterial enzymes

  3. They are involved in oxidative-reductive reactions

  4. Inhibit the absorption of folic acid

  5. Irreversibly inhibit biosynthesis of folic acid, needed for normal bacterial survival

93. In blood serum of a patient a marked increase in activity of trypsine, alpha-amylase and lipase was detected. What disease can be suggested?

  1. Acute pancreatitis

  2. Cholelythiasis

  3. Chronic hepatitis

  4. Malignant tumors

  5. Poisoning with insecticides

94. Pharmaceuticals, containing mercury, arsen or other heavy metals, are inhibiting enzymes, posessing sulfhydril groups. What amino acid is used for reactivation of these enzymes?

  1. Cysteine

  2. Histidine

  3. Isoleucine

  4. Aspartic acid

  5. Glycine

95. In recognition of hepatitis the determination the following enzymes activity in blood has diagnostic significance:

A. Amino transferases

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